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Multi-Target Mechanisms of Portulaca oleracea L. in Rheumatoid Arthritis: A Network Pharmacology and Molecular Docking Study

DOI: 10.31038/JPPR.2025811

Abstract

Rheumatoid arthritis (RA), a chronic autoimmune disorder characterized by synovial inflammation and joint destruction, necessitates novel therapeutic strategies due to limitations in current treatments. This study investigates the molecular mechanisms of Portulaca oleracea L. (POL), a traditional medicinal herb with anti-inflammatory and antioxidant properties, in RA management using network pharmacology and molecular docking. Ten bioactive POL components, including quercetin, luteolin, and kaempferol, were identified via the Traditional Chinese Medicine Systems Pharmacology (TCMSP) database, targeting 208 potential human proteins. RA-associated genes (2,142 targets) were curated from GeneCards, OMIM, and TTD, with 134 overlapping targets identified as POL-RA interaction hubs. Protein-protein interaction (PPI) analysis revealed TNF, AKT1, and IL6 as core targets, while Gene Ontology (GO) enrichment highlighted inflammatory response, apoptotic regulation, and cytokine activity. Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis implicated POL in modulating RA-related signaling cascades, including PI3K-Akt, TNF, and IL-17. Molecular docking confirmed strong binding affinities of quercetin (−7.85 kcal/mol with TNF), luteolin (−7.62 kcal/mol with IL6), and kaempferol (−7.52 kcal/mol with TNF), validating their interactions with key targets. These results demonstrate POL’s polypharmacological effects through multi-component, multi-target, and multi-pathway mechanisms, offering a scientific foundation for its development as a complementary RA therapy. This study bridges traditional medicine and systems biology, providing insights into POL’s therapeutic potential and guiding future drug discovery efforts.

Keywords

Portulaca oleracea L, Rheumatoid arthritis, Network pharmacology, Molecular docking

Introduction

Rheumatoid arthritis (RA) is a chronic, systemic autoimmune disease characterized by persistent synovial inflammation, cartilage destruction, and bone erosion, leading to progressive joint damage and systemic complications [1]. Early-stage clinical manifestations of RA typically include joint stiffness, particularly in the morning, swelling, and pain, which are often symmetrical and affect small joints such as those in the hands and feet. As the disease advances, these symptoms may progress to joint deformities, functional impairment, and even permanent disability, significantly impacting patients’ daily lives and overall well-being [2]. With a global prevalence of approximately 0.5–1%, RA is one of the most common autoimmune disorders, disproportionately affecting women and older adults. The disease not only contributes to significant morbidity but also leads to a reduced quality of life and increased healthcare costs due to the need for long-term management and treatment [3]. The pathogenesis of RA is highly complex and involves a multifaceted interplay of genetic predisposition, environmental triggers, and dysregulated immune responses [4]. Genetic factors, such as specific human leukocyte antigen (HLA) alleles, play a critical role in increasing susceptibility to the disease. Environmental triggers, including smoking, infections, and hormonal changes, may further contribute to the onset and progression of RA. These factors collectively lead to the breakdown of immune tolerance, resulting in the activation of autoreactive T and B cells [5]. Once activated, these immune cells initiate a cascade of inflammatory processes, driving the production of pro-inflammatory cytokines such as tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), and interleukin-17 (IL-17). These cytokines perpetuate synovial inflammation, promote the formation of pannus tissue, and contribute to the destruction of cartilage and bone, ultimately leading to joint damage and systemic complications [6]. While multiple hypotheses exist regarding pathogenesis of Rheumatoid arthritis, the exact mechanisms remain unclear [7].

Traditional treatment regimens include the use of disease-modifying antirheumatic drugs (DMARDs), nonsteroidal anti-inflammatory drugs and steroidal anti-inflammatory drugs [8]. Methotrexate (MTX), a cornerstone of antirheumatic drugs, acts as a folate antagonist with anti-proliferative, anti-metabolic, and anti-inflammatory properties. It modulates immune cell infiltration and reduces pro-inflammatory cytokine levels [9]. However, long-term MTX can produce toxicity and side effects such as bone marrow suppression, pulmonary toxicity, nephrotoxicity and an increased risk of infections [10]. NSAIDs, which inhibit cyclooxygenase to suppress prostaglandin synthesis, provide analgesic, antipyretic, and anti-inflammatory benefits. Despite their efficacy, they pose risks of gastrointestinal ulcer complications (bleeding, perforation), renal dysfunction, cardiovascular events, and mortality [11]. Steroidal anti-inflammatory drugs, though effective as anti-inflammatory adjuncts by supplementing cortisol levels, are clinically controversial due to adverse effects including infections, hypertension, cardiovascular disease, metabolic disorders (diabetes, obesity), osteoporosis, and ocular complications (cataracts, glaucoma) [12]. The treatment landscape for RA has evolved dramatically over the past decade, with the introduction of biologic DMARDs (bDMARDs) and targeted synthetic DMARDs (tsDMARDs) revolutionizing disease management [13]. TNF-α inhibitors, such as etanercept and adalimumab, were among the first bDMARDs to demonstrate efficacy in reducing inflammation and halting radiographic progression [14]. Subsequent developments include IL-6 inhibitors (e.g., tocilizumab), B-cell depleting agents (e.g., rituximab), and Janus kinase (JAK) inhibitors (e.g., tofacitinib and baricitinib), which offer alternative mechanisms of action for patients with inadequate responses to conventional therapies [15,16]. Despite these advancements, a significant proportion of patients experience suboptimal responses or adverse effects, highlighting the need for novel therapeutic targets and personalized treatment approaches [17]. In addition to pharmacological interventions, non-pharmacological approaches, such as physical therapy, exercise, and dietary modifications, play a complementary role in RA management. Regular physical activity has been shown to improve joint function, reduce pain, and enhance quality of life in RA patients [18].

Dietary interventions, including the Mediterranean diet and omega-3 fatty acid supplementation, may exert anti-inflammatory effects and modulate disease activity [19]. However, further research is needed to establish standardized guidelines for integrating these modalities into routine clinical practice. Given the limitations and toxicity profiles of existing therapies, there remains an urgent unmet need for safer, more effective pharmacological interventions to improve RA management and patient outcomes. Studies have shown that traditional Chinese herbs may have significant potential in the treatment of rheumatoid arthritis in recent years [20]. Portulaca oleracea L (POL) belonging to the Portulaceae family and the Portulaca genus is an annual fleshy herbaceous plant., Portulaca has a sour taste and a cold nature. It is reported that this herb was used as a kind of food and medicine for thousands of years in China [21]. As a medicinal and edible plant, it has the effects of clearing heat and detoxifying, cooling blood and stopping bleeding, and stopping dysentery; Meanwhile, purslane has multiple functions such as anti-inflammatory, immune regulation, antioxidant, and hypoglycemic effects. It has been used to treat diabetes, headache, gastrointestinal infection and other diseases [22,23]. Studies have shown that purslane extract can alleviate yeast polysaccharide induced joint inflammation in mice by inhibiting Nrf2 expression [24]. Ehsan Karimi et al. conducted a double-blind, randomized controlled clinical trial The findings demonstrated that purslane supplementation significantly alleviated clinical symptoms, including reductions in joint swelling, tenderness frequency, and morning stiffness duration. At the molecular level, purslane administration led to a marked increase in total antioxidant capacity (TAC) and superoxide dismutase (SOD) activity. indicating a potential anti-inflammatory and antioxidant effect of purslane in RA patients [25]. However, the precise mechanism and related signaling pathways of POL reatment for rheumatoid arthritis has not been elucidated. Network pharmacology is a research field based on systems biology, genomics, proteomics and other disciplines, which is a method to discover new drug targets and molecular mechanisms by combining computational analysis with in vivo and in vitro experiments and integrating a large amount of information [26]. It focuses on studying multiple components, multiple targets, and multiple signaling pathways, providing new ideas for the research of traditional Chinese medicine [27]. Within TCM monographs, network pharmacology serves to explore relationships between active components and TCM targets, elucidating mechanisms of action and potential effects [28]. This study investigates the molecular mechanisms underlying Portulaca oleracea L. (POL) in treating rheumatoid arthritis (RA) through integrated network pharmacology and molecular docking, offering novel therapeutic insights and a scientific foundation for further pharmacological exploration.

Materials and Methods

Databases and Software

This study employed the following databases and computational tools: Traditional Chinese Medicine Systems Pharmacology (TCMSP) (http://tcmspw.com/tcmsp.php) was used to identify bioactive compounds in Portulaca oleracea L. (POL) based on pharmacokinetic parameters. GeneCards (http://www.genecards.org), OMIM (https://omim.org), and Therapeutic Target Database (TTD) (https://db.idrblab.org/ttd) were queried to collect rheumatoid arthritis (RA)-related targets. UniProt (https://www.uniprot.org) standardized gene names and species-specific identifiers. Venny 2.1.0 (http://bioinfogp.cnb.csic.es/tools/venny) generated Venn diagrams to identify overlapping targets. STRING (https://string-db.org) constructed protein-protein interaction (PPI) networks with a confidence score cutoff ≥ 0.4. DAVID (https://david.ncifcrf.gov) performed Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses. Cytoscape visualized and analyzed networks, while PyMOL rendered molecular structures. AutoDock 4.2.6 executed molecular docking simulations. PubChem (https://pubchem.ncbi.nlm.nih.gov) and Protein Data Bank (PDB) (https://www.rcsb.org) provided 3D structures of ligands and receptors, respectively. Weishengxin (http://www.bioinformatics.com.cn) visualized enrichment results.

Network Pharmacology Analysis

Prediction of Active Ingredients and Targets in POL

Active ingredients in POL were retrieved from TCMSP using stringent pharmacokinetic filters: oral bioavailability (OB) ≥ 30% and drug-likeness (DL) ≥ 0.18, thresholds established for predicting compounds with therapeutic potential [1]. Corresponding targets were extracted from TCMSP and cross-validated via UniProt to ensure human gene symbol consistency (taxonomic ID: 9606). Non-human or uncharacterized targets were excluded.

Acquisition of RA Disease Targets

RA-associated targets were systematically collected from GeneCards, OMIM, and TTD using “rheumatoid arthritis” as the search term. GeneCards targets were filtered by a relevance score median ≥ 2.41, a statistically validated cutoff to prioritize high-confidence targets [2]. Duplicate entries across databases were removed to compile a non-redundant RA target dataset.

Intersection Target Screening

POL and RA targets were intersected using Venny 2.1.0 to identify shared therapeutic targets. A compound-target network was constructed in Cytoscape, where nodes represented compounds or targets, and edges denoted interactions. Topological parameters (degree, betweenness centrality) were calculated to rank core bioactive components.

Protein–Protein Interaction (PPI) Network Construction and Analysis

Shared targets were uploaded to STRING (organism: Homo sapiens) to build a PPI network with default parameters (confidence score ≥0.4, hidden disconnected nodes). The network was imported into Cytoscape and analyzed using the Network Analyzer plugin. Key targets were prioritized using a composite score integrating degree centrality, betweenness centrality, and closeness centrality, with the top 20 nodes retained for downstream analysis.

Functional and Pathway Enrichment

DAVID was utilized for GO and KEGG analyses with the following settings: species = Homo sapiens, adjusted p-value <0.05, and enrichment score ≥1.5. GO terms were categorized into biological processes (BP), cellular components (CC), and molecular functions (MF). KEGG pathways were filtered for RA relevance (e.g., inflammation, immune regulation). Enriched terms were visualized as bubble charts using Weishengxin. A drug-target-pathway network was constructed to map POL’s multi-scale therapeutic mechanisms.

Molecular Docking Validation

The molecular docking protocol involved three sequential phases: ligand and receptor preparation, docking simulations, and methodological validation. Canonical SMILES of core POL components (e.g., kaempferol, quercetin) were retrieved from PubChem and converted to 3D structures (.mol2 format) using Chem3D, followed by energy minimization with the MMFF94 force field and Gasteiger charge assignment to generate ligand files in .pdbqt format. For receptor preparation, crystal structures of key targets (e.g., TNF-α: PDB ID 2AZ5; AKT1: PDB ID 3O96) were obtained from the Protein Data Bank (PDB), with PyMOL removing heteroatoms and water molecules, and AutoDockTools optimizing hydrogen placement and charge distribution. Docking simulations were performed using AutoDock Vina with a grid box dimension of 25 × 25 × 25 Å centered on the active site, an exhaustiveness parameter of 20 for conformational sampling, and generation of 10 ligand poses ranked by binding affinity (kcal/mol). The lowest-energy conformation was selected for structural visualization in PyMOL, where hydrogen bonding and hydrophobic interactions were annotated. To validate the protocol, co-crystallized ligands were redocked into their respective receptors, achieving a root mean square deviation (RMSD) of <2.0 Å, confirming the reliability of the docking methodology.

Results

Anti-Rheumatoid Arthritis Active Ingredients and Target Proteins of POL

Ten bioactive components in Portulaca oleracea L. (POL) with potential anti-rheumatoid arthritis (RA) activity were identified via the TCMSP database, including quercetin, luteolin, kaempferol, arachidonic acid, β-carotene, β-sitosterol, 5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)chroman-4-one, isobetanidin, isobetan in-qt, and cycloartenol. These compounds were selected based on pharmacokinetic criteria (oral bioavailability ≥30% and drug-likeness ≥0.18). A total of 208 potential POL-related targets were curated using UniProt, with gene symbols standardized to human orthologs.

RA-associated targets were systematically retrieved from GeneCards (2,065 targets), OMIM (48 targets), and TTD (100 targets). After merging datasets and removing duplicates, 2,142 unique RA-related targets were retained. Intersection analysis using a Venn diagram revealed 134 shared targets between POL and RA (Figure 1A), suggesting their critical role in mediating POL’s therapeutic effects. The compound-target network (Figure 1B) highlights quercetin, luteolin, and kaempferol as core bioactive components with the highest connectivity.

Figure 1: (A) Venn diagram of potential targets for the anti- rheumatoid arthritis of POL; (B) compound–target network of POL for anti- rheumatoid arthritis. The middle red diamond node represents POL, the triangle nodes represent the Key POL Components, and the surrounding Rectangular nodes represent the targets that interact with POL.

Screening of Key POL Components for RA Treatment

A compound-target interaction network (Figure 2) was constructed using Cytoscape 3.10.2 to identify critical bioactive components in Portulaca oleracea L. (POL) for rheumatoid arthritis (RA) therapy. Among 11 candidate bioactive components, quercetin, luteolin, and kaempferol exhibited the highest target connectivity (Table 1), suggesting their pivotal role in mediating POL’s therapeutic effects. Cycloartenol was excluded from network analysis due to the absence of associated targets. A multi-layered drug-component-target-disease network was subsequently generated to systematically explore POL’s molecular mechanisms, highlighting synergistic interactions between bioactive compounds and RA-related pathways.

Figure 2: Construction of the drug–target–disease network. The red diamonds symbolize POL and RA, the orange polygons depict the active components of POL, and the blue ellipses represent the core targets of RA.

Table 1: Thirteen components of CA with potential anti-angiogenic activity.

Molecule Name

OB (%) DL

Degree

Quercetin

46.43

0.28

103

Luteolin

36.16

0.25

45

Kaempferol

41.88

0.24

37

Arachidonic acid

45.57

0.2

25

Beta-carotene

37.18

0.58

19

Beta-sitosterol

36.91

0.75

19

5,7-Dihydroxy-2- (3-hydroxy-4-methoxyphenyl)chroman-4-one

47.74

0.27

5

Isobetanidin

59.73

0.52

5

Isobetanin_qt

30.16

0.52

2

Cycloartenol

38.69

0.78

0

Identification of Core Bioactive Components in POL for RA Intervention

To delineate the therapeutic potential of Portulaca oleracea L. (POL) in rheumatoid arthritis (RA), a compound-target interaction network was constructed using Cytoscape 3.10.2. From 110 candidate bioactive components, quercetin, luteolin, and kaempferol demonstrated maximal target connectivity (degree centrality >15), underscoring their centrality in POL’s anti-RA efficacy. Cycloartenol was excluded due to the absence of validated targets in RA pathogenesis. Subsequently, a multi-scale network integrating drugs, components, targets, and disease pathways was generated, revealing synergistic crosstalk between POL-derived phytochemicals and RA-associated signaling cascades (e.g., TNF, IL-17). This systems-level analysis elucidates POL’s polypharmacological mode of action, driven by multi-target engagement.

Protein-Protein Interaction (PPI) Network Construction

The 134 overlapping targets between Portulaca oleracea L. (POL) and rheumatoid arthritis (RA) were analyzed using the STRING database (confidence score ≥0.4, Homo sapiens), and the resultant PPI network was imported into Cytoscape for topological characterization. The network comprised 133 nodes and 3314 edges, with an average node degree of 56.2, reflecting robust interconnectivity (Figure 3). Node importance was quantified via centrality metrics: degree (number of edges), betweenness centrality (bridging role in network paths), and closeness centrality (proximity to other nodes) (Table 2. Visual attributes (node size and color intensity) were scaled proportionally to composite centrality scores. Hierarchical ranking identified TNF, AKT1, and IL6 as top-ranked hub targets, implicating their critical roles in mediating POL’s anti-RA effects through inflammatory and proliferative signaling modulation.

Figure 3: PPI network diagram of therapeutic targets for rheumatoid arthritis.

Table 2: Top 15 anti-rheumatoid arthritis target information in PPI network.

Number

Target name Degree Betweenness centrality

Closeness centrality

1

AKT1

117

0.050

0.898

2

TNF

117

0.041

0.898

3

IL6

116

0.039

0.892

4

IL1B

108

0.026

0.846

5

MMP9

104

0.027

0.825

6

TP53

104

0.019

0.825

7

PTGS2

102

0.022

0.815

8

CASP3

100

0.016

0.805

9

HIF1A

97

0.015

0.791

10

EGFR

95

0.016

0.781

11

BCL2

95

0.016

0.781

12

TGFB1

94

0.014

0.776

13

PPARG

90

0.013

0.759

14

IFNG

87

0.013

0.746

15

MYC

87

0.012

0.746

Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) Pathway Enrichment Analyses

Functional enrichment analysis of Portulaca oleracea L. (POL) targets was performed using DAVID software. Statistical filtering (p < 0.001) identified 223 significant biological processes, 54 cellular components (p < 0.05), 110 molecular functions (p < 0.05), and 126 KEGG pathways (p < 0.001). The enriched GO terms and KEGG pathways were systematically analyzed to infer the potential biological functions of POL targets in rheumatoid arthritis (RA) pathogenesis. In the GO function analysis, the top 10 enriched GO terms across biological processes (BP), cellular components (CC), and molecular functions (MF) were identified based on adjusted p-values (Figure 4A). In BP, significant terms included negative regulation of apoptotic process (GO: 0043066), inflammatory response (GO: 0006954), response to xenobiotic stimulus (GO: 0009410), cellular response to lipopolysaccharide (GO: 0071222), and positive regulation of gene expression (GO: 0010628), highlighting POL’s roles in inflammation modulation, detoxification, and transcriptional regulation. CC enrichment predominantly localized to extracellular space (GO: 0005615), cytosol (GO: 0005829), membrane raft (GO: 0045121), and nucleoplasm (GO: 0005654), suggesting coordinated signaling across extracellular, cytoplasmic, and nuclear compartments. MF analysis revealed critical interactions involving enzyme binding (GO: 0019899), cytokine activity (GO: 0005125), protein kinase activity (GO: 0004672), and RNA polymerase II-specific transcription factor binding (GO: 0061629), underscoring POL’s engagement with enzymatic, signaling, and transcriptional machinery. These findings collectively implicate POL in multi-layered regulatory mechanisms relevant to RA pathology. The top 20 enriched KEGG pathways were identified and visualized as bubble maps (Figure 4B). A drug-target-pathway network integrating POL components, core targets (e.g., TNF, AKT1, IL6), and enriched pathways was constructed in Cytoscape 3.10.2(Figure 5). Key pathways included PI3K-Akt signaling (hsa04151), TNF signaling (hsa04668), IL-17 signaling (hsa04657), AGE-RAGE signaling in diabetic complications (hsa04933), and Fluid shear stress and atherosclerosis (hsa05418). Additional pathways such as Pathways in cancer (hsa05200), Hepatitis B (hsa05161), Apoptosis (hsa04210), and Influenza A (hsa05164) further implicated POL’s regulatory roles in inflammation, proliferation, and immune response. Annotation of pathway-target interactions revealed POL’s multi-target engagement across these cascades, with TNF, AKT1, and IL6 serving as central hubs. These results demonstrate POL’s polypharmacological properties, characterized by synergistic modulation of interconnected signaling networks relevant to rheumatoid arthritis (RA) pathogenesis and associated comorbidities.

Figure 4: Functional enrichment analyses of the target proteins of POL against RA. (A) Top 10 GO terms in the biological processes (p < 0.001), cellular components (p < 0.05), molecular functions (p < 0.05). (B) Top 20 KEGG pathways (p < 0.001). The depth of the circle color represents “- log10 pvalue”, and the size of the circle represents the number of genes enriched in this signaling pathway.

Figure 5: A drug-target-pathway network integrating POL, target and signaling pathways. The diamond represents POL, the rectangle represents the target of POL action, and the purple circle represents the top 20 signaling pathways.

Molecular Docking Validation

To validate the binding interactions between Portulaca oleracea L. (POL) components and rheumatoid arthritis (RA)-associated targets, molecular docking simulations were performed using AutoDock software. The binding affinities (kcal/mol) of quercetin, luteolin, and kaempferol with core targets (TNF, IL6, AKT1) are summarized in Table 3. Quercetin exhibited the strongest binding affinity to TNF (−7.85 kcal/mol), followed by IL6 (−7.06 kcal/mol) and AKT1 (−6.76 kcal/mol). Luteolin demonstrated optimal binding to IL6 (−7.62 kcal/mol), with affinities of −6.73 kcal/mol (TNF) and −7.31 kcal/mol (AKT1). Kaempferol showed preferential binding to TNF (−7.52 kcal/mol), alongside affinities of −6.15 kcal/mol (IL6) and −6.94 kcal/mol (AKT1). Lower binding energy values (more negative) correlate with stronger ligand-receptor interactions, as confirmed by structural visualization of hydrogen bonding and hydrophobic contacts (Figure 6A-I). These results validate POL’s multi-target engagement, with quercetin emerging as the most potent inhibitor of TNF-driven inflammatory signaling, a hallmark of RA pathogenesis.

Table 3: Binding energies of the molecular docking of POL with targets.

 

Quercetin

Luteolin

Kaempferol

TNF

-7.85 kcal/mol -6.73 kcal/mol

-7.52 kcal/mol

AKT1

-6.76 kcal/mol -7.31 kcal/mol

-6.94 kcal/mol

IL-6

-7.06 kcal/mol 7.62 kcal/mol

-6.15 kcal/mol

Figure 6: Molecular docking pattern between pivotal compounds of POL and the core target protein. (A) Quercetin-TNF; (B) Quercetin- AKT1; (C) Quercetin- IL-6; (D) Luteolin- TNF; (E) Luteolin- AKT1; (F) Luteolin- IL-6; (G) Kaempferol- TNF; (H) Kaempferol- AKT1; (I) Kaempferol- IL-6.

Discussion

Portulaca oleracea L. (POL), a traditional herbal medicine with significant ethnopharmacological relevance, exhibits broad therapeutic potential in inflammation, immune regulation, antioxidant activity, and metabolic disorders [30]. While historical texts document its efficacy against diabetes, headaches, and gastrointestinal ailments [31], its molecular mechanisms in rheumatoid arthritis (RA) remain underexplored. Leveraging network pharmacology and molecular docking, this study deciphered POL’s multi-component, multi-target, and multi-pathway anti-RA properties, addressing the complexity inherent to traditional Chinese medicine. Ten bioactive components were identified through pharmacokinetic screening, with quercetin, luteolin, and kaempferol emerging as core constituents. Quercetin, a multifunctional flavonoid, exhibits both anti-inflammatory and anti-ferroptosis properties. Research indicates that quercetin significantly alleviates the pathological progression of osteoarthritis by inhibiting chondrocyte apoptosis and promoting the polarization of synovial macrophages toward the M2 phenotype [32]. Additionally, quercetin promotes bone health through antioxidant pathways and regulates metabolic balance, further highlighting its therapeutic potential in bone and joint diseases [33,34]. Luteolin, a potent immunomodulator, significantly mitigates neutrophil-driven oxidative stress by inhibiting superoxide anion generation, reducing reactive oxygen species (ROS) production, and blocking the formation of neutrophil extracellular traps (NETs) [35]. Moreover, studies have found that luteolin alleviates osteoblast pyroptosis by activating the PI3K-Akt signaling pathway, thereby promoting bone formation and inhibiting bone resorption, which has the remarkable efficacy in the treatment of postmenopausal osteoporosis [36]. Kaempferol plays a crucial role in the treatment of rheumatoid arthritis (RA) by inhibiting the activation of the MAPK signaling pathway. Research has shown that kaempferol blocks the activation of the MAPK pathway in fibroblast-like synoviocytes, thereby inhibiting synovial invasion and regulating bone metabolism [37]. Quercetin, luteolin, and kaempferol synergistically enhance bone repair and significantly suppress inflammatory cascades through multiple molecular mechanisms. These findings provide robust scientific evidence for the osteoprotective and anti-arthritic potential of POL.

Protein-protein interaction (PPI) network analysis has emerged as a powerful tool for identifying key molecular players in complex diseases such as rheumatoid arthritis (RA). Through this approach, TNF, AKT1, and IL6 have been prioritized as pivotal therapeutic targets due to their central roles in the pathogenesis of RA. TNF-α, a master regulator of RA pathogenesis, orchestrates a cascade of inflammatory and destructive processes within the joint microenvironment. It drives chronic inflammation by upregulating pro-inflammatory cytokines such as IL-1β and IL-6, which perpetuate synovial inflammation and contribute to systemic manifestations of the disease [38-40]. Furthermore, TNF-α promotes osteoclastogenesis, leading to bone resorption and joint destruction, while simultaneously inhibiting bone formation through the upregulation of Wnt antagonist DKK-1 [41]. This dual role in bone remodeling underscores its critical involvement in RA progression. IL-6, another key cytokine identified in the PPI network, plays a dual role in immune regulation. While it is essential for mediating acute immune responses, its dysregulation in RA exacerbates disease pathology. IL-6 activates the Jak/STAT-3 and Ras/Erk/C/EBP signaling pathways, which promote T-cell activation, synovial hyperplasia, and the production of additional inflammatory mediators [42-44]. Clinically, the efficacy of IL-6 receptor inhibitors such as tocilizumab and sarilumab has validated IL-6 as a therapeutic target, demonstrating significant reductions in disease activity and joint damage in RA patients [45]. AKT1, a central node in the PI3K/Akt signaling pathway, has also been identified as a critical therapeutic target through PPI network analysis. This kinase modulates a wide range of cellular processes, including inflammation, endothelial apoptosis, and neutrophil infiltration, all of which are implicated in RA pathogenesis [46-48].

KEGG pathway enrichment analysis revealed that POL (the active compound under investigation) is implicated in several rheumatoid arthritis (RA)-related signaling pathways, including the PI3K-Akt, TNF, and MAPK cascades, which are critical to the pathogenesis of RA. The PI3K/Akt signaling axis plays a pivotal role in regulating chondrocyte apoptosis and extracellular matrix (ECM) remodeling, processes central to joint degradation in RA [49,50]. Studies have demonstrated that pharmacological inhibition of the PI3K/Akt pathway attenuates osteoarthritis progression and subchondral bone sclerosis, highlighting its therapeutic potential in inflammatory joint diseases [51-54]. TNF-α, a key pro-inflammatory cytokine in RA, drives synovial inflammation and joint destruction. TNF-α blockade remains a cornerstone of RA therapy, as evidenced by the clinical success of biologics such as etanercept and infliximab. Molecular docking studies have revealed that quercetin, a bioactive component of POL, exhibits strong binding affinity to TNF-α, suggesting a mechanism by which POL may exert its anti-inflammatory effects [55,56]. Furthermore, the MAPK/ERK signaling pathway, which is modulated by POL components, plays a critical role in bone regeneration and inflammation resolution. Activation of MAPK/ERK signaling has been shown to promote osteoblast differentiation and bone formation, while its dysregulation contributes to inflammatory responses in RA [57,58]. MiR-133a can regulate the MAPK/ERK signaling pathway to rescue glucocorticoid induced bone loss [59,60]. These findings collectively position POL as a polypharmacological agent capable of simultaneously targeting multiple pathological pathways, including inflammation, apoptosis, and metabolic dysregulation, thereby offering a holistic and multi-targeted approach to RA management.

Conclusion

This study delineates POL’s anti-RA mechanisms through network pharmacology and molecular docking, emphasizing its multi-target synergy against TNF-α, IL-6, and PI3K/Akt pathways. While promising, further in vivo validation and clinical trials are warranted to translate these insights into therapeutic applications.

Notes

The authors declare no competing financial interest.

References

  1. Smolen JS, Aletaha D, McInnes IB (2016) Rheumatoid arthritis [published correction appears in Lancet.
  2. Smith MH, Berman JR (2022) What Is Rheumatoid Arthritis? JAMA 22. [crossref]
  3. Scott DL, Wolfe F, Huizinga TW (2010) Rheumatoid arthritis. Lancet 25.
  4. Venetsanopoulou AI, Alamanos Y, Voulgari PV, Drosos AA (2023) Epidemiology and Risk Factors for Rheumatoid Arthritis Development. Mediterr J Rheumatol 34: 404-413. [crossref]
  5. McInnes IB, Schett G (2011) The pathogenesis of rheumatoid arthritis. N Engl J Med 365: 2205-2219. [crossref]
  6. McInnes IB, Schett G (2017) Pathogenetic insights from the treatment of rheumatoid arthritis. Lancet 389: 2328-2337. [crossref]
  7. Firestein GS, McInnes IB (2017) Immunopathogenesis of Rheumatoid Arthritis. Immunity 46: 183-196. [crossref]
  8. Demoruelle MK, Deane KD (2012) Treatment strategies in early rheumatoid arthritis and prevention of rheumatoid arthritis. Curr Rheumatol Rep 14: 472-480. [crossref]
  9. Zhao Z, Hua Z, Luo X, Li Y, Yu L, et al. (2022) Application and pharmacological mechanism of methotrexate in rheumatoid arthritis. Biomed Pharmacother 150. [crossref]
  10. Hamed KM, Dighriri IM, Baomar AF, Alharthy BT, Alenazi FE, et al. (2022) Overview of Methotrexate Toxicity: A Comprehensive Literature Review. Cureus 23. [crossref]
  11. Panchal NK, Prince Sabina E (2023) Non-steroidal anti-inflammatory drugs (NSAIDs): A current insight into its molecular mechanism eliciting organ toxicities. Food Chem Toxicol 172. [crossref]
  12. Cutolo M, Shoenfeld Y, Bogdanos DP, Gotelli E, Salvato M, et al. (2024) To treat or not to treat rheumatoid arthritis with glucocorticoids? A reheated debate. Autoimmun Rev 23. [crossref]
  13. Harrington R, Al Nokhatha SA, Conway R (2020) JAK Inhibitors in Rheumatoid Arthritis: An Evidence-Based Review on the Emerging Clinical Data. J Inflamm Res 13: 519-531. [crossref]
  14. Smolen JS, Landewé RBM, Bijlsma JWJ, Burmester GR, Dougados M, et al. (2020) EULAR recommendations for the management of rheumatoid arthritis with synthetic and biological disease-modifying antirheumatic drugs: 2019 update. Ann Rheum Dis 79: 685-699. [crossref]
  15. Radu AF, Bungau SG (2021) Management of Rheumatoid Arthritis: An Overview. Cells 10. [crossref]
  16. Armuzzi A, Lionetti P, Blandizzi C, Caporali R, Chimenti S, et al (2014) anti-TNF agents as therapeutic choice in immune-mediated inflammatory diseases: focus on adalimumab. Int J Immunopathol Pharmacol 27(1 Suppl): 11-32. [crossref]
  17. Tanaka Y (2021) Recent progress in treatments of rheumatoid arthritis: an overview of developments in biologics and small molecules, and remaining unmet needs. Rheumatology (Oxford). 60(Suppl 6). [crossref].
  18. Hurkmans E, van der Giesen FJ, Vliet Vlieland TP, Schoones J, Van den Ende EC (2009) Dynamic exercise programs (aerobic capacity and/or muscle strength training) in patients with rheumatoid arthritis. Cochrane Database Syst Rev. (crossref)
  19. Sköldstam L, Hagfors L, Johansson G (2003) An experimental study of a Mediterranean diet intervention for patients with rheumatoid arthritis. Ann Rheum Dis 62: 208-214. [crossref]
  20. Wang Y, Chen S, Du K, Liang C, Wang S, et al. (2021) Traditional herbal medicine: Therapeutic potential in rheumatoid arthritis. J Ethnopharmacol 279. [crossref]
  21. Ghorani V, Saadat S, Khazdair MR, Gholamnezhad Z, El-Seedi H, et al. (2023) Phytochemical Characteristics and Anti-Inflammatory, Immunoregulatory, and Antioxidant Effects of Portulaca oleracea L.: A Comprehensive Review. Evid Based Complement Alternat Med 2023. [crossref]
  22. Iranshahy M, Javadi B, Iranshahi M, Jahanbakhsh SP, Mahyari S, et al. (2017) A review of traditional uses, phytochemistry and pharmacology of Portulaca oleracea L. J Ethnopharmacol 205: 158-172. [crossref]
  23. Yang Y, Zhou X, Jia G, Li T, Li Y, et al. (2023) Network pharmacology based research into the effect and potential mechanism of Portulaca oleracea L. polysaccharide against ulcerative colitis. Comput Biol Med 161. [crossref]
  24. He Y, Long H, Zou C, Yang W, Jiang L, et al. (2021) Anti-nociceptive effect of Portulaca oleracea L. ethanol extracts attenuated zymosan-induced mouse joint inflammation via inhibition of Nrf2 expression. Innate Immun 27: 230-239. [crossref]
  25. Karimi E, Aryaeian N, Akhlaghi M, Abolghasemi J, Fallah S (2024) The effect of purslane supplementation on clinical outcomes, inflammatory and antioxidant markers in patients with rheumatoid arthritis: A parallel double-blinded randomized controlled clinical trial. Phytomedicine.
  26. Boezio B, Audouze K, Ducrot P, Taboureau O (2017) Network-based Approaches in Pharmacology. Mol Inform 36. [crossref]
  27. Nogales C, Mamdouh ZM, List M, Kiel C, Casas AI, et al. (2022) Network pharmacology: curing causal mechanisms instead of treating symptoms. Trends Pharmacol Sci 43: 136-150. [crossref]
  28. Li L, Yang L, Yang L, He C, He Y, et al. (2023) Network pharmacology: a bright guiding light on the way to explore the personalized precise medication of traditional Chinese medicine. Chin Med 18. [crossref]
  29. Meng XY, Zhang HX, Mezei M, Cui M (2011) Molecular docking: a powerful approach for structure-based drug discovery. Curr Comput Aided Drug Des 7: 146-57. [crossref]
  30. Kumar A, Sreedharan S, Kashyap AK, Singh P, Ramchiary N (2021) A review on bioactive phytochemicals and ethnopharmacological potential of purslane (Portulaca oleracea L). Heliyon 8. [crossref]
  31. Iranshahy M, Javadi B, Iranshahi M, Jahanbakhsh SP, Mahyari S, et al. (2017) A review of traditional uses, phytochemistry and pharmacology of Portulaca oleracea L. J Ethnopharmacol 205: 158-172. [crossref]
  32. Hu Y, Gui Z, Zhou Y, Xia L, Lin K, et al. (2019) Quercetin alleviates rat osteoarthritis by inhibiting inflammation and apoptosis of chondrocytes, modulating synovial macrophages polarization to M2 macrophages. Free Radic Biol Med 145: 146-160. [crossref]
  33. Feng Y, Dang X, Zheng P, Liu Y, Liu D, et al. (2024) Quercetin in Osteoporosis Treatment: A Comprehensive Review of Its Mechanisms and Therapeutic Potential. Curr Osteoporos Rep 22: 353-365. [crossref]
  34. Yamaura K, Nelson AL, Nishimura H, Rutledge JC, Ravuri SK, et al. (2023) Therapeutic potential of senolytic agent quercetin in osteoarthritis: A systematic review and meta-analysis of preclinical studies. Ageing Res Rev 90. [crossref]
  35. Yang SC, Chen PJ, Chang SH, Weng YT, Chang FR, et al. (2018) Luteolin attenuates neutrophilic oxidative stress and inflammatory arthritis by inhibiting Raf1 activity. Biochem Pharmacol 154: 384-396. [crossref]
  36. Chai S, Yang Y, Wei L, Cao Y, Ma J, et al. (2024) Luteolin rescues postmenopausal osteoporosis elicited by OVX through alleviating osteoblast pyroptosis via activating PI3K-AKT signaling. Phytomedicine 128. [crossref]
  37. Pan D, Li N, Liu Y, Xu Q, Liu Q, et al. (2018) Kaempferol inhibits the migration and invasion of rheumatoid arthritis fibroblast-like synoviocytes by blocking activation of the MAPK pathway. Int Immunopharmacol 55: 174-182. [crossref]
  38. Kalliolias GD, Ivashkiv LB (2016) TNF biology, pathogenic mechanisms and emerging therapeutic strategies. Nat Rev Rheumatol 12: 49-62. [crossref]
  39. Lee SJ, Lee A, Hwang SR, Park JS, Jang J, et al. (2014) TNF-α gene silencing using polymerized siRNA/thiolated glycol chitosan nanoparticles for rheumatoid arthritis. Mol Ther 22: 397-408. [crossref]
  40. Moelants E-A, Mortier A, Van Damme J, et al. (2013) Regulation of TNF-α with a focus on rheumatoid arthritis. Immunol Cell Biol 91: 393-401. [crossref]
  41. Cici D, Corrado A, Rotondo C, Cantatore FP (2019) Wnt Signaling and Biological Therapy in Rheumatoid Arthritis and Spondyloarthritis. Int J Mol Sci 20. [crossref]
  42. Tanaka T, Narazaki M, Kishimoto T (2014) IL-6 in inflammation, immunity, and disease. Cold Spring Harb Perspect Biol 4. [crossref]
  43. Neurath MF, Finotto S (2011) IL-6 signaling in autoimmunity, chronic inflammation and inflammation-associated cancer. Cytokine Growth Factor Rev 22: 83-89. [crossref]
  44. Huizinga TW, Fleischmann RM, Jasson M, Radin AR, van Adelsberg J, et al. (2014) Sarilumab, a fully human monoclonal antibody against IL-6Rα in patients with rheumatoid arthritis and an inadequate response to methotrexate: efficacy and safety results from the randomised SARIL-RA-MOBILITY Part A trial. Ann Rheum Dis 73: 1626-1634. [crossref]
  45. Scott LJ (2017) Tocilizumab: A Review in Rheumatoid Arthritis. Drugs 77: 1865-1879. [crossref]
  46. Cheng C, Zhang J, Li X, Xue F, Cao L, et al. (2023) NPRC deletion mitigated atherosclerosis by inhibiting oxidative stress, inflammation and apoptosis in ApoE knockout mice. Signal Transduct Target Ther 8. [crossref]
  47. Di Lorenzo A, Fernández-Hernando C, Cirino G, Sessa WC (2009) Akt1 is critical for acute inflammation and histamine-mediated vascular leakage. Proc Natl Acad Sci U S A. Aug 25;106(34): 14552-14557. [crossref]
  48. Gao WL, Li XH, Dun XP, Jing XK, Yang K, et al. (2020) Grape Seed Proanthocyanidin Extract Ameliorates Streptozotocin-induced Cognitive and Synaptic Plasticity Deficits by Inhibiting Oxidative Stress and Preserving AKT and ERK Activities. Curr Med Sci 40: 434-443. [crossref]
  49. Peng Y, Wang Y, Zhou C, Mei W, Zeng C. PI3K/Akt/mTOR Pathway and Its Role in Cancer Therapeutics: Are We Making Headway? Front Oncol. 2022 Mar 24;12: 819128. [crossref]
  50. Sun K, Luo J, Guo J, Yao X, Jing X, et al. (2020) The PI3K/AKT/mTOR signaling pathway in osteoarthritis: a narrative review. Osteoarthritis Cartilage 28: 400-409. [crossref]
  51. Ba X, Huang Y, Shen P, Huang Y, Wang H, et al. (2021) WTD Attenuating Rheumatoid Arthritis via Suppressing Angiogenesis and Modulating the PI3K/AKT/mTOR/HIF-1α Pathway. Front Pharmacol 27. [crossref]
  52. Liu C, He L, Wang J, Wang Q, Sun C, et al. (2020) Anti-angiogenic effect of Shikonin in rheumatoid arthritis by downregulating PI3K/AKT and MAPKs signaling pathways. J Ethnopharmacol 260. [crossref]
  53. Shi X, Jie L, Wu P, Zhang N, Mao J, et al. (2022) Calycosin mitigates chondrocyte inflammation and apoptosis by inhibiting the PI3K/AKT and NF-κB pathways. J Ethnopharmacol 28. [crossref]
  54. Lin C, Shao Y, Zeng C, Zhao C, Fang H, et al. (2018) Blocking PI3K/AKT signaling inhibits bone sclerosis in subchondral bone and attenuates post-traumatic osteoarthritis. J Cell Physiol 233: 6135-6147. [crossref]
  55. Lewis MJ (2024) Predicting best treatment in rheumatoid arthritis. Semin Arthritis Rheum 64S.[crossref]
  56. Li H, Shi W, Shen T, Hui S, Hou M, et al. (2023) Network pharmacology-based strategy for predicting therapy targets of Ecliptae Herba on breast cancer. Medicine (Baltimore) 102. [crossref]
  57. Zhou T, Guo S, Zhang Y, Weng Y, Wang L, et al. (2017) GATA4 regulates osteoblastic differentiation and bone remodeling via p38-mediated signaling. J Mol Histol 48: 187-197. [crossref]
  58. Wu Y, Xia L, Zhou Y, Xu Y, Jiang X (2015) Icariin induces osteogenic differentiation of bone mesenchymal stem cells in a MAPK-dependent manner. Cell Prolif 48: 375-384. [crossref]
  59. Wang G, Wang F, Zhang L, Yan C, Zhang Y (2021) miR-133a silencing rescues glucocorticoid-induced bone loss by regulating the MAPK/ERK signaling pathway. Stem Cell Res Ther 12. [crossref]
  60. Chen L, Zhan CZ, Wang T, You H, Yao R (2020) Curcumin Inhibits the Proliferation, Migration, Invasion, and Apoptosis of Diffuse Large B-Cell Lymphoma Cell Line by Regulating MiR-21/VHL Axis. Yonsei Med J 61: 20-29. [crossref]

Can Artificial Intelligence Revolutionize Mental Health? Exploring Cognitive Models, Chatbots, and Future Trends in Digital Psychotherapy and Stress Resilience for Enhanced Emotional Well-being

DOI: 10.31038/AWHC.2025822

Abstract

Mental health challenges among adults and children are becoming increasingly prevalent globally, with technology offering a promising approach for timely interventions. Artificial Intelligence (AI) has emerged as a key player in enhancing mental health care, particularly through cognitive computer-centered models that enable digital analysis of mental health. However, despite its potential, there is limited consensus on AI’s role in mental health care. The novelty of the review lies in its comprehensive assessment of AI-driven digital models that analyze mental health in real-time, integrating data from various digital activities. A systematic approach was adopted to review relevant literature from 2024, including studies on AI in psychotherapy, mental health assessment, and stress detection. For the review, studies were selected based on relevance to AI in mental health, with inclusion criteria exploring AI applications in mental healthcare. Data was extracted systematically, including study design, interventions, outcomes, and AI technologies used. Synthesis involved qualitative analysis of findings to assess trends, challenges, and innovations in AI-driven mental health care. Results indicate that AI technologies, particularly chatbots and machine learning models, have shown promise in identifying mental health issues, offering personalized interventions, and providing real-time emotional support. However, challenges related to privacy, ethical concerns, and the need for more robust datasets were identified. The discussion highlights the need for continuous improvements in AI accuracy and the integration of human oversight to ensure effective mental health care. The conclusion emphasizes the transformative potential of AI in mental health but calls for further research to address existing limitations. Implications for practice suggest that AI could be incorporated into digital mental health interventions, particularly in resource-limited settings. Future research should focus on refining AI algorithms, improving data security, and conducting large-scale clinical trials to assess long-term effectiveness in diverse populations. Limitations include small sample sizes and limited long-term data.

Keywords

Artificial intelligence in health, Mental health, Digital interventions, Psychotherapy, AI-driven mental health assessments

Introduction

The integration of Artificial Intelligence into mental health care has rapidly gained momentum, offering innovative solutions to diagnose, treat, and manage various mental health conditions. AI has the potential to improve the accuracy and efficiency of mental health assessments, enable personalized treatments, and provide scalable solutions for managing large patient populations. However, despite the advancements, there are several critical challenges that hinder the full-scale implementation of AI technologies in this domain. One significant challenge is the lack of transparency and explainability in AI models, particularly those that rely on deep learning techniques. These models, while highly accurate, are often considered “black boxes,” making it difficult to interpret how they arrive at their conclusions. This lack of interpretability can be a significant barrier to widespread adoption in healthcare settings. As noted by [1], Explainable AI (XAI) techniques have emerged as a solution to this issue, helping make AI decisions more transparent and understandable. XAI could provide clearer insights into the rationale behind AI-driven diagnoses and treatment suggestions, thus enhancing trust among healthcare providers and patients. Without this transparency, there is a risk that healthcare professionals and patients may be reluctant to fully trust or adopt AI-driven solutions, especially when it involves critical mental health decisions. [2] also raised concerns about the balance between interpretability and accuracy in AI models used for mental health assessment. While explainability is essential, it should not come at the cost of the model’s ability to provide accurate diagnoses or predictions. The complexity of mental health disorders, which often involve nuanced psychological and emotional factors, requires AI models that can effectively balance these two aspects. Striking this balance is a practical challenge that requires further refinement in AI techniques to ensure both reliability and transparency. These issues contribute to a wider problem of the limited acceptance of AI in clinical settings. Mental health professionals may be hesitant to rely on AI tools due to concerns about their accuracy, the complexity of their deployment, or the lack of a clear understanding of how AI systems work. Consequently, for AI to reach its full potential in mental health care, these challenges must be addressed, and further research is needed to develop more interpretable, reliable, and ethically sound AI models.

The integration of Artificial Intelligence into mental health care is not only driven by technological potential but also accompanied by significant data privacy and ethical concerns. AI applications frequently require access to sensitive patient data, which heightens the risks associated with data security, privacy breaches, and potential misuse of personal health information. As [3] discusses in his comprehensive evaluation of digital mental health literature, these concerns extend to issues of consent, data ownership, and patient autonomy. Ensuring that AI systems are compliant with data protection regulations, such as the General Data Protection Regulation (GDPR) in the European Union or similar laws in other jurisdictions, is crucial. These regulations aim to protect patient privacy and prevent misuse of personal information yet navigating these legal requirements while implementing AI technologies remains a complex challenge. Healthcare providers and developers must prioritize robust data encryption, anonymization techniques, and secure data storage solutions to safeguard sensitive patient information. Ethical considerations also extend to societal and cultural differences that may affect AI-driven mental health care outcomes. [4] highlights the importance of addressing these differences to prevent potential bias and ensure fair treatment. For instance, AI models trained on datasets from predominantly Western populations might not perform as effectively for individuals from diverse cultural backgrounds, leading to inequitable care. To mitigate this issue, AI systems need to be designed with sensitivity to cultural norms, language differences, and the unique mental health needs of various demographic groups. This requires ongoing efforts in diverse data collection, culturally relevant content, and inclusive design practices to create more universally applicable AI solutions.

In addition to ethical and privacy concerns, the accessibility and affordability of AI technologies pose significant barriers to their widespread adoption in mental health care. Gallegos et al. (2024) discuss the potential for AI chatbots to improve mental health but emphasize that their deployment should address issues of accessibility and affordability. Marginalized populations may face barriers such as limited technological access, poor internet connectivity, and financial constraints that prevent them from benefiting from AI-driven tools. For AI to truly transform mental health care, it must be designed to reach all segments of society, including those who might otherwise be excluded due to economic or geographical limitations. Furthermore, the lack of standardized approaches to AI implementation in mental health care complicates efforts to scale and integrate AI interventions effectively. [5] argue that while AI has the potential to revolutionize mental health care, its implementation must be aligned with existing clinical practices and protocols. There is currently no consensus on best practices or regulatory frameworks for the deployment of AI technologies in mental health, leading to inconsistencies in implementation and potential discrepancies in care quality. Establishing standardized models and guidelines for AI use in mental health care is essential for ensuring that AI interventions are safe, effective, and equitable across diverse healthcare settings. Lastly, stigma and skepticism about the role of AI in addressing mental health concerns continue to pose significant challenges. Despite promising applications like cognitive behavioral therapy (CBT) facilitated by AI, as demonstrated by [6], there remains a prevailing skepticism about the effectiveness of AI for serious mental health conditions. The stigma associated with mental health can deter individuals from seeking help through AI systems, as patients may prefer traditional human interactions over engaging with AI-driven tools. Overcoming this skepticism requires targeted education, transparent communication about the benefits and limitations of AI, and demonstrating tangible improvements in mental health outcomes through AI interventions.

The primary objective of the review is to synthesize the growing body of research on AI applications in mental health, focusing on identifying challenges and opportunities for further development. The review aims to explore the role of AI in mental health care, examining various applications such as AI-based diagnostics, chatbots for psychotherapy, and tools for stress detection and resilience building. [7] highlighted AI’s significant potential in stress detection and interventions aimed at building resilience, emphasizing its expanding role in mental health care. Additionally, the review seeks to assess the impact of AI on mental health care by evaluating the effectiveness of AI-driven interventions in improving diagnosis, treatment, and patient monitoring, and its potential to expand access to mental health services. [8] demonstrated how AI can help in understanding complex mental health challenges, particularly in contexts such as war and emotional trauma, highlighting its broader impact. The review will also address ethical, legal, and privacy concerns associated with AI in mental health, including the security of patient data, issues of consent, and AI’s role in clinical decision-making. [3] stressed the importance of tackling these concerns to ensure AI applications are developed and deployed responsibly. Furthermore, the review will identify gaps in the literature and propose directions for future research, particularly in improving AI model transparency and establishing standards for AI-based mental health interventions. [9] suggested that while AI has great potential in enhancing positive mental health, future research should focus on refining these technologies and integrating them into mainstream healthcare systems. Finally, the review will assess technological innovations in the mental health space, especially AI-driven stress detection and intervention technologies. [7] noted the significant advancements in stress detection and resilience-building interventions through AI, an area that offers ample opportunities for future exploration and refinement. By synthesizing existing research, the review aims to provide a comprehensive overview of AI’s current and future impact on mental health care, identifying areas that require further investigation and development.

The novelty of the review lies in its ability to integrate a diverse set of studies, offering a comprehensive and holistic analysis of AI’s role in mental health care, which has not been fully explored in previous literature. While earlier reviews have primarily concentrated on specific applications, such as digital health interventions [10] or the role of AI in psychotherapy [6], the review stands out by encompassing a broad spectrum of AI applications, ranging from AI-driven chatbots to AI-based stress detection tools. This comprehensive synthesis enables a more nuanced understanding of AI’s impact across various facets of mental health care, shedding light on the potential for AI to transform diagnosis, treatment, and patient monitoring. Another unique contribution of the review is its strong focus on the ethical, privacy, and accessibility challenges associated with AI in mental health. While some studies, such as those by [4,11], have acknowledged these concerns, few reviews have delved deeply into how these challenges can be mitigated to enable the successful integration of AI into mental health care systems. Addressing these issues is crucial for ensuring that AI applications not only enhance the quality of care but also protect patient privacy, promote informed consent, and ensure equitable access, particularly among underserved populations. The review, therefore, provides a much-needed exploration of how these ethical and accessibility barriers can be overcome, offering novel insights for developers, healthcare professionals, and policymakers. Furthermore, the review aims to identify gaps in the current body of literature, an area that remains underexplored. It highlights critical issues such as the lack of standardized approaches to AI implementation, the need for improved transparency in AI models, and the potential for AI to serve marginalized groups. [1] emphasized the importance of explainable AI (XAI), yet this aspect remains inadequately studied, presenting a vital area for future research. The review thus not only synthesizes existing knowledge but also paves the way for future investigations into these gaps. Additionally, the review is distinguished by its cross-disciplinary approach, drawing from diverse fields such as stress resilience, mental health, cybersecurity, and healthcare policy. By integrating research from various domains, the review bridges gaps between technological and healthcare disciplines, offering a more comprehensive and multifaceted understanding of AI’s potential in mental health. For instance, studies by [4] highlight the importance of aligning AI technologies with healthcare policies and risk management practices, suggesting that collaboration across disciplines is necessary to address the complex challenges posed by AI integration into mental health care. This interdisciplinary perspective enables a more holistic view of AI’s potential to revolutionize mental health services, ensuring that its adoption is both effective and ethically sound. Ultimately, the review provides a valuable contribution to the literature by synthesizing recent studies on AI in mental health, highlighting key challenges, objectives, and future directions for research. It not only offers a comprehensive analysis of AI’s current and potential impact but also pushes the boundaries of existing knowledge, providing new perspectives on how AI can improve mental health outcomes globally. Researchers, policymakers, and healthcare professionals will find the review particularly valuable as they seek to explore the transformative potential of AI in mental health care, as it offers novel insights into the ways AI can be ethically and effectively integrated into mental health systems worldwide.

Methods

The systematic approach employed for the review was designed to rigorously analyze the current state of artificial intelligence applications in mental health, ensuring the inclusion of high-quality, relevant, and methodologically sound studies. The eligibility criteria formed the foundation for selecting articles that align with the review’s objectives, focusing on the integration of AI in mental health diagnostics, interventions, and therapeutic practices. Topic relevance was the foremost inclusion criterion, ensuring that only studies explicitly addressing AI’s role in areas such as cognitive analysis, psychotherapy, and digital mental health interventions were considered. To maintain the review’s relevance to contemporary advancements, only articles published in 2024 were included, reflecting the latest innovations and research in the field. Moreover, the credibility of the sources was paramount; thus, only studies appearing in peer-reviewed journals or conference proceedings were selected to guarantee methodological rigor and reliability. The criteria for methodological rigor ensured that each study provided comprehensive details on its research design, the AI techniques employed, and the mental health outcomes investigated, offering a robust understanding of the domain. To encompass a broad scope, the review included studies addressing geographical and demographic diversity, analyzing AI-driven mental health interventions across varied populations, including children, adolescents, and adults. Lastly, language served as a practical criterion, with only studies published in English being reviewed, ensuring accessibility and uniformity in understanding. These meticulously designed eligibility criteria provided a structured framework for identifying and selecting studies, enabling a focused and comprehensive evaluation of how AI is transforming mental health care, particularly through cutting-edge technologies and innovative applications. By adhering to these criteria, the review ensured a robust selection process that laid the groundwork for meaningful analysis and insights into this rapidly evolving field.

The exclusion criteria were meticulously defined to maintain the focus and rigor of the review, ensuring that only high-quality, relevant studies were included in the analysis. First, articles that discussed mental health without a substantial emphasis on artificial intelligence or its related technologies were excluded. This step was critical to aligning the review’s objectives with its scope, which aimed to investigate AI-driven advancements in mental health care rather than general mental health studies. For instance, papers that solely addressed traditional psychological interventions, mental health theories, or demographic studies without integrating AI applications were deemed outside the purview of the review. Secondly, studies for which the full text was not accessible were excluded to ensure comprehensive data extraction and accurate assessment. Abstract-only records, unavailable manuscripts, or restricted-access documents posed a significant limitation as they hindered the ability to verify methodology, results, and conclusions, which are crucial for systematic evaluation. Thirdly, non-research articles such as editorials, opinion pieces, and commentaries were excluded to maintain the academic rigor of the review. While such articles may provide valuable insights or contextual discussions, they often lack the methodological framework and empirical evidence required for systematic analysis. Similarly, conference abstracts or summary presentations were excluded due to insufficient detail about study design, methods, or outcomes. These exclusion criteria were essential to uphold the review’s methodological integrity, ensuring that only peer-reviewed, full-text studies with a clear focus on AI applications in mental health were included. This rigorous selection process minimized biases, enhanced the reliability of findings, and supported the synthesis of actionable insights that could contribute meaningfully to the field of AI in mental health.

The study selection process was meticulously designed and implemented through a systematic three-phase approach to ensure the inclusion of high-quality and relevant studies. The first phase, Identification, involved a comprehensive search strategy leveraging academic databases such as PubMed, Scopus, and IEEE Xplore. The search utilized carefully selected keywords, including “Artificial Intelligence,” “mental health,” “digital interventions,” “psychotherapy,” and “AI-enabled cognitive analysis,” to capture a broad yet focused range of relevant studies. In addition to database searches, manual screening of bibliographies of identified articles was conducted to locate supplementary studies that might not have been retrieved during the initial search. This dual approach aimed to enhance the comprehensiveness of the study pool while minimizing the risk of missing relevant literature. The second phase, Screening, focused on an initial review of the titles and abstracts of the identified articles. Two independent reviewers systematically assessed these materials to determine their relevance to the study’s objectives. The dual-reviewer approach minimized subjective bias and ensured consistency in the selection process. Articles failing to meet the inclusion criteria such as those with a non-AI focus, lacking methodological rigor, or not published in peer-reviewed journals were excluded at this stage. This process allowed for the rapid elimination of irrelevant or low-quality studies, ensuring that only potentially relevant articles progressed to the next phase. The third phase, Eligibility, involved a detailed review of the full texts of shortlisted articles. This step was critical in verifying the studies’ alignment with the defined inclusion criteria, such as the focus on AI applications in mental health and sufficient methodological detail. Discrepancies between the two reviewers during the eligibility phase were addressed through discussions, and if necessary, a third reviewer was consulted to achieve consensus. This collaborative resolution process ensured a fair and accurate evaluation of borderline cases, further strengthening the reliability of the selection process. The outcome of this rigorous process was the identification of 12 high-quality studies out of the 50 initially retrieved articles. These studies were selected based on their adherence to the inclusion criteria and their ability to contribute valuable insights to the review. By employing a systematic and transparent approach to study selection, the review ensured that the included literature represented a comprehensive and credible basis for analyzing the role of artificial intelligence in mental health interventions. This robust process underscores the reliability and validity of the subsequent findings and conclusions drawn in the review.

The data extraction process was carried out with precision and adherence to a standardized protocol to ensure consistency and comprehensiveness across all included studies. Key information from each study was systematically recorded in a predefined data extraction sheet, structured to capture all critical elements of relevance. This structured approach began with general information, encompassing the names of authors, the year of publication, and the source of the study, whether it was a journal article or conference proceeding. This basic information provided context and facilitated traceability of the literature. The study objectives section captured the primary research questions or hypotheses addressed in each study, ensuring that the focus on the intersection of AI and mental health was adequately documented. This section also included specific details about how the study explored the role of AI technologies in mental health interventions, such as the use of cognitive models or digital tools. These objectives helped categorize the studies according to their thematic and technological focus, aiding in a more nuanced synthesis of findings. Details of the methodological approaches used in each study were also extracted, ensuring that the review considered a diverse array of research designs. The methodology section captured study designs such as experimental studies, narrative reviews, or bibliometric analyses. Population or sample characteristics, including the demographics or specific groups studied, were noted to assess the generalizability of the findings. For instance, some studies focused on children or adolescents, while others considered broader populations or specialized groups like war-affected individuals. The AI techniques or models employed, such as machine learning algorithms, explainable AI (XAI) frameworks, or chatbot technologies, were also documented. This level of detail provided insights into the technological innovations being applied in the mental health domain and their potential scalability.

The key findings of each study were carefully extracted, focusing on the mental health outcomes analyzed and the unique contributions of the research to AI applications in mental health. Innovations, such as the development of novel AI models or strategies for improving mental health outcomes, were highlighted alongside any limitations noted by the authors. This helped contextualize the studies’ contributions and identify gaps in the literature. Finally, the impact and implications section addressed the real-world applicability of the studies and the future directions proposed by the authors. This included potential applications of the findings in clinical practice, digital therapy, or mental health policy. Additionally, forward-looking insights into how the integration of AI could evolve within the mental health domain were documented. These elements ensured that the review captured not only the current state of research but also its trajectory and implications for future innovation. Overall, this rigorous data extraction process ensured a consistent, in-depth understanding of the included studies, facilitating a comprehensive synthesis of their contributions to the field of AI in mental health.

The data synthesis process employed a structured narrative synthesis approach, focusing on identifying, analyzing, and integrating key themes and trends from the selected studies. The first step, thematic analysis, involved categorizing the extracted data into thematic clusters to explore recurring concepts and areas of focus. One prominent theme was AI-driven diagnostics, as highlighted by [2,10], who discussed the use of cognitive computer-centered digital models for early detection of mental health issues, particularly in children and adolescents. This theme underscored the potential of AI in transforming traditional diagnostic processes by enabling more accurate and timely assessments. Another critical theme was digital interventions and chatbots, with [5] emphasizing the role of AI-powered chatbots in augmenting mental health support systems by offering accessible, immediate, and scalable interventions. A further thematic cluster was explainable AI (XAI) in psychotherapy, explored by [1], which addressed the growing demand for transparency and accountability in AI-driven mental health interventions. XAI models were noted for their potential to enhance trust and efficacy in AI applications by allowing clinicians and patients to understand AI-driven decisions. Lastly, studies like [9] focused on positive mental health and resilience, highlighting AI’s capacity to foster psychological well-being through interventions designed to build resilience and mitigate stress.

The second step, comparative analysis, juxtaposed studies based on their methodologies, AI models, and outcomes. For instance, [7] demonstrated the use of stress-detection algorithms to monitor and intervene in mental health conditions, whereas [8] explored AI applications in analyzing the mental health impacts of war. Comparing these innovations revealed the versatility of AI in addressing diverse mental health challenges and its advantages over traditional therapeutic methods in terms of scalability and precision. Studies also varied in their populations, ranging from adolescents to war-affected individuals, highlighting the adaptability of AI to different demographic and contextual needs. The final step, integration of results, synthesized key findings into a comprehensive narrative. Emerging trends, such as AI’s role in adolescent mental health assessment [2], were emphasized as critical areas of growth. Concurrently, limitations like ethical concerns, data privacy challenges, and biases in AI models, as discussed by [12], were noted as significant hurdles that must be addressed. Future directions proposed by the authors, such as the integration of AI into telepsychiatry [4], were identified as promising avenues for expanding the impact of AI in mental health care. In conclusion, this systematic review methodically analyzed studies published in 2024 to evaluate the state of AI-driven mental health interventions. By adopting rigorous eligibility criteria, a structured study selection process, and a narrative synthesis approach, the review provided a holistic understanding of the advancements, challenges, and potential of AI in mental healthcare. To fully leverage AI’s transformative capabilities, future research must prioritize addressing ethical concerns, improving AI transparency, and exploring underrepresented populations to ensure equitable access to these innovative interventions. This synthesis not only outlines the current landscape but also offers a roadmap for future exploration and application of AI in mental health.

Results and Findings

Artificial intelligence is making significant strides in transforming the landscape of mental health care, offering new opportunities to diagnose, monitor, and intervene in mental health conditions with unprecedented precision. AI’s integration into mental health has garnered considerable attention in recent years, particularly for its potential to enhance diagnostic accuracy, personalize interventions, and improve overall mental well-being. By leveraging advanced technologies such as machine learning algorithms, AI can analyze vast amounts of data, identifying patterns and markers that may otherwise go unnoticed by human clinicians. One notable example is the work of [10], who developed a cognitive computer-centered digital analysis model specifically designed for assessing children’s mental health. Children are often an overlooked group in traditional mental health assessments, making early detection of mental health disorders crucial for effective intervention. Agarwal & Sharma’s AI model utilizes behavioral patterns and digital markers to provide a more objective and accurate approach to diagnosis. Their study highlights the remarkable capability of AI to enhance diagnostic accuracy by up to 85%, significantly outperforming traditional methods, which typically rely on subjective judgment and manual assessments. This advancement is particularly impactful in the context of pediatric mental health, where early intervention is key to improving long-term outcomes. The AI-driven model’s ability to identify subtle patterns in data offers a deeper level of insight into children’s mental health, which may not be immediately apparent through conventional methods. This is especially significant given that many mental health issues in children go undiagnosed due to the complexity of the symptoms and the challenges of assessing them through traditional means. AI’s ability to detect these patterns before they become more pronounced allows for timely interventions, potentially preventing more severe conditions from developing in the future. Furthermore, the study underscores AI’s transformative role in reshaping mental health diagnostics by offering a more consistent, objective, and accurate approach. This is especially critical in addressing the mental health needs of vulnerable populations like children, who may not have access to specialized care or may not be able to articulate their experiences effectively. AI’s ability to provide more reliable and accessible mental health assessments promises to democratize mental health care, ensuring that individuals receive the attention they need regardless of their location or socio-economic status. Overall, the research by [10] exemplifies the growing impact of AI on mental health care, emphasizing its potential to revolutionize how conditions are identified, diagnosed, and treated, with significant implications for enhancing mental well-being across various age groups, particularly those most at risk of being overlooked in traditional settings.

[3] bibliometric analysis provides a thorough examination of the rising role of artificial intelligence in digital mental health research, offering valuable insights into the evolving landscape of AI-powered mental health interventions. The study uncovers significant trends in the application of AI, particularly the increasing adoption of AI technologies in predictive modeling and personalized care. These technologies enable the development of tools for real-time mental health monitoring, allowing for the continuous observation of individuals’ mental well-being. One of the key findings of the analysis is AI’s remarkable ability to predict mental health conditions before they become clinically evident, a breakthrough that could revolutionize preventive care. Predictive AI models can potentially detect early warning signs of mental health disorders, allowing for timely interventions that prevent the onset of more severe conditions. This proactive approach is a significant advancement over traditional models, which often focus on treating mental health conditions after they have already manifested. However, while the promise of AI in preventive care is substantial, [3] also identifies significant challenges in the field, particularly related to ethical considerations and data security. As AI technologies are increasingly used to handle sensitive mental health data, the risks associated with privacy breaches, misuse of data, and the potential for algorithmic bias become more pronounced. Alan emphasizes the need for robust data protection measures and ethical guidelines to ensure the responsible use of AI in mental health applications. This includes safeguarding personal information, preventing discriminatory outcomes, and ensuring the AI models are transparent and accountable. To address these issues, Alan calls for greater interdisciplinary collaboration between AI developers, mental health professionals, and policymakers. Such collaboration is crucial to ensure that AI tools are designed with both ethical and practical considerations in mind, promoting safe and equitable access to mental health care. As AI continues to advance, its potential to transform mental health care is immense, but careful attention to ethical and security challenges will be paramount in ensuring that the benefits of these technologies are realized without compromising individual rights or well-being.

In a similar vein, [4] explores the effectiveness of AI in real-time mental health monitoring and personalized interventions, offering a comprehensive overview of how AI is being used to enhance mental health care delivery, especially in resource-limited settings. The study highlights AI’s potential to automate diagnostic processes, making it possible to scale mental health interventions in ways that traditional models could not. By enabling continuous monitoring without the need for direct human intervention, AI provides a unique advantage in the management of mental health conditions. This capability is particularly valuable in detecting early signs of mental health issues, which can be addressed before they escalate into more severe conditions. Alhuwaydi also stresses that continuous surveillance through AI can mitigate the progression of mental health issues by allowing for immediate intervention, thus preventing long-term negative outcomes. The ability of AI to monitor individuals over time, using real-time data from various sources such as wearables or digital health platforms, means that interventions can be timelier and more personalized, responding to changes in an individual’s mental health status as they occur. However, like Alan, Alhuwaydi also underscores the need for regulatory frameworks to address potential risks associated with the use of AI in mental health. One of the key concerns highlighted by the study is the risk of bias in AI algorithms, which could lead to inaccurate assessments or disproportionate impacts on certain populations. Alhuwaydi argues that AI models must be designed with fairness and equity in mind, ensuring they deliver accurate and unbiased assessments across diverse populations. This includes accounting for demographic factors such as age, gender, race, and socioeconomic status to avoid exacerbating existing disparities in mental health care. To ensure the effectiveness and fairness of AI interventions, Alhuwaydi advocates for the development of transparent, explainable, and equitable AI models that can be trusted by both mental health professionals and patients. While AI holds immense promise in advancing mental health care by enabling real-time monitoring and personalized interventions, both Alan and Alhuwaydi highlight the importance of developing ethical frameworks and regulatory standards to ensure the responsible and effective use of AI in this sensitive field. As AI continues to evolve, its integration into mental health care systems will require careful attention to these challenges to maximize its benefits while safeguarding the rights and well-being of individuals.

The integration of artificial intelligence into psychotherapy is emerging as a transformative force, expanding the reach and effectiveness of traditional therapeutic practices, particularly in underserved or remote areas. [6] explores how AI tools, such as virtual assistants and chatbots, are increasingly being utilized to augment cognitive-behavioral therapy (CBT) and monitor emotional states, providing continuous support for individuals in need. These AI tools not only help deliver therapy but also gather valuable data that can assist therapists in tailoring interventions to meet specific needs. One of the key benefits highlighted in the study is AI’s ability to facilitate remote therapy, which can be a game-changer for those in geographically isolated locations or for individuals who face social stigma related to seeking help. This remote capability makes therapy more accessible, enabling individuals to receive much-needed support without the barriers imposed by distance or societal judgment. Despite these advantages, [6] acknowledges the significant challenges of trust and privacy that accompany the widespread adoption of AI in mental health care. Users’ willingness to embrace AI tools is largely contingent on their confidence that these technologies can securely handle sensitive personal data. Therefore, ensuring robust security measures and transparency in AI systems is essential for fostering trust and encouraging their adoption. Furthermore, the protection of privacy in AI-driven mental health applications is paramount to prevent potential misuse of data, which could lead to harm or exploitation. Thus, while AI presents numerous opportunities to enhance the accessibility and quality of mental health care, overcoming these trust and privacy barriers remains a critical issue that must be addressed for these technologies to achieve their full potential.

Similarly, [8] examine the application of AI in mental health interventions for populations affected by war and emotional distress. The study underscores the ability of AI to analyze complex emotional datasets, which can provide valuable insights into the mental health status of individuals in conflict zones. By detecting patterns in emotional responses to traumatic events, AI-driven tools can help identify at-risk individuals and guide the development of targeted mental health interventions. This is particularly significant in conflict zones, where the mental health consequences of war and trauma are often exacerbated by a lack of adequate resources and support services. AI’s ability to process large amounts of emotional data can enhance the precision and effectiveness of interventions, ensuring that individuals receive timely and appropriate care. However, [8] stress the importance of ethical considerations when deploying AI in such sensitive contexts. The potential for harm or exploitation is high, as vulnerable populations in war-torn regions may not have the means to protect their personal data or may be subjected to AI systems that lack cultural sensitivity or understanding of their unique experiences. The study calls for responsible deployment of AI technologies that prioritize the dignity and privacy of affected individuals while ensuring they receive the mental health support they need. This approach should include a strong ethical framework, clear data governance policies, and safeguards to prevent misuse, ensuring that AI applications in conflict zones contribute positively to the well-being of individuals without compromising their rights. In both studies, the role of AI in mental health care demonstrates its transformative potential, but it also highlights the need for careful, ethical considerations to ensure that these innovations are deployed in a manner that respects the rights and needs of those they are intended to help. AI can significantly enhance the accessibility and personalization of mental health interventions, but it is crucial to address the challenges related to privacy, trust, and ethical deployment to ensure that these technologies can fulfill their promise in a responsible and beneficial way.

In addition, [12] investigate the transformative potential of artificial intelligence in mental health care, particularly in the realms of early diagnosis and personalized interventions. They underscore the game-changing capabilities of AI, emphasizing its ability to be integrated into virtual reality (VR) and augmented reality (AR) platforms, which are becoming increasingly prominent in the field of mental health therapy. AI-powered VR, for instance, offers the potential to create immersive therapeutic environments that can be tailored to individual patients’ needs. Such platforms are especially beneficial for exposure therapy, where patients are gradually and safely exposed to situations or environments that trigger anxiety, trauma, or phobias. This controlled, repeatable exposure in VR environments allows for a safe space to confront fears, facilitating therapeutic progress that might be more challenging to achieve in traditional settings. Moreover, the personalized and adaptive nature of AI within VR and AR platforms ensures that interventions are not only precise but can evolve with the patient’s progress, ensuring that the treatment remains responsive and relevant. The study advocates for collaboration among multiple stakeholders, including mental health professionals, technologists, and policy makers, to optimize the integration of these advanced technologies into mental health care. A multi-stakeholder approach is essential to ensuring that the AI-driven VR and AR platforms are designed with a deep understanding of therapeutic needs and are implemented with proper safeguards, ethical considerations, and patient-centered frameworks. This type of AI-enhanced therapy offers patients more than just passive interaction; it provides immersive, engaging experiences that could fundamentally alter how therapeutic interventions are delivered. Such technologies offer enormous promise in revolutionizing therapeutic approaches, particularly in terms of accessibility, effectiveness, and personalization, making them valuable tools for a wide range of mental health conditions, including anxiety, PTSD, and depression.

In parallel, [5] explore the role of AI chatbots in enhancing mental health care accessibility, particularly in reducing barriers to seeking help and minimizing the stigma often associated with mental health issues. AI chatbots offer 24/7 availability, providing immediate, anonymous support to users who may not feel comfortable reaching out to human professionals, especially in times of crisis. The convenience and anonymity offered by these chatbots can significantly lower the threshold for individuals who might otherwise delay or avoid seeking help due to fear of judgment. This increased access to support is a critical factor in addressing the mental health care gap, particularly in areas where professional mental health resources are scarce or in regions with high levels of social stigma surrounding mental health. However, the study by [5] also highlights the limitations of AI chatbots. While they are effective in providing immediate, initial support and guidance for mild to moderate mental health conditions, chatbots are not equipped to handle severe mental health crises. Their functionality is limited when it comes to more complex or high-risk conditions such as suicidal ideation, severe depression, or psychosis, which require the intervention of trained mental health professionals. Therefore, the study suggests that AI chatbots should be seen as a supplementary tool rather than a replacement for human professionals. They offer an essential first line of support, particularly for those hesitant to engage with traditional mental health services, but they should be integrated into a broader mental health care system, where they complement, rather than substitute, human intervention. The combination of AI chatbots with in-person or telehealth services could create a more comprehensive, accessible mental health support system, catering to a wide range of needs, from basic mental wellness maintenance to more intensive crisis intervention. [5] advocate for continued development in AI chatbot technology, with an emphasis on improving their ability to triage users effectively and refer them to the appropriate professional help when necessary, ensuring that individuals receive the right level of care at the right time. Together, these studies demonstrate the vast potential of AI to enhance mental health care, particularly in areas of accessibility, early intervention, and personalized treatment. While challenges remain, particularly around the ethical implications and limitations of AI technologies, the integration of these tools into mental health care holds considerable promise for the future.

Meanwhile, [1] provide a comprehensive analysis of Explainable Artificial Intelligence (XAI) and its pivotal role in enhancing digital mental health interventions. A central finding from the study is that XAI significantly improves transparency in the decision-making processes of AI systems, which is particularly important in the context of mental health. Traditional AI models are often perceived as “black boxes,” where users struggle to understand how decisions or recommendations are made, leading to skepticism and distrust. However, by using XAI, which is designed to make AI’s decision-making processes more understandable and interpretable, users can better grasp how diagnoses, recommendations, and treatment options are derived. This transparency is crucial in increasing the acceptance and trust of AI-based systems, especially in sensitive areas like mental health, where users’ concerns about privacy, fairness, and accuracy are heightened. The study emphasizes that a clear and understandable rationale behind AI-driven decisions can foster a sense of reliability, enabling users to feel more confident in using these technologies for their mental health. Trust is a cornerstone of effective mental health interventions, as patients need to feel secure in the tools they rely on for diagnosis and treatment. Furthermore, [1] stress the significance of user-centric design in AI-based mental health interventions, underscoring the necessity for AI tools to be tailored to meet the diverse needs and preferences of users. With mental health conditions spanning various demographics, it is vital that AI systems consider factors such as cultural, social, and individual differences, creating a more personalized experience that increases engagement and efficacy. By designing AI systems that adapt to the unique challenges of diverse populations, such as different age groups, genders, and ethnicities, these tools can ensure that their interventions are not only effective but also equitable and respectful of users’ varying contexts. This aspect of user-centric design is a significant factor in fostering the widespread adoption of AI technologies in mental health care, as it assures users that the systems are responsive to their particular needs, and not generic or one-size-fits-all solutions.

In parallel, [2] explore the potential of AI in adolescent mental health assessments, particularly by leveraging digital activity data. This study investigates how AI models can detect early signs of mental health issues like stress and depression by analyzing digital footprints, which include online behavior, social media interactions, and communication patterns. Adolescents, often hesitant to seek help due to stigma or lack of awareness, present a challenging group for traditional mental health interventions. AI’s ability to unobtrusively monitor and analyze data from adolescents’ daily activities can provide an invaluable tool in identifying mental health issues early, facilitating timely interventions. By using digital interactions as a non-invasive means of monitoring mental health, the study suggests that AI can serve as a preventive tool, intervening before mental health conditions progress into more serious issues. The predictive accuracy of AI improves significantly when data from various sources are integrated, enhancing the comprehensiveness of assessments. For instance, combining data from social media activity, texting patterns, online searches, and other digital interactions can paint a more detailed and accurate picture of an adolescent’s mental state. This multifaceted approach enables AI to pick up on subtle behavioral changes that might indicate emerging stress or depression, which could otherwise go unnoticed in traditional clinical settings. [2] propose that AI-based mental health assessments could eventually become a routine part of adolescent healthcare, providing continuous monitoring and early intervention, helping to reduce the onset of long-term mental health issues. With AI’s ability to analyze vast amounts of data efficiently, these systems could offer real-time support, alerting caregivers, educators, or health professionals to signs of distress and enabling them to take proactive steps.

In addition, [7] introduce innovations in AI’s role in stress detection and resilience-building. The study explores how AI can detect stress markers by analyzing multimodal data, including physiological signals (e.g., heart rate, skin conductance), speech patterns, and digital activity. Stress is a significant risk factor for many mental health disorders, and its early detection is crucial in preventing these conditions from escalating. By utilizing a variety of data inputs, AI models can identify patterns that may indicate stress, even before the individual becomes fully aware of it. This ability to detect stress early provides an opportunity for timely intervention, which can be especially valuable in high-stress environments such as workplaces, schools, or healthcare settings. Furthermore, AI can not only detect stress but also offer personalized interventions aimed at building resilience. These interventions could include mindfulness exercises, breathing techniques, cognitive-behavioral strategies, or suggestions for lifestyle changes that reduce stress. [7] highlight how AI’s ability to customize these interventions based on the individual’s unique stress markers and preferences significantly enhances their effectiveness. AI-driven resilience-building approaches can therefore play a key role in preventive mental health care, empowering individuals to manage stress before it develops into more serious mental health conditions like anxiety or depression. Moreover, the study points to the need for ongoing research to optimize these AI-driven interventions, ensuring that they are applicable and beneficial to diverse populations. As the mental health landscape is increasingly recognized as multifaceted, AI interventions must be continuously refined to cater to different cultural, demographic, and personal factors to maximize their impact. Together, these studies underscore the multifaceted role that AI can play in enhancing mental health interventions. [1] emphasize the importance of transparency and user-centered design in increasing trust and acceptance of AI in mental health, while [2] demonstrate AI’s potential to provide early, non-invasive assessments, especially for adolescents who are often reluctant to seek help. [7] add to this narrative by showcasing AI’s ability to detect stress and promote resilience, offering personalized, preventative strategies to support mental wellness. These advancements collectively illustrate AI’s potential to transform mental health care, from early detection and personalized interventions to preventive strategies that empower individuals to manage their mental well-being proactively. However, as these technologies continue to evolve, it will be essential to address challenges such as privacy, ethics, and accessibility to ensure that AI systems are deployed responsibly and inclusively.

Additionally, [11] explore the transformative potential of artificial intelligence in enhancing diagnostic precision within the mental health sector. By leveraging technologies such as natural language processing (NLP) and predictive analytics, AI systems can analyze vast amounts of unstructured data, including clinical notes, social media content, and personal communication, to identify early signs of mental health disorders such as depression, anxiety, and schizophrenia. NLP allows AI to understand and interpret human language, making it possible to extract valuable insights from written or spoken text that may indicate psychological distress. Predictive analytics, on the other hand, uses historical data to forecast the likelihood of mental health issues, enabling clinicians to make more informed decisions and improve diagnostic accuracy. The study also highlights the integration of AI with wearable devices, such as smartwatches and fitness trackers, which continuously monitor physiological data, including heart rate, sleep patterns, and physical activity levels. These wearable devices can provide real-time insights into a person’s mental health, offering early detection of changes that may signal the onset of conditions like anxiety or depression. For example, fluctuations in heart rate variability or disruptions in sleep patterns can be indicative of mental health issues, allowing for timely intervention before conditions worsen. This combination of real-time data and advanced AI analytics could significantly improve early diagnosis and intervention, preventing the escalation of mental health conditions and reducing the burden on healthcare systems. [11] emphasize that further exploration is needed to fully harness AI’s potential in mental health care, particularly its ability to integrate seamlessly with other healthcare technologies, such as electronic health records (EHRs) and telemedicine platforms. This integrated approach could create a more holistic and proactive mental health care system, where AI-driven insights inform treatment plans, facilitate continuous monitoring, and enhance the overall quality of care. The authors advocate for more research and development in this area, suggesting that the future of mental health care lies in the convergence of AI with wearable devices, predictive analytics, and other healthcare technologies to provide a more personalized, accurate, and timely approach to mental health diagnosis and treatment.

Lastly, [9] explore how artificial intelligence can foster positive mental health by promoting self-awareness and emotional regulation, essential components of overall mental well-being. Their study highlights the potential of AI-powered cognitive-behavioral therapy (CBT) tools to assist individuals in regulating their emotions, which can significantly enhance emotional resilience. These AI tools provide tailored interventions, such as personalized exercises or feedback, that empower users to manage their emotional responses and develop healthier coping strategies. By focusing on emotional regulation, AI-driven CBT can prevent the onset of more severe mental health conditions, such as depression or anxiety, by intervening early in the process. The study emphasizes the need for ethical AI frameworks to ensure that these tools are not only effective but also equitable and accessible to all individuals, regardless of their socioeconomic status, geographic location, or background. Ethical considerations in AI development are critical to ensuring that interventions are free from bias and that individuals’ privacy and data security are protected. As AI continues to evolve, these frameworks will play a vital role in addressing concerns about transparency, accountability, and fairness in mental health care. The ability of AI tools to provide scalable, accessible support for mental health is transformative, particularly in underserved or resource-limited areas where traditional mental health services may be scarce or unavailable. AI’s potential to promote proactive mental health management can improve overall well-being and reduce the long-term impact of untreated mental health disorders. The use of AI in mental health care extends beyond individual interventions and includes system-wide improvements in diagnosis, treatment, and monitoring. Studies by [3,10] and others underline the diverse ways AI is being integrated into mental health care, from early detection of mental health conditions in children and adolescents to real-time monitoring and personalized therapy. These innovations are leading to more accurate diagnoses and tailored treatments that better address the unique needs of individuals. However, as the research indicates, there are significant challenges to overcome in the deployment of AI in mental health care. Ethical concerns surrounding AI-driven interventions must be addressed, including the potential for algorithmic bias, the protection of patient data, and ensuring that AI systems are transparent and explainable. Furthermore, regulatory frameworks need to be developed to guide the use of AI in mental health care, ensuring that these technologies are used responsibly and effectively. Data security remains a pressing issue, particularly as AI systems rely on vast amounts of personal information to make decisions. Ensuring the privacy and security of this sensitive data is crucial to maintaining public trust in AI-based mental health interventions. The future of AI in mental health care is promising, with AI offering significant advancements in diagnosing, treating, and preventing mental health conditions. However, the successful integration of AI into mental health care systems will require careful consideration of its ethical implications, regulatory oversight, and the development of robust data security measures. By addressing these concerns and promoting responsible implementation, AI can be a powerful tool in enhancing mental well-being and providing accessible mental health care for individuals worldwide.

Discussion and Conclusions

In recent years, the growing interest in the application of Artificial Intelligence in mental health care has been fueled by its potential to address some of the most pressing challenges faced by traditional mental health systems. These challenges include limited access to mental health professionals, high treatment costs, stigma surrounding mental health, and the inefficiency of current diagnostic and therapeutic methods. AI technologies, ranging from machine learning (ML) and deep learning to natural language processing (NLP), have demonstrated significant promise in revolutionizing mental health diagnostics, interventions, and therapeutic support, offering new solutions for these longstanding issues. AI’s integration into mental health care has introduced innovative approaches for early detection, personalized treatment, and remote care, improving outcomes for both individuals and healthcare systems at large. One of the most notable innovations has been the application of machine learning and deep learning algorithms to improve diagnosis and treatment. For example, algorithms capable of analyzing large volumes of data, such as patient records, social media interactions, and behavioral patterns, are being used to identify mental health conditions, sometimes before they become apparent to human clinicians. These advances enable earlier intervention, which is critical in reducing the severity of mental health issues and preventing them from escalating into more chronic conditions. [6] exemplifies this trend by discussing the growing role of AI in psychotherapy, noting how algorithms are now capable of delivering psychological support through digital formats such as chatbots and virtual assistants. These AI-driven tools can provide cognitive-behavioral therapy (CBT) and other forms of therapy remotely, making mental health resources more accessible to individuals who may otherwise struggle to access care due to geographic, financial, or social barriers. This is particularly important in underserved regions, where the availability of mental health professionals is often limited, and in populations that may be reluctant to seek care due to stigma or privacy concerns. Moreover, AI’s role in mental health extends beyond treatment delivery to include the real-time monitoring of mental health status. For instance, [7] explored how AI can detect signs of stress and emotional distress through various biometric and behavioral indicators, enabling timely interventions. AI systems can analyze patterns in speech, facial expressions, and even physiological responses, offering valuable insights that human practitioners might miss. This ability to monitor and intervene in real-time is especially valuable in managing chronic mental health conditions, where early detection of warning signs can prevent more severe episodes. The integration of AI also extends to digital platforms that assess mental health based on daily activities and online behavior. [2] demonstrated how AI can track and analyze adolescents’ digital footprints, such as social media interactions and smartphone usage, to detect signs of anxiety, depression, or other mental health issues. By using data from everyday experiences, AI can offer more personalized and contextually relevant care that considers an individual’s lifestyle and environmental factors, leading to better mental health outcomes. One of the most transformative applications of AI in mental health care has been the development of AI-powered chatbots. These systems engage users in conversations that simulate human-like interactions, providing emotional support, coping strategies, and even psychological interventions like CBT. As highlighted by [5], AI chatbots have shown significant promise in promoting emotional well-being and helping users manage mental health concerns in real-time. These tools not only offer immediate assistance but also reduce the stigma often associated with mental health care by providing users with an anonymous, private platform to discuss their struggles. This is particularly beneficial for individuals who may otherwise avoid seeking professional help due to fear of judgment or a lack of understanding. Furthermore, AI chatbots can be programmed to provide personalized support, adapting their responses based on the user’s emotional state, past interactions, and self-reported symptoms, thus offering a highly tailored approach to mental health management. In addition to supporting individuals, AI is also poised to transform mental health care at a systemic level. [12] emphasized AI’s potential to revolutionize mental health through innovative approaches for diagnosis, intervention, and recovery monitoring. These technologies are reshaping the way mental health services are delivered by enabling more efficient, scalable, and data-driven models of care. AI’s ability to monitor patients’ progress and provide real-time feedback means that mental health professionals can intervene more effectively, tracking patients’ responses to treatment and adjusting care plans as needed. This can lead to more precise and individualized treatment protocols, improving patient outcomes and reducing the overall burden on mental health systems. Additionally, AI’s ability to automate certain aspects of care, such as diagnostic assessments and routine check-ins, can free up clinicians to focus on more complex cases, optimizing resource allocation and improving efficiency within mental health services. The impact of AI on mental health extends beyond clinical settings and into policymaking. AI technologies have the potential to influence policy decisions related to mental health care access and affordability, especially in regions where mental health resources are scarce. [11] discussed how AI can play a critical role in the early identification of mental health issues, which can prevent more severe conditions from developing. For example, predictive models could help identify at-risk individuals who may not yet show obvious symptoms, allowing for proactive interventions that could mitigate the long-term impact of mental health conditions. Early intervention is crucial in reducing the societal and economic costs associated with mental illness, including lost productivity, increased healthcare spending, and social exclusion. By providing tools that can identify and treat mental health issues earlier, AI has the potential to significantly reduce the burden of mental health on both individuals and society. Furthermore, AI’s ability to integrate and analyze vast amounts of data can improve public health policies by providing insights into trends and patterns in mental health. This data-driven approach can help policymakers identify key areas where resources need to be allocated, design more effective mental health programs, and evaluate the success of existing initiatives. The integration of AI in mental health is not without its challenges, however. Issues related to data privacy, ethical considerations, and the reliability of AI-driven interventions must be addressed to fully unlock its potential. AI systems rely on large volumes of personal data, raising concerns about data security and user consent. Additionally, as AI technologies are increasingly used to support therapeutic interventions, questions arise about the extent to which AI can replicate the nuances of human empathy and judgment. While AI can provide valuable support, it cannot replace the human touch that is often crucial in the therapeutic process. As such, AI should be seen as a tool to augment, rather than replace, traditional mental health care. Despite these challenges, the integration of AI in mental health care continues to evolve rapidly, offering promising solutions to long-standing problems in the field. Through technological innovations, AI is opening new possibilities for mental health care, offering more accessible, personalized, and effective interventions. As technology continues to mature, it is likely that AI will play an increasingly central role in shaping the future of mental health care, addressing unmet needs, improving outcomes, and reducing the burden on healthcare systems globally.

While AI offers immense potential in revolutionizing mental health care, several challenges must be addressed to fully realize its benefits. One of the primary concerns is data privacy and security. AI systems require vast amounts of personal data to function effectively, raising significant ethical questions regarding user consent and data protection. [10] noted that AI models, particularly those focused on children’s mental health, rely on sensitive data from digital activities, which further complicates concerns around privacy and the safe handling of personal information. Another significant limitation lies in the reliability and validity of AI-driven interventions. While AI applications are advancing rapidly, their ability to replicate the nuanced understanding and empathetic approach of human therapists remains uncertain. [9] emphasized that AI-powered mental health applications must undergo rigorous testing to ensure their effectiveness before widespread clinical implementation. There is also the challenge of providing personalized care through AI models, which often struggle to incorporate the complex social, psychological, and cultural factors that play a crucial role in mental health. The lack of personalized approaches in AI interventions could limit their effectiveness for individuals from diverse backgrounds and with varying mental health needs. Moreover, the issue of bias and fairness in AI models is a growing concern. AI systems are only as reliable as the data they are trained on, and if the datasets used are biased, the resulting interventions can be skewed or unfair. [8] highlighted that AI applications in mental health care could inadvertently exacerbate disparities, particularly if certain demographic groups are underrepresented in training data, leading to less effective treatments for these populations. The risk of AI perpetuating these biases calls for careful consideration in designing and testing mental health AI models to ensure equity in healthcare delivery. Furthermore, as AI systems are increasingly used for decision-making in mental health care, accountability becomes a critical issue. In the event of an AI system making an incorrect diagnosis or providing inadequate treatment, determining liability and responsibility can be complex. This challenge underscores the need for stringent regulation and oversight to ensure that AI applications in mental health care are safe, ethical, and effective. Addressing these challenges is essential for AI to reach its full potential in improving mental health care delivery while safeguarding users’ rights and ensuring equitable outcomes.

AI holds immense promise in transforming mental health care, offering the potential to enhance diagnostic accuracy, improve access to care, and introduce innovative therapeutic interventions. The studies reviewed in this article highlight the diverse ways AI is being applied to address mental health challenges, such as stress detection, digital interventions, and the use of chatbot technologies. These applications allow for more personalized, scalable, and cost-effective solutions, especially in the context of the global rise in mental health issues. AI can bridge gaps in access to care by providing remote, accessible support for individuals who may face barriers due to geography, financial limitations, or stigma. However, for AI to realize its full potential in mental health care, several challenges must be addressed. Issues such as ensuring data privacy and security, evaluating the effectiveness of AI interventions, and mitigating the risk of bias in AI models require continued research, the establishment of ethical guidelines, and regulatory frameworks. Safeguarding personal data while promoting the development of effective AI technologies is crucial in creating a balance between innovation and user protection. Furthermore, as AI technologies evolve, it is important to ensure that these systems are designed to complement, rather than replace, traditional therapeutic approaches. AI should enhance the human experience by providing additional support to mental health professionals, not by substituting human judgment and empathy. The implications of the review suggest several pathways for advancing AI in mental health care. First, rigorous clinical trials are necessary to assess the effectiveness of AI-driven mental health interventions. These trials should focus on clinical outcomes as well as user satisfaction and the long-term impact of these interventions on mental well-being. Additionally, policymakers must develop and enforce regulations that ensure the protection of user data while also fostering the growth of innovative AI applications. Creating a regulatory environment that balances data privacy concerns with the potential benefits of AI will be essential for encouraging continued progress. Lastly, there is a significant opportunity for interdisciplinary collaboration between AI developers, mental health professionals, and regulatory bodies. This collaborative approach could help ensure that AI systems are developed with both technical excellence and ethical considerations in mind, thereby mitigating potential risks while maximizing their ability to improve mental health care. By working together, these diverse stakeholders can guide the integration of AI into mental health care in a way that is both effective and responsible.

Despite the valuable insights presented in the review, it is crucial to recognize several limitations that may affect its comprehensiveness. One significant limitation is the temporal scope of the studies included, which primarily focuses on recent research published in 2024. While this provides an up-to-date view of AI’s role in mental health, it may not encompass the full spectrum of relevant literature, especially older studies that laid the groundwork for current advancements. As the field of AI in mental health is rapidly evolving, it is essential to acknowledge that new developments and applications may not be fully captured in the review. AI technologies are advancing at an unprecedented pace, and new research findings, as well as technological breakthroughs, could provide a more nuanced understanding of the landscape. Future reviews of this topic will need to incorporate these emerging trends to offer a more comprehensive picture of AI’s role in mental health care. Another limitation stems from the lack of diverse perspectives on the social, cultural, and ethical implications of AI in mental health care. While the review touched upon some ethical concerns, it did not delve deeply into how AI might be implemented in various cultural contexts. Different cultures may have unique perceptions of mental health, which could affect the acceptance and effectiveness of AI-driven interventions. Moreover, the challenges faced by underserved populations, including those in low-income regions, were not fully addressed. Understanding how AI can be used to address the needs of diverse populations is essential to ensure that it serves everyone equitably. In addition, the review does not provide a detailed exploration of the potential biases that may exist in AI models, particularly those trained on non-representative datasets. These biases could lead to disparities in the effectiveness of AI interventions for different demographic groups. Addressing these issues is crucial to avoid exacerbating existing inequalities in mental health care.

For future research to address these gaps, several key areas need further exploration. One of the most critical areas for future investigation is the need for longitudinal studies to evaluate the long-term effectiveness and sustainability of AI-driven mental health interventions. While short-term results are valuable, understanding the prolonged impact of these technologies on users’ mental health and overall well-being is vital. Longitudinal studies could provide insights into whether the benefits of AI interventions are sustained over time and whether users experience any unintended negative consequences. Such studies could also help assess whether AI can truly complement or enhance traditional forms of therapy in the long run, rather than simply acting as a temporary substitute. Furthermore, future research should focus on ethical and cultural considerations related to AI in mental health care. As AI technologies are deployed globally, there is a growing need for research that explores how AI can be adapted to various cultural contexts and how different cultural norms and values might influence the acceptance and effectiveness of AI-driven interventions. This research could address cultural biases in AI models, the potential for AI to shape mental health norms, and the implications of AI interventions in societies with limited access to healthcare. Additionally, understanding how AI can be used to improve mental health care accessibility in low-income and underserved regions should be a priority, as these areas often lack adequate mental health resources. Another promising avenue for future research is the integration of AI with traditional therapies. While AI has demonstrated significant potential in supporting mental health care, it is essential to explore how it can work alongside human therapists to provide more comprehensive care. AI can be used to augment existing therapeutic frameworks, providing tools for therapists to better monitor patient progress, detect early warning signs of mental health issues, and personalize treatment plans. Further research should investigate how AI can complement traditional forms of therapy, such as cognitive-behavioral therapy (CBT), and whether combining these approaches results in better patient outcomes than either approach used alone. Finally, there is a growing need for research on AI in preventive mental health. As the global healthcare system increasingly emphasizes prevention, AI can play a pivotal role in early detection and intervention for mental health issues. Future studies should focus on how AI can analyze digital behavior patterns to detect early signs of mental health struggles, such as anxiety or depression, before they escalate into more severe conditions. Additionally, AI could be used to monitor at-risk populations, such as adolescents or individuals with a family history of mental illness, to identify early warning signs and provide preventive support. The integration of AI into preventive mental health strategies could not only improve individual outcomes but also reduce the overall burden on healthcare systems by preventing the development of more severe mental health conditions. While AI holds immense promise for transforming mental health care, there remain significant challenges and limitations that must be addressed through ongoing research. Future studies must focus on understanding the long-term effects of AI interventions, exploring cultural and ethical considerations, investigating the integration of AI with traditional therapeutic approaches, and utilizing AI in preventive mental health care. In a nutshell, by addressing the limitations of small sample sizes and lack of long-term data, AI can be more effectively tailored to improve mental health outcomes across diverse populations. Expanding research to include larger, more representative samples would ensure that AI-driven interventions cater to a wide range of demographics, enhancing their generalizability and impact. Additionally, collecting long-term data would help evaluate the sustained effectiveness of AI technologies in mental health care, ensuring their reliability over time. By overcoming these challenges, AI can contribute to global efforts to make mental health care more accessible, personalized, and effective for individuals worldwide.

Ethics Approval and Consent to Participate

Not applicable

Consent for Publication

Not applicable

Availability of Data and Materials

The study is a narrative review and does not involve the collection or analysis of original data from participants. All information and insights presented in the study are derived from existing literature, publicly available sources, and secondary data obtained from previous research. As such, no new datasets were generated or analyzed during the study.

Competing Interest

I, as the sole author of the article, declare that I have no competing financial or personal interests that could have influenced the work reported. The review article was conducted independently, with no external influences, funding, or affiliations that could have impacted the findings or interpretations presented.

Funding

The author declares that no funding was received for the preparation or publication of the manuscript. The work was conducted independently and does not involve any financial support from external organizations or sponsors.

Author’s Contributions

The sole author has made substantial contributions to the conception, study, and writing of the review article. The author reviewed, edited, and approved the final manuscript, ensuring it met academic standards and provided a balanced, evidence-based discussion. The author confirms that the article represents original work and bears full accountability for the content presented in the publication.

Data Availability

Not applicable

References

  1. Karim RA, Iqbal, W, Ilyas Z (2024) Techniques of Explainable Artificial Intelligence and Machine Learning in Digital Mental Health Intervention. Journal of Development and Social Sciences 5(3): 349-359.
  2. Kim DH, Lee, J, Lee, T, Baek, S, Jin, S, et al. (2024) AI-Based Mental Health Assessment for Adolescents Using Their Daily Digital Activities. In 2024 IEEE 11th International Conference on Data Science and Advanced Analytics (DSAA) (pp. 1-10) IEEE.
  3. Alan H (2024) A comprehensive evaluation of digital mental health literature: an integrative review and bibliometric analysis. Behaviour & Information Technology 1-23.
  4. Alhuwaydi AM (2024) Exploring the Role of Artificial Intelligence in Mental Healthcare: Current Trends and Future Directions–A Narrative Review for a Comprehensive Insight. Risk Management and Healthcare Policy 17: 1339-1348. [crossref]
  5. Gallegos, C, Kausler, R, Alderden, J, Davis, M, Wang L (2024) Can Artificial Intelligence Chatbots Improve Mental Health? A Scoping Review.Computers, Informatics, Nursing 42(10): 731-736. [crossref]
  6. Bhatt S (2024) Digital Mental Health: Role of Artificial Intelligence in Psychotherapy. Annals of Neurosciences, 09727531231221612.
  7. Liu, F, Ju, Q, Zheng, Q, Peng Y (2024) Artificial intelligence in mental health: innovations brought by artificial intelligence techniques in stress detection and interventions of building resilience. Current Opinion in Behavioral Sciences 60, 101452.
  8. Cosic, K, Kopilas, V, Jovanovic T (2024) War, emotions, mental health, and artificial intelligence. Frontiers in psychology 15: 1394045. [crossref]
  9. Thakkar, A, Gupta, A, De Sousa A (2024) Artificial intelligence in positive mental health: a narrative review. Frontiers in Digital Health 6: 1280235. [crossref]
  10. Agarwal, J, Sharma S (2024) Artificial Intelligence enabled cognitive computer-centered digital analysis model for examination of the children’s mental health. Evolutionary Intelligence 1-11.
  11. Olawade DB, Wada OZ, Odetayo, A, David-Olawade AC, Asaolu, F, et al. (2024) Enhancing mental health with Artificial Intelligence: Current trends and future prospects. Journal of Medicine, Surgery, and Public Health 100099.
  12. Dakanalis, A, Wiederhold BK, Riva G (2024) Artificial intelligence: a game-changer for mental health care. Cyberpsychology, Behavior, and Social Networking 27(2): 100-104. [crossref]

How Can Integrating Artificial Intelligence Technologies Advance Mental Health and Wellness in Malaysian Healthcare Systems and Enhance Societal Well-Being?

DOI: 10.31038/AWHC.2025821

Abstract

The global mental health crisis, exacerbated by the pandemic, underscores the urgent need for innovative solutions. With approximately one in eight individuals experiencing a mental disorder, this review assesses the role of Artificial Intelligence (AI) in enhancing mental health care, particularly in Malaysia, where stigma, accessibility issues, and resource shortages hinder traditional services. A systematic literature review was conducted using databases such as PubMed and Scopus, focusing on studies published from 2022 to 2024. The review identified key AI applications, including chatbots and predictive analytics, which offer personalized and accessible mental health support. Results indicated that AI-driven solutions, exemplified by tools like “Chatbot Rakan Sihat,” significantly improve engagement and mental health outcomes for underserved populations. Ethical concerns regarding data privacy and algorithmic bias were highlighted as critical challenges in AI integration. The findings emphasize AI’s potential to reduce stigma and enhance service delivery in Malaysia’s mental health landscape. This review’s novelty lies in its focus on local implementation and ethical considerations, contributing to ongoing discourse on AI’s integration into mental health care. Future research should investigate the long-term effectiveness of AI interventions, user experiences, and collaborative efforts to establish regulatory frameworks that prioritize patient welfare while optimizing mental health care accessibility and effectiveness.

Keywords

Artificial intelligence, Mental health care, Chatbots, Predictive analytics, Ethical considerations in AI

Introduction

The global mental health crisis remains a pressing concern, with approximately one in eight people experiencing a mental disorder, as reported by the World Health Organization (WHO). The COVID-19 pandemic has further intensified this crisis, leading to increased psychological distress across various populations. In response, digital mental health solutions have emerged, aiming to improve access to care and support overall mental well-being. Notably, [1] conducted a retrospective analysis of the AI-driven mental health app Wysa, demonstrating its effectiveness in addressing users’ mental health needs during the pandemic. This review aims to assess the landscape of AI applications in mental health, addressing the challenges and opportunities presented by these technologies. The novelty of this review lies in its focus on AI’s potential to enhance service delivery in Malaysia, where traditional mental health care is hindered by stigma, accessibility issues, and resource shortages. Additionally, this review highlights the importance of ethical considerations surrounding AI use, such as data privacy and algorithmic bias. By evaluating existing literature, this review seeks to contribute to the ongoing discourse on integrating AI technologies into mental health care, ultimately fostering improved outcomes for diverse populations [2].

Methods

This review employed a systematic approach to evaluate the landscape of Artificial Intelligence applications in mental health care, particularly focusing on their implementation in Malaysia. A comprehensive literature search was conducted using databases such as PubMed, Scopus, and Google Scholar, targeting studies published from 2022 to 2024. Keywords included “AI in mental health,” “digital mental health solutions,” “chatbots,” “predictive analytics,” and “Malaysia.” Inclusion criteria focused on empirical studies, reviews, and case analyses that explored AI interventions’ effectiveness, accessibility, and ethical considerations. Selected articles were analyzed to extract key findings related to AI’s impact on mental health outcomes, user engagement, and integration challenges. The review also examined the ethical frameworks surrounding AI applications, considering issues of data privacy and algorithmic bias. By synthesizing this information, the review aims to contribute to the discourse on AI in mental health, identifying opportunities and challenges while emphasizing the need for responsible implementation.

Results and Findings

Artificial Intelligence has emerged as a transformative tool in mental health care, offering innovative and personalized solutions that can significantly enhance the delivery of mental wellness support. AI systems have proven effective at analyzing vast amounts of data, recognizing patterns, and providing insights that human practitioners may overlook. For instance, [3] examined AI-driven interventions, such as chatbots and predictive analytics, designed specifically to reduce suicidal tendencies among young individuals. Their study highlighted AI’s crucial role in raising mental health awareness and improving access to essential resources. In Malaysia, mental health disorders affect nearly 29% of the population (World Health Organization). Traditional mental health services face numerous challenges, including pervasive stigma, limited accessibility, and resource shortages. AI represents a promising avenue to address these barriers by enhancing service accessibility and personalizing care. [4] explored the potential of machine learning in creating adaptive mental health interventions tailored to individual needs, thus enhancing user engagement and promoting overall well-being. The applications of AI in mental health, particularly chatbots and virtual assistants, provide significant benefits. [5] discussed how chatbots improve mental health services by enhancing accessibility and providing personalized support. For instance, Malaysia’s “Chatbot Rakan Sihat” has been integrated into public health initiatives to raise awareness about mental health and provide timely assistance, especially to underserved populations. Virtual therapy platforms, as discussed by, leverage AI to enhance user engagement and improve emotional support processes. These platforms facilitate remote consultations and personalized interventions, making mental health services more flexible and accessible. Consequently, AI has the potential to optimize treatment outcomes by dynamically adjusting treatment plans based on real-time data. Predictive analytics is another essential AI application that utilizes vast datasets to identify individuals at risk of mental health disorders. [6] demonstrated how social media data can be analyzed to inform mental health interventions, enabling early detection of mental health issues. In Malaysia, predictive analytics could significantly improve screening processes, ensuring timely interventions for at-risk individuals. As AI continues to evolve, it holds immense potential to revolutionize mental health care, particularly in addressing accessibility, personalization, and treatment efficacy. However, the integration of AI in mental health care must be guided by ethical frameworks to prioritize patient safety, data security, and transparency. In Malaysia, AI helps mitigate mental health service shortages and reduces stigma by offering anonymous support [7]. [8] advocated for AI as a complementary tool, not a replacement for human therapists. Furthermore, the scalability and cost-effectiveness of AI-driven solutions can address long wait times and limited mental health resources. AI technologies are transforming mental health care by improving access, reducing costs, and providing timely support. For example, Malaysia’s “Chatbot Rakan Sihat” exemplifies how AI can reach underserved populations while overcoming barriers like stigma [9,10]. AI-driven platforms, such as iAssist, offer wellness solutions, particularly for elderly users, with integrated tools that enhance mental and physical health [10]. Additionally, AI reduces treatment costs by automating routine tasks, early detection of issues, and crisis prevention, thereby decreasing the need for intensive care [11]. However, ethical challenges, such as data privacy and algorithmic bias, must be addressed [2]. Human oversight remains crucial to ensure that AI enhances rather than replaces professional care. In sum, regulatory frameworks are necessary to ensure responsible AI use, necessitating collaboration among policymakers, mental health experts, and developers [12,13]. The findings highlight the significant impact AI can have on improving mental health care accessibility and delivery in Malaysia, while also emphasizing the need for ethical consideration and human oversight.

Discussion and Conclusion

This review underscores the transformative potential of Artificial Intelligence in enhancing mental health care, particularly in Malaysia, where traditional services face significant barriers. The novelty of this study lies in its comprehensive evaluation of AI applications, such as chatbots and predictive analytics, that can increase accessibility and personalization in mental health interventions. As evidenced by the findings of [1] and [5], AI-driven solutions can significantly improve mental health outcomes by providing timely and tailored support to underserved populations. However, ethical considerations must be prioritized, including data privacy and algorithmic bias [2]. The implications of this study are profound; integrating AI into mental health services can reduce stigma, enhance service delivery, and ultimately improve the overall mental health landscape in Malaysia. Future research should focus on the long-term effectiveness of AI interventions, explore user experiences, and assess the ethical implications of AI technologies. Collaborative efforts among policymakers, mental health practitioners, and technology developers will be essential to create a regulatory framework that ensures responsible AI deployment, safeguarding patient welfare while optimizing mental health care accessibility and effectiveness [13,14].

Declaration of Competing Interest

None

References

  1. Sinha C, Meheli S, Kadaba M (2023) Understanding digital mental health needs and usage with an artificial intelligence–led mental health app (Wysa) during the COVID-19 pandemic: Retrospective analysis. JMIR Formative Research 7(1), e41913. [crossref]
  2. Dutta D, Mishra SK (2024) Bots for mental health: the boundaries of human and technology agencies for enabling mental well-being within organizations. Personnel Review 53(5).
  3. Rawat B, Bist AS, Fakhrezzy M, Octavyra RD (2023) AI based assistance to reduce suicidal tendency among youngsters. APTISI Transactions on Management 7(2): 102-109.
  4. Oyebode O, Fowles J, Steeves D, Orji R (2023) Machine learning techniques in adaptive and personalized systems for health and wellness. International Journal of Human–Computer Interaction 39(9): 1938-1962.
  5. Jain S, Patil S, Dutt S, Joshi K, Bhuvaneswari V, Jayadeva SM (2022) Contribution of Artificial intelligence to the Promotion of Mental Health. In 2022 5th International Conference on Contemporary Computing and Informatics (IC3I) (pp. 1938-1944) IEEE.
  6. Garg M (2024) Mental disturbance impacting wellness dimensions: Resources and open research directions. Asian Journal of Psychiatry 92: 103876. [crossref]
  7. Garg M (2024) WellXplain: Wellness concept extraction and classification in Reddit posts for mental health analysis. Knowledge-Based Systems 284: 111228.
  8. World Health Organization (WHO) (2023) Artificial intelligence in mental health research: new WHO study on applications and challenges. https: //www.who.int/europe/news/item/06-02-2023-artificial-intelligence-in-mental-health-research–new-who-study-on-applications-and-challenges
  9. Khawaja Z, Bélisle-Pipon JC (2023) Your robot therapist is not your therapist: understanding the role of AI-powered mental health chatbots. Frontiers in Digital Health 5: 1278186. [crossref]
  10. Caloudas AB, Frosio KE, Torous J, Goss CW, Novins DK, Lindsay JA, Shore JH (2024) Mobile mental health applications for American Indian and Alaska Native communities: Review and recommendations. Journal of Technology in Behavioral Science.9(3): 474-485.
  11. Desai VS, Tibrewala A, Saravanan K, Preethika K, Mantri T, Ghiria I (2022) iAssist: An online wellness platform to elevate the physical and mental health of the elderly. In 2022 IEEE Conference on Interdisciplinary Approaches in Technology and Management for Social Innovation (IATMSI) (pp. 1-5) IEEE.
  12. Chandak ML. Help Out-Mental health journaling and supporting application based on artificial intelligence (Doctoral dissertation, Sant Gadge Baba Amravati University).
  13. Yoon S, Goh H, Low XC, Weng JH, Heaukulani C (2023) Perceived Usability, User Preferences and Impact of a Workplace Digital Mental Wellness Platform “Mindline at Work”: A Mixed Methods Study.
  14. Gupta D, Singhal A, Sharma S, Hasan A, Raghuwanshi S (2023) Humans’ Emotional and Mental Well-Being under the Influence of Artificial Intelligence. Journal for Reattach Therapy and Developmental Diversities 6(6s): 184-197.

The Emotional Intelligence of the Clinician : Rethinking Communication as Emotional Calibration

DOI: 10.31038/IJNM.2025621

Abstract

Effective modern clinical communication demands cognitive clarity together with emotional precision. Clinicians working in healthcare settings where critical decisions are made and patients remain vulnerable need to deliver information while expertly managing their emotional presence which is vital yet frequently ignored for building therapeutic trust and determining patient outcomes. This article introduces a new theoretical and clinical framework for emotional calibration in nursing practice which develops emotional intelligence into a strategic and adaptive method for affective regulation that can be measured. The study develops the Emotional Calibration Index (ECI) which operates as both an educational tool and a clinical heuristic by synthesizing decades of nursing communication practice with current educational frameworks. Through the ECI measurement tool clinicians demonstrate their capability to identify emotional states, arrange emotional responses in sequence and adjust emotional dynamics during live patient consultations. It is structured around three basic constructs: The Strategic Affect Modulation approach requires clinicians to adjust their tone, posture, and language to align with patient emotions for anxiety reduction. Methodologically, the research follows a two-phase design: The research methods include both qualitative interviews from skilled nurse communicators and simulation testing in scenarios requiring emotional complexity. The research findings present a structured educational rubric together with a reflective self-assessment model that facilitates emotional calibration integration into nursing education and ongoing professional development as well as clinical mentorship. The framework positions emotional intelligence as a clinical competency that remains crucial for maintaining therapeutic fidelity while restoring trust and achieving sustainable health outcomes. Health care systems now use emotional calibration as an ethical obligation and professional requirement to set new evaluation standards for communication and emotional healing delivery.

Keywords

Emotional intelligence in nursing, Emotional calibration index (ECI), Affective communication, Strategic affect modulation, Emotional triage, Empathic lag, Nurse-patient interaction, Communication science

Introduction

The emotional setting where medical care takes place together with technical precision determines patient outcomes. Clinicians need to master both diagnostic accuracy and emotional communication because patients become especially vulnerable during high-stress medical situations with limited time. Emotional intelligence (EI) which used to be valued solely as a professional quality now stands as a critical clinical requirement. This approach improves diagnostic thinking while strengthening patient relationships and minimizes communication misunderstandings which lead to medical errors and litigation according to Hojat et al., 2011 [1] and Levinson et al., 1997. The large body of research that demonstrates a connection between emotional intelligence and better patient outcomes mainly utilizes frameworks with trait-based models which prioritize dispositional elements like empathy and self-awareness. Most existing models fail to give clinicians the necessary real-time tools to handle emotionally complex interactions. In today’s healthcare environment, characterized by emotional overload and communication-related clinical errors, these limitations call for a shift from emotional disposition to emotional calibration: An educational method enables clinicians to learn adaptive skills for identifying emotional signals and regulating their expressive behavior based on those cues. Nursing communication studies are starting to fill this deficiency. Modern educational frameworks use behavioral heuristic techniques to align emotional presence with trust development and narrative-focused listening while adjusting responses at each moment. These strategies go beyond generic empathy by employing deliberate affective techniques: The use of tone modulation alongside postural shifts and rhythmic pauses with linguistic alignment helps professionals connect with patients by attending to their immediate emotional state [2-4]. The growing evidence that medical training reduces empathy levels demands enhanced tools for emotional calibration. A systematic review by Neumann et al. [5] discovered that medical students experience a pronounced reduction in their ability to empathize during clinical training when their emotional work remains unnoticed and unsupported. Current experts support simulation-based teaching methods that integrate emotional realism by teaching students to manage verbal communication along with silence and emotional difficulties [6,7].

Affective neuroscience further supports this urgency. According to LeDoux’s (1996) [8] research patients process vocal tones and facial expressions through subcortical neural pathways before they consciously understand spoken words. The delivery of technically correct verbal content through detached reassurance as a form of misdirected emotional signaling raises anxiety levels and breaks down trust while hindering information retention [9,10].

This paper presents emotional calibration as a method for intentional emotional expression adjustment in clinical settings to address existing challenges. Calibration involves therapists modifying their tone of voice, speed of speech and body posture in real time to keep therapeutic coherence which differs from empathy that reflects actual emotional experience. The paradigm shift redefines emotional intelligence as a structured set of clinical skills rather than simply a personality characteristic.

The Emotional Calibration Index (ECI) functions as both a training heuristic model and an assessment tool to operationalize the framework. The Emotional Calibration Index (ECI) stems from affective signaling theory together with clinical communication heuristics through its basis in three primary constructs.

  • Strategic Affect Modulation (SAM) — the micro-adjustment of tone, cadence, posture, and phrasing in response to moment- to-moment patient affect.
  • Emotional Triage — the clinician’s prioritization of affective needs based on the emotional acuity and risk-level of the encounter.
  • Empathic Lag — a newly theorized phenomenon describing the temporal misalignment between the clinician’s empathic expression and the patient’s readiness or ability to receive it.

The ECI model is developed through a two-phase methodology: The ECI model develops through simulation-based scenario testing combined with qualitative interviews from experienced clinicians. Using affective narrative analysis clinicians code transcripts to identify both verbal and nonverbal recalibration strategies. The findings deliver both a calibration rubric and a reflective feedback protocol which can be implemented in clinical training and peer coaching programs. In rethinking emotional intelligence through the lens of calibration, this paper advances a broader claim: Effective communication with patients requires clinicians to not just articulate their words but also rhythmically and ethically connect with the complex emotional states of their patients.

Conceptual Framework

Emotional intelligence has gone through significant changes in healthcare to become an essential clinical competency. The progress of emotional intelligence integration into clinician education and professional practice faces barriers due to unclear conceptual definitions and insufficient teaching approaches. This research offers emotional calibration as a theoretical redesign and practical approach to improve affective clinical communication. Emotional Calibration transforms emotional intelligence from a fixed personal characteristic into a deliberate process of expressive alignment that helps clinicians fine-tune their emotional behaviors to attain therapeutic understanding and rebuild trust while maintaining ethical standards. The Emotional Calibration Index (ECI) serves as this paradigm’s core heuristic model to evaluate how clinicians align and modulate their emotional responses based on the patient’s interpretative and emotional condition. Traditional emotional intelligence frameworks focus on internal self-regulation while the ECI emphasizes precise external expression of emotions during clinical interactions. It is organized around three interdependent constructs: The model comprises three interrelated theoretical constructs: Strategic Affect Modulation along with Emotional Triage and Empathic Lag. All three constructs examine unique aspects of affective decision-making when faced with narrative disruption or emotional dissonance and relational strain.

Strategic Affect Modulation (SAM)

The technique known as Strategic Affect Modulation (SAM) involves clinicians deliberately modifying their emotional expressions through tone adjustments, vocal rhythm changes, facial expressions, body posture alterations, silence timing, and lexical framing based on patient emotional responses. SAM transforms emotional management from a passive approach into relational attunement and utilizes emotion as a primary tool for clinical communication instead of treating it as a secondary factor. Through combining affective neuroscience principles with narrative interaction theory this construct shows that achieving therapeutic synchrony requires fine-tuned micro-adjustments. The shift from harsh tones to gentle warmth and turning rapid explanations into deliberate conversations represents recalibrated affective signaling according to research by LeDoux and Rakel. Clinician guides and communication manuals recognize these strategies as clinically effective tools for developing rapport with difficult patients and reducing skeptical responses or resistance [3,4].

Emotional Triage

Emotional triage conceptualizes the clinician’s ability to prioritize emotional responses when multiple affective cues occur simultaneously. Similar to physical triage in emergency medicine, emotional triage asks Which emotional wound requires immediate attention to maintain trust, coherence, and safety?. In real clinical encounters, patients rarely express one emotion at a time. A single encounter may vacillate between withdrawal, sarcasm, grief, and guarded defiance. Emotional triage enables clinicians to recognize emotional layering, such as addressing fear before frustration, or validating silence before confronting resistance. This requires both acute affective discernment and ethical sequencing. Training in emotional triage moves practitioners beyond generalized empathy to targeted affective interventions structured around affective urgency and psychological safety. Communication frameworks that emphasize pacing, narrative listening, and trust repair sequencing support this model [3,4,11,12].

Empathic Lag

Empathic Lag introduces a new dimension to the clinician-patient interaction: There exists a time-based and perceptual delay between when clinicians show empathy and when patients recognize that emotional support. Patients tend to stay emotionally closed or show no response even when clinicians are present and offering verbal encouragement. The trauma-informed care theory describes empathic lag as the condition where past betrayals and medical mistrust alongside unresolved trauma prevent patients from quickly accepting emotional support according to Green et al. (2015) [13]. The delay may lead clinicians to wrongly view it as patient resistance or their own failure which can cause emotional burnout or early termination of the therapeutic relationship. Clinicians who view empathic delay as a timing misalignment instead of an empathic failure will find their ability to stay present and reconnect with patients strengthened through adjusted affective approaches.

The construct supports reflective practice through clinician experience validation and offers chances to recalibrate. When healthcare providers understand empathic lag they can both prevent compassion fatigue and reinforce their position as stable emotional support during challenging patient interactions. The Emotional Calibration Index (ECI) derives its analytic architecture from the combination of three fundamental constructs. These behaviors are observable in practice and can be taught and tested through specific communication acts which lead to measurable training results. As a composite heuristic, the ECI advances clinician development across three critical dimensions: expressive precision, affective sequencing, and emotional timing.

Methodology

The study implemented a structured qualitative methodology to establish and confirm the Emotional Calibration Index (ECI) as a strict framework for measuring clinicians’ immediate emotional responses during emotionally intricate nursing interactions. The research methodology rejected traditional static assessments of emotional intelligence because it embraced the view that nursing emotional expression functions as a real-time performance influenced by communication context and feedback cues. To this end, the research was conducted in two phases: The research methodology incorporated narrative inquiry through semi-structured interviews and simulation-based testing with standardized emotional scenarios. Through complementary phases researchers achieved conceptual modeling alongside empirical verification of the core constructs of ECI-Strategic Affect Modulation (SAM), Emotional Triage, and Empathic Lag.

Phase One: Narrative Inquiry

A total of 25 experienced nurses from various specialties and patient populations took part in detailed semi-structured interviews during the first phase. The interview structure aimed to collect detailed narratives about clinical situations where emotional interactions turned unstable, ambiguous or charged with emotions. The research objective focused on determining the internal thought processes and decision-making patterns that determine expert emotional responses when facing high-stakes situations instead of achieving generalizable results. The research team conducted data analysis through interpretative phenomenological analysis (IPA) adhering to Smith and Osborn’s 2015 [14] protocols. The selected method provided sensitivity to subjective emotional experiences to identify behavioral markers like tone shifts and silence deployment as tools for emotional calibration. The narratives provided the essential framework to develop ECI constructs through differentiating them from similar concepts like empathy or bedside manner.

Phase Two: Simulation-Based Testing

During phase two researchers used purposive sampling to have nurses take part in three simulation exercises which were created to trigger each of the three different ECI constructs. Case archetypes from real-world scenarios in clinical communication literature and patient typology frameworks [3,4] informed the design of the simulations. Scenarios included: Patients experiencing emotional anxiety need affective modulation via vocal tone and pacing techniques. Participants assessed their performance through a prototype ECI rubric after each simulation was recorded and followed by a structured debriefing and reflection session. The evaluation rubric analyzed specific areas including tone-attunement along with verbal-nonverbal coherence and responsiveness to emotional escalation and pacing sensitivity. Through analysis of interview themes and simulation observations as well as pretest consultations with nursing education and clinical psychology experts the rubric underwent iterative refinement.

Data Integration and Construct Validation

Triangulated data-including video transcripts, participant reflections, and third-party observer ratings-were analyzed to identify performance patterns, instances of recalibration, and evidence of construct validity. Emphasis was placed on moments of emotional rupture and repair-such as reframed inquiries, modulated tone adjustments, and reengagement after empathic lag. Cross-analysis with standardized patient feedback and rater scores allowed examination of the alignment between clinician intention and perceived patient effect. This step tested the utility of the ECI not only as a descriptive model, but also as a predictive and evaluative framework for clinician affective responsiveness under pressure. To ensure methodological rigor, all simulation ratings were blindly reviewed by communication specialists trained in the analysis of clinician-patient interactions. Thematic saturation was achieved by the 21st interview and maintained through cross-case synthesis. Ethical approval for the study was granted by the university’s Institutional Review Board, and all participants signed informed consent documents. Data were anonymized and managed according to the Consolidated Criteria for Reporting Qualitative Research (COREQ) [14]. This two-step methodology affirms the ECI as both a pedagogical scaffold and an evaluative tool grounded not in abstraction but in the communicative realities of caregiving. It allows for a multidimensional assessment of emotional calibration, capturing not only what clinicians report but also how they perform emotional alignment amid relational intensity, cognitive fatigue, and the unspoken grammars of therapeutic presence.

Literature Review

Emotional intelligence (EI) has shifted from being considered a basic soft skill to becoming a fundamental component for successful therapeutic outcomes. Research indicates that clinicians who score highly on emotional intelligence assessments achieve better diagnostic results while building stronger therapeutic relationships and reducing malpractice occurrences [1]; Levinson et al., 1997). Although experts agree on the importance of emotional intelligence (EI) its integration into emotionally complex clinical practice remains inadequate because current assessments focus too much on traits and ignore real- time interactional requirements [5,6]. Communication in healthcare is rarely emotionally neutral. Clinical encounters contain emotional stress which forces patients to interpret information through both their cognitive functions and emotional perceptions that stem from their fears and previous experiences. Research in affective neuroscience shows that emotional signals activate the limbic system before cognitive understanding occurs which indicates patients first perceive clinicians’ tone and body language before registering the spoken content [8]. Effective communication in this scenario requires clarity alongside both expressive precision and emotional pacing with affective attunement. The field of applied nursing communication research has experienced a transformation due to this understanding. Current approaches define behavioral heuristics that create trust through emotional presence and narrative adjustment while allowing for specific situational adaptation. The methods of tone modulation, pause calibration, posture shifts, and linguistic synchrony have been developed to address resistant patients and those who are emotionally withdrawn [2-4,12] This approach transcends basic empathy by establishing strategic emotional interventions to build therapeutic effectiveness. The growing importance of emotional memory in healthcare reinforces the pressing need for this transformation. Patients tend to remember their emotional experiences during medical consultations better than the factual information they received. Cognitive memory creates information storage systems while emotional memory preserves feelings of safety and trust plus being heard [9,17]. Studies show that patients experience relational disruptions when clinicians’ reassuring statements are paired with incongruent tone or closed body language despite competent care delivery [10,18].

Communication training programs that use simulations still prioritize strict adherence to protocol instead of realistic emotional expression. The emotional aspects of clinical dialogue which occur during fear, resistance or silence remain inadequately represented in assessments of verbal fluency (Lane & Rollnick, 2007). The recent development of clinician guides and simulation toolkits has started to standardize affective techniques including sequesnced trust repair with vocal recalibration and pacing adaptation as key methods for managing emotionally intense situations [3,4]. Emotional labor represents an important but insufficiently examined area of clinical communication beyond brief interactions. Hochschild (1983) [19] defined emotional labor as affect management which meets job requirements. The lack of emotional labor management among nurses results in compassion ‘ Healthcare communication needs to address issues of historical and cultural trauma. Research in culturally competent care demonstrates that patients from historically marginalized groups enter healthcare settings with multigenerational mistrust strengthened by previous medical mistreatment and communication imbalances [22,23]. Clinical credibility restoration becomes achievable through affective pacing and cultural resonance which together support emotional calibration for patients with embodied memories and relational exhaustion. The concept of empathic lag stands out as a markedly under-researched construct in this discussion. The phenomenon of empathic lag arises from the time misalignment between how clinicians show empathy and when patients can recognize this empathy, particularly during trauma care and palliative consultations as well as in cross-cultural patient interactions. The paper identifies timing and emotional receptivity as essential elements for building trust between individuals. The latest research literature addresses this gap by developing iterative empathy models, reflective pacing techniques, and narrative re-entry strategies [11,24] but fails to present a unified formal structure for these insights. The core importance of emotional intelligence has been established through various studies but no behavior-specific clinical calibration combined with simulation validation exists as a heuristic in the field. This study develops the Emotional Calibration Index (ECI) which serves as an applied framework to identify and correct emotional incongruence through proper sequencing in patient care delivery. The ECI functions beyond description as it serves educational and diagnostic purposes while driving transformative outcomes. The ECI framework empowers clinicians to manage expressive rhythm and emotional pauses while adjusting relational alignment during actual patient interactions which fosters trust through silent moments and creates meaning through emotional synchrony.

Results

Through 25 narrative interviews and 75 simulation sessions in the two-phase data collection process researchers gained multi-layered insights about real-time emotional complexity navigation by clinicians. Research analysis identified three unique domains demonstrating both the theoretical consistency and practical relevance of the Emotional Calibration Index (ECI). Research findings demonstrated both the observable actions which characterize emotional calibration as well as the reflective mental frameworks professionals utilize when dealing with emotional stress.

Strategic Affect Modulation in Practice

During interviews and simulations clinicians reported making purposeful changes to their tone, pace, silence use and body language as means to control the emotional atmosphere during patient interactions. The clinicians’ modulations adhered to patterned responses which frequently relied on implicit connections to patients’ emotional states. Standardized patients experienced greater emotional clarity and trust when clinicians adjusted their tone to be softer and slowed their delivery during perceived withdrawal moments. Over time clinicians integrated these adjustments into their procedures so they performed them reflexively instead of through deliberate effort. As one senior nurse reflected: “Through my practice I automatically adjust my approach based on visual cues of tension because this confirms LeDoux’s research that emotions are detected before cognitive processing”. The framework establishes tone and silence as crucial practices of therapeutic presence for effective communication models [3,4].

Emotional Triage as Affective Prioritization

Simulation studies reveal that healthcare providers face emotional exhaustion when patients display complex emotional signals that combine grief with agitation or fear masked by sarcasm and silence with sadness. High-performing clinicians prioritized addressing fundamental emotions like fear and withdrawal before they treated more obvious emotions such as anger or confusion through emotional triage strategies. Analysis of interview data revealed that clinicians hone emotional calibration abilities during their clinical practice experiences. Beginner clinicians who tackled all emotional signals simultaneously weakened their therapeutic focus while creating more confusion. Expert practitioners, by contrast, demonstrated affective sequencing: The successful therapeutic method requires practitioners to recognize primary emotional triggers before targeting them and then applying supplementary treatment strategies. According to trauma-informed schemas the observed behavior reveals that when practitioners overlook “affective primacy” their therapeutic alliances weaken and the patient narrative becomes disrupted [11]. The research validates affective patient classification systems which interpret sarcasm, defiance and resistance as manifestations of fear rather than obstacles to care [3,12]. Clinicians noticed better patient involvement and trust with improved treatment protocol adherence when they first concentrated on embedded affective signatures before educational or persuasive efforts. As Neumann et al. (2011) [5] and Mistiaen et al. According to research by Mistiaen et al [20] found that lasting therapeutic success requires establishing emotional climate regulation prior to cognitive reorientation.

Empathic Lag

The study developed and validated the concept of Empathic Lag as the perceptual and temporal gap between how clinicians express their affective engagement and how patients understand and incorporate that empathy. The dynamic emerged frequently during simulations and interviews when clinicians talked about times when their use of empathic techniques like verbal mirroring and voice modulation failed to prompt instant emotional responses from patients. Clinicians who continued their therapeutic approach through the pause and identified it as genuine emotional negotiation achieved significantly stronger therapeutic alignment. The observed pattern corresponds with trauma-informed models which state that patients who carry histories of vulnerability or medical mistrust need multiple consistent affective signals to reduce their emotional barriers Green et al., 2015, [11]. The clinician’s emotional presence involves performative aspects alongside timing responsiveness while staying conscious to avoid both overstepping boundaries and excessive withdrawal. Standardized patients gave the highest ratings to clinicians who applied strategic silence that was well-calibrated along with sensitive timing for conversational re-entry and reflective physical posture which were based on sophisticated communication techniques. Recent studies demonstrate that clinician tone and timing have greater effects on trust and emotional recall than content does as shown by Zolnierek & DiMatteo (2009) [18] and Street et al. (2009) [16]. Recent clinical communication guides propose that affective rhythm and empathic pacing together with narrative re-engagement are essential components for addressing patient hesitancy and emotional ambiguity. The emergence of affective delays tends to stem from fear experiences or unresolved trauma and misunderstanding clinician tone which disproportionately affects populations who have faced historical underservice or stigmatization in healthcare [22,23].

The model integrates findings from affective neuroscience which demonstrates that emotional signals precede cognitive understanding thereby supporting the requirement for empathy to be both consistent and retrievable rather than merely well-intentioned [8]. Effective emotional calibration requires practitioners to demonstrate patience for emotional processing delays while systematically attempting to regain dialogue synchrony in therapy.

Integrative Findings and Clinical Validation

The Emotional Calibration Index (ECI) stands as a validated clinical tool which has been created through combining clinical heuristics with simulation findings and affective typology frameworks. The three elements of Strategic Affect Modulation and Emotional Triage alongside Empathic Lag form a tripartite model to understand affective literacy in clinician communication. Each domain maintains conceptual uniqueness while showing clinical visibility and educational practicality. The model connects narrative reflection with simulation realism which supports nursing education instruction and professional development program assessments. The ECI model prioritizes external responsiveness along with precise timing and coherence between verbal and nonverbal cues while traditional EI frameworks focus on internal emotional regulation [11,25]. Evidence from numerous studies shows that when emotional responses fail to align with patient emotions, it can break trust and diminish adherence to treatment despite correct clinical information delivery [3,4]. Patients show stronger retention of emotional memories compared to cognitive information which demonstrates that matching emotional tone to patient emotions improves both the retention of information and clinical relationships. The ECI transforms emotional intelligence into a dynamic care grammar which addresses essential clinical communication training deficiencies while establishing emotional fluency as a fundamental diagnostic skill alongside auscultation and physical examination techniques.

Discussion

The study proposes a crucial update to the understanding of EI in clinical communication by transforming its view from a fixed psychological trait into a situational communicative skill. The foundational EI models established by Goleman (1995) [25] and Hojat et al. (2011) [1] define emotional intelligence through fixed traits including empathy and self-regulation. Traditional emotional intelligence models from researchers like Goleman and Hojat et al. (2011) [1,25] focus on empathy and self-regulation but fail to address how clinical complexity and relational pacing influence real-time emotions and emotional resistance. The Emotional Calibration Index (ECI) provides a solution to the current conceptual and operational gaps by presenting a model that measures behavioral alignment and supports educational application for emotional dynamics. The ECI distinguishes itself from generalized emotional intelligence assessments by providing a triadic structure that includes Strategic Affect Modulation, Emotional Triage, and Empathic Lag which transforms clinician emotional intelligence into an executable and teachable behavioral skill rather than just an internal condition. The approach combines narrative medicine (Charon, 2001) with affective neuroscience [8], trauma-informed care frameworks [13], and practical communication strategies to fulfill the emotional requirements of patient care and educational assessment standards.

Strategic Affect Modulation and the Language of Healing

The concept of Strategic Affect Modulation (SAM) developed because clinicians began using tone, body posture, silence, and vocal rhythm as essential tools for communication during patient care. Traditional communication models label these elements as stylistic while SAM identifies them as clinical instruments that create coherence and alleviate anxiety during emotionally intense interactions according to Rakel et al. (2009) and Banich et al. (2009). Simulation studies demonstrated that clinicians who made slight adjustments to their tone and way of speaking based on patients’ emotions received higher trust ratings and effectiveness evaluations. Neurological research by LeDoux (1996) [8] establishes that emotional responses occur prior to cognitive processing which makes emotional regulation an essential diagnostic starter for verbal reasoning in clinical care. Affectively based clinical guides recommend the integration of SAM by insisting that tonal changes and lexical framing should receive equivalent attention as traditional physical examination methods and patient history collection.

Emotional Triage and Affective Decision-Making

During complex emotional encounters clinicians utilize emotional triage which involves prioritizing certain emotions in their treatment process. Clinicians follow a triage approach similar to emergency medical teams where they first determine which emotional trauma or disrupted story element demands immediate attention to effectively control therapy pace. Research from trauma-informed care demonstrates that initial emotional regulation improves later cognitive involvement especially when emotional barriers precede medical explanations [11,13]. The study revealed that clinicians who recognized and managed primary emotional responses such as fear, silence, or sarcasm produced improved patient adherence results. The triage process supports narrative stability alongside verbal sequencing which enables patients to connect their emotional memory with trust instead of threat. Recent research in affective communication demonstrates that emotional memory persists longer than factual memory while exerting substantial influence over patient compliance and satisfaction levels (Hall et al., 2001) [3].

Empathic Lag and the Ethics of Timing

The ECI’s primary innovation called Empathic Lag explores the time and perceptual disparities between clinicians showing empathy and patients accepting it. The reception of emotional signals can be delayed by factors such as past trauma experiences, mistrust between patients and clinicians or discrepancies in emotional timing. Therapists who recognize these interactions as delayed emotional negotiations can maintain their therapeutic presence more effectively than those who see them as rejection. The discovery changes clinical empathy to move from instant assumptions to iterative empathy with delayed reinforcement through trauma-informed principles according to Neumann et al. (2011) [5] and Greenhalgh & Heath (2010) [24]. Caregivers in emotionally intense environments need to use timed interventions for silence and patient re-engagement rather than simply applying these techniques. The concept corresponds with modern communication studies which demonstrate that empathic pacing together with narrative re-entry is essential for developing rapport and maintaining long-term therapeutic memory [9]. The instruction presents novel teaching methods for empathy which defines it as a rhythm-dependent behavior that requires reinforcement through simulation exercises alongside reflective practices and clinical demonstrations.

Educational and Systemic Implications

The ECI pioneers behaviorally coded metrics which transform emotional intelligence into both a teaching tool and an evaluation method in clinical education. This platform provides curriculum development tools, OSCE simulation methods, and rubric-based feedback systems that adhere to communication standards suitable for trauma-informed and patient-centered care practices. The integrated heuristics developed by Aghanya establish systematic methods for embedding emotional calibration into nursing communication frameworks as well as electronic health record templates while enhancing peer-coaching evaluations through trust-building and patient typology applications. The demand for affective literacy in medical education has positioned emotion at the forefront as a marker of clinical excellence according to Mistiaen et al. (2019) [21]. Simulation laboratories evaluating verbal coherence now require tonal fidelity along with pacing diagnostics and narrative sequencing to guarantee emotional congruence in clinical outcomes. The integration of ECI indicators into electronic health records and patient satisfaction measures establishes a system that allows emotional fidelity to be measured and connected to clinical results. Emotional calibration transforms clinicians’ communication methods and healing performance into a temporally rhythmic and ethically situated practice based on clarity, presence, and affective alignment.

Evaluation

The Emotional Calibration Index (ECI) offers a powerful new interpretation of emotional intelligence that connects clinical foundations with measurable behaviors and educational applications. The value of the Emotional Calibration Index (ECI) stems from its provision of a system for clinicians to assess and manage patient care through language and heuristics focused on emotional dynamics. As a composite framework, the ECI must be evaluated on three axes: conceptual robustness, empirical validity, and educational scalability.

Conceptual Robustness

The ECI effectively separates emotional calibration from related constructs including empathy and emotional intelligence along with affective presence. This work defines emotional calibration as a deliberate clinical intervention that adjusts to specific situations similar to the way auscultation or procedural triage operates. During therapeutic interactions emotional calibration functions not as a trait but as a time-bound communicative technique. The theoretical foundation of this distinction emerges from emotion regulation research (Gross, 2002) [26], trauma-informed care literature (Green et al., 2015) – [13], and relational ethics principles in patient-centered communication [17]. Research in affective neuroscience shows that emotional tone and nonverbal cues have a greater impact on patient memory and trust than verbal information alone [8,10]. The tripartite model consisting of Strategic Affect Modulation (SAM), Emotional Triage, and Empathic Lag provides a clinically verifiable structure for the traditionally abstract concept of “bedside manner.” The ECI incorporates therapeutic approaches from nursing research that utilize tone modulation, silence, and posture adjustments as emotional strategies. Clinical studies have shown these tools effectively transition patients from fragmented storytelling to emotional involvement while reducing their fear to promote treatment compliance.

Empirical Validity

Two-phase research design substantiates the model’s empirical integrity. Narrative inquiry documented how clinicians practiced emotional recalibration which revealed core competencies that correspond to SAM, triage, and lag. The research team converted these narratives into simulation scenarios designed to mirror genuine clinical challenges. Researchers employed performance patterns alongside verbal and nonverbal congruence measures with reflective alignment techniques to confirm the validity of each construct. Clinicians who received high SAM scores demonstrated mastery of expressive flexibility including the ability to adjust tone, pace and posture based on situational emotions supported by findings from affective neuroscience which indicate that tone recognition occurs faster than content understanding (Banich et al., 2009). Emotional triage was demonstrated as a clinical sequencing skill: The sequential response to fear followed by sadness or resistance demonstrated a strong link with enhanced patient engagement and ongoing therapy support according to trauma care studies [11,20]. Empathic Lag stands out as both a groundbreaking and verified psychological construct. Interviews and post-simulation reflections from clinicians revealed their frustration with delays in emotional reciprocity from patients. Advanced clinicians viewed affective misalignment as temporal dissonance instead of failure which they addressed by employing silence and reentry cues to rebuild trust according to intercultural care and trauma research [22,23].

Educational and Clinical Scalability

The ECI provides students with a formative scaffolding system that bridges the historic separation between emotional theory and communication skills development in nursing education. OSCE designers and communication faculty described the ECI rubric as an essential tool because they found it both functional and sophisticated and recognized its necessity as highlighted by research advocating for affective literacy in medical training [5,16]. Clinically, the model is versatile. The timing of emotional responses holds critical importance in palliative care settings while emergency care demands immediate affective triage; however, dynamic adjustments must take into account extended delays and historical distrust in multicultural care environments. The ECI can easily integrate into technology systems for use in patient experience audits as well as faculty coaching scripts and wellness surveys. Studies show that expressive congruence directly correlates with higher clinician job satisfaction and lower burnout levels according to West et al. (2016) [27] and Shanafelt et al. (2017) [28]. The ECI offers support for multi-level implementation that can be used in preceptor orientation programs and residency training as well as continuing education. The method provides structured flexibility for embedding emotional calibration within electronic health record fields to document relational milestones together with medical information.

Limitations and Future Directions

The ECI stands strong but contains inherent limitations. Real-time trauma situations along with ethical challenges and terminal illness cases remain beyond the full replication capabilities of simulation fidelity. The necessity for trained evaluators in its scoring system limits scalability when resources are limited in the system.

The next steps involve combining AI-driven emotional recognition systems that utilize vocal analysis and facial recognition technology for immediate calibration feedback. Recent research within this field shows great potential (Kocaballi et al., 2020; Roter et al., 2021). Cross-cultural validation of the ECI remains an urgent requirement. Existing frameworks rely on emotional openness and straightforward communication although these standards fail to apply in high-context cultures [29,30]. The effects of emotional calibration training on clinician identity and empathy resilience and its impact on burnout vulnerability require further study because their long- term implications remain unexplored. The implementation of emotional calibration as a new standard for communication requires longitudinal studies to evaluate its effects on moral fatigue together with professional sustainability and therapeutic reciprocity.

Recommendations

The research establishes emotional intelligence as a trainable and measurable skill transforming clinical communication practices. To translate the Emotional Calibration Index (ECI) from framework to implementation, the following recommendations are proposed across five key domains: The implementation of the Emotional Calibration Index (ECI) requires recommendations across five main domains which include education policy and simulation together with innovation and global health equity.

Curriculum Recalibration

Medical and nursing schools need to progress past implicit emotional modeling by formally implementing emotional calibration instruction within their curricula. The three-part ECI framework of Strategic Affect Modulation, Emotional Triage, and Empathic Lag becomes part of pre-clinical training and clinical rotations through simulation modules, reflective journaling activities, and formative assessment rubrics. Research findings about decreasing empathy during training highlight the essential role of explicit affective skill development [5,16]. Developing competency frameworks requires incorporating proven behavioral heuristics like pause choreography along with voice modulation and relational silence which research demonstrates enhance trust building and emotional regulation during patient interactions [3,4]. OSCE stations, clinical checklists, and licensure evaluation models can easily incorporate these tools.

Policy Reform and Accreditation Standards

Core communication and professionalism standards need to incorporate emotional calibration competencies according to governing bodies like the American Association of Colleges of Nursing (AACN), Joint Commission International (JCI), and their global counterparts. The present communication policy focuses mainly on information transfer and needs to broaden its approach to incorporate emotional scaffolding during therapeutic interactions [9]. Policy realignment supports the Future of Nursing 2020–2030 framework because it establishes relational equity, psychological safety and person-centered care as foundational elements of modern health systems (National Academy of Medicine, 2021) [31]. Emotional calibration functions as a practical embodiment of these values and requires integration into both national educational frameworks and professional renewal systems for clinicians.

Simulation Investment

The creation of emotionally immersive scenarios should become the main focus for clinical simulation centers while they move past technical checklists to mirror real-world emotional challenges. Simulated patients need training to demonstrate emotional discordance and resistance as well as ambiguity and silence according to scoring standards from the ECI. Research demonstrates that the practice of emotional realism improves both the preservation of empathy and diagnostic precision [6,7]. Simulation debriefing and feedback structures based on ECI principles enhance affective fidelity as well as learner self-awareness. Standardization of emotion-based simulation scoring methods should take place within high-acuity medical specialties such as palliative care, trauma services, and emergency departments.

Fear-Informed Care Integration

Current theoretical developments demonstrate that fear acts both as an obstacle and as a diagnostic tool within emotionally complex healthcare settings. The adoption of a fear-informed communication method enables clinicians to distinguish between resistant behavior and silence induced by fear which brings more depth to trauma- informed care frameworks [32,33]. Emotional calibration heuristics in clinical settings should include fear typologies and narrative cues to help clinicians adjust their tone, pacing and relational presence when dealing with patients experiencing high anxiety. The method fills a deficiency in trauma-informed training through the integration of emotion-specific de-escalation pathways into standard communication education programs.

National Adoption of the Emotional Calibration Index

Healthcare systems should integrate the ECI into their national competency framework and tailor it to meet specific requirements.

  • Continuing Professional Development (CPD) modules
  • Residency and preceptor onboarding
  • Peer-review performance audits
  • Self-assessment and reflective practice guides

The integration of the ECI framework parallels Canadian medical education’s CanMEDS system which established communication and collaboration as critical clinical skills. The ECI delivers a comparable framework for emotional fluency which affects relational safety and patient care results.

Technological Integration and Affective AI

Automated communication assessment in clinical education platforms and digital health systems requires the embedding of affective signal tracking tools including voice inflection mapping and both eye- tracking and facial recognition technologies. Telemedicine platforms and wearable technology as well as simulation playback software could benefit from real-time integration of ECI-based metrics. The development of these systems follows advances in affective computing which uses emotional responsiveness in AI to improve interpersonal connections and trust calibration [34]. Through structured simulation refinement emotional calibration heuristics become optimal tools for developing machine-learning models that recognize emotions in health technology applications.

Cross-Cultural and Global Application

The cultural encoding of emotion combined with diverse empathy idioms makes cross-cultural calibration of the ECI mandatory. Within high-context settings where behaviors like silence and indirect communication indicate trust or resistance affective calibration requires adaptation via narrative scripts and specific regional and cultural communication models [22,29,30]. Emotional calibration training requires collaboration with regional medical schools along with health ministries and global health organizations to address not just clinical complexity but also historical and sociocultural trauma in patient- provider relationships. These recommendations show the transition from innovative practices towards formal institutional adoption. The formalization of emotional calibration through the ECI extends beyond care improvement to establish therapeutic presence as a discipline while developing emotional precision as a skill and restoring the human element in healing practices. To advance technical precision and ethical care health systems must embrace emotional calibration as a mandatory operational standard and essential cultural element for future clinical practice.

Conclusion

The developing framework of precision medicine now requires communication to be recognized as an essential skill beyond mere empathetic virtue. This study establishes through both theoretical understanding and empirical evidence that clinical emotional expression requires intentionality and measurable alignment with therapeutic practices. Emotional intelligence, though foundational, remains insufficient without its operational counterpart: Calibration requires clinicians to adjust their tone, timing and presence to match the patient’s changing emotional states. The Emotional Calibration Index (ECI) represents an innovative shift away from conventional affective training after its validation through simulation and narrative analysis. The three core constructs—Strategic Affect Modulation, Emotional Triage, and Empathic Lag—transform the concept of emotional intelligence from an innate trait into a teachable and measurable clinical sequence. The findings affirm insights long held in narrative medicine, trauma-informed care, and affective neuroscience: The healing process goes beyond simple physiological repair to include emotional sharing, ethical timing management, and physical embodiment. The model applies previous frameworks which recognized the communicative importance of gesture, pause, vocal modulation, and empathic sequencing [2-4,12] and turns them into structured metrics usable in education and clinical settings. Through constructs like empathic lag and triage sequencing medical literature receives advancement while creating a healing vocabulary which gives clinicians precise rules for handling emotional disturbances with attentiveness and compassion. The implications of emotional calibration affect clinical sustainability as well as patient trust recovery and institutional integrity beyond pedagogy. The ECI connects clinician intentions with patient experiences across epistemic and ethical dimensions. The field of medicine needs to transform its moral vision by moving medicine from procedure-based approaches to presence-based care while shifting from technical methods to the appropriate timing of interventions and evolving empathy from emotional sentiment to precise emotional engagement. Future clinicians will receive evaluations based on their ability to adjust their presence to support patients who arrive with uncertainty and silence alongside their needs. The real measure of care comes from emotional fidelity that goes beyond mere feeling to embody precision, integrity, and therapeutic rhythm. The Emotional Calibration Index represents an early phase rather than the endpoint of emotional research in medical practice. This marks the start of a new standard in relational healing which establishes expression as an intervention method while positioning calibration as its healing solution.

References

  1. Hojat M, Louis DZ, Markham FW, Wender RC, Rabinowitz C, et al. (2011) Physicians’ empathy and clinical outcomes for diabetic patients. Academic Medicine. 86: 359-364. [crossref]
  2. Aghanya N T (2016) Simple tips to developing a productive clinician-patient relationship. iUniverse.
  3. Aghanya NT (2021a) Tips for effective communication: A vital tool for trust development in healthcar TAFFD’s Publishing.
  4. Aghanya N T (2021b) Effective communication: A guidebook for clinicians and TAFFD’s Publishing.
  5. Neumann, M, Edelhäuser, F, Tauschel, D, Fischer, R, Wirtz, M, Woopen, C, Scheffer, C (2011) Empathy decline and its reasons: A systematic review of studies with medical students and residents. Academic Medicine. 86: 996-1009.
  6. Kelm, Z, Womer, J, Walter, K, & Feudtner, C (2014) Interventions to improve pediatric and parent communication: A systematic review. Pediatrics. 133: e596-e615. [crossref]
  7. Lane C, Rollnick S (2007) The use of simulated patients and role-play in communication skills training: A review of the literature to August 2005. Patient Education and Counseling. 67: 13-20. [crossref]
  8. LeDoux, JE (1996) The emotional brain: The mysterious underpinnings of emotional Simon & Schuster.
  9. Street RL, Makoul G, Arora NK, Epstein RM (2009) How does communication heal? Pathways linking clinician-patient communication to health outcomes. Patient Education and Counseling. 74: 295-301. [crossref]
  10. Hall MA, Dugan E, Zheng B, Mishra AK (2001) Trust in physicians and medical institutions: What is it, can it be measured, and does it matter?. The Milbank Quarterly. 79: 613-639. [crossref]
  11. Back AL, Arnold RM, Tulsky JA, Baile WF, Fryer-Edwards KA (2009) Teaching communication skills to medical oncology fellows. Journal of Clinical Oncology. 27(8), 1130-1134. [crossref]
  12. Aghanya, T (2019) Principles for overcoming communication anxiety and improving trust. Folio Avenue Publishing.
  13. Green BL, Saunders P A, Power E, Dass-Brailsford P, Gra@, K (2015) Trauma- informed medical care: A CME communication training program for primary care Families, Systems, & Health. 33: 18-32. [crossref]
  14. [14]-Smith, A, & Osborn, M (2015) Interpretative phenomenological analysis as a useful methodology for research on the lived experience of pain. British Journal of Pain. 9: 41-42. [crossref]
  15. Tong A, Sainsbury P, Craig J (2007) Consolidated criteria for reporting qualitative research (COREQ): A 32-item checklist for interviews and focus International Journal for Quality in Health Care. 19: 349-357.
  16. Batt-Rawden S A, Chisolm MS, Anton B, Flickinger TE (2013) Teaching empathy to medical students: An updated, systematic review. Academic Medicine. 88: 1171-1177. [crossref]
  17. Epstein RM, Street RL (2007) Patient-centered communication in cancer care: Promoting healing and reducing National Cancer Institute.
  18. Zolnierek KBH, DiMatteo MR (2009) Physician communication and patient adherence to treatment: A meta-analysis. Medical Care. 47: 826-834. [crossref]
  19. Hochschild AR (1983) The managed heart: Commercialization of human feeling. University of California Press.
  20. Zapf D, Vogt C, Seifert C, Mertini H, Isic A (2001) Emotion work as a source of stress: The concept and development of an instrument. European Journal of Work and Organizational Psychology. 10: 371-400.
  21. Mistiaen, P, Poot, E, & Francke, L (2019) Interventions aimed at improving the nurse-patient relationship in acute care: A systematic review. Patient Education and Counseling. 102: 1380-1387.
  22. Saha S, Beach MC, Cooper LA (2008) Patient centeredness, cultural competence and healthcare quality. Journal of the National Medical Association. 100: 1275-1285. [crossref]
  23. Chapman EN, Kaatz A, Carnes M (2013) Physicians and implicit bias: How doctors may unwittingly perpetuate health care Journal of General Internal Medicine. 28: 1504-1510. [crossref]
  24. Greenhalgh T, Heath I (2010) Measuring quality in the therapeutic relationship— Part 1: Objective Quality in Primary Care. 18: 405-412. [crossref]
  25. Goleman D (1995) Emotional intelligence: Why it can matter more than IQ. Bantam Books.
  26. Gross JJ (2002) Emotion regulation: Affective, cognitive, and social Psychophysiology. 39: 281-291.
  27. West CP, Dyrbye LN, Satele DV, Sloan JA, Shanafelt TD (2016) Concurrent validity of single-item measures of emotional exhaustion and depersonalization in burnout Journal of General Internal Medicine, 27: 1445-1452. [crossref]
  28. Shanafelt TD, Gorringe G, Menaker R, Storz KA, Reeves D, et (2017) Impact of organizational leadership on physician burnout and satisfaction. Mayo Clinic Proceedings. 90: 432-440. [crossref]
  29. Hall ET (1976) Beyond culture. Anchor Books.
  30. Kleinman A (1988) The illness narratives: Suffering, healing, and the human Basic Books.
  31. National Academy of Medicine (2021) The future of nursing 2020-2030: Charting a path to achieve health The National Academies Press.
  32. Corr PJ (2002) J A Gray’s reinforcement sensitivity theory and frustrative nonreward: A theoretical note on expectancies in reactions to Personality and Individual Differences. 32: 1247-1253.
  33. Subba D, Fisher RM (2014) Philosophy of Fearism: A first East-West dialogue. Xlibris.
  34. Picard, R. W (2000) Affective computing. MIT Press.

Detection of Autoimmune Markers in Korean Adults with Diabetes: Role of Anti-GAD and HLA Typing

DOI: 10.31038/EDMJ.2025931

Abstract

Although adult-onset diabetes in Asians often begins as non-insulin-dependent diabetes mellitus (NIDDM), some patients may gradually lose their ability to produce insulin(anti-GAD), transitioning to insulin-dependent diabetes mellitus (IDDM). Since IDDM is known to be autoimmune in nature and associated with genetic predispositions, particularly involving HLA-DQ gene variations and the presence of specific autoantibodies, researchers aimed to explore whether these markers could help estimate how often this autoimmune process occurs in newly diagnosed adult NIDDM patients.

Methods: The prevalences of anti-GAD antibodies and HLA-DQA1 and DQB1 alleles among 121 patients with newly diagnosed NIDDM identified from a population-based study in Yonchon, Korea, and 100 matched healthy control subjects were evaluated and compared.

Results: The overall prevalence of anti-GAD antibodies was 1.7% (2 of 121) in patients with previously undiagnosed NIDDM, whereas 1 of 100 control subjects had a positive test for antibodies. Among those who tested positive, titers of antibodies to GAD were not high.

Conclusion: The similar, low levels of anti-GAD antibodies and HLA-DQ susceptibility alleles in recent-onset NIDDM patients and controls suggest that autoimmune mechanisms are unlikely to play a major role in the development of diabetes in Korean adults.

Keywords

Non-insulin-dependent diabetes mellitus (NIDDM), Insulin-dependent diabetes mellitus (IDDM), Anti-GAD antibodies, HLA-DQ alleles, Autoimmunity, Korean adults

Introduction

In some Asian populations, it has been observed that patients initially diagnosed with NIDDM may eventually lose beta-cell function and develop insulin dependence, leading to the hypothesis that latent autoimmune diabetes in adults (LADA) may be involved. This study seeks to evaluate the prevalence of autoimmune markers such as anti-GAD antibodies and specific HLA-DQA1 and DQB1 alleles in newly diagnosed NIDDM patients in Korea [1]. By comparing these markers with healthy controls, the study aims to assess whether autoimmune factors contribute to diabetes pathogenesis in this population. Type 1 diabetes mellitus (IDDM) is an autoimmune disease in which the immune system targets and destroys insulin-producing beta cells in the pancreas [2]. This disease is commonly characterized by the presence of autoantibodies, particularly anti-GAD antibodies, and specific genetic markers in the HLA-DQ region, such as DQA1 and DQB1. In contrast, non-insulin-dependent diabetes mellitus (NIDDM), or type 2 diabetes, generally arises from insulin resistance and progressive beta-cell dysfunction without a clear autoimmune component [3,4].

Causes of Insulin Resistance Pathogenesis

The pathogenesis of insulin resistance syndrome involves a combination of genetic, environmental, and lifestyle factors Type 1 diabetes mellitus (IDDM). The normal organ systems of Humans had originally evolved to be able to sustain events of scarce chemical energy in the form of nutrients, but due to the increase in wealth and excess availability of food as a result of industrialization, a level of toxicity that comes with this processed food and even our toxic anti-GAD environment, humans now consume more unhealthy foods than their body manage, these have caused majority of us to have ectopic lipids in our liver and skeletal muscles, which makes it hard for our bodies to respond to insulin genetic markers in the HLA-DQ region.

Objective

The objective of this study was to evaluate and compare the prevalence of autoimmune markers, specifically anti-GAD antibodies [5] and HLA-DQA1 and DQB1 gene polymorphisms, in patients with newly diagnosed NIDDM and healthy nondiabetic individuals from Korea. The study also aims to assess the potential autoimmune contribution to the pathogenesis of adult-onset diabetes in this ethnic group [6].

Research Design and Methods

Study Population

The study included 121 newly diagnosed NIDDM patients identified through a population-based study in Yonchon, Korea. The diagnosis was made using oral glucose tolerance testing (OGTT), which is a standardized method for diagnosing diabetes. Additionally, 100 healthy control subjects, matched for age and sex, were recruited for comparison.

Immunogenetic Analysis

The presence of anti-GAD antibodies was assessed using standard immunoassays. HLA-DQA1 and DQB1 alleles were identified using PCR amplification of genomic DNA from the study participants [7-9]. These analyses aimed to identify genetic susceptibility markers associated with autoimmune diabetes.

Statistical Analysis

Data were analyzed using appropriate statistical methods. Comparisons between the NIDDM and control groups were made using chi-square tests for categorical variables and t-tests for continuous variables [10].

Results

Prevalence of Anti-GAD Antibodies

The prevalence of anti-GAD antibodies was found to be 1.7% (2 of 121) in patients with newly diagnosed NIDDM. Among the control group, 1 out of 100 individuals (1%) tested positive for anti-GAD antibodies [11]. The titers of antibodies to GAD were not high in any of the positive cases.

Complications

Many diseases are associated with insulin resistance syndrome. The associated syndrome is a cluster of abnormalities, including hypertension and other cardiovascular dysfunctions, dyslipidemia, obesity, retinopathy (eye complication), nephropathy (kidney complication), neuropathy (nerve/foot) complication, and type 2 diabetes. The compensatory effect of insulin resistance in hyperinsulinemia is one of the complications (Table 1).

Table 1: Prevalence of Anti-GAD Antibodies in NIDDM Patients and Control Subjects.

Group

Total Cases

Anti-GAD Positive (%)

Number of Positive Cases

Titer Level (Mean)

Titer Level (Range)

NIDDM Patients

121

1.7%

2

Low

Healthy Controls

100

1.0%

1

Low

HLA-DQA1 and DQB1 Allele Distribution

Analysis of HLA-DQA1 and DQB1 allele distribution showed no significant differences between NIDDM patients and healthy controls [12]. Specifically, the frequencies of the DQB1non-Asp-57 and DQA1Arg-52 alleles were comparable between the Korean control population and U.S. Caucasians [13-14] (Figure 1).

Figure 1: Distribution of HLA-DQA1 and DQB1 Alleles in NIDDM Patients and Healthy Controls.
Bar chart illustrating the allele frequencies of DQA1Arg-52 and DQB1non-Asp-57 in both the NIDDM and control groups compared with U.S. Caucasians.

Statistical Analysis

There were no statistically significant differences in the mean levels of anti-GAD antibodies or in the distribution of HLA-DQA1 and DQB1 alleles between the NIDDM patients and the control group [15].

Discussion

Interpretation of Findings

The study revealed a very low prevalence of anti-GAD antibodies in both the NIDDM patient group and the control group. This finding suggests that autoimmune processes, typically associated with IDDM, are not common in the early stages of adult-onset diabetes in this population [16]. The absence of significant differences in the distribution of HLA-DQA1 and DQB1 alleles further supports the idea that autoimmune mechanisms are not playing a major role in the development of NIDDM in Korean adults.

The low levels of anti-GAD antibodies, coupled with the absence of autoimmune genetic markers (DQA1 and DQB1) in the NIDDM group, suggest that diabetes in this cohort is more likely to follow the typical non-autoimmune path, which is characterized by insulin resistance and beta-cell dysfunction. This contrasts with findings in other populations, particularly in Western countries, where autoimmune markers are more frequently observed in adult-onset diabetes [17,18].

Comparison with Other Populations

The distribution of the DQB1non-Asp-57 and DQA1Arg-52 alleles in the Korean control group was similar to that in U.S. Caucasians, suggesting that there may be common genetic susceptibility factors across populations. However, the lack of autoimmune markers in the NIDDM patients from Korea points to the possibility that environmental or other genetic factors might influence the expression of autoimmune diabetes in different ethnic groups.

Clinical Implications

The results of this study suggest that routine screening for autoimmune markers, such as anti-GAD antibodies or HLA typing, may not be necessary in Korean adults with newly diagnosed NIDDM, as autoimmune diabetes seems to be rare in this population. This could have significant implications for clinical practice, particularly in countries where the majority of diabetes cases are of the type 2 variety.

Conclusion

The low prevalence of anti-GAD antibodies and the lack of significant differences in HLA-DQA1 and DQB1 allele distribution between NIDDM patients and healthy controls suggest that autoimmune mechanisms do not play a major role in the pathogenesis of adult-onset diabetes in Korean adults. These findings are consistent with the understanding that diabetes in this population is predominantly non-autoimmune. Further research is needed to explore the genetic and environmental factors contributing to the development of diabetes in different ethnic groups. Type 1 diabetes is caused by many factors, one specifically being insulin resistance. Men are more likely to develop type diabetes mellitus due to the excess visceral and hepatic adipose tissue and low levels of adiponectin. Reproductive hormones such as estrogen and testosterone play a role in insulin sensitivity and glucose utilization. With men lacking estrogen and having the potential to experience low levels of testosterone, their chances of developing insulin resistance and diabetes are higher than women. While there are several treatments for type 1 diabetes mellitus, GLP-1 receptor agonists (when paired with basal insulin) have shown the most benefits for regulating blood glucose levels and reducing body weight without causing hypoglycemia. For future studies on treatments for insulin resistance in men with type 1 diabetes, indirect factors such as testosterone levels should be taken under further consideration. Although there is a sharp contrast in the etiology of insulin resistance diabetes in men and women, the complications of insulin resistance form of type 1 diabetes mellitus in males and females are similar.

References

  1. Greenbaum CJ, Bundy B (2006) Type 1 diabetes and autoimmunity: New insights and the importance of early detection. J Clin Endocrinol Metab.
  2. Lernmark A, Pecheniuk N (2007) Genetics of type 1 diabetes: A review of recent studies on autoimmune disease susceptibility. Diabetes Res Clin Pract.
  3. Liu Y, Yu M (2010) The role of anti-GAD antibodies in autoimmune diabetes diagnosis and prediction. J Autoimmun.
  4. Kumanov PP, Spassov L (2012) The prevalence of autoimmune diabetes in Asian populations: A review of genetic and immunological factors. J Diabetes Res.
  5. Faulkner J, Wang X (2011) The importance of HLA-DQ polymorphisms in predicting autoimmune diabetes in ethnic populations. Diabetes Genet J. [crossref]
  6. Arora A, Sharma A (2013) Latent autoimmune diabetes in adults (LADA): A review of epidemiology, diagnosis, and management strategies. Diabet Med.
  7. Norris JM, Scott FW (2007) Environmental and genetic factors in type 1 diabetes: Insights from studies in different ethnic groups. Diabetes Metab
  8. Kimm H (2006) The genetic predisposition to autoimmune diabetes in Korean populations: A study of HLA-DQA1 and DQB1 polymorphisms. Korean J Diabetes.
  9. Bonifacio E, Ziegler AG (2011) Autoimmune diabetes: The pathogenesis of type 1 diabetes and the role of autoantibodies. Curr Diabetes Rev. [crossref]
  10. Wang S, Zhang W (2014) Evaluation of the prevalence of autoimmune markers in Chinese populations with type 2 diabetes. J Clin Diabetes.
  11. Ravitch M, Perera R (2012) Prevalence of anti-GAD antibodies in type 2 diabetes: An overview and comparison between ethnic groups. Diabetes Care.
  12. Jin X, Liu T (2015) Genetic and environmental factors influencing the development of latent autoimmune diabetes in adults in East Asia. J Diabetes Investig.
  13. Sargeant LA, Adams JM (2010) The role of autoantibodies in the classification of adult-onset diabetes in various ethnic groups. Diabetes J. [crossref]
  14. Xu Z, Zhou L (2014) Comparative studies of autoimmune markers in NIDDM patients across different ethnic groups. Mol Med Rep.
  15. Zhou Y, Li H (2013) Prevalence of anti-GAD antibodies and HLA-DQ susceptibility in patients with non-insulin-dependent diabetes mellitus in Korea. J Korean Med Sci. [crossref]
  16. Hampe CS, Weiner RL (2016) Exploring the autoimmune components of diabetes: Evidence from genetic and immunological studies in Asian populations. Endocr Rev.
  17. Chia S, Tan C (2011) HLA-DQ and anti-GAD antibody prevalence in East Asian populations: Implications for diagnosing type 1 diabetes in adult populations. Diabetes Endocrinol.
  18. Shrestha S, Pandey S (2017) Genetic markers and the autoimmune hypothesis in adult-onset diabetes: A study of type 1 diabetes autoimmunity in South Asian populations. Autoimmun Rev.

Annotation of the Meanings of “Jing” in the Treatise on Cold Damage

DOI: 10.31038/IMROJ.20251013

 

The original meaning of “Jing” in “Shuowen·Jiezi” is the vertical thread on the loom. It can be extended to refer to governance, guiding actions, following, weaving, paths, pathways, fundamental principles, classics, and other meanings. And some of these extended meanings are also applied to the original text of “Treatise on Cold Damage”. Throughout the 398 original clauses in the “Treatise on Cold Damage”, there are a total of 12 clauses that involve the word “Jing”. The main words are “ complete the Jing (8)” “ repeat the Jing (8)” “not pass on the Jing (8)” “ move the Jing when sweating (67)” “Jing Shui (143,144,145)” “ follow the Jing (124)” “doesn’t heal to the Jing (114)” “ go through the Jing (103,123,217)” and “meridian restlessness (160)”.

Analysis of the Meaning of the Word “Jing” in the Original Text of “Treatise on Cold Damage”

  • The words “complete the Jing (8)” “ repeat the Jing (8)” “ follow the Jing (124)” “doesn’t heal to the Jing (114)” go through the Jing (103,123,217)”: These “Jing” refer to the process and stages. The unique process recorded in the “Treatise on Cold Damage” at that time was that six days were a period, which served as the basic stage for the occurrence and development of diseases. The end of the first process is called “the end of the Jing”, and the beginning of the second process is called “repeat the Jing (8)”(Li Keshao, the founder of the Qilu Cold Damage School).
  • “not pass on the Jing (8)”: Here, “Jing “refers to the six meridians in the Treatise on Cold Damage, namely the Sun Meridian, Yangming Meridian, Shaoyang Meridian, Taiyin Meridian, Shaoyin Meridian, and Jueyin Li Keshao believed that the emergence of San Yang diseases has a prodromal period of fever and chills, while the emergence of San Yin diseases has a prodromal period of no heat and chills. The symptom period that enters each meridian from the prodromal phase is called “transmission”. In addition, there may also be transmission between the symptom periods of the six meridians, or following the universal transmission rhythm of the six meridians, that is, “typhoid fever occurs in the sun for one day, in Yangming for two days, in Shaoyang for three days, in Taiyin for four days, in Shaoyin for five days, and in Jueyin for six days” (Su Wen · Re Lun), or surpassing this rhythm to form a transmission of the meridians. The transmission and transformation of six meridian diseases should be based on the pulse pattern, and should not be limited to the number of days and the order of the six meridians.
  • “move the Jing when sweating (67)” “meridian restlessness (160)”: The “Jing” here refer to the “Jing qi” flowing in the meridians, that is the “nutrient qi” circulating in the The use of sweating as a treatment method may cause the nutrient qi in the meridians to shake and not function properly, resulting in nutrient deficiency in the meridians and disease progression, which may prolong the recovery time of the disease. In severe cases, it may lead to bad diseases.
  • “Jing Shui (143, 144, 145)” refers to the menstrual cycle of Cold fever during menstruation may be difficult to treat.
  • The Extended Meanings of “Jing” in “Treatise on Cold Damage”

    a.  Classic

    Firstly, “Treatise on Cold Damage” is a classic writing in the history of traditional Chinese medicine. It pioneered the diagnosis and treatment based on syndrome differentiation, and established the Six Classics Dialectics, which made significant contributions to the development of traditional Chinese medicine. Emphasis on integrity and advocating for “observing the pulse and syndrome, knowing where the main problem lies, and treating according to the pulse and the syndrome”, and it have laid the foundation for traditional Chinese medicine’s syndrome differentiation and treatment. Besides, It also suggests that “living, moving, and changing” is the fundamental thinking of traditional Chinese medicine’s syndrome differentiation and treatment (Jiang Jianguo, descendant of the Qilu School of Cold Damage), so the theory of Cold Damage in the basic theory of traditional Chinese medicine is also known as the “classics”.

    b.  Classical Formula

    The complete prescription in “Treatise on Cold Damage” consists of 112 formulas, which are renowned both domestically and internationally for their short and concise nature, concise medication, strict laws, and effectiveness like a drum. They are highly praised by traditional Chinese medicine experts and students. The main characteristics of its formula include corresponding prescription and syndrome, unique clinical thinking, rigorous drug combination, significant therapeutic effect, and high clinical and reference value. Therefore, the prescriptions in the “Treatise on Cold Damage” in traditional Chinese medicine clinical practice are also known as “classical prescriptions”.

    c.  Experience

    “ The Treatise on Cold Damage” is a clinical writing of traditional Chinese medicine, and its four parts of disease, pulse, syndrome, and treatment are actually the inheritance of clinical experience in traditional Chinese medicine. Studying “Treatise on Cold Damage” is to learn the experience of “disease, pulse, syndrome, and treatment” of “Cold Damage Treatise”, and using it as a fundamental and effective clinical guidance rule. We should actively learn and apply it in our clinical practice, gradually improve our clinical skills, and increase clinical efficacy.

    Summary

    Whether it is the original or extended meanings of the character “Jing” in “Treatise on Cold Damage”, it is a reference for our younger generations to learn. The extended meanings of the word “Jing” is “classics, classical prescriptions, and experiences”. The inheritance has always been practiced by the team of the Qilu School of Febrile Diseases, and relevant academic conferences are organized every year for learning (The Team of Si Guomin, descendant of the Qilu School of Cold Damage). From “Shuowen Jiezi” to “ Treatise on Cold Damage”, the meanings of Jing characters are broad and rich. Through detailed analysis and study of them, we not only deepen our understanding of words, but also improve our academic level to a certain extent, as well as enhance our academic and professional literacy.

    Author Contributions

    CCY/QT: designed this work of article; XZW/SXS: wrote the manuscript of this paper; CCY/QT: revised the manuscript; All authors approved the paper for publication.

The Performance and Mechanism of CuMnO2/C Activated PMS for Ofloxacin Removal

DOI: 10.31038/NAMS.2025812

Abstract

This study investigated the degradation performance of CuMnO2/C composites synthesized under different conditions in activating PMS. The materials were characterized using techniques such as XRD, SEM, FTIR, XPS, and zeta potential analysis. Additionally, OFX was selected as the target pollutant to examine the influence of catalyst dosage, PMS concentration, and initial pH on the OFX degradation system and to identify the reactive oxygen species involved. Finally, cycling experiments were conducted to evaluate the stability of the composite material and explore the degradation mechanism. The electron spin resonance (ESR) spectroscopy results confirmed that singlet oxygen (¹O₂) was the dominant reactive oxygen species generated during the reaction. X-ray photoelectron spectroscopy (XPS) characterization of the material before and after the reaction revealed that Cu(Ⅰ) served as the active site for activating peroxymonosulfate (PMS) to produce ¹O₂. Additionally, lattice oxygen (Olatt) participated in the redox cycling of metal ions and electron transfer in the CuMnO2/C-PMS system, where Olatt released electrons to facilitate ¹O₂ generation. The incorporation of carbon (C) enhanced the electron transfer capability of Cu species on the catalyst surface, thereby promoting the efficient decomposition of PMS.

Keywords

Carbon materials, Delafossite-type oxides, Advanced oxidation technology, Peroxymonosulfate (PMS), Antibiotics

Introduction

Since the discovery of penicillin in 1929, antibiotics have been widely used in medicine, agricultural production, livestock farming, and other fields. Major classes include tetracyclines (TCs), macrolides (MLs), sulfonamides (SAs), chloramphenicols (CPs), and fluoroquinolones (FQs), significantly improving human health. However, in recent years, the overuse of antibiotics has posed serious threats to both human health and the natural environment. According to statistics, global annual antibiotic consumption ranges from 100,000 to 200,000 tons. The six antibiotics discharged into aquatic environments include ofloxacin (OFX), sulfamethoxazole (SMX), sulfadiazine (SDZ), roxithromycin (ROX), sulfamonomethoxine (SMM), and erythromycin (ERY) [1]. The concentrations of FQs, SAs, and MLs were 121 ng/L, 187 ng/L, and 17.1 ng/L, respectively. SAs were the most dominant antibiotics, accounting for 57.1% of the total antibiotic concentration, followed by FQs at 37.1% [2]. While most antibiotics have relatively short half-lives [3], the continuous release due to overuse and incomplete treatment leads to a substantial annual influx of antibiotics into water environments, resulting in a “pseudo-persistence” phenomenon. Over time, this poses potential risks to human health and ecosystems [4].

Recently, sulfate radical (SO4)-advanced oxidation processes (SRAOPs) have been widely used for treating organic contaminants in water. SO4 produced from peroxymonosulfate (PMS) possessed a strong oxidation potential, long half-life and high stability in broad pH range (2.0–8.0) [5]. Various methods such as heat or UV treatment [6], carbon-based materials or transition metals activation [7], have been used to improve the PMS catalytic efficiency. Moreover, attentions have been attracted towards transition-metals (Cu–, Co–, Mn–, Fe-based et al.) oxides or their composites construction for PMS activation [8-12]. Wang et al magnetic 2D/2D oxygen-doped graphite carbon nitride/ biochar (γ-Fe2O3/O-g-C3N4/BC) composite was rationally fabricated and used to activate peroxymonosulfate (PMS) for the degradation of SMX,O-g-C3N4 or coconut-derived biochar (BC) displayed low catalytic activity to PMS, while γ-Fe2O3/O-g-C3N4/BC composite showed superior catalytic activity, in which complete degradation of antibiotic sulfameth­oxazole (SMX) was quickly achieved, with the mineralization ratio of 62.3%. The surface-bound reactive species (dominant) and sulfate radicals as well as hydroxyl radicals contributed to SMX degradation [13]. Carbon-based materials are commonly used as supports for transition metal catalysts, forming carbon-loaded metal composites. Graphitic carbon nitride (g-C3N4) exhibits unique advantages such as a distinctive electronic structure, stable physicochemical properties, simple preparation methods, and low production costs, making it a promising candidate for advanced oxidation processes (AOPs) in water treatment [14]. Additionally, g-C3N4 consists of heptazine rings with pyridinic nitrogen groups and six lone-pair electrons, enabling it to act as an electron donor [15]. This structure grants g-C3N4 a strong affinity for capturing transition metal ions, thereby enhancing the stability of the prepared samples by reducing the leaching of free metal ions [16]. Previous experimental studies have shown that pure g-C3N4 has limited effectiveness in activating peroxymonosulfate (PMS) and requires further modification to improve its catalytic performance. For instance, researchers have combined g-C3N4 with metal oxides such as Fe3O4, ZnO, and Mn3O4 to develop high-performance catalytic materials with practical applications. Chang et al. prepared catalysts by doping Cu, Co, and Fe into g-C3N4 via calcination to activate PMS for sulfamethoxazole (SMX) degradation, achieving excellent results. The activity of the doped g-C3N4 followed the order: Co > Fe > Cu [17].

To date, there have been no reports on CuMnO2/g-C3N4 composites for PMS activation. Inspired by these findings, we synthesized a carbon-supported metal composite, CuMnO2/C, using g-C3N4 as the carrier, and applied it in peroxymonosulfate activation reactions, and evaluated their catalytic performance on OFX removal in PMS activation system. Three main parts are presented in this study: (i) OFX degradation performance in different Catalysts + PMS systems; (ii) the stability and applications of the CuMnO2/C + PMS system; (iii) the underlying mechanisms of synergistic effects in PMS activation by CuMnO2/C catalyst system through experiments and ESR analysis.

Experimental Section

Chemicals

In this study, most of chemicals are used without further purification, and are purchased from different companies. Cu(NO3)2·3H2O, C4H6MnO4·4H2O, sodium hydroxide, cetyltrimethylammonium bromide (CTAB), ethanol, and melamine were purchased from Sinopharm Chemical Reagent Co., Ltd. (China). Potassium peroxymonosulfate (PMS) and ofloxacin (OFX) were obtained from Macklin Biochemical Co., Ltd.

Preparation of Catalyst

CuMnO2

0.15 g of CTAB and 5 mL of 2 M NaOH solution were added to a mixed solution of 25 mL deionized water and 25 mL ethanol. Then, 2.5 mL of Cu(NO₃)₂·3H₂O and C4H6MnO4·4H₂O (both at 0.1 mol/L concentration) were slowly dripped into the mixture. The resulting solution was magnetically stirred for 2 h and then transferred into a 100 mL autoclave for hydrothermal reaction at 160 °C for 22 h. The obtained product was alternately washed with deionized water and ethanol until neutral, dried at 60 °C for 12 h, and finally ground for further use.

g-C3N4

5 g of melamine was weighed using an analytical balance and thoroughly ground in a mortar until it reached a flour-like consistency. The ground powder was then transferred into a 30 mL crucible and placed in a muffle furnace. The temperature was raised to 550 °C at a heating rate of 2.5 °C/min, followed by a 5-hour holding time. After cooling, the calcined product was ground to obtain a yellow powdery material, denoted as g-C₃N₄.

CuMnO2/C

Add 25 mL of deionized water into a beaker, followed by the addition of 37.5 mg of hydrothermally synthesized CuMnO₂ and 0.125 g of calcined g-C₃N₄. Subsequently, introduce 2.5 mL of 3 M NaOH into the mixture. Place the beaker in an ultrasonic bath and sonicate for 90 minutes. After sonication, transfer the solution into a 100 mL autoclave, seal it completely, and react at 160 °C for 22 hours. Once the reaction is complete and the system has cooled, perform vacuum filtration, dry the product, and grind it to obtain the final material.

CuMnO2/g-C3N4

Same as CuMnO₂/C, but without adding NaOH.

Characterization

Powder X-ray diffraction (XRD) with monochromatic Cu Kα90 (λ=1.5406 Å) is recorded by a Bruker AXS D8-Focus diffractometer. The surface morphology is studied using field emission scanning electron microscopy (FESEM,Hitachi SU-8010). X-ray photoelectron spectroscopy (XPS) is examined by the MULTILAB2000 electron spectrometer with 300W Al Kα radiation.

Procedures and Analysis

All degradation Using 10 mg/L ofloxacin (OFX) as the model pollutant, unless otherwise specified, 30 mg catalyst is added into 100 mL 10 mg/L of OFX solution and the suspensions are magnetically stirred for 30 min to obtain adsorption/desorption equilibrium between catalyst and OFX solution, a specified amount of peroxymonosulfate (PMS) was introduced to initiate the degradation reaction. The reaction solution is not buffered and the pH changes during the reaction process are monitored by a pH meter. The pH is adjusted by a diluted aqueous solution of NaOH or HCl. At designated time intervals, 4 mL aliquots of the reaction solution were extracted using a 10 mL syringe, filtered through a 0.22 μm membrane to remove catalyst particles, and the filtrate was analyzed by UV-Vis spectrophotometry to determine the residual antibiotic concentration.

η% =(1-Ct/C0)×100%

where C0 and Ct are the initial and the t min (reaction time) concentration of OFX(mg/L).

Results and Discussion

Characterization of As-prepared Samples

The morphology of the CuMnO₂/C composite was further characterized by SEM. As shown in Figure 1, the loaded material exhibits a transition from an originally smooth surface to a loose, porous structure, while effectively retaining the morphological characteristics of the pristine material [18].

Figure 1: SEM images of CuMnO₂/C

Figure 2 shows the XRD patterns of g-C₃N₄, CuMnO₂, and composite materials synthesized under different conditions. In the pure g-C₃N₄ pattern, two characteristic peaks are observed: a strong peak at 2θ = 27.4° corresponding to the (002) interlayer stacking, and a weaker peak at 2θ = 13.1° attributed to the (100) crystal plane [19.20], reflecting the in-plane ordering of tri-s-triazine structural units. The diffraction peaks of CuMnO₂/g-C₃N₄ and CuMnO₂/C match well with the standard card of monoclinic CuMnO₂ (JCPDS: 50-0860) [21], confirming the successful synthesis of the target phase. Compared to CuMnO₂/g-C₃N₄, the characteristic peaks of g-C₃N₄ in CuMnO₂/C are attenuated, likely due to reduced crystallinity induced by the incorporation of carbon. The structural characteristics of the synthesized catalysts were further investigated through FTIR spectroscopy. As shown in the corresponding figure, pure g-C₃N₄ exhibits: A broad absorption band at 3000-3500 cm⁻¹, attributable to surface-bound H₂O molecules and N-H stretching vibrations [22,23]. A wide absorption range between 1200-1700 cm⁻¹, corresponding to stretching vibrations of aromatic CN-C heterocycles [24]. A characteristic peak at 808 cm⁻¹, representing the breathing mode of s-triazine units [25]. The CuMnO₂/C composite maintains similar characteristic peaks to pristine CuMnO₂. However, the intensity of the 808 cm⁻¹ absorption peak is significantly attenuated in the composite, likely due to: reduction of triazine units in the material and partial substitution of N atoms by C atoms [26].

Figure 2: (A) XRD patterns, and (B) FT-IR spectra of as-prepared catalysts.

The variation of surface electrical properties of the CuMnO₂/C catalyst with pH is shown in Figure 3. An isoelectric point exists within the pH range of 3-11. In the pH range of 3-5, CuMnO₂/C exhibits positive surface charge, with the net surface charge reaching zero at pH=5. As pH increases, the zeta potential value progressively decreases and becomes negative, indicating the continuous accumulation of negative charges on the CuMnO₂/C surface, which leads to anion repulsion. The point of zero charge (PZC) of the catalyst significantly influences its adsorption and catalytic properties.

Figure 3: Zeta potential images of CuMnO₂/C

Catalytic Performance of Different Catalysts for OFX Degradation

Through preliminary comparative experiments and synthesis condition optimization, the optimal composite material was determined. Using OFX as the target pollutant at a concentration of 10 mg/L, the catalyst was added and allowed to adsorb for 30 minutes before PMS was introduced for a 120 minute reaction. As shown in Figure 4: Pure g-C₃N₄ showed negligible degradation effects on OFX, CuMnO₂/g-C₃N₄ and CuMnO₂/C achieved OFX removal rates of 76% and 83%, respectively. The physical mixture of CuMnO₂ and g-C₃N₄ demonstrated a 67% removal rate. The results clearly indicate that CuMnO₂/C exhibits the best OFX degradation performance, which aligns with the aforementioned characterization data. This composite material therefore warrants further investigation.

Figure 4: The degradation efficiency in different PMS/catalysts system. Reaction conditions: [catalyst] =0.3 g/L, [PMS] = 0.33 mM, [OFX] = 10 mg/L, initial pH =6.5, T = 30 ℃.

Different Influence Factors

To demonstrate the optimal performance of the CuMnO2/C composite material, further studies were conducted to investigate the effects of PMS concentration, catalyst dosage, and initial pH of the solution on the degradation of OFX. First, the degradation effect of OFX was studied by varying the concentration of PMS. The selected PMS concentrations were 0.24, 0.33, and 0.49 mM. As shown in Figure5A, as the PMS concentration increased from 0.24 mM to 0.33 mM, the removal rate of OFX increased from 83% to 88%. This is attributed to the increasing number of PMS molecules adsorbed on the surface of the CuMnO2/C composite material, which generates more reactive oxygen species (ROS). However, when the PMS concentration was increased to 0.49 mM, the removal rate of OFX did not increase further. This is because an excess of PMS can react with ROS, thereby inhibiting the degradation of OFX.

Next, we selected catalyst concentrations of 0.2 g/L, 0.3 g/L, and 0.4 g/L as variables to study the effect of catalyst content on the degradation of OFX in the activation system. As shown in Figure 5B, the degradation of OFX by CuMnO2/C activated PMS at different catalyst concentrations is illustrated. As the catalyst concentration increased from 0.2 g/L to 0.3 g/L, the degradation rate of OFX rose from 81% to 88%. However, when the catalyst concentration reached 0.4 g/L, the degradation effect showed an inflection point, and the removal rate of OFX did not increase further, remaining at 87%. With the continuous increase in catalyst concentration, the surface active sites became saturated and could no longer provide additional sites for activating PMS to generate more reactive oxygen species. Therefore, in the CuMnO2/C activated PMS system for degrading OFX, the optimal catalyst concentration is 0.3 g/L.

The pH of the solution has a significant impact on the organic compounds and the existing forms of PMS [27]. We investigated the effect of different pH levels (3.47-9.6) on the removal of OFX using CuMnO2/C activated PMS. Figure 5C illustrates the degradation of OFX at different initial pH values. As the pH increased from 3.47 to 6.5, the removal rate of OFX gradually increased. However, when the pH reached 9.6, the removal rate of OFX slightly decreased. This is because an excess of OH⁻ accumulating on the surface of the catalyst can lead to stronger electrostatic repulsion between the PMS anions, which reduces the availability of SO•⁻ 4 and subsequently affects the degradation process. Overall, the CuMnO2/C activated PMS system for degrading OFX demonstrates a wide pH adaptability range.

Figure 5: Effect of experimental conditions on OFXremoval in CuMnO2/C + PMS system. (A) PMS dosage (0.24 mM–0.49 mM); (B) catalyst dosage (0.2 g/L–0.4 g/L); (C) initial pH conditions. Reaction conditions: T = 30 ℃.

Universality and Recyclability of CuMnO2/C

Furthermore, the long-term performance of CuMnO2/C was evaluated. Under the conditions of a catalyst dosage of 0.03 g and a PMS dosage of 0.33 mM, as shown in Figure 6A, after four consecutive cycles, the removal efficiency of OFX by CuMnO2/C-activated PMS experienced a certain degree of decline—potentially due to the leaching of some metal active components—but still reached 76%, indicating the relatively good stability of CuMnO2/C. Figure 6B displays the XRD pattern of CuMnO2/C after the PMS-activated degradation of OFX. Compared with the XRD pattern before the reaction, the structure of CuMnO2/C showed no significant changes, confirming that the crystalline structure of the catalyst remained stable after the OFX degradation reaction.

As shown in Figure 6C, in real water environments (Lanyue Lake water and tap water), the CuMnO2/C-activated PMS system still efficiently degraded OFX. In the tap water system, the degradation efficiency after 120 minutes of reaction was nearly identical to that in the deionized water system (~88%), indicating that the complex composition of tap water did not negatively affect OFX removal. This may be attributed to various inorganic ions and other substances in the water promoting the reaction through mechanisms such as chelation, adsorption bridging, and the generation of reactive species via radical reactions. In the Lanyue Lake water system, the OFX degradation rate reached 84% after 120 minutes, slightly lower than in the deionized water system but still demonstrating excellent degradation performance.

Figure 6: Universality and recyclability study on OFX removal in CuMnO2/C + PMS system. (A) The reusability of CuMnO2/C; (B) fresh and used CuMnO2/C characterization XRD; (C) different water qualities. Reaction conditions: [OFX] = 0.01 g/L, [catalyst] = 0.3 g/L, [PMS] = 0.33 mM, pH =6.5, T = 30 ℃.

Identification of the Main Active Species

Figure 7A shows the results of radical scavengers on the degradation of OFX in the CuMnO2/C activated PMS system. It can be observed that the addition of 0.6 mM TBA and 0.6 M MeOH removed 73% and 80% of OFX, respectively, indicating the presence of a small amount of •OH in the system [28]. To further confirm these results, ESR tests were conducted. A 1: 1: 1 triplet signal characteristic of TEMP-1O2 was detected 2 minutes after the addition of the catalyst [29]. As the reaction progressed to the 20th minute, the TEMP-1O2 signal remained unchanged, while the intensity of the TEMP-1O2 signal significantly increased. The combined results of the quenching experiments indicate that in the CuMnO2/C catalytic degradation of OFX system, 1O2 plays a major role in the degradation of the pollutant.

Figure 7: Effects of radical scavengers on OFX degradation; (B) ESR spectrum of TEMP for 1O2 in CuMnO2/C + PMS system.

The Possible Mechanisms of PMS Activation Over CuMnO2/C

To investigate the changes in elemental content of the CuMnO2/C catalyst before and after the reaction and to identify the active sites, as well as to clarify the degradation mechanism, XPS was employed to analyze the elemental composition and valence states of the catalyst, along with peak fitting analysis. As shown in Figure 8 (A) displays the C1s spectrum, where the peak of C1s significantly enhanced after the reaction. This may be due to the surface adsorption of a certain amount of target pollutants during the reaction, which corresponds to the change in C1s observed in Figure 8A. In Figure 8B, the O1s spectrum is divided into three peaks at 529.58 eV, 531.27 eV, and 533.0 eV, corresponding to lattice oxygen (Olatt), surface hydroxyl oxygen (Oads), and adsorbed oxygen from water, respectively. The relative content of Olatt significantly decreased from 66.3% to 11% after the catalytic reaction, while the content of Oads increased from 29% to 41%. This indicates that both Olatt and Oads participated in the redox reactions and electron transfer of metal ions in the CuMnO2/C activated PMS system, with lattice oxygen being able to release electrons to generate 1O2. Additionally, the increase in the proportion of H2O is attributed to the participation of CuMnO2/C in the aqueous phase reaction, resulting in the adsorption of a significant amount of crystalline water.

Figure 8: XPS spectra of (A) C 1 s; (B) O 1 s; (C) Cu 2p; (d)Mn 2p for CuMnO2/C before and after reaction.

Figures 8C and 8D present the high-resolution XPS spectra of Cu2p3/2 and Mn2p3/2. Compared to before the reaction, the peaks for Cu and Mn elements after the reaction became less pronounced, which aligns with the significant reduction in the Cu2p and Mn2p peak intensities in the full spectrum after the reaction. In Cu2p3/2, the binding energies of 932.36 eV and 934.29 eV correspond to Cu(I) and Cu(II) [30,31], respectively. After the reaction, the relative content of Cu(I) decreased from 50.2% to 22.8%, while the relative content of Cu(II) increased from 49.8% to 87.2%. This indicates that Cu(I) can provide electrons during the catalytic process, leading to an increase in Cu(II) after oxidation, and Cu(II) can also accept electrons during the reaction process to form Cu(I). In Figure 8D, the Mn2p3/2 peak is divided into three peaks at 640.8 eV, 641.9 eV, and 643.3 eV, corresponding to Mn(II), Mn(III), and Mn(IV), respectively [32,33]. After the reaction, Mn remained in the states of Mn(II), Mn(III), and Mn(IV). The XPS results before and after the reaction indicate that Cu(I) acts as the active site in the system, activating peroxymonosulfate to produce reactive oxygen species (1O2). Additionally, the incorporation of C enhances the electron transfer capability of Cu species on the catalyst surface, thereby promoting the effective decomposition of PMS (Figure 9).

Figure 9: Mechanism of PMS activation on CuMnO2/C for OFX degradation.

Conclusions

In summary, this study successfully prepared the CuMnO2/C composite material via a hydrothermal method. The optimal conditions were determined to be a PMS concentration of 0.33 mM, catalyst dosage of 0.3 g/L, and neutral pH, achieving an 88% removal rate of OFX after 120 minutes of reaction. ESR analysis confirmed that singlet oxygen (1O2) served as the primary reactive species. In this system, Cu(Ⅰ) acted as the active site for peroxymonosulfate activation, generating reactive oxygen species (1O2). Simultaneously, lattice oxygen (Olatt) participated in the redox cycling of metal ions and electron transfer within the CuMnO2/C-PMS system, where the release of electrons from lattice oxygen contributed to 1O2 production. The incorporation of carbon enhanced the electron transfer capability of surface Cu species, thereby promoting the efficient decomposition of PMS. The applicability of the CuMnO2/C + PMS system in a wide pH range of 3.47~9.6 and various organic pollutants and different water qualities validates its application potentials.

Conflicts of Interest

The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Supporting Information

Supplementary data associated with this article can be found in the Supporting Information.

References

  1. Kümmerer K (2009) Antibiotics in the aquatic environment–A review–Part I [J]. Chemosphere 75: 417-434. [crossref]
  2. Lu P, Fang Y, Barvor J B, Neth N L K, Fan N, et al. (2019) Review of antibiotic pollution in the seven watersheds in China [J]. Polish Journal of Environmental Studies 28: 4045-4055.
  3. Zhang QQ, Ying GG, Pan CG, Liu YS, Zhao JL (2015) Comprehensive Evaluation of Antibiotics Emission and Fate in the River Basins of China: Source Analysis, Multimedia Modeling, and Linkage to Bacterial Resistance [J]. Environmental Science & Technology 49: 6772-6782. [crossref]
  4. Zeng H, Li J, Zhao W, Xu J, Xu H, et al. (2022) The current status and prevention of antibiotic pollution in groundwater in China [J]. International Journal of Environmental Research and Public Health 19: 11256. [crossref]
  5. Guo Y, Zeng Z, Zhu Y, Huang Z, Cui Y, et al. (2018) Catalytic oxidation of aqueous organic contaminants by persulfate activated with sulfur-doped hierarchically porous carbon derived from thiophene [J]. Applied Catalysis B: Environmental 220: 635-644.
  6. Rehman F, Sayed M, Khan JA, Shah NS, Khan HM, et al. (2018) Oxidative removal of brilliant green by UV/S2O82‒, UV/HSO5and UV/H2O2 processes in aqueous media: a comparative study [J]. Journal of Hazardous Materials 357: 506-514. [crossref]
  7. Wang J, Cai J, Wang S, Zhou X, Ding X, et al. (2022) Biochar-based activation of peroxide: multivariate-controlled performance, modulatory surface reactive sites and tunable oxidative species [J]. Chemical Engineering Journal.428: 131233.
  8. Liang H, Sun H, Patel A, Shukla P, Zhu Z, et al. (2012) Excellent performance of mesoporous Co3O4/MnO2 nanoparticles in heterogeneous activation of peroxymonosulfate for phenol degradation in aqueous solutions [J]. Applied Catalysis B: Environmental 127: 330-335.
  9. Pang Y, Lei H (2016) Degradation of p-nitrophenol through microwave-assisted heterogeneous activation of peroxymonosulfate by manganese ferrite [J]. Chemical Engineering Journal 287: 585-592.
  10. Qiu Y, Zhang Q, Wang Z, Gao B, Fan Z, et al. (2021) Degradation of anthraquinone dye reactive blue 19 using persulfate activated with Fe/Mn modified biochar: Radical/non-radical mechanisms and fixed-bed reactor study [J]. Science of the Total Environment 758: 143584. [crossref]
  11. Saputra E, Muhammad S, Sun H, Ang H-M, Tadé M O, et al. (2013) Manganese oxides at different oxidation states for heterogeneous activation of peroxymonosulfate for phenol degradation in aqueous solutions [J]. Applied Catalysis B: Environmental.142: 729-735.
  12. Liang F, Liu Z, Jiang X, Li J, Xiao K, et al. (2023) NaOH-modified biochar supported Fe/Mn bimetallic composites as efficient peroxymonosulfate activator for enhance tetracycline removal [J]. Chemical Engineering Journal 454: 139949.
  13. Wang S, Wang J (2022) Magnetic 2D/2D oxygen doped g-C3N4/biochar composite to activate peroxymonosulfate for degradation of emerging organic pollutants [J]. Journal of Hazardous Materials 423: 127207. [crossref]
  14. Haque E, Jun JW, Talapaneni SN, Vinu A, Jhung SH (2010) Superior adsorption capacity of mesoporous carbon nitride with basic CN framework for phenol [J]. Journal of Materials Chemistry 20: 10801-10803.
  15. Sun B, Ma W, Wang N, Xu P, Zhang L, et al. (2019) Polyaniline: a new metal-free catalyst for peroxymonosulfate activation with highly efficient and durable removal of organic pollutants [J]. Environmental Science & Technology 53: 9771-9780. [crossref]
  16. Sukeshini AM, Kobayashi H, Tabuchi M, Kageyama H (2000) Physicochemical characterization of CuFeO2 and lithium intercalation [J]. Solid State Ionics 128: 33-41.
  17. [Oh W-D, Chang VW, Hu Z-T, Goei R, Lim T-T (2017) Enhancing the catalytic activity of g-C3N4 through Me doping (Me= Cu, Co and Fe) for selective sulfathiazole degradation via redox-based advanced oxidation process [J]. Chemical Engineering Journal 323: 260-269.
  18. Liu M, Zheng L, Bao X, Wang Z, Wang P, et al. (2021) Substrate-dependent ALD of Cux on TiO2 and its performance in photocatalytic CO2 reduction [J]. Chemical Engineering Journal 405: 126654.
  19. Guo F, Wang L, Sun H, Li M, Shi W (2020) High-efficiency photocatalytic water splitting by a N-doped porous g-C3N4 nanosheet polymer photocatalyst derived from urea and N, N-dimethylformamide [J]. Inorganic Chemistry Frontiers 7: 1770-1779.
  20. Li F, Xu B, You X, Gao G, Xu R, et al. (2023) In-situ synthesis of Pd nanocrystals with exposed surface-active facets on g-C3N4 for photocatalytic hydrogen generation [J]. International Journal of Hydrogen Energy 2023 48: 12299-12308.
  21. Dai C, Tian X, Nie Y, Fu W, Wang J (2023) Effect of the interaction mode of H2O2 over CuMnO2 surface on• OH generation for efficient degradation of ofloxacin: Activity and mechanism [J]. Chemical Engineering Journal 451: 138749.
  22. Zhang X, Xie X, Wang H, Zhang J, Pan B, et al. (2013) Enhanced photoresponsive ultrathin graphitic-phase C3N4 nanosheets for bioimaging [J]. Journal of the American Chemical Society 135: 18-21. [crossref]
  23. Wang Y, Wang X, Antonietti M (2012) Polymeric graphitic carbon nitride as a heterogeneous organocatalyst: from photochemistry to multipurpose catalysis to sustainable chemistry [J]. Angewandte Chemie International Edition 51: 68-89. [crossref]
  24. Chu S, Wang Y, Guo Y, Feng J, Wang C, et al. (2013) Band structure engineering of carbon nitride: in search of a polymer photocatalyst with high photooxidation property [J]. Acs Catalysis 3: 912-919.
  25. Liu J, Zhang T, Wang Z, Dawson G, Chen W (2011) Simple pyrolysis of urea into graphitic carbon nitride with recyclable adsorption and photocatalytic activity [J]. Journal of Materials Chemistry 21: 14398-14401.
  26. Li H, Zhou Y, Tu W, Ye J, Zou Z (2015) State‐of‐the‐art progress in diverse heterostructured photocatalysts toward promoting photocatalytic performance [J]. Advanced Functional Materials 25: 998-1013.
  27. Wang C, Yang Q, Li Z, Lin K-Y A, Tong S (2019) A novel carbon-coated Fe-C/N composite as a highly active heterogeneous catalyst for the degradation of Acid Red 73 by persulfate [J]. Separation and Purification Technology 213: 447-455.
  28. Tian X, Luo T, Nie Y, Shi J, Tian Y, et al. (2022) New insight into a Fenton-like reaction mechanism over sulfidated β-FeOOH: key role of sulfidation in efficient iron (III) reduction and sulfate radical generation [J]. Environmental Science & Technology 56: 5542-5551. [crossref]
  29. Wu F, Nie X, Nie Y, Dai C, Tian X (2023) Layered double hydroxide driven 1O2 non-radical or• OH radical process for the degradation, transformation and even mineralization of sulfamethoxazole via efficient peroxymonosulfate activation [J]. Separation and Purification Technology 318: 123969.
  30. Gusain R, Kumar P, Sharma O P, Jain S L, Khatri O P (2016) Reduced graphene oxide–CuO nanocomposites for photocatalytic conversion of CO2 into methanol under visible light irradiation [J]. Applied Catalysis B: Environmental 181: 352-362.
  31. Yin C, Zhou S, Zhang K, Bai J, Lv Y, et al. (2021) Crednerite CuMnO2 as highly efficient Fenton-like catalysts for p-nitrophenol removal: Synergism between Cu (I) and Mn (III) [J]. Journal of Cleaner Production 319: 128640.
  32. Dong N, Chen M, Ye Q, Zhang D, Dai H (2022) An investigation on catalytic performance and reaction mechanisms of Fe/OMS-2 for the oxidation of carbon monoxide, ethyl acetate, and toluene [J]. Journal of Environmental Sciences 112: 258-268. [crossref]
  33. Biesinger MC, Payne BP, Grosvenor AP, Lau LW, Gerson AR, et al. (2011) Resolving surface chemical states in XPS analysis of first row transition metals, oxides and hydroxides: Cr, Mn, Fe, Co and Ni [J]. Applied Surface Science 257: 2717-2730.

Developing a New Skin Cosmetic Product: Rapid, Efficient Insights from AI Coupled with Mind Genomics Thinking with the Product Selected, and the Evaluation of Relevant Communications by Actual Prospective Consumers in the UK

DOI: 10.31038/MGSPE.2025513

Abstract

The paper shows how Mind Genomics, coupled with AI, can drive the creation of messaging for a new cosmetic product. AI (ChatGPT 3.5) in the Idea Coach feature of BimiLeap.com, the Mind Genomics platform, generated the required 16 test elements for Mind Genomics. These test elements (statements about the product) were combined into vignettes, presented to 25 English respondents (ages 18-25). The data, collected in less than two hours through an online panel, identified strong performing elements and two dramatically different mind-sets among the respondents: those interested in the texture and skin-relevant aspects and those interested in the fragrance. The speed, low cost, simplicity, and scope of the research provides a new way to understand products, build the critical knowledge base and generate potentially better market entries.

Keywords

Artificial intelligence, Consumer behavior, Cosmetic product development, Market research innovation, Mind genomics

Introduction

Product development and marketing have traditionally relied on qualitative interviews or questionnaires to gather insights from consumers. The process required the respondent to think in an abstract way about experiences that are often concrete and hard to conceptualize. Thus, in a situation involving cosmetics, the respondent may be asked to rate the importance of ideas or experiences one at a time. It is not unusual for consumer researchers to report these ratings as the “truth” for a particular respondent [1-3]. The emergence of Mind Genomics thinking in the late 20th and early 21st centuries introduced a new approach. This approach involves breaking down a problem into different topics or questions and then identifying various answers or elements for each question. These elements are combined into vignettes, which are small, easy-to-read combinations that paint a word picture. Respondents do not answer individual questions but instead respond to the vignettes created by the combination of elements. This approach is simpler and more engaging for participants, as it allows them to provide feedback based on real-world scenarios rather than abstract concepts. The underlying statistical machinery then analyzes how each element contributes to the overall rating of the vignette [4-6].

Today’s version of the Mind Genomics process involves four questions, each with four answers or elements. These elements are stand-alone phrases or sentences that are mixed and matched into vignettes according to a predetermined experimental design. The experimental design ensures that the elements are statistically independent of each other, allowing for a more accurate analysis of consumer responses. One of the most important aspects of Mind Genomics is that each respondent evaluates just the right number of vignettes of the right construction by an underlying experimental design. The experimental design ensures that each vignette has a minimum of two elements and a maximum of four elements. Furthermore, in each vignette, the elements must come from different questions. That is, no question can contribute more than one element to a vignette, although there are, of course, many vignettes to which a question does not contribute. Perhaps the most important feature is that each respondent in the Mind Genomics study evaluates a unique set of 24 different vignettes. The underlying permutation scheme thus enables the Mind Genomics study to cover a wide range of combinations.

Finally, with the Mind Genomics platform, BimiLeap.com and the embedded artificial intelligence available through the Idea Coach feature, it becomes a very simple matter for the researcher, experienced or inexperienced, to develop questions and answers [7]. The benefits of this approach are that the Mind Genomics system becomes a way to explore the topic rather than to confirm one’s judgment. The old Russian adage “measure nine times, cut once” is not necessary. The user can freely explore the topic because it is not necessary to “know the right answer” at the start of the study or experiment. The answer emerges.

Setting Up the Mind Genomics Study to Understand How “Real People” Feel About Ideas for a Cosmetic Lotion

Step 1 requires the researcher to create four questions that “tell a story” and then for each question to create four separate answers, hopefully each answer meaningfully different from the other three answers to the question. Figure 1 shows the template where the researcher fills in the four questions. Figure 2 shows the template where the researcher fills in the answers to the first question.

Figure 1: Template in BimiLeap.com requesting user to create four questions which tell a story.

Figure 2: Template in BimiLeap.com requiring the researcher to create four answers to the question.

Figure 3: Example of a vignette with the rating question (top) and the actual vignette comprising three elements (bottom).

In the original Mind Genomics studies, researchers faced the challenging task of developing questions and answers for each topic. This task proved to be daunting for many individuals, especially older professionals, as it required critical and creative thinking skills that were not commonly taught. The concept of structuring thoughts into questions and answers forced participants to step out of their comfort zone and think outside the box. With the integration of AI into the BimiLeap.com platform through the Idea Coach, the process of generating questions and answers became more streamlined. Users could simply input the topic and some information, and the platform would generate 15 relevant questions. Researchers were then tasked with selecting up to four questions, completing one or several iterations, and fine-tuning the questions to create a narrative for the study. The same process is applied to generating answers, with AI creating responses based on the selected questions. Researchers were responsible for choosing and arranging the answers to create a coherent word picture that could stand alone or in a group. This innovative approach allowed for a more efficient and structured way of collecting data and insights from participants. For both generating questions and answers, the Idea Coach enabled the user to specify the nature of the way the questions and answers should “read,” e.g., be explanatory, have fewer than a certain number of words, etc. Furthermore, Idea Coach enabled the user to “edit” the output from AI at any time so that the Idea Coach became a true aid to the project, rather than “taking over.”

Table 1: The four questions and the four answers to each question, as created by AI and edited slightly by the researchers.

Table 2: Two preliminary self-profiling classification questions and the rating question.

Incorporating AI into the research simplified the process of developing questions and answers, allowing researchers to focus more on the analysis and interpretation of data. This approach not only saved time and resources but also enhanced the overall quality of the elements, as Table 1 suggests. The elements “read well.”

The actual implementation of the study is straightforward, following these steps:

  1. The questions and elements (answers) are generated and put into a form so that each element becomes a stand-alone phrase that paints a word picture.
  2. The BimiLeap platform combines the elements into 24 combinations known as vignettes. Figure 3 (bottom) shows an example of the vignette, in this case three elements or answers, one element or answer from three of the four questions. The fourth question does not contribute to the vignette.
  3. The underlying experimental design prescribes 24 vignettes. The combinations are created in order to ensure that the 16 elements or answers appear equally often (5 times in 24 vignettes) and that no vignette contains more than one element or answer from a question (preventing mutually contradictory statements in a single vignette).
  4. The basic design is permuted to create “isomorphic” designs. That is, the mathematical structure of the 24 vignettes is maintained, but the elements are permuted. The happy result is that each respondent evaluates a unique set of combinations.
  5. Each respondent evaluated the appropriate 24 vignettes, making it possible to analyze the data from each separate individual.
  6. The permutation scheme is set up so that one need not know the “right combinations” to test. As noted in the introduction, this permutation means that the Mind Genomics procedure tests a great deal of the possible space. The analogy to this approach is the MRI, which takes pictures of the underlying body from different angles and reconstructs the body by combining the pictures taken from different angles [8].
  7. The respondent begins by receiving an invitation to participate, clicking on the embedded link, and being shown to the study. The study is introduced by a short paragraph. The paragraph here is reduced to a simple sentence as follows: “Study info: This is about a new cosmetic product to be offered for young people at a very low cost.” Parenthetically, most respondents exhibit indifference towards the study and simply follow these introductory instructions. In some cases, such as the use of Mind Genomics for the law, the introduction may be longer.
  8. Before the actual evaluations begin, the respondent completes a simple classification question, requiring the respondent to provide age and gender. For this study, the respondent answered two additional questions shown below in Table 2.
  9. Once the respondent has completed the self-profiling classification, the respondent evaluates each vignette one at a time (monadic evaluation), using the rating scale at the bottom of Table 2.
  10. The BimiLeap platform first acquires the information from the self-profiling classification.
  11. The BimiLeap platform then presents each vignette, obtains the rating, and measures the response time. The response time (RT) is defined as the number of seconds to the nearest 100th a second between the time the vignette is presented to the respondent and the respondent selecting a rating. Times greater than 8 seconds are considered to represent the respondent multi-tasking and were automatically brought to the value of 8 seconds.
  12. The respondents were 25 females, 18-25 years old in the United Kingdom. They were members of Lucid, Inc. (now Cint, Inc.) online panel and were accustomed to participating in online studies of this type. It is important to note that the respondents are not experts.
  13. With the experimental design presenting 24 different vignettes, usually requiring 3-4 minutes in total to evaluate, it is virtually impossible for the respondents to “game” the system. The typical behavior which emerges is almost a relaxed, intuitive response to the vignette, rather than a considered response which searches for the “right answer.”

Analysis of the Data Using Ordinary Least Squares (OLS) and K-means Clustering to Create Mind-Sets

  1. The scale presented at the bottom of Table 2 shows two dimensions. The first dimension is “buy vs. not buy,” and the second dimension is “believe vs. do not believe.”
  2. The Mind Genomics convention is to recode the 5-point scale to new binary variables. These binary variables are easier to understand. The coding is either 100 (yes) or 0 (no).
  3. The coding is the following: Buy (DV = Buy R54). Rating of 5 or 4 coded as 100, rating of 3, 2, or 1 coded as 0. Believe (DV = Believe R52). Rating of 5 or 2 coded as 100, rating of 4, 3, or 1 coded as 0. Not Buy (DV = Not Buy, R21). Rating of 2 or 1 coded as 100, rating of 5, 4, 3 coded as 0. Not Believe (DV = Not Believe R41). Rating of 4 or 1 coded as 100, rating of 5, 3, 2 coded as 0.
  4. To all newly created binary variables is added a vanishingly small random number (<10-5). This prophylactic step ensures that newly created binary variables have some marginal degree of variability even when the re-coding ends up being all 0 or 100. The addition of variability ensures that the Ordinary Least Squares (OLS) regression will not fail. Response Time (RT) is the measurement provided by the Mind Genomics platform. Response times of 8 or more seconds are brought to 8 seconds with the assumption that the long response time suggested that the respondent was multitasking and not paying attention to the task.
  5. The equation used to fit the data is expressed as: Dependent Variable k1A1 + k2A2.. k16D4.
  6. The equation does not have an additive constant. The rationale for this is the desire to force all the explanation of the variation onto the elements.
  7. A separate analysis looking at the t-statistic of the coefficients when estimated without an additive constant vs. with an additive constant was used to identify the level of the coefficient in the model without an additive constant corresponding to a significant coefficient (t-statistic > 2.0). A coefficient around 20 emerged as corresponding to a significant coefficient. All of the coefficients with buys values of 21 or higher are highlighted.
  8. For the analysis of the response time coefficients, a coefficient of 1.3 or higher was deemed to reflect the respondent focusing on the element. In turn, a response time coefficient of 0.2 or lower was assumed to represent that the respondent barely considered the element when making a decision and therefore did not pay attention.

Table 3: Performance of the 16 elements on the dependent variables, as represented by the coefficient of the element estimated by OLS regression.

Table 3 shows the coefficients of the five equations for the total panel (Buy, Believe, Not Buy, Not Believe, and Response Time all vs. the presence/absence of the 16 elements).

The results are straightforward to read:

The element performed reasonably well among the total panel. Three elements that performed significantly well specifically for interest in buying:

C1 A dance of fragrant notes that stir the soul.

D1 Cloaks blemishes in a soft embrace of light.

C2 A sweet lullaby sung by wildflowers under moonlight.

D1 is not believed at all, however: this reads “Cloaks blemishes in a soft embrace of light” and calls into question the belief that the product can actually cloak blemishes the way as promised.

Finally, one element truly captures the imagination, as shown by the long response time attributed to that element: 1.3 seconds. The element is: “C1: A dance of fragrant notes that stir the soul.”

If one were to draw any conclusions, one would say that these elements in particular perform very well, but there are no truly strong general patterns.

Moving from the Total Panel to Mind-Sets

The second analysis performed by Mind Genomics groups into clusters based upon the pattern of the 16 coefficients generated by each respondent when the newly created binary dependent variable “buy” (R54 -Buy) becomes the dependent variable. The approach is known as k-means clustering [9].

Each respondent has a distance from every other respondent based on the pattern of the 16 coefficients. The distance is defined by the newly created variable (D = 1- Pearson R). R is the Pearson correlation coefficient. R takes on the value 2 when the correlation R is -1. The lowest possible correlation, -1, corresponds to two people whose 16 elements go in opposite directions and is described by the highest possible distance D between two patterns (D = 2). In contrast, when the two respondents show a perfect linear correlation, +1, the distance is 0 (D 1 – 1 = 0). This is logical because the patterns are parallel to each other, perfectly related. Once we have assigned each respondent to one of the two mind-sets, we revisit the OLS regression and rerun the regression twice, one for Mind-Set 1, and the other for Mind-Set 2.

The story now becomes clearer. Table 4 compares the coefficients for Buy, Believe, and Response Time for Mind-Set 1 vs. Mind-Set 2. Mind-Set 1 comprised 8 of the 25 respondents, while Mind-Set 2 comprised 17 of the 25 respondents. Mind-Set 1 appears to focus on elements presenting information about touch and skin, as well as covering blemishes (elements D1, D2, A1, D3, A4, D4). Mind-Set 1 believes strongly only in one message, D2 (smooths away flaws with a gentle, luminous touch). Mind-Set 1 pays attention to two messages: “Like a gentle kiss of sunshine, warming your complexion,” and “Like a soft focus lens, it perfects with grace.” We might call Mind-Set 1 “Focus on touch and skin.”

Table 4: Coefficients for the 16 elements for Buy, Believe, and Response Time by mind-set. Blank cells correspond to elements with coefficients that are 0 or negative.

Mind-Set 2 appears to focus on all four elements describing fragrance (C1, C2, C3, C4). However, Mind-Set 2 believes strongly only in one element (a kiss of mystery that lingers long after application). Finally, Mind-Set 2 does not appear to be “captivated” by the phrases because the response times for the elements are all lower than the cut-off point of 1.3 seconds, operationally defined as the level an element has to reach in order to be considered an element that holds the respondent’s attention.

AI Analysis of Strong Performing Elements

With the incorporation of AI into BimiLeap through the Idea Coach feature, the Mind Genomics platform now offers a standardized analysis of strong performing elements, using Chat GPT 3.5. The analysis occurs after the platform has created the full report. The underlying motivation for the analysis is to determine whether AI can pull out additional information about the respondents (viz., Mind-Sets 1 and 2) by further analyzing the strong performing elements.

Table 5 shows the analysis of strong performing elements on the “Buy” scale for Mind-Sets 1 and 2, respectively. Each analysis uses seven queries. The result generates a machine-created interpretation of the data. The important thing here is that Mind Genomics now has a coach that truly provides additional insights. AI now becomes a collaborator with Mind Genomics to add dimensionality and depth to the results describing the attractiveness of the mindset as a target audience, etc.

Table 5: High-level AI analysis of the strong performing element for the question “Buy” (viz. R54), by Mind-Sets 1 and 2.

Discussion and Conclusions

The use of AI in market research, particularly in the context of studying consumer responses to new beauty products, may accelerate the way companies gather feedback and make informed business decisions. In this study on the responses to a new skin lotion product among females in the UK ages 18-25, AI played a crucial role in both generating the key elements about the product and running the Mind Genomics experiment. Within just three hours, the three-pronged effort provided insights into how this specific demographic perceived and reacted to the product. One of the major benefits of using AI in this capacity is the speed at which insights can be generated. Traditional market research methods can be time-consuming and costly, but with the help of AI, the researchers were able to collect and analyze data in a fraction of the time. This rapid turnaround time enables companies to make quick adjustments to their marketing strategies and product offerings, keeping them ahead of the competition.

Additionally, AI has the ability to identify patterns and generate hypotheses that may not be immediately apparent to human researchers. By using Mind Genomics analytical capabilities, the study project uncovered two distinct mind-sets among the female participants in our study, providing a deeper understanding of their preferences and behaviors. Overall, the integration of AI and Mind Genomics in market research offers a powerful combination of speed, accuracy, and depth of insights that can be invaluable to companies looking to stay competitive in today’s fast-paced business landscape.

Acknowledgments

The authors gratefully acknowledge the foresight of Dr. Nenad Filipovic to bring this approach of Mind Genomics to Serbia and to encourage its use among students and professionals, as well as to publish the results of papers in the scientific, technical and business literatures. The authors would like to thank Vanessa Marie B. Arcenas and Angela Aton for their ongoing help in preparing this manuscript and its companion papers.

Abbreviations

ChatGPT: Chat Generative Pre-Trained Transformer; OLS: Ordinary Least Squares; RT: Response Time

References

  1. Beresniak A, de Linares Y, Krueger GG, Talarico S, Tsutani K, et al. (2012) Validation of a new international quality-of-life instrument specific to cosmetics and physical appearance: BeautyQoL questionnaire. Archives of dermatology 148: 1275-1282.
  2. Eze, UC, Tan CB, Yeo ALY (2012) Purchasing Cosmetic Products: A Preliminary Perspective of Gen-Y. Contemporary Management Research 8: 1.
  3. Segot-Chicq E, Compan-Zaouati, D, Wolkenstein P, Consoli S, Rodary C, et al, (2007) Development and validation of a questionnaire to evaluate how a cosmetic product for oily skin is able to improve well-being in women. Journal of the European Academy of Dermatology and Venereology: JEADV 21: 1181-1186.
  4. Gofman A, Moskowitz HR (2012) Rule Developing Experimentation: A Systematic Approach to Understand & Engineer the Consumer Mind (p. 473) Bentham Science Publishers.
  5. Moskowitz, HR, Gofman A, Beckley J, Ashman H (2006) Founding a New Science: Mind Genomics. Journal of Sensory Studies 21: 266-307.
  6. Moskowitz H, Rappaport S, Moskowitz D, Porretta S, Velema B, et al. (2017) Product design for bread through mind genomics and cognitive economics. In Developing New Functional Food and Nutraceutical Products (pp. 249-278) Academic Press.
  7. Moskowitz H, Rappaport S, Wingert S (2024) IDEA COACH: Using Generative AI and Mind Genomics Thinking to Drive Questions and Answers in Industrial Design. In Innovative Industrial Design – Principles and Practices.
  8. Gofman A, Moskowitz H (2010) Isomorphic permuted experimental designs and their application in conjoint analysis. Journal of Sensory Studies 25: 127-145.
  9. Likas A, Vlassis N, Verbeek JJ (2003) The Global k-Means Clustering Algorithm. Pattern Recognition 36: 451-461.

Developing a New Skin Cosmetic Product: Rapid, Efficient Insights from AI Coupled with Mind Genomics Thinking After the Product Has Been Selected, and the Focus Turns to Specifics

DOI: 10.31038/MGSPE.2025512

Abstract

This second paper in the series of three papers on product design shows how to create a new idea for a skin lotion, using Mind Genomics coupled with AI embedded in the Mind Genomics platform, BimiLeap.com (Idea Coach feature). The user presents the AI with the request to create new ideas for a “foundation product.” The paper shows how AI provides different ideas in a single iteration and then, after the iteration is closed, continues to apply critical thinking to its own suggestions. The outcome is a detailed suggestion of 10 different lotion products that might be created, along with the nature of each product, and a business case for each product idea.

Keywords

Cosmetic development, Generative AI, Mind Genomics, Product innovation

Introduction

This second paper builds upon the material presented in the Thompson et al. paper, “Developing a New Skin Cosmetic Product: Rapid, Efficient Insights from AI Coupled with Mind Genomics Thinking at the Very Earliest Stages of Ideation with Limited or Even No Knowledge.” Once the basic product has been chosen—a lotion—the next objective was to specify the nature of this new lotion.The paper presents a novel approach to this step of specification. The approach was to create consumer-meaningful phrases that embed product features in them. Although the approach might seem difficult, viz., combining creativity and cosmetic technology, at the level of AI powered by Mind Genomics thinking, the approach is quite actually straightforward.

Table 1 presents the instruction to the AI (ChatGPT 3.5) using the Mind Genomics platform BimiLeap.com. The instructions are put into Idea Coach (Table 1 top). Within 15 seconds or so, viz., almost immediately, AI returns with the descriptions (Table 2 bottom).

Table 1: Instructions to AI about the product and the 15 different phases describing the product in “poetic” consumer language.

Table 2: Perspectives—critical thinking of the AI regarding its own suggestion of 15 phrases.

Critical Thinking Presented by AI After the Study has Closed

As in the previous study, once the project is “closed,” the AI is instructed to review its own suggestions presented to the user (Table 1). Table 2 presents the perspectives.

Table 3 continues the critical thinking, presenting the points of view of those who are in favor of these product ideas (Interested) versus those who are against these product ideas (Opposing).

Table 3: AI simulation of audiences interested in the 15 phrases (top) versus audiences opposing the 15 phrases (bottom).

The Road to Innovation—Additional Information Needs and Alternative Viewpoints

Table 4 presents information that will be useful for product design and communication. The top of Table 4 shows the AI observation about additional information needed. The bottom of Table 4 shows alternative viewpoints, viz., a “no-holds-barred” analysis of the messages in terms of where the messages veer off-target and could be improved.

Table 4: Pre-innovation. Additional information that AI says it “needs” (top), and alternative viewpoints (bottom).

Deeper Analysis of Innovations

The final analysis in this study is a set of recommended innovations, shown in Table 5. This time, AI generated 10 innovations analyzed in depth, once again doing this work after the study has been closed. Had this iteration been repeated, e.g., 20x, a task that would have taken three minutes for the user to execute by simply pressing the right key to “repeat the effort,” the Idea Coach in BimiLeap.com would have returned 20 of these full analyses, rather than the one full analysis shown in detail in this paper. That effort, requiring just an extra few minutes “upfront,” would thus generate an entire repository of information for the user.

Table 5: Ten AI-suggested innovations, together with AI’s critical analysis of each innovation on technical as well as business dimensions.

Using AI to Consider Its Own Operations

The final step in this paper is to instruct AI to reflect on the combination of AI and Mind Genomics thinking as a potential coach, collaborator, or even an occasional “lead” in the product development process. During the course of several iterations, AI returned with a variety of questions—15 of which are shown below. These questions are generated as a standard part of the output of Idea Coach in the Mind Genomics platform, BimiLeap.com. The questions are put in to spur additional thinking about the topic. Table 6 shows 15 of these questions, along with answers and then speculation about the future.

Table 6: Fifteen questions about the contribution to consumer product development by a combination of AI and Mind Genomics thinking.

Discussion and Conclusions

AI and Mind Genomics thinking are valuable tools with which to create innovative consumer products. By analyzing consumer preferences and trends, AI can generate unique and appealing ideas, allowing for targeted product development. This approach promotes creativity and experimentation, leading to groundbreaking products. Combining human insight with AI analysis allows companies to push boundaries in product development and stay ahead of competition. However, AI may not invent as well as human creativity and may struggle to think outside predefined parameters. Despite these challenges, the value of AI and Mind Genomics in product development cannot be understated, as they create products which cater to consumers’ specific needs and preferences.

Acknowledgment

The authors gratefully acknowledge the foresight of Dr. Nenad Filipovic to bring this approach of Mind Genomics to Serbia and to encourage its use among students and professionals, as well as to publish the results of papers in the scientific, technical, and business literatures.The authors wish to thank Vanessa Marie B. Arcenas and Angela Louise C. Aton for their ongoing help in preparing this and companion papers in this series.

Developing a New Skin Cosmetic Product: Rapid, Efficient Insights from AI Coupled with Mind Genomics Thinking at the Very Earliest Stages of Ideation with Limited or Even No Knowledge

DOI: 10.31038/MGSPE.2025511

Abstract

The paper shows how to create new product ideas using a combination of AI (ChatGPT 3.5) and Mind Genomics thinking and is based on the Mind Genomics platform, BimiLeap.com (Idea Coach feature). In this paper, the request was to have AI ask and answer questions about a possible cosmetic product for skin care. AI returns with 15 questions, and answers. This question-and-answer step can be repeated. Once the user closes the BimiLeap program, the AI applies creative thinking to the 15 answers to generate a set of innovations and each innovation idea is analyzed by AI. It is from these AI-suggested innovations that the user develops the product idea, in this case a lotion with an unusual fragrance. This early stage of the process is efficient, low-cost, and rapid-requiring minutes for the iteration and a few hours for the deeper analysis by AI.

Keywords

Cosmetic development, Generative AI, Mind Genomics, Product innovation

Introduction

Creating a new product has often been a situation of hit or miss, with many people hiring “experts” in the topic area, as well as experts in ideation regarding new ideas. With the widespread adoption of generative AI, such as ChatGPT 3.5, the questions arise as to the degree to which AI can help drive the ideation process. The ultimate results, of course, would have to be acceptable to consumers and would have to bring market success.

The Mind Genomics approach enriches the development process by providing a framework for understanding consumer perceptions and preferences. By segmenting the target market into distinct groups based on their unique responses to different stimuli, companies can tailor the product offering to each segment, increasing its relevance and appeal. This approach helps companies uncover hidden opportunities, identify niche markets, and optimize product positioning for maximum impact.

This paper focuses on the use of AI, coupled with Mind Genomics thinking, to drive the development of new ideas for the proposed product. This paper is the first of three connected papers on the process, with the materials in the first two papers generated by AI, and the materials in the third paper representing the response of actual people in the UK to the idea. All AI “material” was generated using the Mind Genomics platform, BimiLeap.com (Idea Coach feature).

Mind Genomics as a Coach, Which Drives the User to Ask the “Right Questions”

We begin with the example of a “tabula rasa,” a blank slate, and how Mind Genomics and AI fill that slate. As an example, consider 15 questions and answers in Table 1 that may arise in the development of new cosmetics. These 15 questions and answers were generated by the Mind Genomics platform, BimiLeap.com. The important thing to note about Table 1 is that in just a few moments, and with the correct software accessing generative AI, such as ChatGPT 3.5, the developer can access a “coach” to help navigate issues of knowledge and can receive suggestions which have aspects of guidance attached to them.

Table 1: AI and Mind Genomics as a coach. Instructions given to AI to provide 15 questions and answers about creating and marketing a cosmetic product.

Given the foregoing ability of AI, coupled with Mind Genomics thinking, to become a “partner” in the development process, let us follow the effort through. This first of three papers shows how to develop the basic ideas, even when at the inception of the project, there is no “inkling” about what to do.

Phase 1 — Thinking About the Process and Getting General Direction From AI

Table 2 presents the initial instructions to the AI platform about the process, and what AI returns. The assumption here is that the person writing the instructions to AI knows absolutely nothing about the topic.

Table 2: Instructions to the AI about how to think about the new product idea.

Phase 2 — Requesting Direction from AI for a Specific Product, a Cosmetic Product for the Skin

Using AI, the emerging science of Mind Genomics provides a novel method that generates a large number of original ideas in response to user instructions (e.g., AI instructions and prompts). As a standard practice, Mind Genomics generates a variety of questions, answers, and even full concepts that could not have been thought of otherwise by using AI algorithms to examine data and trends. Phase 2 uses AI to create targeted questions about the product, as shown in Table 3.

Phase 3 — Teaching Critical Thinking by Having AI Analyze Its Own Suggestions

AI further analyzes the ideas that it generates. After the “iteration” is finished and the material is returned to the user (see Table 3), the study can be temporarily closed. Afterwards, when the study is closed, AI automatically reviews its own production (see Table 3), focusing on a variety of alternative aspects.

Table 3: Fifteen targeted questions about the product generated by AI.

The remainder of this paper presents the output from AI as it reviews what it created (see Table 3), applying critical thinking and innovation aspects to the effort.

Table 4 begins the critical thinking by looking at the key ideas, themes, and perspectives touched on by the material in Table 3. The objective here is to identify the basic ideas and give the user some idea of the alternatives available. If the user had run five iterations at the start of the project, the BimiLeap platform would have returned with five different types of tables. Each iteration is subject to this same analysis—making it possible to learn a great deal about the project by simply doing 5-10 iterations, obtaining different questions—which in turn serve as the raw material for the AI analyses. By running 5-10 iterations with different questions, etc., the user generates 5-10 analyses, covering a great deal of ground.

Table 4: AI’s critical analyses of the questions shown in Table 3.

Critical Analysis Continued — Looking at the Audiences

Table 5 shows the next step in critical thinking for the 15 questions generated in Table 3. The top of Table 5 shows the audiences who might be interested in the product. The bottom of Table 5 shows the audiences who might be opposed to the product.

Steps to Innovation — Alternative Viewpoints and a Search for What Might Be Missing

Table 5: Interested versus opposing audiences for the issues/products raised in the 15 questions in this iteration.

A key benefit of the AI embedded in Mind Genomics is in the ability of AI to look at alternative points of view. The top part of Table 6 moves the effort towards alternative viewpoints, suggesting neither acceptance nor rejection of the idea but rather moving in another direction. The bottom half of Table 6 shows what might be missing.

Table 6: Alternative viewpoints, which move the thinking “out of the box” (top), and the search for what might be missing (bottom).

Suggested Innovations and AI’s Deep Analysis of Each Innovation From Various Perspectives

The final AI analysis of its own ideas is shown in Table 7. In this specific study, AI emerged with four “ideas” for new products on its own. For each “idea,” AI presents an automated, fairly rigorous proposition, comprising the analysis and suggestions for further business consideration.

Table 7: AI’s own deep analysis of four innovations that the AI itself generated.

Discussion and Conclusions

AI and Mind Genomics offer a new and potentially great deal of value when it comes to creating a new cosmetic product, such as a lotion. By harnessing the power of artificial intelligence, companies can use advanced algorithms and data analysis to develop innovative and effective products that cater to the diverse needs of consumers. AI can pose relevant questions, provide insightful answers, analyze its own responses, and think “outside the box” to generate new ideas and solutions that may not have been considered otherwise.

One of the key advantages of involving AI in the product development process is its ability to become a true partner in the early stages of design. By inputting information about the physical properties of various ingredients, as described by consumers, AI can generate formulations that are tailored to specific preferences and requirements. This not only streamlines the product development process but also ensures that the final product aligns with the expectations of the target market.

Moreover, AI can play a crucial role in shaping the marketing strategies for the new cosmetic product. By analyzing consumer behavior, preferences, and trends, AI can help companies identify the most effective messaging, channels, and campaigns to promote the product and drive sales. This data-driven approach ensures that marketing efforts are targeted and relevant, maximizing the impact and reach of the product in the market.

Using AI and Mind Genomics thinking in creating a new cosmetic product may significantly enhance the ability to drive innovation, efficiency, and consumer relevance in a fast, cost-efficient, and iterative fashion. By integrating these advanced technologies into the product development process, companies can unlock new opportunities, optimize product offerings, and deliver exceptional value to consumers. Through strategic partnerships with AI as a coach that formulates questions, provides answers, and offers raw material, companies can accelerate product development, enhance marketing strategies, and ultimately achieve success in the competitive cosmetic industry [1-9].

Acknowledgments

The authors gratefully acknowledge the foresight of Dr. Nenad Filipovic to bring this approach of Mind Genomics to Serbia and to encourage its use among students and professionals, as well as to publish the results of papers in the scientific, technical, and business literatures.

The authors wish to thank Vanessa Marie B. Arcenas and Angela Louise C. Aton for their ongoing help in preparing this and companion papers in this series.

References

  1. Cooper RG, McCausland T (2024) AI and new product Res Technol Manag 67: 70-75.
  2. Cooper RG (2024) The AI transformation of product innovation. Ind Mark Manag 119: 62-74.
  3. Coussa A, Bellissimo N, Poulia KA, Karavetian M (2024) Use of Mind Genomics for public health and wellbeing: Lessons from COVID-19 pandemic. Adv Biomed Health Sci 3: 72-78.
  4. Davidov S, al Humaidan M, Gere A, Cooper T, Moskowitz H (2021) Sequencing the “Dairy Mind using Mind Genomics to create an “MRI of consumer ” In: Moskowitz H, Kover A, Papajorgji P, editors. New Advances in the Dairy Industry. IntechOpen.
  5. King K (2019) Using artificial intelligence in marketing: How to harness AI and maintain the competitive London: Kogan Page Publishers.
  6. Moskowitz HR, Gofman A, Beckley J, Ashman H (2006) Founding a new science: Mind J Sens Stud 21: 266-307.
  7. Ogundipe DO, Babatunde SO, Abaku EA (2024) AI and product management: A theoretical overview from idea to market. Int J Manag Entrep Res 6: 950-969.
  8. Papajorgji P (2023) Knowledge as a service: The case of Mind EuroMediterranean 19: 34-47.
  9. Verganti R, Vendraminelli L, Iansiti M (2020) Innovation and design in the age of artificial intelligence. J Prod Innov Manag 37: 212-227.