Monthly Archives: January 2021

Opinion: Why Should We Care about Endocrine Disruptors?

DOI: 10.31038/CST.2022711

 

The Endocrine Disruptors (EDCs) are defined as “exogenous chemical, or mixture of chemicals, that interfere with any aspect of hormone action”, and in 2015, the Endocrine Society convened a large group of experts to review in-depth the state of science on EDCs [1]. Over the years a massive accumulation of data supports growing concern on EDCs’ harmful effects on humans and all other living organisms. 

A. Why Do We Care so much about EDCs?

  1. We care because EDCs interfere with the normal function of the endocrine system and can harm every organ of a living organism.
  2. EDCs are especially dangerous for the developing fetus and their effects can persist to affect early life, adulthood, and even follow to the next generations.
  3. EDCs are present in food, water, air, soil, cosmetics, medicines, toys, and other items. They accumulate in living organisms and the aquatic species are particularly vulnerable. 

B. What Do We Need to Know for Efficient Detection and Monitoring of EDCs?

  1. The status on the methods of detection 

C. Why Do We Need Public Awareness of EDCs Effects?

Because their presence in the environment is not well sufficiently regulated, and the screening methods do not always include a biological read-out. An excellent example is Bisphenol A (BPA) which was synthesized in 1936 as an estrogenic compound. Subsequently it was discovered that BPA activates other nuclear receptors, including thyroid receptor (TR). Despite recent restrictions, BPA is one of the highest production-volume chemicals used in manufacturing polycarbonate plastics and epoxy resins.

  1. Several major manufacturers of baby bottles removed BPA from their products after a public outcry.
  2. Unfortunately, all of us have BPA in our bodies because it is in food, household, and industrial items, including linings of canned foods and drinks.

D. Why are We Still Deliberating about Harmful Effects of EDCs?

  1. The major reasons are that we lack uniform agreement among scientific community on “safe” levels of EDCs. Some consider that any exposure is unacceptable, while others call for establishing a low dose limit for specific products.
  2. Regulatory agencies world-wide have not provided sufficient restrain for continuing accumulation of EDCs in the environment.
  3. Industry and environmental non-government organizations present conflicting information, and the lay press oversimplifies the research results, leading to a confusing state of information for many EDCs.

A. Why Do We Care so much about EDCs?

The endocrine system evolved to respond to very low levels of hormones [2-4]. Because of common receptor-mediated mechanisms, EDCs that mimic natural hormones are likely to have biological effects in humans and other species [4-6]. Moreover, small changes in hormonal concentrations can have biologically important consequences [2,4]. Thus, EDCs can have adverse effects on living organisms, and even low doses of contaminants cannot be ignored.

Many EDCs exert their effects as agonists or antagonists by direct interaction with hormonal receptors: estrogen (ERs), progesterone (PR), androgen (ARs), thyroid hormone (TRs), and with nuclear receptors that regulate metabolism and differentiation, such as aryl hydrocarbon (AhR), retinoid X (RXR), peroxisome proliferator-activated (PPARs), liver X (LXRs), and farsenoid X receptors (FXRs) [7]. Following ligand binding, the receptors become transcription factors that regulate expression of many genes.

The most sensitive time for exposure to EDCs is during fetal development [8]. Some EDCs affect fetal development in late pregnancy [9] whereas others are harmful even before the woman is aware of her pregnancy [10,11]. EDCs can also lead to harmful traits carried over to future generations (transgenerational effects) [12], although they do not induce changes in DNA sequence [13]. Thus, the harmful effects may not be immediately apparent, which makes it difficult to discern from other causes.

Long-lasting effects on male and female fertility in several species are particularly of concern [14,15] and the decline in male and female fertility has been detected world-wide [16]. Detection of EDCs in blood, urine, milk, and tissues showed alarming results reflecting global exposure [10].

EDCs can harm every organ in the body. Let’s start with the brain. EDCs can change the expression, abundance, and distribution of steroid hormones and other nuclear receptors in the developing brain. There are multiple documented functional consequences of altered receptor action in fish brain and the most widely studied compounds are BPA and polychlorinated biphenyls (PCBs) [17,18]. All living organisms that consume untreated water are exposed because water is frequently contaminated by pollutants originating from municipal and industrial wastewater effluents, as well as runoffs from livestock and agricultural areas.

In addition to harmful effects on the brain, perinatal exposure to low doses of BPA causes metabolic derangements: increased body weight; adiposity; alterations in blood levels of insulin, leptin, and adiponectin; as well as a decrease in glucose tolerance and insulin sensitivity in an age-dependent manner [19-21].

One of most studied group of EDCs are estrogenic compounds which regulate estrogen receptor (ER) with broad effects on bone mineralization, immunity, male and female reproduction, metabolism, and many other biological processes. The presence of estrogenic substances in the environment has been known for over a century and increased significantly across the globe in the last 50 years. Clover species were documented to contain high amounts of estrogen receptor-activating compounds leading to reproductive disorders in cows and sheep fed with clover-rich diet [22]. Because hormonal synthesis and their world-wide use exploded during the 1940’s, toxicologists noticed their presence in the environment and described the effects on organisms. In US, studies in 1965 [23], in 1970 [24] and thereafter increased public concern for estrogenic chemicals. Although in 1990 the United States Congress updated the US Safe Drinking Water Act to include screening programs to detect estrogenic contaminants, harmful effects of estrogens [25,26] and progestogens, specifically on fish reproduction, have been increasingly documented [27,28].

Thyroid hormone (TH) disruptors are also of particular concern because they govern neurodevelopment and metabolic homeostasis. Exposure during pregnancy has been linked to the rise in autism and cognitive disorders [29-32], as well as increased risk to develop thyroid cancer [33]. Because TH cooperates with progesterone during implantation, TH disruptors also impair pregnancy [34]. Thyroid receptor interacting compounds are widely spread in the US rivers [35,36]. The agonists and antagonists are especially prevalent in water downstream of intense urbanization and livestock production. Triiodothyronine (T3)-like activity are reported in effluents from water treatment plants (WWTP) in Japan [37], and anti-T3 hormonal activity was found in WWTP effluent in Thailand [38].

Weakened immune systems with increased susceptibility to infections are likely due to exposures to glucocorticoids alone or in combination with other EDCs, have been associated with fish kills [39-42].

These are only a few examples of well-documented studies on harmful effects of EDCs.

B. What Do We Need to Know for Efficient Detection and Monitoring of EDCs?

Because of the growing concern on contamination of the environment [1,37,38,43-46], significant attention and investment has been devoted to their detection [47]. Laborious chemical methods of isolation and identifications by a combination of HPLC, liquid or gas chromatography and/or mass spectroscopy, were followed by “omic” approaches (genomics, transcriptomics, proteomics, and/or metabolomics) in fish and other affected organisms [48,49]. Unfortunately, these assays are laborious, costly and identify only a single compound. In addition, lack of uniform quantification and uncertainty of their biological effects limit their use. Thus, analytical strategies based on target chemical analyses have been insufficient to depict meaningful environmental contamination.

Technical innovations using luciferase reporters or fluorescent tags in genetically engineered yeast, mammalian cell lines, or whole organisms, such as zebra fish, led to development of assays in which the read-out is a biological effect elicited by a specific receptor [35,36,50-53]. Many of these methods are sensitive in the below nanomolar range, amenable to high throughput and do not require identification of ligand’s chemical structure.

C. Why Do We Need Public Awareness of EDCs Effects?

Extensive documentation on the adverse effects of exposure to BPA on reproduction and development, cardiovascular, neurological, metabolic, and immune systems [54,55], led to reduction of reference dose by European Food Safety Authority, stronger restrictions and regulations on the production and usage of BPA in North America in 1990, European Union and in Canada in 2010 [56]. It was estimated that 93% of Americans have measurable amounts of BPA in urine [57,58] and because of the wide-spread contamination with BPA, these levels are likely to persist. After substantial public pressure, in 2008 six major manufacturers of baby bottles removed BPA from their products and the trend continues in developing BPA-free goods and materials.

However, many recently developed BPA analogues have also been detected in the environment. Some have similar estrogenic, antiandrogenic and TH disrupting activities [59]. Thus, sustained public awareness and negative publicity is needed to remove BPA and its analogs to prevent further environmental contamination and human exposure.

D. Why are We Still Deliberating about Harmful Effects of EDCs?

Lack of consensus in the scientific community on quantitative methods for detection and “safe” levels of sex hormones in the environment and other EDCs is a major obstacle for development of a rational policy for efficient monitoring and establishing safety limits to protect wildlife and human health. Scientific evidence indicates complex mechanisms operating at low doses showing nonmonotonic dose-response curves (2). A largely unexplored issue is the combined effect of a mixture of EDCs detected in the same sample. Many water sites have several EDCs that interact with glucocorticoid, estrogen, progesterone, thyroid, aryl hydrocarbon and other nuclear receptors [35,52,60-63]. The combinations further modify the biological outcomes as these mixtures are likely to have unexplored effects on target tissues [4,64]. Interactions with receptors, nuclear cofactors, and chromatin remodelers through “assisted loading” mechanisms further modify gene expression [47,65,66]. Some of these epigenetic changes may be long-lasting and possibly inheritable.

As presented in this Opinion, scientific evidence linking EDCs to health effects is strong, but regulations have not kept up with the endocrine science. Despite EPA regulation in US, and WHO efforts in periodic updates (most recently in 2012) the state of science on contamination of water, air and soil, EDCs threaten the integrity of the planet’s ecosystems and pose serious concerns for human and animal health [1,46].

The potential to link epidemiological studies with individual exposure assessments is now feasible. Current eHealth programs, such as All-of-Us, can be critical in evaluating pathophysiology and establishing the temporal relationship between markers of exposure and long-term effects. This is the time for high-level meetings to bring together all critical players with the twin goal of sharing information and considering options for investment in global EDCs detection and monitoring. Only then we can advise on regulatory policies with particular emphasis in relation to human disease. Virtual platforms, popular since 2020 during the COVID-19 pandemic, can make such efforts possible. Scientific knowledge gives national and international agencies an informed opinion on controlling specific aspects of environmental contaminants. A coordinated program encompassing governmental and public organizations and industry leaders with scientists would enable a science-based approach to better understand and halt the impact of EDCs pollution on ecosystems and human health.

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A Case of Severe Exercise Associated Hyponatremia after Running Marathon

DOI: 10.31038/IJNUS.2020213

Abstract

Exercise associated hyponatremia (EAH) can cause serious neurological manifestations. We report a case of EAH presented with convulsion and drowsiness after running marathon. The patient’s plasma sodium level on presentation was 119 mmol/L. He was given intravenous hypertonic saline infusion for 2 times. His conscious level improved after hypertonic saline and plasma sodium level corrected. He regained full consciousness 3 days after admission and was discharged in good condition. In this report, we reviewed the underlying pathophysiology, clinical features, risk factors, prevention measures, and treatment options of this disease entity. Early recognition of this disease entity and timely treatment with hypertonic saline is life saving.

Background

Exercise associated hyponatremia (EAH) is not uncommon and can cause serious neurological manifestations and even death. Early recognition of the diagnosis and timely treatment can be life saving. We here report a case of EAH and review the management for this disease entity.

Case Report

A 39-year-old gentleman with good past health was admitted to Princess Margaret Hospital after developing an episode of tonic clonic seizure. On the day of admission, he had been participating in a marathon run from 8:30 am till 4:30 pm. He did not have any fever, headache, neck pain, photophobia, weakness or numbness beforehand. He took an over-the-counter “Japanese medication” before the race, which was suspected to be a non-steroidal anti-inflammatory drug (NSAID). Otherwise he did not have any history of drug abuse or herbal medication consumption. He had no family or personal history of epilepsy.

On arrival at the emergency department, the patient was drowsy with Glasgow Coma Scale (GCS) of E2V1M4. His seizure had aborted spontaneously. He was normothermic with stable hemodynamics. Blood pressure was 135/75 mmHg and pulse 65/min. His spot glucose was 8.6 mmol/L. On physical examination, he was well hydrated. His pupils were equal and reactive to light and there were no focal neurological deficits or meningism. ECG and CXR were unremarkable. CT brain showed mild cerebral edema. Blood tests revealed a plasma sodium (Na) level of 119 mmol/L. His plasma potassium, urea, creatinine, and creatinine kinase were 3.4 mmol/L, 7.2 mmol/L, 85 µmol/L, and 2732 U/L respectively. Urine myoglobin was negative. White cell count was 17 x 109/L, otherwise the complete blood count and liver function tests were normal. Further workup for hyponatremia were performed. Paired plasma osmolality, urine osmolality, and spot urine sodium checked 5 hours later were 244 mmol/Kg, 580 mmol/Kg, and 46 mmol/L respectively. There were no adrenal insufficiency or hypothyroidism.

Hypertonic saline (HTS) 20 ml 5.85% sodium chloride (NaCl) in 100 ml normal saline infused intravenously over 2 hours was given for 2 times. The patient’s conscious level improved as the plasma sodium level was corrected and his plasma sodium level normalized to 137 mmol/L. He regained full consciousness 3 days after admission and was subsequently discharged home on the third day.

Discussion

Incidence

Exercise associated hyponatremia is defined as hyponatremia that occurs during or up to 24 hours after physical activities, especially after endurance events [1]. It has been reported in marathons, military training, long distance hiking, and even yoga [1]. It is unheard of until 1981, as historically, runners are advised to restrict fluid intake during races [2]. After 1981, runners were advised to consume as much fluid as possible, so asymptomatic EAH is common with an incidence of 12-15% [3,4], and up to 50% among ultramarathon runners [5,6]. Symptomatic EAH is less common with incidence range from 0.1-1% [6,7], but can be as high as 38% in longer distance events [8]. Deaths are rare though, with only 14 reported in literature [7,9].

Pathophysiology

The mechanism leading to hyponatremia during exercise is mainly by dilution [7]. During exercise, fluid ingestion is driven by thirst and conditioned behavior. The abundant fluid supply during the race and the recommendation to drink in order to avoid dehydration can result in excessive fluid ingestion relative to fluid loss. The hypotonic replacement fluid results in an increase in total body water (TBW) relative to total body exchangeable sodium. Metabolism of glycogen store and triglyceride also produce free water. As a result, hyponatremia occurs due to dilution. Overhydration alone, however cannot fully explain the pathophysiology of EAH as hyponatremia can still occur in athletes who drink less than the maximum water excretion capacity [7]. This suggests that a defect in renal water excretion through an increase in antidiuretic hormone (ADH) also play a role in the development of EAH. ADH during exercise is not just stimulated by volume depletion, but also by other nonspecific stresses like physical exercise, pain, emotion, and cytokine release during muscle injury [10]. Therefore the ADH level can be inappropriately elevated during marathon running even when volume depletion is not present, resulting in hyponatremia [3]. Catecholamine and angiotensin II release during exercise may also impair the dilution capacity of the kidneys. This explained why the urine osmolality of our patient was inappropriately high.

Exchangable sodium stores also play a role in EAH. Although overhydration is a feature of EAH, 70% athletes with increased TBW did not develop hyponatremia in a study done by Noakes et al [7]. The author suggested that some people can mobilize osmotically inactive sodium from bone and cartilages so as to maintain normonatremia. EAH may develop if the body is unable to mobilize osmotically inactive sodium [7].

Overhydration is the number one risk factor for developing EAH as evident by a fall in the incidence after revising the upper limit of fluid consumption to 1-1.5 L/hour [11]. Intra-race weight gain is suggestive of overhydration. Participants with smaller body weight are also at risk as they tend to ingest more fluids relative to TBW [12]. Exercise duration of longer than 4 hours or in slow runners correlate with increased water consumption and increased sodium loss [13]. All these risk factors contribute to the development of hyponatremia in EAH. NSAID is also found to be associated with EAH in some studies by theoretically potentiating the effect of ADH [14-16]. Our patient ran for 8 hours and was suspected to have taken NSAID. He also had significant muscle injury as evident by the elevated creatinine kinase level, which might have further stimulated ADH release [10]. All these predisposed him to develop EAH.

Clinical Features

Most patients with EAH are asymptomatic or have non-specific symptoms like dizziness, nausea, and headache only. Symptoms are more likely to occur if Na <126 mmol/L, but the rate and extend of the drop in extracellular tonicity are more important determinants [1]. Severe symptoms including confusion, seizure, and altered mental state are caused by cerebral edema secondary to hyponatremia. Respiratory distress due to non-cardiogenic pulmonary edema may also occur.

Treatment

Vigilance of the diagnosis is most important. Ideally, medical facilities at endurance events should be equipped to measure serum Na. In the absence of Na level, empirical treatment should be initiated if clinically suspicious [9].

For asymptomatic patients, fluid restriction till urination is enough. If the serum Na <130 mmol/L, oral HTS with 3% NaCl 100 ml or 4 broth cubes dissolved in ½ cup water may be administered to reduce risk of progression to symptomatic EAH [9,17]. Mildly symptomatic patients should be given oral HTS [9,17,18]. Hydration with normal saline may cause further decrease in Na level if ADH level remain elevated and therefore should not be given until diuresis occur [17].

For severe symptomatic patients, HTS 3% saline 100 ml administered every 10 minutes until clinical improvement is recommended [17]. In patients with significant antidiuresis, higher dose of HTS 3-4 ml/kg/hr with administration of loop diuretics may be necessary [1]. In Hong Kong, we use 5.85% (1 mmol/ml) HTS. Since EAH develops acutely, rapid correction of hyponatremia is safe and no cases of osmotic demyelination syndrome have been reported [17].

For the prevention of EAH, recommendation by the Statement of the Third International EAH Consensus Development Conference 2015 is to drink according to thirst [9]. Using the innate thirst mechanism to guide fluid consumption should limit drinking in excess and developing hyponatremia while providing sufficient fluid to prevent excessive dehydration [9]. Measuring serial body weights during training can guide the amount of fluid replacement. Sports drinks are hypotonic fluids and will not prevent EAH in runners who overdrink, as all sports drinks have a significant lower Na level (10-38 mmol/L) than serum (~140 mmol/L) [9]. Education is the cornerstone for preventing EAH.

Timely administration of HTS is paramount in treatment of severe EAH. For those runners presenting with symptoms of severe EAH, emergent treatment with intravenous HTS is necessary and should not be delayed pending laboratory measurement of serum Na level [9]. Medical practitioners, especially medics who work at the field during endurance events should be well aware of this disease and be familiar with its treatment.

References

  1. Rosner MH, Kirven J (2007) Exercise-associated hyponatremia. Clin J Am Soc Nephrol 2: 151-161.
  2. Noakes TD (2003) Overconsumption of fluids by athletes. BMJ 327: 113-114.
  3. Hew-Butler T, Dugas JP, Noakes TD, Verbalis JG (2010) Changes in plasma arginine vasopressin concentrations in cyclists participating in a 109-km cycle race. Br J Sports Med 44: 594-597. [crossref]
  4. Speedy DB, Noakes TD, Rogers IR, Thompson JM, Campbell RG et al. (1999) Hyponatremia in ultradistance triathletes. Med Sci Sports Exerc 31: 809-815. [crossref]
  5. Lebus DK, Casazza GA, Hoffman MD, Van Loan MD (2010) Can changes in body mass and total body water accurately predict hyponatremia after a 161-km running race? Clin J Sport Med 20: 193-199. [crossref]
  6. Hoffman MD, Hew-Butler T, Stuempfle KJ (2013) Exercise-associated hyponatremia and hydration status in 161-km ultramarathoners. Med Sci Sports Exerc 45: 784-791. [crossref]
  7. Noakes TD, Sharwood K, Speedy D, Hew T, Reid S, et al. (2005) Three independent biological mechanisms cause exercise-associated hyponatremia: evidence from 2,135 weighed competitive athletic performances. Proc Natl Acad Sci U S A 102: 18550-18555. [crossref]
  8. Lee JK, Nio AQ, Ang WH, Johnson C, Aziz AR, et al. (2011) First reported cases of exercise-associated hyponatremia in Asia. Int J Sports Med 32: 297-302. [crossref]
  9. Hew-Butler T, Rosner MH, Fowkes-Godek S, Dugas JP, Hoffman MD et al. (2015) Statement of the 3rd International Exercise-Associated Hyponatremia Consensus Development Conference, Carlsbad, California, 2015. Br J Sports Med 49: 1432-1446. [crossref]
  10. Robertson GL (2006) Regulation of arginine vasopressin in the syndrome of inappropriate antidiuresis. Am J Med 119 (suppl 1): S36-42. [crossref]
  11. Noakes TD, Speedy DB (2006) Case proven: exercise associated hyponatraemia is due to overdrinking. So why did it take 20 years before the original evidence was accepted? Br J Sports Med 40: 567-572. [crossref]
  12. Almond CS, Shin AY, Fortescue EB, Maniix RC, Wypij D, et al. (2005) Hyponatremia among runners in the Boston Marathon. N Engl J Med 352: 1550-1556. [crossref]
  13. Hew TD, Chorley JN, Cianca JC, Divine JG (2003) The incidence, risk factors, and clinical manifestations of hyponatremia in marathon runners. Clin J Sport Med 13: 41-47. [crossref]
  14. Wharam PC, Speedy DB, Noakes TD, Thompson JM, Reid SA, et al. (2006) NSAID use increases the risk of developing hyponatremia during an Ironman triathlon. Med Sci Sports Exerc 38: 618-622. [crossref]
  15. Ayus JC, Varon J, Arieff AI (2000) Hyponatremia, cerebral edema, and noncardiogenic pulmonary edema in marathon runners. Ann Intern Med 132: 711-714. [crossref]
  16. Whatmough S, Mears S, Kipps C (2018) Serum sodium changes in marathon participants who use NSAIDs. BMJ Open Sport Exerc Med 4: e000364.
  17. Hew-Butler T, Loi V, Pani A, Rosner MH (2017) Exercise-Associated Hyponatremia: 2017 Update. Front Med (Lausanne) 4: 21. [crossref]
  18. Bridges E, Altherwi T, Correa JA, Hew-Butler T (2020) Oral Hypertonic Saline Is Effective in Reversing Acute Mild-to-Moderate Symptomatic Exercise-Associated Hyponatremia. Clin J Sport Med 30: 8-13.

Identity Style and Academic Burnout with Internet Addiction in Students

DOI: 10.31038/ASMHS.2020414

Abstract

Introduction: In a world becoming more complex, the necessity of using the internet for human especially students is more than ever, because the internet can play a major role in gaining mastery. Students as those who can have an important role in current situation and especially the future of a country in order to be favorable conditions for using cyberspace are undoubtedly more vulnerable to the dangers of cyberspace. Therefore, this research intends to determine whether identity styles and academic burnout are effective on internet addiction in students?

Method: To investigate this, we used the correlation research method and the Pearson and regression statistical method. And among all students of the Islamic Azad University of Sari, three sample groups were selected 155 people equally as examples and were used to collect data required from the ISI Browinsky identity questionnaire and for educational assessment of the questionnaire and to measure the Internet addiction assay from the Kimberly Young questionnaire.

Conclusion: There is a relation between identity styles and Internet addiction in students, it is found that the link between the style of identity and normative information identity with Internet addiction is negative. It may be because the use of the internet is slowly addicted to the negative attractiveness of the internet, creating the impression that it can provide psychological and emotional needs. It is also found that there is a correlation between academic exhaustion with Internet addiction and increasing the Internet addiction، Perhaps the reason for this is that the Internet addiction has the ability to recruit an individual as it tries to pay attention to the educational tasks

Introduction

Computer and internet as essential tools of life are responsible for facilitating the lives of people who have created new dangers that one of these risks is the creation of neglect or academic burnout in students [1]. In a world becoming more complex, the necessity of using the internet for human especially students is more than ever, because the internet can play a major role in gaining mastery [2]. On the other hand, anonymity appears on the internet and virtual communities to give people a chance to play with their identity or build a new identity so that they can have different personalities and affect the lifestyle of people and their types of emotions, and studies have shown that technology addiction affects the actual purposes of technology users. This is primarily due to the maladaptive understanding that is thus shaped as a result of technology addiction [3]. Also the results of research have shown that social networks lead to changes in the lifestyle of youth in the fields such as leisure time, attention and tendency to the body to how to cover, style of speech, creating conditions for communication with opposite sex and gaining ability of the day in attitude toward the world. People with low-risk seeking experience enjoy a healthier lifestyle [4]. Student as those who can play an important role in the current situation and especially the future of a country, the students are more likely to be exposed to the dangers of cyberspace to be conducive to the use of cyberspace. As the main pillar of the educational system of the country in achieving the goals of the educational system, they have a special role and status, so paying attention to this huge and young people of society, fertility and prosperity have the most educational system in society. The main objective of any educational system is to create suitable ground for learning and actualization of potential human potential. On the other hand, gaining success and learning needs to have a healthy and lively spirit and all the efforts done in the process of education tend to develop healthy personality of students [5]. Considering the negative role of internet addiction in the desire to educate [6] and also the role of internet addiction in reducing academic performance [7], this research intends to determine whether the style of identity and academic burnout with internet addiction is effective in students? In this regard, by reviewing the literature and literature, some basic hypotheses have been formed and that there is a relationship between identity styles and internet addiction. Also there is relation between identity styles and academic burnout in students. And some other research hypotheses…

Method and Result

To examine this issue, correlation research method and the Pearson and regression statistical method was used. Of all students of the Islamic Azad University of Sari, three sample groups were selected 155 people equally as examples. To collect data required from the ISI Brownsky identity style questionnaires and for educational assessment academic burnout questionnaire, and the extent to which Internet addiction Kimberly Young questionnaire has been used, and finally to investigate the first process of research using Pearson correlation test, the following techniques were extracted.

 

Styles Number Coefficient of correlation Research coefficient Probability value
Information identity style 155 -0.454 0.206 0.000
Normative identity style 155 -0.426 0.181 0.000
Confused identity style 155 -0.464 0.215 0.000

 

On the basis of these data, the relationship between identity styles and internet addiction is confirmed and also for the study of the second process, the relationship between academic burnout and internet addiction has been used and the following data were extracted.

 

Variable Number Coefficient of correlation Probability value
Academic burnout 155 0.461 0.000

 

Accordingly, the relationship between academic burnout and internet addiction is confirmed.

To investigate the relationship between identity styles and academic burnout, Pearson correlation statistical method was used.

 

Styles Number Coefficient of correlation Determination coefficient Probability value
Information identity style 155 -0.460 0.184 0.000
Normative identity style 155 -0.420 0.176 0.000
Confused identity style 155 -0.467 0.218 0.000

 

According to the above data, the relationship between identity styles with academic burnout is also confirmed.

It is also used to examine the fourth hypothesis, each of the identity styles in the prediction of Internet addiction in different students from a step- by- step analysis method between identity styles and Internet addiction. And the result has shown that each of the identity styles is different in explaining Internet addiction.

Conclusion

The main purpose of this study was to investigate the relationship between identity styles and academic burnout with internet addiction in Azad university students. According to the proposed hypotheses, we discuss each of these hypotheses. The first hypothesis is that there is a relationship between identity styles and internet addiction among students, it was found that the relationship between informational and normative identity style with internet addiction is negative, This finding is inconsistent with Jamshidei and Sarvqad’s [8] findings, and its direction is positive in relation to the confused identity with the Internet addiction that aligns with findings of Jamshidei and Sarvqad [8] and Piri [9] and Kamali et al. [10]. The reason for this can be explained by Dastjerdi’s [11] research under the title An Investigation of the role of Cyber Networks in Cultural Identity of Students at the University of Isfahan, based on the false attractiveness of the internet, which creates the impression that it can provide psychological and emotional needs.

Therefore, replacing social networks on the internet instead of presence and interaction with people in the real world will cause users social and emotional relationships to be disrupted.

In the study of the second hypothesis that academic exhaustion with Internet addiction has been found on students, there is a relationship between them. The results of this study are based on the results of Ganji [6] and Pourmirzai [7] based on the negative role of addiction to internet and performance and education; in explaining this, it can be concluded Jin et al. [12] and Shahbaziyan [1] researches; that there is a positive and significant relationship between procrastination in preparing academic term papers with dependence on internet and a negative and significant relationship with academic self- efficacy. Procrastination in preparing for the exam is not correlated with Internet dependence and academic efficiency, but between Internet dependence and academic self-efficacy plays a major role in predicting the degree of Internet dependence, and in the second step, procrastination in homework could play a significant role. Based on the findings, male students reported more Internet dependence than female students, which is in line with the process presented in this section. In examining the third hypothesis; Based on that; there is a relationship between identity styles and academic burnout in students, according to the results, it was found that there is a negative relationship between informational and normative identity style and academic burnout. In the context of this finding based on Bruce [13] results, it can be said that stress and avoidance of academic burnout that several factors such as social support failure, stress over size and personality traits can be the cause of academic burnout. The fourth hypothesis is that the contribution of each identity style to internet addiction is different in students. In examining the fourth hypothesis that the contribution of each identity style in predicting Internet addiction in students is different. The data show that identity styles are simultaneously effective in the occurrence of Internet addiction and the share of each identity style among Internet addiction is different, which can be concluded based on the results of Sadeghi and et al. [14] and Thomas [15] explained. According to this study, identity style has a significant negative relationship with information identity with Internet addiction and confused identity style has a positive relationship with Internet addiction, and therefore the relationship between normative identity style and Internet addiction is not significant.

References

  1. Shabaziyan A (2017) Distinguish between students with academic procrastination and ordinary students based on Internet addiction. Daneshvar Medicine 131: 1-10.
  2. Sindermann C, Peterka J, Sha P, Zho M, Montag C (2019) The relationship between internet use disorder, depression and burnout among Chinese and German college students. Addictive Behaviors 89: 188-99.
  3. Chen L, Nath R (2016) Understanding the underlying factors of Internet addiction across culture. ‏Electronic Commerce Research and Applications 17: 38-48.
  4. Muchacka A, Tomaszek K (2020) Examinating the relationship between student school burnout and problematic internet use. Education Sciences 20: 16-31.
  5. Bahadori J, Hashemi T (2012) Internet attachment styles, coping strategies and mental health with Internet addiction. Iranian Developmental Psychology 8: 177-188.
  6. Ganji B, Asadi S, Babak F (2016) Investigating the relationship between Internet addiction and students’ academic motivation. Journal of Educational Strategies in Medical Sciences 9:150-155.
  7. Pourmirzai H, Asgari G (2017) Predicting Internet Addiction as a Factor Affecting Academic Performance Based on D-Personality Type and Humorous Styles in Medical Students. Iranian Journal of Medical Education 17: 1-10.
  8. Jamshidi M, Sarvqad S (2015) The mediating role of identity styles in relationship between differentiation of self and internet addiction. Journal of psychological methods and models 6: 37-54.
  9. Piri Z, Amiri M (2019) The mediating role of coping strategies in the relationship between emotion difficulty and Internet addiction. Ofogh Danesh Scientific Research Journal 26: 38-53.
  10. Kamali N, Houseini F (2020) A study of the relationship between neuroticism and Internet addiction among young people. Study of Borazjan Azad University students. Bushehr Disciplinary Science Quarterly 10: 69-75.
  11. Dastjerdi N (2014) An investigation of the role of Cyber network in cultural identity of students at the university of Isfahan. Applied Sociology 25: 159-70.
  12. Liu S, Jin C (2018) The relationship between college students mobile phone addiction and learning burnout: personality as a moderator. Chinese Journal of Special Education 2: 86-91.
  13. Bruce S (2016) Recognizing stress and avoiding Burnout. Currents in Pharmacy Teaching and Learning 1: 57-64.
  14. Doostani P, Sadeghi A (2019) Predicting career goal discrepancy based on career- related stress, career goal feedback, and field of study in students. Journal of Counseling Research 17: 22-43.
  15. Thomas D (2016) Cellphone addiction and academic stress among university students in Thailand. International Forum 19: 80-96.

Mapping Contextual Drivers of HIV Vulnerability: A Qualitative Study of African, Caribbean, Black Youth in Windsor, Canada

DOI: 10.31038/AWHC.2020353

Abstract

Background: Based on POWER study: Promoting and owning empowerment and resilience among African, Caribbean, and Black Canadian (ACB) youth, this paper explored the contextual factors that expose ACB youth to HIV infection.

Method: We conducted six focused community-mapping sessions with 43 purposively drawn ACB youth living in Windsor, Canada. Based on socio-environmental approach, we investigated a number of issues including, where to find ACB people, places afraid to go, places to find casual partners, where they spend leisure time, healthy and unhealthy places.

Results: The findings showed that ACB population mainly resides in poor areas, with close proximity to bars, strip shops, recreational/sports places. And, multifaceted factors, such as economic deprivation, marginalization, discrimination, and substance use provided an enabling environment for ACB youth exposure to HIV/AIDS. Conclusion: Future HIV/AIDS prevention must be locality specific and culturally sensitive, by taking into account individual, structural, environmental and socio-cultural factors in future HIV prevention strategies.

Keywords

HIV/AIDS, ACB youth, Community mapping, Contextual factors

Introduction

According to 2018 HIV surveillance report in Canada, Ontario accounted for the highest population of HIV cases (39.2%), with the second highest reported cases among 20-29 at 22.5% Gay, bisexual and men who have sex with men (gbMSM) continue to account for the highest exposure to HIV 58.1%, while heterosexual transmission accounts for 32.3%, of which 15.4% are from HIV endemic countries [1]. Similarly in 2017, Ontario accounted for the highest population of new HIV cases (38.9%), and ACB people infected with HIV through heterosexual contact account for 20% of the estimated total of all HIV-positive people, and youth aged 15 to 29 accounted for 23% of HIV cases, and between 2016 to 2017 a 17% increase in 15 to 19 and 4% decrease among 20 to 29 [2]. More so, the Black population, which makes up 3.9% of the population accounts for 22.5% of persons living with HIV in the province [3]. It also has been estimated that in Ontario, Windsor diagnosis of HIV new cases of 5.7 was fifth, with Toronto having the highest diagnosis rate of 15.7 [4].

Community-based and participatory action research programs on HIV/AIDS risk behaviors have reported that mapping of locations with high concentrations of bars, shops, strip clubs, trucking places, sex workers and other geographical places is crucial in identifying at-risk places, groups, as well as, in designing and implementing effective and sustainable HIV prevention interventions [5]. Community mapping has been used to address development and health issues across multidisciplinary sectors, particularly health issues like infectious diseases [6-8] and HIV/AIDS [9,10]. Other focus of community mapping includes HIV prevention intervention [11,12], and health promotion [13], sex and HIV education [14].

However, mapping as a social research approach has become a growing basis for many interventions in developing countries/contexts, on development interventions to promote HIV prevention [15-17]. Community mapping is a mixed method approach that involves brainstorming and geographical mapping to visually present ACB youth ideas and perceptions of their vulnerability and resilience to HIV/AIDS. Participants actively participated in ensuring that the maps are explicit, representing and providing adequate knowledge that represents the diverse views of participants.

The present paper explores the factors that expose young ACB youth to HIV infection in a border city, Windsor, Ontario Canada. It focuses on individual, interpersonal, societal and environmental factors (e.g. access to resources, oppression, discrimination, poverty, and racism) that are often beyond the control of individuals [18-21].

Theoretical Perspectives

Based on socio-environmental approach, this paper recognizes that individual and collective health are intertwined, such that health disparities are the outcomes of intersecting social determinants including neighborhoods, access to economic and social resources, everyday encounters of discrimination and racism, and social exclusion [22]. Integral to this paper are the concepts of masculinity and vulnerabilities. According to UNAIDS [23], people’s vulnerability to HIV depends on their personal circumstances, societal factors such as disempowering cultural practices and laws, and the extent to which they have access to appropriate services and supports. However, the UNAIDS definition of HIV vulnerability neglects the role of structural determinants, such as various forms of social oppression, deprivation, and poverty [24]. This paper measures vulnerability in terms of individual attributes such as self-esteem, personal competence, optimism, and related attributes. The focus on individual factors makes invisible those situational and socio-environmental factors (e.g. cultural safety, access to resources, social capital, intergenerational trauma) that are often beyond the control of individuals [21].

Methodology

Study Community

Windsor, located in southwestern region of Ontario, and has also been identified as has one the highest rates of immigrants proportional to its population, having the sixth largest concentration of people who have ancestral ties to Africa [25]. According to Statistics Canada (2011) [26], Windsor has the highest proportion (33.3%) of low-income population living in very low-income neighborhoods. Windsor with the fifth highest HIV diagnosis rate (5.7) among new cases is also a border town with Detroit, Michigan, USA, which has 603 positive sero-status persons per 100,000 people [27]. In addition, its low legal age for alcohol and tobacco consumption, attracts young Americans to visit Windsor bars regularly on weekends and has opened more avenues for social and sexual networking [28]. This networking is likely to create unique local issues. Therefore, it becomes crucial to conduct a study that focuses on Windsor because issues such as youth’s and parents’ socioeconomic status, inter-country migration or mobility, social hubs, and diversity may nurture cross-border politics and relations.

This study is based on the community mapping of a larger CIHR (2009-2012) funded project on “Promoting and owning empowerment and resilience among African, Caribbean and Black youth in Windsor (POWER)”. Engagement process began by organizing a public forum for ACB youth and community based organizations and stakeholders. At the public forum, we developed a list of volunteers to serve in the Youth Advisory Committee (YAC). YAC became a bridge that links the project to the study communities, target population (youth) and promoted participatory involvement of youth at all levels of the research process. We provided a brief overview of the project and particularly the community-based approach that focus on partnering with the communities and target group as significant actors in the project implementation.

Data Collection

Two investigators and three staff undertook six focused community mapping group sessions between May and November 2015 with 18-24 years ACB youth living in Windsor. The six group sessions comprised of Youth Advisory Committee (YAC) of university of Windsor students (7), St Claire College (7), Caribbean non-students (7), Black non-students (8) and African non-student (7). Purposive sampling was used to recruit a total of 43 participants. Each group session comprised of homogenous participants in terms of racial/ethnic groups and student status. Two project staff facilitated after being trained over one-week training on community mapping. Each focused group session included seven to eight participants of the same ethno-racial group organizations and student status. Two staff and one investigator facilitated the focused sessions. To begin each session, facilitators introduced the community mapping methodology, including a de-briefing on what the project purpose and goals. Facilitators used a focused semi-structured guide containing prompt questions to lead the discussions, exploring commonalities and differences across the conversation. After each session, the project team debriefed with facilitators, providing additional coaching on issues or ideas that arose during the session. Going around the table, each participant was giving the opportunity to contribute to the discussions. Participants were provided with sticky notes to put down their response if too shy to speak out. Participants had ample uninterrupted time to respond promptly. Participants as a group placed some of their answers on the map of Windsor. Each session lasted between 90 and 120 minutes. The language of communication was English. We took notes and audio taped the discussions. We served snacks and paid participants stipend of $25, which included $5 for transportation.

Data Analysis

The staff transcribed the audio recordings verbatim. Two investigators verified the transcripts for accuracy. Project coordinator created the codebook used for coding the transcripts. We used pattern coding by Miles and Huberman (1991) to summarize each transcript. Codes were compiled to record the experiences and perceptions of barriers that tend to expose ACB youth to HIV/AIDS. Staff and two investigators re-examined the coded transcripts for accuracy. And, N6 qualitative software, online coding and data management was used to organize and code the transcripts. The coding process resulted in the identification of the data supporting the emergent themes and the corresponding quotations buttressing the arguments. We made a table of emergent themes, sub-themes and corresponding quotations, which was further reviewed by staff and one investigator for validation. The team overseeing the community mapping read and re-read the themes against the quotations to identify the pattern of arguments.

Results and Discussion

Background of Participants

Table 1 shows that participants of African heritage make up the majority (51.2 percent), those of Black heritage were 23.3%, while Caribbean were 20.9% and only 4.6% classified themselves as of mixed heritage. Additionally, in terms of gender, males were 55.8% and females were 19%. All the sessions were held in a place of close proximity to the participants. For example for university of Windsor and St. Claire College, the sessions were held in the two campuses, while others tended to be held at downtown Windsor.

Table 1: Participants’ Background Characteristics.

Characteristics

Frequency

Percent

Race/Ethnicity (N= 43)

No.

 

African

22

51.2

Black

10

23.3

Caribbean

9

20.9

Mixed

2

4.6

Gender (N=43)
Female

19

44.2

Male

24

55.8

Places to Find ACB People

The study probed for the places where ACB people commonly lived. The participants reported that ACB people commonly resided in places where there were affordable housing, with close proximity to social institutions and amenities such as schools, recreations centers. Government provided most of affordable housing tailored to income of tenants. Public maintenance of these housings was timely and at no extra cost to the tenant. More importantly, it was a common practice for newcomers to seek and identify residential places populated by ACB people. Participants identified the west, around sandwich, central and downtown areas as the places to find most ACB people, while they are sparsely located in South Wood Lake area, where the wealthy and affluent ACB families reside. More ACB people are congregated in the west end/Sandwich, central and downtown, which are crime and poverty-ridden areas. They also noted that a high population of ACB youth, as students, wage earners and those not gainfully employed resided in these areas, either alone or with parents/guardians. Participants also reported a number of social vices such as availability and accessibility to drugs like marijuana, partying, and sex work, which are common around affordable housing places. These social vices expose ACB youth to risk behavior and HIV infection.

In terms of their opinion on living in these places, there were varied ideas. In the Black Canadian mapping session, participants described these areas as: Dirty, lot of prostitutes, Rough area that used to be more violent back in (10), it’s a bad area, prostitution, people get robbed beat up all the time (13), it’s so retched, ghetto, lots of poverty, No money or jobs are here, A lot of drugs and violence.

The YAC Group Noted That

There are a lot of young people; a lot of influence, peer pressure, drugs, sports, unprotected sex, good or poor academics, some of the neighborhoods are associated with public housing, immigrant settlement, Glengarry has a waterpark, STAG, community centers, where people can go, ———————, black people are excluded from networking (union)

In the University Students’ Session, a Participant Noted

Relatively impoverished; roads and everything is poorly cared; not much of the city funds go there; a little dangerous; its more affordable; but there is always some type of altercation on my lawn or across the street; I just assumed I would find something more affordable in West Windsor; familiar; they might also feel they can find someone they can relate to (Female Caribbean).

While in the Non-student Group Session, a Participant Added

Black people are spread out in little areas; West Windsor; bad; but I think it is inclusive, culturally sensitive a good place; unkempt; drugs, boarded houses; not true; there is Windsor housing for immigrants.

Discrimination and Contact with the Police

Despite the importance of social networking with friends and peers, participants reported that the presence of ACB youth in predominantly white residential neighborhoods at out-skirts of Windsor, high-end stores, and electronic sections/units of departmental stores, grocery stores and around police stations raises suspicion. Other places identified where teen health center and blood clinic (cited by University group), and prisons (African non-students). The common reasons provided for avoiding these areas are to avoid confrontations with the police, and confrontations involving wrong identity. Participant noted that “If a conflict/confrontation occurs- automatically the Black person(s) will be confronted even though the fight was from another race” (African female session). Other youth reported that “violence and crime” are high at downtown Windsor, and ACB youth are often the first suspects.

Participants also reiterated their experiences with the police in a number of places such as residential areas around downtown, west end, university areas; clubs – Boom Boom, house parties; highways and other places such as the mall and stores. Often such encounters with peers and relatives end up as mistaken identity, or it involves highway offense and road checks. A youth noted that with police in Windsor, “they think all Blacks look alike” (African Female, AF). A participant reported that there was a time when a “girl’s house was robbed; a dozen police car were present, the last one had a gun pulled out, stopped us for an hour, asked foolish questions, and said you fit the description”.

A participant also noted an incident downtown, where ACB boys were hanging out at “McDonalds with white girls, cops harassed us, told us to go home or be arrested for loitering, and promised to call the girl’s parents.” Police officers would stop an ACB youth and say, “Are you up to something? Are you from Somalia?” (African Male) A student participant also noted: “walking home from university, 20 minutes-walk from home, 2am I was questioned about seeing someone in the area” (AM).

Where do Youth Spend their Free Time?

In response to the question, “where do youth spend their free time?” participants highlighted a number of places in west of Windsor, such as Sandwich and downtown areas where ACB youth most frequently spend their free time. These places included bars, clubs, strip shops, parks, and sport centers like St. Denis center at the University of Windsor and YMCA, house parties, malls, University library – Leddy and at the theaters. These were common meeting places where they engage in social and sexual networking with each other. Data also showed gender differences as males frequented more places for sports and clubbing, while females tended to patronize places that are less costly, for dancing and were often in company with older siblings and friends. During the walking tours of these areas, the research team and staff were informed that other ACB youth residing in other places in Windsor tended to visit and congregate in these areas to be in company of other peers and friends. We also probed for healthy and unhealthy places in Windsor. The participants reported diverse settings. The healthy places ranged from sport places like gyms at YMCA and St. Denis of the University of Windsor; leisure places like STAG, water front located at downtown Windsor; faith-based institutions-churches and mosques, NGO offices like Windsor Women Working With Immigrant Women, Women Entrepreneur Skills Training, New Canadian Center for Excellence, AIDS Committee of Windsor, Youth Connection Association, Salvation Army, and community centers like STAG, Caribbean center. For these youth, these places provided low cost services and were safe and fun places. However, they noted that unhealthy places included parks; downtown area, street allies, and places where many sex workers line the streets, and house parties. The reasons provided ranges from availability of drugs, sexual networking, and exposure to unhealthy behaviors such as sexual activities, drugs and despicable behaviors such as sexing in public places like parks. A participant in identifying what makes these places unhealthy said: Downtown; drugs and alcohol; white women approach Black men; border city; girls from Cincinnati, Pittsburgh, Detroit; 1 in 4 Americans have an STI; Black women give stink eye because it’s not healthy (sexually networking with men who have exposed themselves to “risky” White women); strip clubs; studio 4; Teasers; human and drug trafficking; leopards owns 2 houses; keep green cards in safe; European girls; you don’t know what they have; police department; racial profiling; west end (street level crime); university of Windsor; break ins and misdemeanours (Caribbean Black Male).

Where to Find Casual Sex Partners

Participants identified downtown area and facilities -bars, strip clubs, house parties, Studio 4, casino, riverside after hour, massage parlors, parking lots, university library and residences, High school, St Clair, workplaces – factories, street corners – next to Bistro, shops – sex shops (Maxine, Dougall), residential Areas – condos downtown, restaurants – McDonalds (Escorts) as places to find casual sex partners. These places have close proximity to places where ACB people reside provided easy access to “alcohol and casual sexual activity” (African Female, AF). A participant in the University community mapping session said:

You will be surprised at what goes on at this campus. A friend finds a message at Leddy “for a good time call this number” (African Male, AM).

Another participant added, “campus for variety and safety” (African Female, AF)

A participant from the university also said:

AM: bars, strip clubs; university (you would be surprised at what goes on at this campus); speaks about friend who finds a message at Leddy; “for a good time call this number; meet at a house;” (African Male, AM)

Silvers on Seminole, Casino (Caribbean Female, CF).

Secret Places for Secret Things

To the probe on the secret places where ACB visit and/or congregate to do secret things, not to be heard or known by their parents/guardians, the participants reported bars/s clubs, located in the Sandwich and downtown areas, and specifically university and college campuses where a variety of activities occurred including “alcohol and casual sexual activity” (AF), and youth solicitation for sexual activity. Other activities included drugs, illicit sex, unsafe sex, and prostitution, which are unhealthy and expose persons to STIs including HIV/AIDS. The common reason given for engaging in these activities at these places is that they are “away from home and parents and no need to keep good name”.

P4 AF: residence; houses near campus; sell drugs; Askin street near the university; friends of friends; word of mouth

P1 BM: university; residence; college life involves it; alcohol and weed; houses right by campus

P6 CF: apartments on Peter Street; people come in and out at odd hours

P5 ACF: parks; accessible for sex and drugs

P7 AM; coronation school pike park; when house party ends, can go there to be loud or drink

CBM: Riverfront (car sex); hotels on Huron church (strippers from Ottawa, nova scotia); downtown Windsor condos by police station (drugs); Wyandotte and Windermere (S and M club); massage parlours downtown; houses in west end (coke spots); south Windsor (behind Devonshire mall area; cocaine); Banwell (ecstasy).

Discussion

Community mapping sessions and walking tours provided the researchers and staff a journey into the lived experiences and observations of ACB youth in Windsor, Ontario. The common thread in these accounts and activities was the social inequality, which was more along racial lines that tended to create social exclusion, perpetuating feelings of discrimination and overt racism, which have been reported to have serious impact on ACB communities particularly youth [18,19,29,30] and their attitude to the police [31]. Although these experiences results in lack of entitlement and privilege, thus threatening the social existential survival of ACB population, particularly youth, the community mapping strategies, gave back to these youth some elements of power not just as research participants but also as researchers in the front drive of data collection, informing and making contributions to all stages in the project.

The findings that neighborhoods’ context and organization promote ACB youth vulnerability to HIV infection has been buttressed by similar findings from existing studies from the United States and Canada depicting the influence of neighborhood environment and social disorder [19,20,32] neighborhood economic disadvantage [33-35] on HIV exposure.

The study also reported that the proliferation of some neighborhoods densely populated by ACB populations with bars, street allies, abandoned houses, availability and accessibility to drugs and alcohol, perpetuate risky behaviors like drug and alcohol use, accessibility and availability of female sex workers. Of significance is the report by participants that there have been rape cases of male and female victims in such neighborhoods due to bad people hiding in abandoned properties, and coercing or luring young persons and children into such places. Similarly, a few studies [36-38] suggest that physical environment influences sexual risk and HIV vulnerability. For instance [36], study notes that characteristics of the urban environment influence a wide variety of health behaviors and disease outcomes. They contend that the physical, social and cultural characteristics of urban environment have tolerant social policies through which behaviors and identities may be enacted with less fear. Also noted that inadequately housed individuals tend to be socially isolated or involved in networks that support risky behaviors such as drug use, unstable intimate relationships, multiple sex partners, casual sex exchange and low rates of marriage [39].

The present study also found that a majority of ACB population resides in affordable housing for low to medium very income people families. According to Statistics Canada (2011) [26], Windsor as a town has the highest proportion of low-income populations living in very low-income neighborhoods. Research evidence also shows that people living in very low-income neighborhoods appear to have higher HIV risk profile than those living in higher income areas [18]. Similarly, studies from North America also bear credence to the findings by its association of poverty from social and economic deprivation with HIV risk behaviors [39,40].

Of great importance are past evidence that local bars in Windsor, which attracts youth across the border due to its lower age for alcohol consumption increases the scope of social and sexual networking among Canadian and American youth [28]. Noting that the HIV prevalence rate is very high across Windsor’s border city of Detroit (35 new cases per 100,000 residents), and coupled with the early initiation of sex in youth and the poor attitude to and low use of condoms [27,41] the networking between the two cities is likely to increase the exposure of youth to HIV infection. In addition, participants reported going to hidden places away from parents and homes to use drugs, party and indulge in sexual activity. These findings have been documented in other empirical studies showing that young boys and girls use drugs like marijuana and alcohol, which may affect their decision-making [42], and invariable lead to risky behaviors including anal sex [43-46], violence [47-51], unprotected sex [52], and having casual and/or opportunistic sex [53-58].

Finally, low parent-child communication on sex also matters. It has been well documented that there is lack of sex talks in families and particularly between parents and children [59-61]. This gap exposes younger ACB youth to risky sexual behaviors such as low condom use and ability to negotiate sex, which has been reported to have serious sexual and reproductive heath consequences like exposure to sexually transmitted infections including HIV/AIDS. However, existing studies on Caribbean population have shown parents willingness to talk about sex and related issues with children [62]. And, it has been reported that parents talk about sex with children leads to abstinence, postponement of sexual initiation, positive attitude to safe sex practices including condom use, and engagement in monogamous relationships [63-68]. Invariably, parent-child communication about sex better prepares children when faced with the decision to have or not to have sex [69]. On the contrary, other studies however reported that some parents feel talking about sex matters with their children and adolescents will introduce them into sexual activities and therefore, they avoid such conversations [64,70]. Although studies remain inconclusive on the outcomes of parent-child talk about sex matters, parental efficacy to improve effective parent-child communication about sex matters remains important [71-85].

Conclusion

For decades, many HIV prevention research focused on determining, planning and implementing interventions to address individual-level risk behaviors that expose individuals to HIV infection. This present study indicates the importance in examining the environment, social and cultural impediments influencing risky behaviors. African, Caribbean and Black youth in Windsor, specifically young men face pressure from parents and families on children to conform to the social and cultural gendered expectations that makes you a woman (practicing abstinence) and a real man, like being the provider, economically stable, having multiple sex partners, and engaging in unprotected sex, which invariably are likely to increase exposure to HIV infection. This gives credence to this study that engaged AB youth as both research participants and as researchers, through membership in the Youth Advisory Committee, and actively engaged in recruiting and participating in community mapping and walking tours. More future research need to adopt a mixed method approach, which includes community and/or concept mapping, and other qualitative methods like focus groups, in-depth interviews, photovoice, and questionnaire to study specific subgroups of ACB population like self-identified heterosexual ACB youth, men and women, on a broader scale, provincially or regionally. So doing, we will then be able to establish the differences and similarities across space, neighborhood, race/ethnic subgroups, religion, class and gender in the general population.

The mapping and construction of factors in the environment, neighborhoods, social and cultural contexts among ACB boys, men, girls and women would gain immensely from further investigations. Such interests may provide broader-based data on perceptions of HIV vulnerability, environment and neighborhood factors, with issues of masculinity, specifically perceptions of black masculinity and sexuality that affect sexual scripts, what having sex means, condom use decision making, opportunistic sex, and perceptions of HIV testing.

Furthermore, the findings from this study can begin to inform HIV prevention strategies among ACB youth on how best to increase HIV prevention services. Such programs will focus efforts on addressing multi-level factors by adopting multidimensional, effective and sustainable interventions, which address individual, social, cultural and environmental risky behaviors, like unsafe sexual practices (having multiple sex partners, lack of effective condom use), while also addressing and implementing policies and interventions to improve the environment, neighborhoods, and socio-cultural factors like perceptions of a real black man that hamper the delivery of HIV services aimed at buttressing the sexual and reproductive health of ACB population, specifically youth.

Acknowledgements

Canadian Institutes of Health Research (CIHR) provided the funding. The ACBY team includes Kenny Gbadebo, Youth Connection Association; Eleanor Maticka-Tyndale, University of Windsor; Valerie Pierre-Pierre, African Caribbean Council of HIV in Ontario; Robb Travers, Wilfrid Laurier University; Jelani Kerr, University of Louisville, Louisville, KY. Thanks to the study participants for their contribution. The content is solely the responsibility of the author.

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Application of Drainage Position Ventilation and Real- Time Bedside Monitoring in Mechanical Ventilation of Patients Infected with nCov-19

DOI: 10.31038/IMROJ.2020543

Abstract

At present, the new coronavirus has spread to more than 200 countries and regions around the world. Up to now, no specific antiviral drugs are proved effective in defeating the new coronavirus, some measures, such as postural drainage ventilation, real-time bedside pulmonary ultrasound and chest electrical impedance monitoring may provide some new ideas for mechanical ventilation patients infected with new coronavirus.

Keywords

New coronavirus, ARDS, Mechanical ventilation, Bioelectrical impedance tomography, Pulmonary ultrasound

Etiology and Pathogenesis

The novel coronavirus (2019-nCoV) belongs to the beta genus of coronavirus, the S protein of the new coronavirus binds to the angiotensin-converting enzyme 2 (ACE2) receptor of human alveolar type II epithelial cells, and then enters into the cell to replicate and spread through respiratory droplets and contact [1].

Clinical Manifestation

Fever, dry cough and fatigue are the main symptoms of the people infected with novel coronavirus. Critically ill patients usually have dyspnea and (or) hypoxemia one week after the onset of the disease. Some patients can rapidly progress to acute respiratory distress syndrome, septic shock, uncorrectable metabolic acidosis, coagulation dysfunction and multiple organ failure [1].

Chest Imaging

Chest radiographs showed multiple small patch shadows and interstitial changes in the lungs, especially in the lateral pulmonary zone in the early stage of the patients infected with new coronavirus. Then it developed into multiple ground glass shadows and infiltration shadows in both lungs, and in severe cases, lung consolidation could occur [1-3].

Pulmonary Pathophysiology

Lung pathology showed focal hemorrhage and necrosis, marked proliferation of the type II alveolar epithelial cells in the lung tissue. Serous, fibrin exudates, and hyaline membrane formation were seen in the alveolar cavity; it could also be observed that the alveolar septal vascular congestion and edema, and some alveolar exudates organization and pulmonary interstitial fibrosis. Part of the bronchial mucosa epithelium was shed; mucus and mucus emboli could be seen in the bronchial lumen. A small number of alveoli were over-inflated, the alveolar septum was broken or the cysts were formed [4].

Thus, critically ill patients infected with new coronavirus may present abnormal pathophysiological changes such as obstructive ventilation disorder, lung gas exchange disorder, imbalanced ventilation blood flow ratio, and increased shunt.

Antiviral Therapy

During the emergency clinical trial of antiviral drugs, a number of randomized, double-blind, antiviral-placebo controlled studies have been carried out, but no antiviral drugs proved effective in treating the new coronavirus infection.

Mechanical Ventilation

Early and appropriate invasive mechanical ventilation is an important treatment for critically ill patients. In general, when PaO2/FiO2 is less than 150 mmHg, the effect of high flow oxygen therapy or noninvasive ventilation is not good, endotracheal intubation should be considered in time for invasive mechanical ventilation in severe and critical ill cases [2]. The strategies of lung protective mechanical ventilation and lung recruitment are implemented. If there is no contraindication, it is suggested to implement prone position ventilation at the same time. Prone position ventilation can improve oxygenation in patients with ARDS by increasing functional residual volume, improving ventilation/blood flow ratio (V/Q), reducing shunt (Qs/Qt), improving diaphragmatic movement and promoting secretion excretion. In the airway management, posture drainage and sputum suction by bronchoscope should be adopted to promote the sputum drainage and lung rehabilitation [2].

Lung Protective Mechanical Ventilation Strategy

The individualized strategy of mechanical ventilation is to adopt the most suitable methods or parameters in ventilation mode, lung recruitment, tidal volume, PEEP and mechanical ventilation posture for patients according to their different pathophysiological conditions, so as to achieve the best treatment effect. At present, low tidal volume, high PEEP, lung recruitment and prone position ventilation are widely used in patients infected with new coronavirus [2]. The characteristics of severe new coronavirus cases, such as inflammatory serous and fibrin exudate, exudate organization, pulmonary fibrosis, alveolar septum destruction, atelectasis and pulmonary bullae, coexist in the patients’ lung [4]. Large tidal volume is not suitable for patients infected with new coronavirus due to the potential mechanical ventilation lung injury [2]. The selection of PEEP should be guided by the best pulmonary mechanics, the reduction of pulmonary shunt, the improvement of oxygenation and the function of stable circulation, while the effect of pulmonary recruitment should be examined by CT, MRI, bioelectrical impedance tomography (EIT) and ultrasound imaging. In the process of lung recruitment, there is the possibility of lung over inflation and the original pulmonary injury aggravation, and the effect on the hemodynamics should be concerned at the same time. The optimal method, opportunity and parameters of lung recruitment have not been determined, but it is necessary to judge the potential of pulmonary reinflation under real-time bedside EIT and ultrasound pulmonary monitoring.

The Advantage of Real Time Bedside Monitoring of EIT and Ultrasound

The goal-oriented mechanical ventilation is to adjust the mechanical ventilation strategy in time with the aim of imaging, respiratory and oxygen dynamics monitoring, blood gas examination, the function of circulatory system and the condition of other organs [2]. Blood oxygen saturation, blood gas, hemodynamics and respiratory mechanics are still routine and convenient monitoring methods of mechanical ventilation. Traditional lung images, such as X-ray, CT, MRI, certainly have the characteristics of clear images and easy analysis and diagnosis, but they are complicated to operate under the special circumstances of isolation and transportation of patients infected with new coronavirus. The chest electrical impedance tomography cannot provide clear image, but it is convenient to operate and can be continuously imaged [5]. Ultrasound lung images also have unique advantages in the diagnosis of pneumonia and the effect of ventilation [6]. These two methods can be real-time bedside monitoring, which are simple and practical to guide lung recruitment, to diagnose pneumonia, and to evaluate the mechanical ventilation effectiveness. In addition, while monitoring respiratory mechanics and oxygenation parameters during mechanical ventilation, we should pay close attention to the corresponding changes in the circulatory system and make timely adjustments.

Electrical Impedance Tomography

Electrical Impedance Tomography (EIT) is to use the impedance changes of living organisms or biological tissues, biological organs, and biological cells under the action of a safe current below the excitability threshold to obtain the organism internal resistance rate of distribution and changing images through image reconstruction [5,7]. The resistivity of different tissues or the same tissue under different physiological and pathological conditions is different. The periodic changes of air and blood flow in the lungs together determine the changes in the electrical impedance of the chest. The advantage of EIT lies in the use of the rich physiological and pathological information carried by bio-impedance to obtain damage-free functional imaging and medical image monitoring. Chest X-rays and CT are widely used in the diagnosis of lung infections. But they cannot monitor lung lesions in real time, cannot measure lung ventilation status, and most importantly cannot be used in patients with severe pneumonia and respiratory failure who cannot easily access these examination, so their application are limited. Lung EIT, as a brand new medical imaging technology, which is different from traditional imaging technology and conventional lung function monitoring, has outstanding features such as injury-free, portable, low-cost, functional imaging, and image monitoring. EIT can real-time dynamic monitor the pulmonary ventilation and blood flow distribution, evaluate the effectiveness of clinical treatment methods such as mechanical ventilation by measuring electrical resistance under different ventilation conditions [5,7].

At present, the commonly used methods to monitor the effectiveness of lung recruitment strategy and the suitability of PEEP include arterial blood gas analysis, peripheral oxygen saturation, pulmonary and chest maximum compliance, static pressure volume curve and so on, but these methods cannot meet the requirements of dynamic monitoring of regional lung perfusion. A number of studies have showed that in mechanical ventilation patients with ARDS, EIT has been used to accurately measure the whole lung and regional lung ventilation distribution, to show the influence of PEEP changes on alveolar expansion and collapse by gradually increasing and decreasing PEEP level, and in the end to obtain the optimal value of PEEP, which improves the ratio of ventilation and blood flow (V/Q), and plays an important role in individulized lung protective ventilation strategy [5,7].

Pulmonary Ultrasound

Bedside lung ultrasound can be used for the diagnosis and differential diagnosis of various lung diseases by using a low-frequency convex probe of 3 to 5 MHz and a high-frequency linear probe of 8 to 12 MHz [8]. Normal lung ultrasound images include bat sign, lung sliding sign, and A-line. Pathological images mainly include abnormal pleural lines, pulmonary consolidation, interstitial syndrome, fragmentation sign, dynamic bronchial signs, pleural effusion and so on [9].

With the development of ultrasound technology, pulmonary ultrasound is gradually found to be of great value in diagnosing acute respiratory distress syndrome, pulmonary edema, pneumonia, pneumothorax, pulmonary embolism and so on [6,10,11]. It can be used to monitor the changes in lung ventilation, to guide clinical fluid management and evaluate prognosis, especially in patients with severe diseases. Since chest X-rays and CT examinations are unsuitable for rapid diagnosis of critical diseases due to the shortages of inconvenient carrying, radiation exposition, poor reproducibility, position limitations, and high costs, and compared with chest CT, bedside lung ultrasound has advantages of non-invasive, dynamic and repeatable observation of patients with lung disease.

The Advantage of Drainage Position Ventilation

At present, prone position mechanical ventilation is widely used in patients infected with new coronavirus, which may be helpful to the drainage of pulmonary inflammation and the reduction of pulmonary shunt volume [2]. So far, no effective antiviral drugs have been found in defeating new coronavirus, so drainage becomes an important treatment for pulmonary inflammatory lesions. Because of inflammatory lesions in different parts of the lung, prone position ventilation is not suitable for all patients, and it may be more beneficial to adopt drainage position mechanical ventilation combined with tracheal suction with the infected side of lung lesions upper side. For example, the lateral and head-down position mechanical ventilation with the inflammatory lung upper side according to the characteristics of pulmonary imaging of some patients infected with new coronavirus. The lateral prone position can be tried to improve the inflammatory side lung ventilation, reduce pulmonary shunt, increase blood reflux and improve hemodynamics. However, it is important to avoid excessive head down, which increases abdominal pressure on the chest cavity.

In summary, based on the autopsy, clinical manifestations, lung pathological characteristics and present treatment of the patients infected with the new coronavirus, this article describes some possible improvement measures for the mechanical ventilation strategy. We believe that postural drainage ventilation, real-time bedside pulmonary ultrasound and chest electrical impedance monitoring will improve the clinical treatment of critical patients based on the previous guidelines for ARDS treatment. These methods provide some new ideas for clinical treatment and need to be used and verified in future clinical work.

References

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