Monthly Archives: October 2019

Preparing Nursing Students to Meet Public Expectations While Preserving Professional Values: Mind Genomics Cartography of The Public’s Voice

DOI: 10.31038/AWHC.2019262

Abstract

We present a new approach to designing a school and its curriculum. The approach is based upon experimental design of ideas, in which the researcher combines different features of a curriculum, creates a set of vignettes or test combinations, obtains responses from prospective students and others, and then deconstructs the response into the contribution of each individual element or idea. The approach is efficient, cannot be ‘gamed,’ and enables the designer to identify new to the world mind-sets of prospects. These mind-sets entail different ideas about what members of each mindset want. We finish by showing a personal viewpoint identifier, which enables the designer to assign a new person, student, faculty, or donor to one of the mind-sets uncovered. This approach can become a tool for designing a health-professional curriculum.

Introduction

With the increasing costs of medicine in these early decades of the 21st century, the profession of nursing is undergoing a renaissance. Nurses are becoming recognized as major players in the profession of health care [1, 2]. Nursing has advanced from care to a professional skill in various specialties growing towards a graduate profession status [3, 4]. As with any profession, there is a continuing need to monitor what the desire of customers. This study examines expectations of the public from nursing school. We present the general population with a variety of concepts or ‘vignettes’ about a nursing school, measure their reactions to these vignettes, and then uncover the most appealing concepts per mind-set.

The professional role of nurses is based on the socialization of a set of patterns of behavior. These patterns are embodied in the patient-nurse interactive relationship. The behavior requires skills, knowledge and behaviors based on values, attitudes, guided by the overarching goal of promoting a positive clinical outcome and patient well-being [5]. Nurses assimilate their professional identity through teaching and clinical practice, a combination which generates the ability to cope with the tension between the professional standardization and the nurse’s own individuality and proclivities [6]. Professional education in nursing functions as a disciplinary mechanism design to engender a professional ‘ideology’ and a professional identity as a medical profession stressing the biomedical model [5]. In contrast, the reality of nurses in clinical practice eventuates into what might well be described as shock as they witness traumatic events in the healthcare environment. The unexpected events which occur, often quite frequently, coupled with the individual styles of behavior displayed by senior professional nurses lead to anxiety and dissonance, responses often evident in the published literary discourse regarding the education in Nursing. Anxiety and dissonance are responses to the chasm separating the “theoretical-educational nursing learned in the classroom, the theory as opposed to the reality, the clinical practice experience at hospitals.

There is a looming gap between professional idealism and clinical- practice realism [7, 8]. Professional idealism highlights values of compassion, empathy, holism, cultural competency, and patient-centered care [9, 10]. Reality occasionally eventuates into other behaviors. The ability of nursing students to introject and then realize these values is inhibited by organization constraints and processes, burnout of nurses and staff shortages. All of the former have negative consequences, diminishing the opportunity to develop meaningful relationships with patients, and chipping away at both the satisfaction and sense of mission among nursing students [11]. After completing their education, nursing students were found divide into at least three groups; sustained idealists, compromised idealists and crushed idealists, respectively [12]. There are other effects [8]. views the professional socialization as leading to desensitization toward patients due to experiencing cynicism of senior nurses, and anxiety accompany their efforts to cope with and ameliorate the suffering patients in their care. To preserve themselves in a stressful, demanding at times, chaotic work environment, upon completing their education, nurses adapt emotional desensitization [5, 13]. The idealism of new entrants to Nursing gives way to disillusion after the nurses begin to face an onslaught of never-ending practical concerns [5]. Vulnerable and disoriented nurses, new to the nursing occupation, aspire to “fit in,” resulting in radical changes in understanding, attitudes and behavior towards patients.

Nurses Encounter Three Kinds of Dualism:

  1. The good nurse they introjected as themselves versus the bad nurse they encounter in hospitals.
  2. their genuineness based on their emotions versus the cynicism they experience as they witness nurses who only care about money
  3. An ambiguous identity of authority of the nurses who supervise them, and the lack of morality in the hospital setting.

The Nursing literature concludes that socialization into professional nursing is deeply problematic. Nurses who identify with their professional ideals throughout their education often end up losing professional values, and decline from their ideals to accepting the fact that they compromise, and deliver poor care [14, 15, 16]. The desire to articulate the impact of nursing practice propels professional preparation beyond the existence fuzzy fringes of medicine towards a unique contemporary identity [2].

This study represents an exploration of a method for understanding what the ‘public’ wants in a nursing school. The objective is to create a system to guide education, the system grounded in the feelings of the public towards general, operationally feasible topics and strategies that the nursing school can address. The success of the method (Mind Genomics) has been in understanding the mind of people for a variety of situations. With this success it may be possible for Mind Genomics to contribute to the world of nursing education.

The Background and Contribution of Mind Genomics to Aid Understanding

Mind Genomics is an emerging science, the focus of which is the experimenting science of the everyday. Research tells us a great deal about ‘what is’ but does not tell us how people make decisions about the quotidian, ordinary issues of their daily lives. We know that people have definite opinions about what they want and why they want it; polls and surveys provide us that information. We do not know however, their weighting schemes when they choose what to do. We know what people say, retrospectively, but we do not have a deep knowledge of the decision criteria for the events of the everyday. Rather than asking people to say what they would do Mind Genomics presents people with different combinations of features of a typical situation (here a nursing school) and instructs them to rate the entire combination. From the pattern of their choices for different combinations, Mind Genomics emerges with a set of weights, showing which option(s) or feature(s) in the combinations really ‘drives’ the decision. Through experiment, therefore, Mind Genomics reveals the ‘mind’ in a way that surveys and observations cannot. Mind Genomics shows causality, at least in terms of what the respondent says she or he would do when presented with the type of information one would encounter in a situation. The origin of Mind Genomics comes from statistics experimental design [17] from mathematical psychology conjoint measurement [18] from marketing applications of conjoint measurement [19, 20] and from psychophysical thinking [21]. The foundations have been explicated in several seminal papers, including how the science was founded [22] the major applications [23] and some of the specific mathematics which make the approach and the analyses possible, and actually quite straightforward [24]. The original approaches were patented. Mind-Genomics has been applied to health in several recent studies [25–30].

The Mind Genomics Method

Mind Genomics begins with the Socratic method of question and answer.

Step 1 defines the topic, which is a ‘New Nursing Services Company’

This first step seems so obvious, but it is important to the Mind Genomics experiment that each question and its associated set of answers be relevant to the topic.

Step 2 asks four questions which ‘tell a story’

As simple as that sounds, it requires a great deal of thinking. We are accustomed to facts, not to systematic thinking about a problem. Figure 1 show a screen shot where the researcher is instructed to write out the four questions.

MIND GENOMICS-029_AWHC_F1

Figure 1. Screen shot showing the screen in the program where the researcher must ask the four questions.

Step 3 Instructs the Researcher to Give Four Different Answers to Each Question

It is the answers which will be presented to the respondent. The answers may either be simple words when the topic is clear and concrete, easy to visualize (here a nursing school), or may be simple phrases when the concept is not clear and concrete, not easy to visualize (e.g., the daily routine of the nursing student in the school.). Figure 2 shows a screen shot of the page where the researcher must provide answers to question #3 (How does it train the students?)

MIND GENOMICS-029_AWHC_F2

Figure 2. Screen shot showing the page where the researcher provides the four answers to question #3.

The final array of questions and answers appears in Table 1. It will be the answers, in combination, which comprise the test stimuli. The respondent never sees the actual questions motivating the answers. The questions are simply there to create the structure and to motivate the answers.

Table 1. The four questions and the four answers to each question.

 

Question A: What is the major objective of the organization?

A1

to teach

A2

to prepare

A3

improve local health

A4

serves as test location for new medical development

 

Question B: Where do you see growth coming from?

B1

supported and promoted by local hospitals

B2

allies closely with local community

B3

allies closely with government

B4

supported by UN

 

Question C: how does it train the students?

C1

provides local training in homes

C2

fly students around the world for training

C3

places students in local doctor’s offices

C4

brings nurses to local community centers

 

Question D: how do you raise funds for this?

D1

supported by government contributions

D2

supported by citizens paying low fee for service

D3

allow researchers to work and help support

D4

supported by public appeals

Experimental Design and Test Vignettes

The foundation of Mind Genomics is the use of experimental design to combine disparate ideas, present these ideas to the respondent, obtain ratings, and relate the presence/absence of the ideas (also called answers or elements) to the ratings. At first glance one might confuse Mind Genomics with a survey, because a survey instructs the respondent to answer questions. The difference is that Mind Genomics is an experiment. The stimuli are pre-defined, systematic and structured mixtures of messages. The rating is assigned by the respondent based upon the impression of the entire message. The respondent assigns a single rating, mentally weighting the different elements in the vignette. It is the mental weights which are of interest to the researcher, for they reveal what are important features, and what are unimportant features.

The ratings are analyzed by the well-accepted method of OLS (ordinary least-squares, curve fitting) regression. The OLS reveals causality, how the individual elements in the vignettes or combinations ‘drive’ the ratings. It is also worth noting that the same element or answer appears many different times, continually combined with a variety of answers from other questions. This strategy produces, in the words of psychologist William James of Harvard University in the end of the 19th Century a ‘blooming, buzzing confusion,’ a phrase taken from his description of the world of the baby, but apt for the way the combinations of messages must appear to the respondent. The continual mixing and remixing of messages make it virtually impossible for the respondent to ‘game’ the system. The Mind Genomics experiment reveals quite quickly how the respondent really feels about the combinations, rather than providing answers which might be appropriate and ‘politically correct.’

The experimental design used in this study comprises 24 different vignettes or combinations. Each vignette comprises at most one answer from each question, but in many vignettes one or two questions do not contribute an answer, so that vignette is said to be ‘incomplete.’ The rationale for this strategy is a statistical consideration, namely, to allow the subsequent regression analysis (see below) to provide absolute values for the coefficients.

Every respondent evaluated a unique set of 24 vignettes. Each set was constructed so that the combinations of elements differed, even though the basic structure of the experimental design was maintained. This approach, so-called ‘permutation of the design’[24] allows the Mind Genomics experiment to measure responses to a great number of the possible combinations, albeit with each combination appearing only once or twice across all the respondents. This permutation strategy can be likened to the MRI, which takes ‘pictures’ of underlying tissue from many angles, and combines them by computer to create a three-dimensional image. Each picture in the MRI may be ‘noisy’ just like the data underlying each vignette is ‘noisy.’ Nonetheless, it is the pattern of pictures, and the pattern of responses which emerges clearly in both cases, even though the individual observations are noisy. In contrast, conventional research, specifically conjoint analysis, suppresses the noise through replication, but only covers a limited number of combinations.

A parenthetical note about worldviews in science. Much of science operates on the world view of suppressing noise by replicating the study many times, in order to get a better estimate of the ‘central tendency, i.e., the mean. Inferential statistics tells us that the precision of the measurement increase with the square root of the number of observations. Following this dictum, most researchers opt to increase the number of respondents testing the same stimuli in an experiment or responding to the same questionnaire in a survey. Mind Genomics differs because it looks at the patterns generated by many different combinations, not the response to one combination measured with great precision.

Executing the Mind Genomics study

The actual study takes approximately 3–5 minutes in the field, once the respondent is invited. The effort to run studies is simplified by a service, Luc.id Inc., which hosts on-line surveys, and is linked to the Mind Genomics program as an option. One can also send the study link to other respondents, but the approach of using a panel makes the recruitment more objective, and the panelists more cooperative, since they already do other studies.

The 40 respondents who participated were invited by Luc.id through a link. Most respondents participated within the first hour of launching the study, and all participated within the first two hours, allowing the Mind Genomics experiment to become one step in an easily iterated process. One need not know the answer. One can iterate quickly. The answer, if there is one, appears within the first 1–3 iterations, and certain by the fifth iteration. The key phase is ‘if there is one,’ i.e., if there is a real answer.

The respondent was first presented with an introduction, which simply said: Read our new medical vision. Do you think we will be successful? The respondent then read single vignettes, combinations of elements as shown in Figure 3. The respondent rated the vignette on the 9-point scale. The computer acquired the response, measured the response time between the appearance of the vignette and the rating, and then automatically sequenced to the next vignette. The typical response times are approximately 5 seconds (see Table 2). As just noted above, entire sequence takes 3–5 minutes at most, an experience which is not onerous to those accustomed to surveys lasting 30 minutes but may irritate the purist who wants the respondent to have an experience which is as much fun as a game.

Table 2: Average ratings for total panel, self-defined subgroups, and three emergent mind-sets.

 

9-Point Rating

Binary: Positive-Outcome (7–9)100

Binary: Negative-Outcome (1–3) 100

Response Time

Total

5.4

36

21

2.6

Female

5.6

39

20

2.9

Male

5.2

32

22

2.2

Age 15–24

5.3

33

28

1.6

Age 25–40

5.5

39

17

2.0

Age 41+

5.5

36

19

4.0

Mind-Set 3E

5.6

42

23

2.4

Mind-Set 3D

5.3

31

21

2.7

Mind-Set 3C

5.5

37

18

2.8

MIND GENOMICS-029_AWHC_F3

Figure 3. Example of a test vignette, configured for the smart phone.

Transforming the Data

The initial results come in the form of 9-point Likert scales, easy to create and administer, but very difficult to interpret. Indeed, it is not surprising that the standard practice of consumer research is to transform the 9-point rating scale (or other type of rating scale) to a binary scale, more easily understood by managers. Managers who are tasked with the job of ‘doing something with the data’ often ask simple questions like ‘what does an 9 or an 8 mean on the 9-point scale?’ or ‘should I be worried if I got a 5 or lower?’ and so forth.

One ongoing solution to the problem of interpreting the scale simply divides the scale into two parts, often of unequal size. We follow the conventions of consumer research, creating two new scales:

Positive-Outcome

Ratings 1–6 are converted to 0 to denote that these are ‘not positive’ outcomes. They are not ‘Negative-Outcomes,’ but rather just not positive ones. Ratings of 7–9 are converted to 100 to denote that these are ‘positive’ outcomes. The choice of the cut-point is arbitrary, and can be made more stringent by including only ratings of 8 or 9, or even only 9, and less stringent by including ratings such as 6–9, rather than 7–9 as ‘positive.

Negative-Outcome

Ratings of 1–3 are converted to 100 to denote that these are ‘negative’ outcomes. Ratings of 4–9 are converted to 0 to denote that these are not ‘negative’ outcomes. They are not Positive-Outcomes, necessarily, but certainly not Negative-Outcomes. The arbitrary choice holds once again, with possible cut-points being 1–2 as 100, or even only 1 and 100.

A very small random number (<10–5) is added to each rating in order to ensure that there is some variability within an individual’s ratings, were that individual to limit the ratings to regions where all of their ratings for the vignette would be coded either 0 or 100. Such a situation would cause the individual-level regression modeling to fail. The small random number does not affect the regression model, while ensuring the necessary variation in the dependent variable in order for the regression model to run.

Initial Results – Average Ratings Across Groups

A logical first analysis looks at averages for total and across groups, to determine whether there are any dramatic group to group difference. Table 2 shows the averages for the total panel and for key subgroups as well as three emergent mind-sets to be explicated later. The ratings suggest only a modest level of belief in the success of the enterprise, on average. It will have to be the individual elements which propel success, and not simply the basic idea.

The response time (RT) measured in seconds shows some interesting differences among groups. Females take longer to read the vignettes than do males, on average (2.9 seconds vs 2.2 seconds.) Older respondents take longer to read the vignettes than do younger respondents (4.0 seconds for those age 41+ versus a very fast 1.6 seconds for respondents ages 15–24.)

Despite these differences, we still do not know the relation between the individual elements in the vignettes and the Positive-Outcome, the Negative-Outcome, or the response time, respectively. The analysis of the data by deconstructing the patterns laid out through the experimental design will allow us a far better understanding of the mind of the respondent.

Modeling

The experimental design ensures that the 16 elements or answers are statistically independent of each other. By pooling together all data we generate a database from which we trace ‘causality,’ or the relation between the elements that we put into the vignettes and the responses that individuals make.

The models for the Positive and the Negative-Outcomes are estimated with an additive constant and appear in (Table 3). The additive constant is modest for Positive-Outcome (38) and quite low for Negative-Outcome, respectively (16). We conclude that the respondents feel that it will have to be the element themselves which must do a lot of the work to convince the respondent that there will be a good outcome.

Table 3. Parameters of the equations relating the presence/absence of the 16 elements to Positive-Outcomes (ratings 7–9 converted to 100), Negative-Outcome (rating 1–3 converted to 100), and response time (in seconds.)

 

 

Positive-Outcome

Negative-Outcome

Response Time

 

Additive constant

38

16

NA

A1

to teach

3

1

0.3

A2

to prepare

2

-1

0.2

C4

brings nurses to local community centers

2

0

0.9

B2

allies closely with local community

1

5

0.8

C1

provides local training in homes

1

-1

1.2

C3

places students in local doctor’s’ offices

1

-3

0.9

A3

improve local health

0

0

0.2

B1

supported and promoted by local hospitals

0

1

0.6

B4

supported by UN

0

2

0.5

D1

supported by government contributions

0

4

0.7

B3

allies closely with government

-1

5

0.9

D2

supported by citizens paying low fee for service

-1

0

0.8

A4

serves as test location for new medical development

-2

-2

0.7

D4

supported by public appeals

-2

3

1.3

D3

allow researchers to work and help support

-4

4

1.1

C2

fly students around the world for training

-7

1

1.2

When we look at the 16 individual coefficients, we find that there are no elements which strongly drive the Positive-Outcome. For the Negative-Outcome, only two elements really drive additional negativity:

allies closely with community

allies closely with government.

When we look at response time, we do not use an additive constant. The response time does not measure positive or negative, but rather engagement, i.e., time to read and digest the information. The longest response time was 1.3 seconds, supported by public appeals.

Interactions Between ‘Objective Of The Organization’ And Other Elements – Scenario Analysis

The permutation scheme created a large number of different vignettes, with only a few vignettes duplicated. A benefit of this strategy is the ability to uncover interactions between pairs of elements and show how some combinations generate coefficients far higher or far lower than would be expected from looking simply at the performance of the single elements.

Our focus is on how way the different ‘goals of the school’ (answers to question A) ‘interact’ with the remaining elements from the other questions. The process, known as ‘scenario analysis,’ follows these steps:

  1. Sort the data set into the five strata, i.e., sets of vignettes. These five strata are where there is no answer from Question A (goal of the organization), and then four remaining strata where the answer appearing in the vignette is A1, A2, A3, and A4, respectively.
  2. Run a separate regression analysis on each stratum.
  3. The independent variables for each of the five new regression analyses are now the 12 remaining elements or answers, (B1-B4; C1-C4; D1-D4). The variables A1-A4 do not appear in the regression model because they are constant for each regression analysis, and thus are not predictors.
  4. The actual analysis is straightforward and shown in Table 4 when the dependent variable is ‘Positive-Outcome,’ Table 5 when the dependent variable is ‘Negative-Outcome,’ and Table 6 when the dependent variable is Response Time. The very strong performing elements are shown by shaded cells, with coefficient values in bold type.
  5. Positive-Outcome: Table 4 shows pairs of elements where the stated goal or objective for the school either strongly increases the coefficient of the element (synergism) or strongly suppresses the coefficient of the element (suppression).
  6. An example of synergism is the combination of ‘provides local training in homes,’ element C1. In the absence of any objective stated, it generates a coefficient of +7. When combined with the objective ‘to teach’ the coefficient for ‘provides local training in homes’ jumps to +15.

Table 4: Scenario analysis – How the different objectives of the nursing school synergize with other elements to drive the prediction that the outcome will be positive.  Only combinations with strong synergism or suppression are shown.

 

Positive-Outcome

None

to teach

to prepare

improve local health

serves as test location for new medical development

 

 

A0

A1

A2

A3

A4

 

 Additive constant

18

49

28

38

53

C3

places students in local doctor’s offices

23

-13

20

-11

-8

D4

supported by public appeals

14

-12

-6

7

-8

C1

provides local training in homes

7

15

7

8

-16

B2

allies closely with local community

-3

-3

1

9

-3

D2

supported by citizens paying low fee for service

-5

-14

12

9

-6

Table 5: Subgroup models relating the presence/absence of elements to Positive-Outcome.

 

 

Total

Male

Female

Age

15–24

Age

 25–40

Age

41+

 

Additive constant – Positive Outcome

38

27

48

45

31

43

A1

to teach

3

-2

7

-3

10

-2

A2

to prepare

2

-2

5

-12

13

-2

C4

brings nurses to local community centers

2

10

-5

1

5

-2

C3

places students in local doctor’s offices

1

3

-1

-7

-1

8

B2

allies closely with local community

1

13

-8

11

-5

0

A3

improve local health

0

-6

4

-6

8

-6

 

 Additive constant – Negative Outcome

 

 

 

 

 

 

 

 

16

26

9

27

9

18 

B1

supported and promoted by local hospitals

1

-5

6

-4

8

B2

allies closely with local community

5

-2

10

0

12

B3

allies closely with government

5

-5

13

1

7

D3

allow researchers to work and help support

4

-1

8

1

4

 

 

 

 

 

 

 

 

 

 Response Time

 

 

 

 

 

 

D4

supported by public appeals

1.3

1.2

1.3

1.1

1.1

1.8 

C1

provides local training in homes

1.2

0.9

1.5

0.4

0.8

 2.3

C2

fly students around the world for training

1.2

1.0

1.5

0.9

0.9

1.9 

D3

allow researchers to work and help support

1.1

0.5

1.5

0.5

1.0

 1.5

C3

places students in local doctor’s offices

0.9

0.8

1.1

0.9

0.3

1.6 

C4

brings nurses to local community centers

0.9

0.9

1.0

0.9

0.3

1.6 

B3

allies closely with government

0.9

0.9

0.8

0.7

0.4

 1.4

D2

supported by citizens paying low fee for service

0.8

0.2

1.2

0.4

0.4

1.5 

Key Subgroups

The ability to create models for each individual means that it is easy to create models for pre-defined subgroups. Tables 4–6 show parameters of the models for key subgroups, when the respondents fall into the pre-defined subgroups generated from the self-profiling classification. For this analysis we look at the gender and age, respectively. In the interest of space, we show only those elements which score well in at least one subgroup.

Table 6: The three mind-sets and their reaction to elements in terms of ratings of ‘Positive-Outcome. 

 

Positive-Outcome

MS1

MS2

MS3

 

Additive constant

47

14

66

 

Mind-Set 1:  Focuses on training venue

 

 

 

C3

places students in local doctor’s offices

10

4

-16

C1

provides local training in homes

9

2

-10

A2

to prepare

8

1

-5

 

Mind-Set 2: Focus on practicality of support

 

 

 

B4

supported by UN

-2

17

-21

D1

supported by government contributions

-18

15

-6

B1

supported and promoted by local hospitals

-8

14

-12

D3

allow researchers to work and help support

-17

14

-14

B2

allies closely with local community

-7

13

-8

D4

supported by public appeals

-21

8

3

 

Mind-set 3 – Basically positive but can be ‘spooked’

 

 

 

 

No element drives a strong positive response beyond the additive constant (baseline)

 

 

 

 

Not a strong driver of any mind-set

 

 

 

A4

serves as test location for new medical development

4

-12

5

D2

supported by citizens paying low fee for service

-19

7

4

A1

to teach

7

1

-2

C4

brings nurses to local community centers

6

0

-2

A3

improve local health

5

-3

-2

C2

fly students around the world for training

-7

-7

-14

B3

allies closely with government

2

6

-16

Table 5 (top panel) shows the parameters of the models created for the subgroup when the dependent variable was chosen to be Positive-Outcome. The additive constant provides us with a with a baseline of expected Positive-Outcome in the absence of elements. For the total panel the additive constant is 38, but much higher for females (constant = 48), for younger respondents (age 15–24, constant = 45) and for the oldest respondents (age 41+, constant = 41+). If we were to hazard a rationale for the results it would be that females are basically more interested in the nursing school, as are those contemplating but not yet ready (age 15–24) and those who have made a career decision (age 41+.) Males are less interested, confirming the literature report that there is a dearth of males in professional nursing.

Table 5 (Middle panel) shows the parameters of the models for the subgroups when the dependent variable was chosen to be Negative-Outcome. The additive constants are all low. The highest additive constants are from males (constant = 26) and from age 15–24 (additive constant = 27.) Across the subgroups the key elements driving a predicted Negative-Outcome tends to be ‘allies closely with government,’ and ‘allies with the local community.”

Table 5 (bottom panel) shows the coefficients for the response time model by key subgroups. the longest response times are shaded. The data suggest that the oldest respondents take the longest to process the information. This tends to be a general pattern. It is not clear whether this longer time is because the older respondents take longer to read, longer to comprehend, or longer to respond, or any combination thereof.

Mind Sets

People can be divided by who they ARE, by what they DO, or by their BELIEFS. These ways of dividing people put people into complementary groups with the hope that people in the different groups will think ‘similarly’ about a specific topic. Once groups of people are discovered who ‘think alike,’ they can be efficiently targeted with messages engineered to appeal to them. Conventional research easily creates these clusters of individuals, these segments, based on situational data, behavioral data, or even responses to general questionnaires about a topic. The segments which emerge from these conventional methods are coherent, but only coherent with respect to the measures from which the clusters or segments were derived. People in the same behavioral segment behave similarly on the measures used. People in the same attitudinal or so-called psychographic segment, respond similarly to the general questions [31].

There is a fundamental flaw in most of the segmentation scheme in use today, namely the failure of the ‘top down segmentation’ to be specific and prescriptive at the level of action. The problem of top-down segmentation, dividing people on the basis of general patterns, is the problem of granularity, or more properly the inability of the general segmentation to deal with the granular application, the specific need. When we assume that people in attitudinal or psychographics respond ‘similarly,’ we are dealing with general responses. They may respond quite differently when the topic is far more specific, more granular, and far less general. With the data we have here, a two people might be in the same general segment for education yet respond quite differently when we deal with granular topic of nursing education.

Mind Genomics works at the level of the granular, where everyday life is lived. Rather than looking for these large segments, Mind Genomics operates at the level of specifics, granularity, at the level of the actual questions and answer for the topic. Mind Genomics works from the bottom up, in the manner of a pointillist artist, focusing on the segments which can be uncovered from the granular, individual-level data of a specific project.

The process to discover these Mind-Sets in the population is again quite straightforward, driven by a combination of statistical methods which are ‘objective,’ and interpretation, which is ‘subjective’. The method creates an individual-level model for each respondent, and clusters the models using cluster analysis [32] The results comprise a small number of groups, the so-called clusters, with the property that the patterns of coefficients within a cluster are all similar, whereas the pattern of averages of the coefficients differs dramatically from cluster to cluster. In simple terms, a cluster represents a group of like-minded individuals, based upon the pattern of their coefficients. The individuals are like-minded only with respect to the top of the nursing school. That is the clustering is based upon granular thinking of a specific topic.

The subjectivity of clustering comes when the researcher must decide how many clusters to select, and what to name the clusters for future work. The decision is based upon searching for the smallest number of clusters (parsimony), but with each cluster ‘telling a story’ based upon the pattern of its 16 coefficients (interpretability). These clusters become Mind-Sets in the terminology of Mind Genomics, namely groups which ‘think alike’ in the granular topic of this ‘nursing school.’

The clustering was based on the pattern of coefficients for Positive-Outcome. Once the clusters or mind-sets are established, we can look at the elements which drive Positive-Outcome, as well as Negative-Outcome and Response Time. Tables 6–8 show these three mind-sets, and the elements which drive the three dependent variables, respectively.

Table 7: The three mind-sets and their reaction to elements in terms of ratings of ‘Negative-Outcome.’ The table shows only the elements which drive a strong estimate of ‘Negative-Outcome’ for at least one of the three mind-sets.

 

Negative-Outcome

MS1

MS2

MS3

 

Additive constant

10

22

15

 

Mind-Set 1: Focuses on training venue

 

 

 

D3

allow researchers to work and help support

14

-4

4

 

Mind-Set 2: Focus on practicality of support

 

 

 

 

No element drives a strong negative response beyond the additive constant (baseline)

 

 

 

 

Mind-set 3 – Basically positive but can be ‘spooked’

 

 

 

B3

allies closely with government

7

-3

15

B4

supported by UN

2

-4

9

B1

supported and promoted by local hospitals

3

-6

8

Table 8: The three mind-sets and their reaction to elements in terms of Response Time. The table shows only those elements which generate a long response time (>1.4 seconds) for at least one mind-set.

 

Response time

MS1

MS2

MS3

 

Mind-Set 1: Focuses on training venue

 

 

 

D3

allow researchers to work and help support

1.5

0.4

1.6

C2

fly students around the world for training

1.4

1.5

0.8

 

Mind-Set 2: Focuses on practicality of support

 

 

 

C1

provides local training in homes

1.2

1.5

1.0

D4

supported by public appeals

1.2

1.3

1.4

C4

brings nurses to local community centers

0.8

1.3

0.7

 

Mind-set 3 – Basically positive but can be ‘spooked’

 

 

 

 

allow researchers to work and help support

1.5

0.4

1.6

 

supported by public appeals

1.2

1.3

1.4

Finding Mind-Sets In the Population

Mind Genomics usually uncovers the different minds in the population. The mind-sets emerge clearly because the input material underlaying the mind-sets are phrases which are ‘cognitively meaningful and rich.’ What does not emerge so quickly is a way to discover these mind-sets in the population. The mind-sets do not distribute by the conventional ways of dividing people, as Table 9 shows, for the distribution of mind-sets by gender and by age, respectively. Even psychographic divisions of people, such as their interest in education and so forth, often do not co-vary with the mind-sets. The mind-sets exist, but it is difficult to assign a new person to the proper mind-set unless the person participates in the research.

Table 9: Distribution of mind-sets by gender and age.

 

Total

Mind-Set 1: Focuses on training venue

Mind-Set 2: Focuses on practicality of support

Mind-set 3: Basically positive, but can be ‘spooked’

Total

40

12

16

12

Male

18

4

10

4

Female

22

8

6

8

Age 15–24

10

3

3

4

Age 25–34

16

7

5

4

Age 41+

14

2

8

4

Recently, author Gere has developed a set of algorithms using Monte Carlo simulations, in order to create a set ‘questions’ based on the elements. The pattern of answers to these questions allow the new person to be assigned to the most likely mind-set. The method is called the PVI, the personal viewpoint identifier. It is based on a Monte Carlo simulation, in which the likely pattern of responses to six questions created from six of the elements co-varies with membership in each of the three mind-sets. Figure 4 shows the six questions and the two answers to each question. There are 64 patterns based upon six questions and two answers. Each pattern is most likely with one of the two mind-sets. When a respondent generates a pattern by answering the question the most likely mind-set associated with that pattern becomes the mind-set to which the new person is assigned.

MIND GENOMICS-029_AWHC_F4

Figure 4. The six question PVI (Personal Viewpoint Identifier) for this study.

Discussion and Conclusions

The traditional topics of curriculum, approaches, and values have been left to the professionals in the field. The role of the ordinary person has generally been to get support for nursing schools (and indeed other types of schools), to fund schools and their programs, and then to quietly hand over the reins of control to professionals. The professional literature is replete with the points of view of professionals about what the curriculum should be, how the student should be taught, and trained to be ready to deliver nursing-care. The general public is often excluded from these discussions. Often, however, it is the general public, or at least those who RECEIVE nursing-care who are the ones able to add most to what is missing. Those involved in teaching, in the world of purveying knowledge, may not realize the changes occurring in their own field and the public expectations from Nursing. Up to now, Nursing has been considered a ‘weak signal,’ rather than the emerging need it really is, to increase patient trust, patient-adherence, patient experiences and patient resilience [33, 34].

Across mind-set segments, the public expects Nursing programs to better prepare nurses by enhancing their professionalism through exposure to more medical settings, as they encounter their clinical practice. For example, the data from the public, non-nursing world, suggests that nursing students should receive clinical practice at doctors’ offices, at local community health centers and at patients’ homes, each beyond the traditional hospital settings. The public also expects local community hospitals to support training of nursing students. Furthermore, the public expects nursing programs to allow researchers to support training and professionalism.  Future studies may test the effect of interventions to adopt the above recommendations on the tensions nursing students experience as they complete their professional education.

Postscript Mind Genomics Research as the Public’s Input and Guide for Educational Institutions

There is an emerging recognition that the fast-changing world of today requires different modalities for learning. Emblemizing this change in the world of textbooks, as an example. The era of heavy, expensive textbooks has gone, or is in the process of departing. These traditional textbooks enjoying two, three, four or more editions, provided a standardized body of knowledge updated regularly. The demands for knowledge are changing, forcing many schools to create their own unique ‘textbooks’ by cobbling together papers available on the Internet, and in the university’s own private collection. The need for creative thinking to develop professional schools for ‘today’ is beginning to be recognized. When we look at the data presented here, the requirements for a nursing school, not from the point of view of the teaching profession but from the point of view of the public, we see these results in a different light.

Acknowledgment

Attila Gere wishes to acknowledge the Premier Post-Doctoral Research Program of the Hungarian Academy of Sciences.

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Social Media Controversy Affecting the Introduction of HPV Vaccination for Young Girls in Cameroon

DOI: 10.31038/AWHC.2019255

Background

Cervical cancer is the second most frequent type of cancer in Cameroon [1]. More than 7.1 million Cameroonian women aged 15 and above are at risk of this disease [2]. In the past ten years, various pilot projects have demonstrated the efficacy and acceptability of Gardasil TM, the vaccine against Human Papillomavirus (HPV) [3,4]. Based on these successful demonstration phases, with the support of the Global Alliance for Vaccines and Immunization (GAVI), the HPV vaccine is finally being implemented countrywide by the Ministry of Public Health. The main objective of the vaccine roll-out will be to immunize at least 80% of 9-year-old girls, and thus reduce the morbidity and mortality due to cervical cancer and other HPV-related infections in Cameroon.

Controversy: social media campaign against HPV

In Cameroon, as in other countries, social media has become a powerful instrument for public communication, allowing users to initiate, modify, share and discuss personal experiences, information, opinions, images, video clips and just about everything online [5]. Although this novel communication channel can be an invaluable tool for networking and visibility on the global arena, it also carries the great potential of heavily negative influence on health campaigns. Studies have shown that false and unverified information is propagated on popular social media platforms such as Facebook, WhatsApp, Twitter, Instagram, Snapchat, with far-reaching and long-lasting deleterious impact on the health of our communities [6].

The launching of the HPV vaccine in Cameroon on 29 October 2014 did not raise as much controversy as the recent announcement by the Minister of Public Health on the decision to finally implement the use of the vaccine to the general population in the coming months. The recent fiery debate emanates from various anti-HPV vaccine campaigns carried out mainly on WhatsApp and Facebook that highlight adverse effects such as sterility that allegedly occurred in Japan and other countries [7].

Although Cameroonian parents are generally more inclined towards vaccinating their children [8], contrary social media campaigns are likely to negatively affect the government’s efforts to implement the use of this HPV vaccine for young girls. Studies have shown that parents and teenagers who have been exposed to anti-HPV vaccine messages on social media are more likely to remember the harmful effects than the health benefits reported [9]. More so, parents who listen to the negative stories are more likely to delay or even refuse the vaccination of their children [9]. Many Cameroonians have experienced the destructive effect of public scrutiny through social media in the face of national events and tragedies. In these instances, the narratives received by the public were almost completely controlled by social media, making it nearly impossible for the government to control the situations and protect its citizens. In the case of the HPV vaccine, social media videos, images and text messages are feeding the community with unsubstantiated myths and misinformation. This anti-campaign undermines the government’s efforts, in concertation with international health communities, to diligently work towards curbing the progress of cervical cancer in the country. On 13 September 2019, a press conference was held by experts from the Ministry of Public Health and the Association of Science Journalists and Communicators for Health Promotion in Cameroon in order to dispel the ambiguities around the controversies on the large-scale implementation of the HPV vaccine in the country.

Cultural and religious beliefs

Culture is known to weigh heavily on health behavior. It affects the perception of health, illness, beliefs about the causes of illness, approaches to health promotion, vaccination, experiences and expressions of disease, places where and people to whom patients go for help, and the type of care that patients prefer [10]. The videos widely spread through social media may promote cultural prejudices that suggest that vaccination is intended to sterilize children [8]. One of these videos cited some studies conducted in Japan and in other countries, alleging that sterility was among the adverse events highlighted in Japan [7]. It is thus not surprising that the planned implementation of HPV vaccination for young girls in Cameroon runs the risk of being rejected if effective community sensitization on the necessity of the vaccine is not carried out.

Conclusion and Recommendation

Vaccination against the Human Papillomavirus is an effective approach for the primary prevention and reduction of the burden of cervical cancer among young girls. The Cameroonian scientific community thus has the impetus to counteract the greatly negative influence of social media on the subject by setting the records straight through presenting empirical and scientific evidence that will leave no grounds for these myths and misinformation.

References

  1. Cameroon Human Papillomavirus and Related Cancers, Fact Sheet 2018 (2019) https://hpvcentre.net/statistics/reports/CMR_FS.pdf. Accessed on 03 October 2019.
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Midlife Women and the Opioid Crisis: Commentary on the Role of Integrative Health

DOI: 10.31038/AWHC.2019261

 

Midlife women are experiencing increased rates of opioid use disorder (OUD) [1] and fatal overdose in the United States (US) [2]. Rates of opioid-related mortality have increased more rapidly among women than men [3], and when stratified by age, the increase in opioid-related mortality is particularly notable among middle-aged women [4]. Unique risk factors for opioid misuse and opioid use disorder (OUD) in women have been identified, including higher pain levels and increased opioid withdrawal symptoms [5] among women with OUD and higher rates of psychological comorbidities [6,7]. In addition, midlife women with co-occurring chronic pain and menopausal symptoms experience increased rates of risky opioid use including long-term opioid use,  high-dose opioid use, and co-prescription of CNS-depressants and opioids [8]. Thus, addressing pain, menopausal symptoms, and psychological comorbidities may help reduce rates of OUD and ultimately prevent fatal overdose among midlife women.

Complementary therapies (e.g., acupuncture, massage, and mindfulness) and an integrative approach to care (e.g., relationship-based, patient-centered, strengths-based coaching) are ideally poised to treat OUD and associated comorbidities [9]. As women utilize healthcare in greater rates than men [10], including complementary therapies, it seems plausible that the integration of IH modalities may improve women’s outcomes. Of particular interest is the evidence supporting acupuncture as a modality that may decrease psychological distress and therefore reduce OUD and the potential for overdose in women [11]. This brief commentary will provide an overview of the topic of midlife women and OUD, describe the relevance of complementary therapies and a person-centered, relationship-based approach to treatment, and provide suggestions relevant to future policy initiatives and research.

Compared to men, women experience more pain-related disease, have an increased sensitivity to pain [12], are more likely to be prescribed opioids [13], are more likely to “telescope” from use to misuse and first admission to treatment [1], and are at greater risk than men for the misuse of prescription opioid medications and thus for the development of OUD. Sex and gender differences occur in opioid risk and risk mitigation: rates of heroin use have increased at a faster rate while rates of nonmedical prescription opioid use have declined at a slower rate among women compared to men [14]. Women have also seen a sharper increase in opioid-related mortality than men [3]. Between 1999 and 2010, mortality rates increased by 400% for women and 237% for men [3]. Among persons with OUD, women experience a greater risk of mortality compared to the general population (SMR 5.1 95% CI: 4.5, 5.7) than men (SMR 4.3 95% CI: 4.0, 4.6), with an 18% increased risk of death among women compared to men (RR 1.18, 95% CI 1.02–1.36) [2]. When stratified by age, the increase in opioid-related mortality is particularly notable among middle-aged women; between 1999 and 2017, fatal opioid overdose rates increased by 485% among women aged 30–64 years [4]. Thus, identifying novel ways to promote health and prevent OUD among midlife women is critical.

Psychological and emotional distress have been identified as risk factors for OUD among women but not among men [15]. Research indicates that OUD is associated with intimate partner violence victimization, particularly among women, and that women may be particularly susceptible to such violence when under the influence of opioids [16]. Further, opioid-dependent women are more likely than their male counterparts to report higher levels of psychiatric morbidity (e.g., depression and anxiety), to use opioids in response to interpersonal stress, and to use opioids because of affective distress [6,7,15]. Post traumatic stress disorder (PTSD) is more strongly associated with opioid misuse and OUD among women than men. Of note, the desire to avoid symptoms of PTSD has been associated with higher odds of opioid misuse and OUD among women [17].

An integrative approach to care is uniquely situated to address the complex biopsychosocial aspects that fuel the chronic pain syndrome as well as provides care that is situated in a feminist praxis that values mutuality, growth and nurturance, shared power, reciprocity, and individualism. Integrative healthcare (IH) “reaffirms the importance of the relationship between practitioner and patient, focuses on the whole person, is informed by evidence, and makes use of all appropriate therapeutic approaches, healthcare professionals and disciplines to achieve optimal health and healing.” [18] IH includes both conventional or biomedical interventions (provided by physicians, nurses, pharmacists and others) as well as complementary therapies provided by credentialed therapists (i.e., naturopaths, herbalists, acupuncture/Traditional Chinese Medicine practitioners, and massage therapists). In an integrative health approach, plans to address pain would be developed collaboratively and tailored to address whole person (body-mind-spirit) condition, available resources (financial, material, human), and their values/goals. Rather than treating all chronic pain as similar and all clients seeking care as identical, the integrative approach listens deeply to the woman’s story, ensures that the authentic full voice of the person is heard, considers all aspects of the pain experience (benefits as well as limitations) and seeking solutions that are informed by evidence but selected in a manner that affirms the woman’s life purpose and values [19]. Therefore, rather than prescribing an opioid to address chronic pain, an integrative approach might include a complex intervention that includes progressive meditative movement (yoga or tai chi), nutritional changes (anti-inflammatory diet), and acupuncture that would address the complex mind-body mechanism associated with chronic pain [20].

Complementary therapies such as acupuncture, massage therapy, and mindfulness have been found to reduce OUD and associated comorbidities. Acupuncture has been evaluated for the treatment of pain and reduction of OUD in several studies. A meta-analysis was conducted across nine studies and acupuncture and electro-acupuncture were each more beneficial than sham acupuncture for the reduction of cravings for opioids and for the improvement of insomnia and depression [21]. Preliminary evidence suggests that acupuncture may also be beneficial in decreasing opioid dose and increasing opioid abstinence when combined with medication-assisted treatment (MAT) [22]. Further, acupuncture may offer decreased odds of opioid initiation. Compared to visiting a primary care provider, individuals with new-onset low back pain who visit an acupuncturist first demonstrate 91% decreased odds of short-term opioid use (95%CI 0.07 to 0.12) and 95% decreased odds of long-term opioid use (0.07, 95%CI 0.01 to 0.48) [23]. Mindful Awareness Body-oriented Therapy (MABT) has also demonstrated preliminary feasibility and acceptability when provided as an adjunct to MAT for those with OUD and has demonstrated decreased craving among women previously diagnosed with substance use disorder [24].  Additionally, Mindfulness Oriented Recovery Enhancement (MORE) reduces opioid craving among individuals with OUD taking MAT [25], and increases positive psychological health, as well [26].

 Multiple large-scale surveys of complementary and alternative medicine (CAM) [1] use in the United States (US) have been conducted, including data from the 2002, 2007, and 2012 Adult Alternative Medicine supplement to the National Health Interview Surveys [27]. Among US adults, “the prevalence of CAM use in the past 12 months” ranged from 32.3% in 2002 to 35.5% in 2007 and was most recently 33.2% in 2012. Among women seeking acupuncture, for example, nationwide prevalence is low (1.1%); however that translates to over one million American women. In addition to seeking IH services from a provider, women are utilizing IH independently. For example, women in the US are already practicing meditation more than men and presence of pain, anxiety/depression, and sleeping problems are some of the main factors that predict meditation use [28]. This indicates that IH is not only acceptable to women but also sought-after by those who have some of the very issues associated with opioid misuse and OUD among midlife women.

Since IH interventions such as acupuncture, MABT and MORE are promising in the treatment of OUD and associated comorbidities and since women are utilizing complementary therapies, it would seem beneficial to women for healthcare policy to support women’s affordable access to complementary therapies. Suggestions regarding policy include the provision of healthcare benefit coverage of complementary therapies, however the most recent data (from 2012) indicate that only a  minority of people in the US have health insurance coverage for complementary therapies such as acupuncture (20% of respondents reported at least partial coverage) and massage (15%) [29]. Because research findings regarding complementary therapies are likely to inform policy changes, additional research is needed to clarify the combined benefits of complementary therapies on pain, mental health conditions, and other symptoms on opioid use and concurrent use of medications such as benzodiazepines for anxiety, which are associated with higher rates of fatal opioid overdose. Further, additional studies of complementary therapies efficacy and effectiveness to reduce rates of OUD and associated comorbidities are needed to then translate those findings to real-world effectiveness studies. We encourage future work in these directions that might result in improved outcomes for women with OUD.

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  12. Pieretti S, Di Giannuario A, Di Giovannandrea R, Marzoli F, Piccaro G, et al. (2016) Gender differences in pain and its relief. Ann Ist Super Sanita 52: 184–189. [crossref]
  13. Frenk SM, Porter KS, Paulozzi LJ (2015) Prescription opioid analgesic use among adults: United States, 1999-2012. NCHS Data Brief : 1–8. [crossref]
  14. Marsh JC, Park K, Lin YA, Bersamira C (2018) Gender differences in trends for heroin use and nonmedical prescription opioid use, 2007-2014. J Subst Abuse Treat 87: 79–85. [crossref]
  15. Back SE, Lawson KM, Singleton LM, Brady KT (2011) Characteristics and correlates of men and women with prescription opioid dependence. Addict Behav 36: 829–834.
  16. Smith PH, Homish GG, Leonard KE, Cornelius JR (2012) Intimate Partner Violence and Specific Substance Use Disorders: Findings from the National Epidemiologic Survey on Alcohol and Related Conditions. Psychol Addict Behav 26: 236–245.
  17. Smith KZ, Smith PH, Cercone SA, McKee SA, Homish GG (2016) Past year non-medical opioid use and abuse and PTSD diagnosis: Interactions with sex and associations with symptom clusters. Addict Behav 58: 167–174.
  18. Health ACfIMa. Definition of integrative medicine and health.  http://www.imconsortium.org/about/about-us.cfm. Accessed 10/8/19.
  19. Koithan M (2015) The Promise of Integrative Nursing. Creat Nurs 21: 193–199. [crossref]
  20. Thompson S, Wagner (2019) J Integrative nursing management of pain In: Kreitzer MJ, Koithan M, (eds.). Integrative Nursing. 2nd edn. New York, NY: Oxford Press.
  21. Chen Z, Wang Y, Wang R, Xie J, Ren Y (2018) Efficacy of Acupuncture for Treating Opioid Use Disorder in Adults: A Systematic Review and Meta-Analysis. Evid Based Complement Alternat Med 2018: 3724708. [crossref]
  22. Zhou K, Jia P, Bhargava S, Zhang Y, Reza T, et al. (2017) Opioid tapering in patients with prescription opioid use disorder: A retrospective study. Scand J Pain 17: 167–173. [crossref]
  23. Kazis LE, Ameli O, Rothendler J, Garrity B (2019) Observational retrospective study of the association of initial healthcare provider for new-onset low back pain with early and long-term opioid use. BMJ Open 9: e028633. [crossref]
  24. Price CJ, Merrill JO, McCarty RL, Pike KC, Tsui JI (2019) A pilot study of mindful body awareness training as an adjunct to office-based medication treatment of opioid use disorder. J Subst Abuse Treat [crossref]
  25. Garland EL, Hanley AW, Kline A, Cooperman NA (2019) Mindfulness-Oriented Recovery Enhancement reduces opioid craving among individuals with opioid use disorder and chronic pain in medication assisted treatment: Ecological momentary assessments from a stage 1 randomized controlled trial. Drug Alcohol Depend 203: 61–65. [crossref]
  26. Garland EL, Hanley AW, Riquino MR, Reese SE, Baker AK, et al. (2019) Mindfulness-oriented recovery enhancement reduces opioid misuse risk via analgesic and positive psychological mechanisms: A randomized controlled trial. J Consult Clin Psychol 87: 927–940. [crossref]
  27. Clarke TC, Black LI, Stussman BJ, Barnes PM, Nahin RL. Trends in the use of complementary health approaches among adults: United States, 2002-2012. Natl Health Stat Report 2015: 1–16.
  28. Upchurch DM, Burke A, Dye C, Chyu L, Kusunoki Y, et al. (2008) A sociobehavioral model of acupuncture use, patterns, and satisfaction among women in the United States, 2002. Womens Health Issues 18: 62–71. [crossref]
  29. Nahin RL, Barnes PM, Stussman BJ (2016) Insurance Coverage for Complementary Health Approaches Among Adult Users: United States, 2002 and 2012. NCHS Data Brief Pg No: 1–8. [crossref]

[1] “CAM” is a term that was previously used to identify interventions such as acupuncture, massage, and mindfulness and the commonly used term now is “complementary therapies.”

Evaluation of Efficacy of Hypertonic Saline and Mannitol in Combination in Patients with a Traumatic Brain Injury

DOI: 10.31038/JNNC.2019211

Abstract

Title: Evaluation of Efficacy of Hypertonic Saline and Mannitol in Combination in Patients with a Traumatic Brain Injury

Background: Traumatic Brain Injury (TBI) is a major cause of disability and death. In 2013, an estimated 2.5 million emergency department visits were related to TBI. In current practice, hyperosmolar therapy such as bolus doses of intravenous mannitol 20% and sodium chloride 3% are commonly used as single agents for the treatment of Cerebral Edema And Intracranial Pressure (ICP) reduction. The Brain Trauma Foundation guidelines do not recommend a preferred agent, nor do they comment on the use of these agents in combination. Currently, there are no published studies evaluating combination hyperosmolar therapy for ICP reduction. The primary objective of this study is to evaluate the efficacy of bolus doses of intravenous mannitol 20% and sodium chloride 3% utilized as monotherapy or in combination in patients with TBI.

Methods: This single-center retrospective study identified cases using a medication usage report generated through the electronic medical record at Advocate Christ Medical Center. Subjects 14 years and older admitted to the trauma service following a diagnosis of TBI who received an intravenous bolus of mannitol 20% and/or sodium chloride 3% from August 1, 2013 through August 1, 2018 were included. Subjects without known trauma confirmed by radiographic imaging, those who received a sodium chloride 3% continuous infusion, pregnant patients, and those who expired within twenty-four hours of admission were excluded. The following data points were collected: age, weight, gender, race, serum creatinine, serum sodium, serum osmolality, mean arterial pressure, initial Glasgow Coma Score (GCS), diagnostic imaging, presence of cerebral edema and size of midline shift on computed tomography, dose and frequency of hyperosmolar agents, neurosurgical intervention, vasopressor requirements, intravenous fluids, Hospital And Intensive Care Unit (ICU) Length Of Stay (LOS). All data was recorded without patient identifiers, maintained confidentially, and was analyzed using descriptive and inferential statistics.

Results: A total of 1000 patients were screened of which 176 met the inclusion/exclusion criteria. In-hospital mortality was experienced by 6 of 24 patients in the combination group compared to 18 of 152 patients in the monotherapy group (p=0.08). Statically significant reductions were seen in need for neurosurgical intervention (p=0.04), vasopressor utilization (p=0.03), and ICU LOS (p=0.02) demonstrating a benefit of monotherapy over combination. No difference was seen in laboratory values or vitals measurements.

Conclusion: Combination therapy was associated with a trend towards increase mortality compared to monotherapy use.

Keywords

hypertonic saline, intracranial pressure, mannitol, Traumatic brain injury

Introduction

Traumatic Brain Injury (TBI) is a major cause of disability and death in the United States. According to the Center for Disease Control and Prevention there are approximately 2.5 million emergency department visits related to TBI each year. These injuries resulted in 282,000 hospitalizations and 56,000 deaths.[1] in 2010, the total economic impact of TBI was estimated to be $76.5 billion.[2]

A TBI is defined as a bump, blow, or jolt to the head that disrupts the normal function of the brain commonly caused by falls, blunt trauma, and motor vehicle crashes. The severity of injury ranges from mild to severe.[1] The Glasgow Coma Scale is a validated tool used to assess the initial severity of brain injury. A GCS score of 13–15 is considered mild injury, 9–12 is considered moderate injury, and 8 or less is considered severe TBI.[3] For those who survive, the effects of a TBI can be temporary or leave an individual with permanent deficits. Effects of TBI can include impaired thinking, memory, movement, emotional, and social functioning.[1] These issues not only affect individuals but can have lasting impacts on families, communities, and the healthcare system.

A primary mechanism of poor neurologic outcomes in TBI stems from cerebral edema and subsequent increase in Intracranial Pressure (ICP). Tissue swelling from the injury can increase pressure inside of the skull, alter blood perfusion, and cause additional damage to the brain. A normal ICP ranges from 5–15mmHg.[4] A sustained ICP of greater than 20mmHg for greater than five minutes is associated with increased morbidity and mortality.[5]

In current practice, osmotic therapy with intravenous mannitol or hypertonic saline is used in symptomatic patients with cerebral edema or ICP elevation. Hyperosmolar therapy creates an osmolar gradient across the blood-brain barrier and also causes a reduction in blood viscosity by decreasing red blood cell rigidity and cohesiveness improving microvascular circulation. Mannitol, a sugar alcohol, works as a potent osmotic diuretic. It is administered in Intravenous Piggyback (IVPB) bolus doses of 0.25–1 mg/kg every 6–8 hours. Adverse effects include hypovolemia, hypotension, acute kidney injury and metabolic disturbances. Hypertonic saline is supplied in a variety of concentrations, the 3% concentration is dosed 250–500mL (128–256 mEq sodium) IVPB bolus every 4–6 hours. Adverse effects include hypervolemia, hypertension, and electrolyte disturbances.[6] The two therapies are not mutually exclusive and may be used in combination. Guidelines from the Brain Trauma Foundation make no recommendation on a preferred agent, nor do they comment on the use of combination therapy.[7] Currently, there are no published studies evaluating combination hyperosmolar therapy for ICP reduction. The purpose of this study is to evaluate the safety and efficacy of the combination of mannitol and hypertonic saline versus each agent used as monotherapy.

Methods

Patient population and setting

The single study site was a large, urban level 1 trauma center located on the Southside of Chicago, Illinois. Eligible patients were identified using a medication usage report generated through the electronic medical record for those admitted from August 1, 2013 through August 1, 2018. Screening for further inclusion and data collection was completed using the financial identification number of each patient. This study was approved by the local Institutional Review Board.

Inclusion/exclusion

Patients were included if they were at least 14 years old. Patients also must have been admitted to the trauma service, have radiographic imaging confirming TBI, and receive at least one of the study drugs to be included. Patients were excluded if they were less than 14 years old, pregnant, died within 24 hours of admission, did not have a history of recent trauma or radiographic evidence of a TBI, or did not receive study drug as a bolus.

Outcomes

The primary outcome of this study was incidence of in-hospital mortality. Secondary outcomes included the occurrence of neurosurgical evacuation, change in serum sodium, creatinine, and osmolality, Mean Arterial Pressure (MAP), and hospital and ICU LOS. Change in baseline laboratory measurements was defined as change from prior to 24 hours after the first dose of hyperosmolar therapy. Change in baseline MAP measurements was defined as change from prior to 30 minutes after the first dose of hyperosmolar therapy.

Statistical Analysis

A sample size of 800 patients was calculated to achieve 80% power to detect a difference of 10 percentage points between groups for the primary outcome of in-hospital mortality. Demographic and baseline data points were calculated as mean or median dependent upon their normality as assessed by the Shapiro-Wilk Statistic. Statistical analysis of all endpoints was done by combining the HTS and MAN group to make a monotherapy group that was tested against combination. Chi-Square tests were performed for categorical data and Mann-Whitney U tests were performed for continuous data. All tests were two-tailed and a p-value of 0.05 was considered statistically significant in all analyses.

Results

A total of 1000 patients were screened for inclusion in this study and 176 patients met the criteria. A total of 81 patients received only sodium chloride 3% IVPB bolus, 71 patients received only mannitol 20% IVPB bolus, and 24 patients received a combination of these two agents in scheduled alternating IVPB bolus form. Patient demographics of the study groups did not differ statistically (Table 1). The typical patient was middle aged, male, of Caucasian or African American decent. Patients who received combination therapy tended to be younger, were more likely male, and more likely African American. The median dose of HTS for all patients who received a dose was 250mL (128mEq). The average mannitol dose was 0.8g/kg for all patients who received a dose. Most patients received 1–2 days of therapy as denoted by number of doses received.

Table 1. Patient Demographics

HTS (n=81)

MAN (n=71)

HTS+MAN (n=24)

Age (years), mean

53.7

50.8

41.2

Male, n (%)

63 (76.5)

54 (76.1)

20 (83.3)

Weight (kg), mean

84.1

92.8

81.4

Race, n (%)

Caucasian

37 (45.7)

36 (50.7)

8 (33.3)

African American

29 (35.8)

33 (46.5)

14 (58.3)

Hispanic

10 (12.3)

0

1 (4.2)

Unknown

5 (6.2)

2 (2.8)

1 (4.2)

Characteristics and severity of TBI at initial presentation were collected and are displayed in table 2. Patients who received combination therapy tended to have lower GCS scores than those receiving monotherapy, however this difference was not statistically significant. All patient groups were similar in terms of rates of cerebral edema and midline shift as well as imaging findings of types of hemorrhage.

Table 2. Injury Severity and Characteristics. Values are median [interquartile range] except those specified with † are mean ± standard deviation

HTS (n=81)

MAN (n=71)

HTS+MAN (n=24)

GCS

12 [7–15]

12 [7–15]

9.2 ± 4†

Presence of Cerebral Edema, n (%)

35 (43.2)

36 (50.7)

11 (45.8)

Presence of Midline Shift, n (%)

26 (32.1)

42 (59.2)

11 (45.8)

Imaging, n (%)

Subdural Hemorrhage

53 (65.4)

48 (67.6)

16 (66.7)

Subarachnoid Hemorrhage

47 (58.0)

34 (47.9)

15 (62.5)

Intraparenchymal Hemorrhage

30 (37.0)

24 (33.8)

7 (29.2)

Epidural Hemorrhage

3 (3.7)

6 (8.5)

2 (8.3)

Diffuse Axonal Hemorrhage

4 (4.9)

2 (2.8)

0

Intracerebral Hemorrhage

2 (2.5)

1 (1.4)

0

Results of the primary and secondary outcomes of the study are shown in table 3. For the primary endpoint of mortality, a non-significant relationship was identified between combination therapy and mortality, with 11.8% of those on hypertonic saline or mannitol expiring after 24 hours as compared to 25.0% of those on hypertonic saline and mannitol expiring after 24 hours (p=0.08).

Table 3. Primary and secondary study outcomes. Values are median [interquartile range] except those specified with † are mean ± standard deviation. * indicates significance at p=0.05.

Monotherapy

Combination

P-value

HTS (n=81)

MAN (n=71)

HTS+MAN (n=24)

Mortality, n (%)

7 (8.6)

11 (15.5)

6 (25)

0.08

Neurosurgical Procedure sPPrprIntervention, n (%)

14 (17.3)

32 (45.1)

11 (45.8)

0.04*

Craniotomy, n (%)

10 (12.4)

18 (25.3)

3 (12.5)

Craniectomy, n (%)

4 (4.9)

13 (18.3)

8 (33.3)

Both, n (%)

0

1 (1.4)

0

Vasopressors Used, n (%)

6 (7.4)

5 (7)

5 (20.8)

0.03*

Fluid Bolus Used, n (%)

16 (19.8)

23 (32.4)

8 (33.3)

0.43

Hospital LOS (days)

10.9 [6.2–16.4]

12.0 [7.6–18.6]

13.8 ± 7.4†

0.55

ICU LOS (days)

6.0 [3–9]

5.0 [3–10]

9.1 [5.5–11.6]

0.02*

Initial Serum Sodium (mmol/L)

139 (±3.9)†

139 [137–141]

138.5 (±3.7)†

0.63

Repeat Serum Sodium (mmol/L)

142.7 (±6.3)†

140 [138–144]

142.5 [140–146.5]

0.13

Initial Serum Creatinine (mg/dL)

0.9 [0.8–1.2]

1.0 [0.8–1.2]

0.9 [0.8–1.1]

0.61

Repeat Serum Creatinine (mg/dL)

1.0 [0.6–1.0]

0.8 [0.7–1.1]

0.8 [0.7–1.2]

0.63

Low Serum Osmolality (mOsm/kg)

299.9 (±12.9)†

293.8 (±13.4)†

303.6 (±21.6)†

0.11

High Serum Osmolality (mOsm/kg)

302 [293–322]

314.5 [304–328]

317.2 (±20.5)†

0.56

Initial MAP (mmHg), mean

92.7

97.0

97.4

Repeat MAP, n (%)

0.10

No Change

57 (70.4)

46 (64.8)

12 (50)

Increase > 10 mmHg

11 (13.6)

11 (15.5)

3 (12.5)

Decrease < 10 mmHg

13 (16)

14 (19.7)

9 (37.5)

For the secondary endpoint of ICU LOS, a significant relationship was identified with those who received either hypertonic saline or mannitol having a median ICU LOS of 6.0 as compared to those who received both hypertonic saline and mannitol having a median ICU LOS of 9.1 (p=0.02). A total 7.2% of those on hypertonic saline or mannitol received vasopressor therapy, compared to 20.8% of those on hypertonic saline and mannitol (p=0.03). Neurosurgical intervention was needed on 30.3% of those on hypertonic saline or mannitol as compared to 45.8% of those on combination therapy (p=0.04). No difference was seen in fluid bolus requirements (p=0.43) or hospital LOS (p=0.55). None of the baseline values or repeat laboratory values were found to be significantly different between the groups. Furthermore, no significant result was found on MAP measurements (p=0.10).

A post-hoc sub analysis was performed on the primary endpoint and the hypertonic saline group (Table 4). Hypertonic saline had statistically lower mortality compared to combination therapy (p=0.03). However, it was not statically superior to mannitol when compared directly (p=0.19).

Table 4. Primary Outcome Sub Analysis. * indicates significance at p=0.05.

Sub analysis: Sodium Chloride 3% vs Combination

HTS (n=81)

HTS+MAN (n-24)

P-value

Mortality, n (%)

7 (8.6)

6 (25)

0.03*

Sub analysis: Sodium Chloride 3% vs Mannitol

HTS (n=81)

MAN (n-71)

P-value

Mortality, n (%)

7 (8.6)

11 (15.5)

0.19

Discussion

In this retrospective study, TBI patients were administered hyperosmolar therapy to decrease intracranial pressure. We found a trend towards a decrease in in-hospital mortality associated with monotherapy use with either sodium chloride 3% or mannitol 20% compared to combination therapy. The dosing of both agents was in accordance with current practice and first doses were often administered immediately after the patient presented to the emergency department with traumatic injuries. All groups were similar in demographic and injury characteristics with the typical patient presenting with a moderate TBI.

We predicted that the mannitol group may experience more adverse events such as acute kidney injury and hypotension. However, we did not find these results as serum sodium, creatinine, osmolality and MAP measurements did not significantly change 24 hours after the first dose of hyperosmolar therapy. Previous literature may overestimate the detrimental effects of hyperosmolar therapy including mannitol, or the initial dosing used in our cohort may be low enough to avoid these effects. The patients included in our study were primarily young, otherwise healthy adults who may better tolerate the medications compared to older adults with a higher likelihood of co-morbid renal and cardiovascular conditions.

We found that monotherapy was associated with a decrease in neurosurgical interventions. This decrease likely led to a significant decrease in ICU and overall hospital LOS. These reductions result in a great cost savings and imply better outcomes for patients. The sub analysis of our primary outcome revealed a statically significant reduction in mortality with the use of sodium chloride 3% monotherapy compared to combination therapy with mannitol. However, sodium chloride 3% was not significantly better than monotherapy with mannitol. Sodium chloride 3% may be the preferred agent for ICP reduction after TBI, but further research is needed in this area. Based on the results of the primary outcome being nonsignificant, it was determined that mannitol alone would not be statistically superior than combination therapy at lowering in-hospital mortality as the composite of mannitol and hypertonic saline was not significant.

Our study suffered from several limitations. This data was collected from a single center in a retrospective manner. It did not meet power for the primary endpoint. The combination therapy group had a small sample size of 24 patients and these patients had a lower initial GCS score. This could mean this was a more critically ill group and thus more likely to need advanced therapies, have poorer outcomes and expire. However, none of the baseline data points were statistically significant between groups. We did not collect data on other injuries beyond those of the head which often contribute to patient death from traumatic causes. There was also variance in the dosing of hyperosmolar therapy, and timing of blood pressure and laboratory measurements. Lastly, our institution does not routinely use ICP monitors, consequently our efficacy data was purely symptom based.

Conclusion

Combination therapy was associated with a trend towards increased mortality compared to monotherapy use. Compared to combination therapy, subjects treated with monotherapy had a statistically significant reduction in ICU LOS, need for neurosurgical evacuation of hemorrhage, and vasopressor therapy to maintain MAP goals.

As this is the first published study evaluating the use of combination hyperosmolar therapy in TBI, further evaluation is needed. Specifically, the evaluation of a continuous infusion of hypertonic saline in addition to mannitol IVPB maybe an area of promise. Additionally, a prospective study would be able to set standard dosing and monitoring regimens. A randomized control study of monotherapy versus combination therapy for hyperosmolar agents in TBI would allow the establishment of a causal association of these therapies with outcomes such as mortality, ICU LOS, and need for neurosurgical interventions.

References

  1. Taylor CA, Jeneita M Bell, Matthew J Breiding, Likang Xu (2017) Traumatic Brain Injury – Related Emergency Department Visits, Hospitalizations, and Deaths – United States, 2007 and 2013. MMWR. US Department of Health and Human Services 66: 1–16.
  2. Faul M, Likang Xu, Marlena M. Wald, Victor G. Coronado (2010) CDC, National Center for Injury Prevention and Control.
  3. Teasdale G, Jennett B (1974) Assessment of coma and impaired consciousness. A practical scale. Lancet  2: 81–4.
  4. Boone MD, Oren-grinberg A, Robinson TM, Chen CC, Kasper EM (2015) Mannitol or hypertonic saline in the setting of traumatic brain injury: What have we learned? Surg Neurol Int 6: 177.
  5. Peters NA, Farrell LB, Smith JP (2018) Hyperosmolar Therapy for the Treatment of Cerebral Edema.US Pharmacist 43: 8–11.
  6. Muizelaar JP, Wei EP, Kontos HA, Becker DP (1983) Mannitol causes compensatory cerebral vasoconstriction and vasodilation in response to blood viscosity changes. J Neurosurg 59: 822–8.
  7. Carney N, Totten AM, Oʼreilly C (2017) Guidelines for the Management of Severe Traumatic Brain Injury, Fourth Edition. Neurosurgery 80: 6–15.

Cartography of Doctor-Patient Relationship: A Mind- Genomics Exploratory Study about the Public’s Response to Patient-Centered-Care

DOI: 10.31038/JCRM.2019251

Abstract

The nature of the doctor-patient interaction significantly affects the trust in their relationship. Barriers in communication which ignore the emotional needs of patients reduce patient trust in the doctor, as well as challenge the delivery of patient-centered-care, the preferred approach of care. Based on previously acknowledged determinants of patient trust in the patient-doctor relationship, we identified two patient mind-set segments which supersede age and gender. Patients in one mindset expect their doctor to greet them respectfully, to be empathic, to listen carefully without interrupting, and in the end feel that their doctor understands them. Patients in the second mind-set segment expect the doctor to enhance their internal locus of control. This second mind-set wants the doctor to educate them, providing clear, relevant, tailored, information and ensuring that they understand the information. This second mind-set wants the doctor to let them feel comfortable asking questions about what they didn’t understand, and walk them through a change process, by steps, towards self-management of their disease.

Introduction

Patient-Centered Care (PCC) has been demonstrated to improve clinical outcomes (IOM, 2001). The IOM defines patient centered care as “care that is respectful of and responsive to individual patient preferences, needs, and values” and that ensures “that patient values guide all clinical decisions” (IOM, 2001). From the perspective of the patient, the eight characteristics of care which indicate high quality and safe care are, respectively, respect for patient’s values; preferences and needs; coordinated and integrated care; clear, high-quality information; education for the patient and family; physical comfort; emotional support; involvement of family members; continuity in care-transitions; and access to care [1,2]. PCC leads to improved clinical outcomes. The pinnacle of PCC is the active engagement the patient when fateful health care decisions must be made; when the patient is at crossroads of medical options, and the divergent paths have meaningful consequences for the patient and family [3]. Patients at crossroads of medical action are vulnerable, have needs they cannot fulfill on their own, and rely on and have positive expectations from a doctor [4]. To address dimensions of PCC, the doctor is called upon to implement and evaluate care systems and work together with patients to produce optimal clinical outcomes. In these situations the patient-doctor interaction can strongly drive cooperation and ultimate outcome [5].

Trust is an attitude by which, in the absence of the ability to predict what will happen in the future, the patient believes that in the moment of truth, the doctor will behave according to expectations [4, 6, 7]. Trust by the patient in the doctor entails the acceptance by patient of her or his vulnerability [8]. The interaction with physicians may create this patient-trust or perhaps patient-distrust in a doctor. The importance of patient-trust in a doctor emerges from evidence indicating that patient trust is related to patient adherence to medication and to guidelines. Patient trust in a doctor is associated with fewer readmissions, better health outcomes better long-term health and higher quality of life [9–12]. In psycho-social discourse between doctor-patient the doctor can clarify patient’s expectations, whether clear or ambiguous, making the expectations concrete, and shaping the precise nature of these expectations. Lack of such discourse, i.e., treating the patient but not really interacting with the patient as a person, may be negatively affect the ultimate outcome, despite the doctor’s efforts to provide optimal care, and despite the sophistication of the medical treatment itself.

A model of an improved way to interact with patients comes from the world of psychotherapy. Research continues to demonstrate that high quality relationships between therapists and their clients result in more positive outcomes, Medicine continues to borrow characteristics of positive relationships from the field of Psychotherapy to doctor-patient relationships [13, 14]. Positive relationships entail attitudes and behaviors; acceptance, empathy, concern, support, flexibility, honesty, confidence, human warmth, openness and respect for the patient, and so forth. These characteristics nurture patient trust in the doctor and patients’ ability to assume responsibility for their health [15, 16]. The quality of the relationship depends on active listening, maintaining patient focus, on creating a calm and warm atmosphere, enhancing patient’s information and knowledge; n legitimizing expressions, avoiding directives, or too much information, and finally using language which expresses closeness [17,18].

When interacting with doctors, the patient relies on the knowledge, abilities, and skills of the doctor, especially when the interaction is done when the patient is suffering. In turn, the doctor depends on the patient who can provide accurate and comprehensive information about the specific symptoms of the disease in his body, information which lead to the accurate diagnosis, and in turn the accurate and appropriate treatment [19, 20]. This mutual dependence for the best outcome demands that the patient feel comfortable with the doctor, allowing the patient to expose weaknesses and limitations. The relation becomes a two-way street. In turn, good doctor-patient communication may build trust, a necessity for a beneficial and effective doctor-patient relationship [21–26].

According to studies, the more the doctor is empathic, technically competent, listening, reliable, honest and concerned for the patient’s well-being, compassionate, the greater appears to be the patient trust in the doctors. Patients who rated their doctors’ inter-personal abilities as high reported greater trust [27]. The higher the reputation of the doctor, the more the patient trusted the doctor. Finally, research shows that the more the doctor meets the patient’s expectations, the higher is the patient’s satisfaction, and the highest is the trust [28–30]. The patient’s ‘perceived locus of control’ has been report to be important for the trust that the patient puts in the doctor [18]. Perceived control, a psychological construct, is grounded in social learning theory. Perceived control moves along the continuum from perceived external locus of control to perceive internal of control focus [31]. Patients with internal locus of control perceive everything in their world as their responsibility. Patients with external locus of control attribute events in their lives to external factors, e.g., luck, boss, weather, and so forth [18, 31–33].

Patients with internal locus of control are directed to action [33, 34]. They look for relevant information on their illness and are more involved in decision-making. These patients with internal locus of control take responsibility for improving their health behaviors, reducing harmful health behaviors and accelerating recovery from illness [35–39]. A retrospective study also found that using communication that targets patient’s perceived control reduced the number of readmissions [9]. These findings suggest that one opportunity to improve outcomes is the adoption of communication style and content which enhance the patient’s internal locus of control. The actual behavior may be to guide patients to think about resources, both those in themselves, and those external to themselves, in order to improve health. These external resources may be forums, mobile phone reminders for taking one’s drugs, and so forth [40, 41]. The world of the doctor-patient interaction is shifting quickly, morphing into a less personal relationship. The increasing complexity of medical science, along with technology and business consideration prevent doctors from establishing a close bond with the patient. In the interest of efficiency, technology and business appear to be reducing the opportunity to create a beneficial bond between doctor and patient. The ‘patient intake’ may occur through portals at home; computer facilitated intake at the office. The traditional psycho-social model of patient-doctor interaction, whether true or simply somewhat romanticized, has given way to capitation, to short, tightly scheduled visits with the patient, in order to deliver optimal outcomes. The amount of communication is limited, the type of communication is reduced and so is the span of attention of the doctor [42]. This study examines patient preferences as to what to strengthen in doctor-patient communication by mind-set segmentation and what to avoid in communicating with patients in each mindset.

Methods

The Mind Genomics approach

Mind Genomics is an emerging psychological science which studies decision processes of the ‘every day.’ People live in the ordinary world, confronted by what is by now ‘standard problems,’ such as what to wear, what to buy, and of course when to go to their physician, and what truly private information can they feel comfortable when they share with their physician. Much of what we know about the psychology of the everyday comes from large-scale attitude and usage studies, usually done with the focus of selling a product or a service. These studies, also called habits and practices, are commissioned by corporations with the objective to understand possible opportunities with consumers, opportunities which emerge from the everyday. These studies do not look at the aspects of everyday life as the basis to understand the ‘algebra of the mind,’ the rules of decision making, except in isolated cases, and disconnected experiments.

Mind Genomics was developed in the 1980’s by author [43, 44, 45] to create an archival base of knowledge showing how people react to the different facets of a common situation. Since 2015 Mind Genomics is used in the health context [44, 46, 47, 48, 49, 50, 51, 52]. Rather than looking at isolated situations, and disconnected experiments, the ingoing vision was to take a specific ‘vertical’ of related experiences, and for each experience or ‘topic,’ identify the features of the experience and then list alternatives possible with each feature. Explained another way, Mind Genomics takes a topic, such as the patient’s experience when the visiting the doctor, divides the topic into questions defining the different aspects of the visit, and then provides a set of answers to each question. These answers represent alternatives which could happen. The final step combines these ‘answer’s (alternative events in visiting one’s doctor), creating many ‘vignettes,’ presents these vignettes to people, and gets their reactions to the different vignettes. The result is a portrait of how people react to these different answers, different aspects of visiting a doctor.

Sample

A sample of 25 patients who were asked to relate to their primary physician and define themselves as choosing to be healthy. This sample is a preliminary step in creating a baseline dataset, showing major trends. The small number of respondents is satisfactory for these early stage studies, where the objective is to get a sense of the topic areas which are very important to respondents. Each respondent participates in what is best considered to be an individual-level experiment. The pattern of the data from one individual suffices to show the mind-set of the individual toward the topic, i.e., what is important and what is not. Increasing the number of respondents does not add more precision, but rather allows different mind-sets to emerge. Early stage research, where the topic is not well researched and the key variables not yet known, benefits from a series of such small, exploratory studies, probing different facets of the topic. This first study falls into the class of the small, easily done, affordable explorations, the larger set of which can be woven into a detailed tapestry. Such research is usually not done when the effort is expended against one part of a topic, ignoring most others.

Procedure

Mind Genomics is an experiment, rather than a survey. The objective is to trace a path of causation, between what is described in the doctor-patient interaction and the patient’s response. The approach combines Socratic question/answer with experimental design, to create the inputs necessary for the experiment. The process follows these straightforward steps, forcing the researcher to think in a structured fashion, and in so doing produce the requisite input for the experiment.

Step 1: Define The Topic:  The topic here is the patient’s description of how she or he was treated, and felt, after a consult with the physician

Step 2: Ask Four Questions Pertaining to the Consult with the Physician: The four questions must tell a story. Asking the four questions requires the critical thinking by the researcher. The exercise becomes the foundation for either a good experiment or a poor experiment. (Table 1) presents the specific set of four questions focusing on the doctor-patient trust building interaction. We limited the amount of questions to avoid the research being onerous for respondents and for creating the science through straightforward insights, the ultimate goal.

Table 1. The four questions and the four answers for each question.

 

Question A: What is internal locus of control?

A1

Doctor encouraged to ask about what I didn’t understand

A2

Involved as much as I want to be with this doctor

A3

Doctor discussed the next step appropriate for me

A4

Doctor set up a clear follow up plan with me

 

Question B: How did the doctor educate the patient?

B1

Doctor gave me information about my condition

B2

Doctor referred me to where I can learn more about my condition

B3

Doctor made sure I understood the information

B4

Doctor validated and ensured my relevant information

 

Question C: How was the time spent in the consult?

C1

Doctor let me talk without interruption

C2

Doctor spent as much time as I needed

C3

Doctor interested in what I thought about the situation

C4

I felt the doctor understood me

 

Question D: What nonverbal language was used by the doctor?

D1

Doctor kept the contact with me

D2

Doctor listened carefully

D3

Doctor greeted me respectfully

D4

Doctor focused on me and not on the computer

Step 3: Provide Four Answers to Each Question: The four answers present different facets of the question, different alternatives. It will be the answers that will be seen by the respondent, in various combinations, the vignettes described below. The respondent will never see the questions. The only purpose of the question is to motivate the answers. (Table 1) shows the answers. They are presented in simple format, usually a declarative sentence, occasionally with a short reprise of the question in one/two words, a colon, and then the answer. (Table 1) shows the format of the answer, generally begun with the word ‘doctor’ in the starting part of the answer, unless the meaning of the answer would be distorted (A2, C4).

Materials

Step 4: Create Vignettes Using the Principles of Experimental Design: The standard approach to understand the patient’s feeling about the consult with the doctor uses a survey, a set of questions that are to be answered with a scale. Mind Genomics works differently because it is an experiment. Mind Genomics creates test descriptions, combinations of answers, and the vignettes, presents them to the respondent, and obtained an answer. The ratings of the vignettes are then deconstructed to provide a sense of how each element ‘drives’ the rating. Vignettes rather than single phrases provide three distinct benefits for the research.

  1. It is impossible to ‘game the system,’ to provide answers which tell a specific story. Virtually all respondents who begin with the attempt to provide a specific pattern of answers ‘give up’ because the combination is simply too difficult to deconstruct. The respondent soon adopts a strategy of assigning ratings by intuition, by ‘gut reaction,’ the precise criterion necessary for valid information.
  2. Respondents are more accustomed to stories than to single facts. The combination by vignettes presents a story.
  3. The experimental design allows the researcher to measure interactions among different answers, specifically whether the combination of two answers together is more powerful than one might expect, or engage the respondent’s attention longer (see response time below.)

The actual experimental design requires that the 16 answers be combined into 24 combinations, vignettes, with the vignettes comprising no more than one answer from each question, but sometimes absent answers from one or two questions. That is, the vignettes comprise 2–4 answers. The vignettes are incomplete, allowing the 16 answers, now elements in the vignette, to be statistically independent of each other. That statistical independence will allow the use of OLS (ordinary least-squares) regression to relate the presence/absence of the elements to the response.

The vignette is rated as a totality, using the rating scale below:

How likely are you to revisit this doctor and/or recommend to friends?

(1= don’t want to revisit, 9 = want to revisit).

Figure 1 (left panel) shows the four questions as they are entered into the BimiLeap program (www.BimiLeap.com), whether on an android device or on the web. Figure 1 (middle panel) shows the four answers to each question, as they are entered into the program. The BimiLeap program, the technology underlying the Mind Genomics science, enables the researcher to structure her or his thinking,

MIND GENOMICS 028_JCRM_f1

Figure 1. The left panel shows the four questions, ready to be entered. The middle panel shows the four answers to the first question, ready to be answered. The right panel shows a vignette, ready to be rated.

Recent developments in experimental design by [53] have created what is called ‘systematic permuted design.’ This advance generates several hundred permutations of the one basic design underlying the 4×4 structure (four questions, four answers.) The combinations in the permuted designs are different from each other, but each design is isomorphic to every other design. Thus, one need not be worried that the 24 combinations chosen for the experiment are the ‘correct combinations.’ Each respondent will see a different set of combinations, similar to the way the MRI (Magnetic Resonance Image) in medicine takes many pictures of the same tissue, from different angles, and puts them together. Each picture in the MRI is incomplete, but the combination reproduces the view of the underlying organ. In the same way, each set of 24 vignettes is a picture, but not the whole picture. It is the combination of the different vignettes in one large regression analysis which will provide the full picture.

Step 5: Invite the respondents to participate, using an e-panel (online) sample provider. For many studies it is tempting to source the respondents for the study using friends and others, such as people one knows on social media. The sourcing of respondents that way may work, but the time to do the research stretches into the days and weeks. A more efficient way works with a sample provider, who charges a small fee to recruit the panelists from a large pool of individuals, according to specific recruitment criteria. The panel provider for this study was Luc.id, Inc. The respondents were invited to participate. Within two hours the study was completed.

Step 6: Present the respondents with the systematically varied combinations, the vignettes, whether on a smartphone of any type, on a tablet, or on a personal computer. The Mind Genomics platform presents the vignettes on any platform, introduces the topic, presents the vignettes one at a time, records the rating and also records the response time, defined as the number of seconds between the presentation of the vignette and the response. When the rating is assigned, the vignette automatically disappears, and the next vignette appears. This process makes the experiment last 3–5 minutes, and does not frustrate the respondent. (Figure. 1) (Right panel) shows an example of one of the vignettes, along with the rating scale.

Results

The raw data from the Mind Genomics studies comprise the ratings and the response times. The users of the data are much more interested in no/yes answers. To make the data more useful, we divide the scale twice, first into the revisit/recommend ‘binary scale’ (ratings 8–9 transformed to 100, ratings 1–7 transformed to 0), and then into the not-revisit/not-recommend ‘binary scale (ratings 1–2 transformed to 100, ratings 3–9 transformed to 0.) The choice of the cut-point when bifurcating the scale is left to the researcher and may be altered depending upon the topic

The ratings are on a 9-point scale, are not very instructive to those who use the data. The standard approach in Mind Genomics is to transform the data, so that ratings of 1–6 are transformed to 0, and ratings of 7–9 are transformed to 100. In this study the majority of ratings are encompassed by the range 7–9. There would be very little to learn from the standard transformation. When we apply the more stringent criterion of ratings 8–9, we may learn more. Furthermore, there is something to be learned from ratings 1–2–3, the rejection range. To keep the analysis symmetric, we choose ratings 1–2 to analyze as well.

Creating a Model

The experimental design allows the researcher to relate the presence/absence of the elements to the ratings, by ensuring that the 16 elements are presented in combinations, so that the 16 elements are statistically independent of each other. Statistical independence enables the researcher to use OLS (ordinary least-squares) regression to relate the presence/absence of the elements to the binary ratings, and to the response time, respectively. The regressions are run first at the level of the individual respondent, the regression coefficients which will be stored, and used for clustering, discussed below. The regressions are then run with ALL the data from a particular subgroup included in the data (e.g., responses from all individuals declaring them females, or of a certain age range, etc.)

The data enable us to create three different models:

  1. Models relating the presence/absence of the elements to the Top2 Rating (Revisit/Recommend)
  2. Models relating the presence/absence of the elements to the Bottom2 Rating (Not Revisit/Not Recommend)
  3. Models relating the presence/absence of the element to the response time.

For the self-defined sub-groups. We will look at five groups, comprising Total Panel, two genders, and two age ranges, respectively.

Recommend/Revisit (Top 2)

The additive constant shows the estimate percent of the times that a rating would achieve the rating of 8–9 in the absence of elements. The additive constant refers to a hypothetical case, since all the vignettes comprises 2–4 elements as dictated by the underlying experimental design. Nonetheless, the additive constant is a good baseline.

(Table 2) shows an additive constant of 49 for the total panel, and similar values hovering around 50 for the genders. We concluded that in the absence of elements, about half the respondents will say they would revisit/recommend. Age makes a difference, with respondents under 40 less likely to revisit/recommend, versus respondents older than 40 more likely to revisit/recommend.(Table 2) shows the strong performing elements, with an element appearing in (Table 2) only when the element scores highly in at least one subgroup:

Table 2. Performance of the elements in terms of driving positive responses (Top2, Revisit/Recommend). Only strong performing elements in at least on key subgroup are shown (coefficient >9).

 

Top 2 (Revisit/Recommend)

Total

Male

Female

Age < 40

Age 40+

 

Additive constant

49

51

47

33

60

D2

Doctor spent as much time as I needed

9

16

4

9

8

D3

Doctor interested in what I thought about the situation

8

16

1

4

8

B1

Doctor gave me information about my condition

4

9

1

-4

8

C4

I felt the doctor understood me

3

-6

10

-1

5

D1

Doctor let me talk without interruption

2

7

-2

9

-4

Not-Recommend/Not-Revisit (Bot2)

The additive constant shows the estimate percent of the times that a rating would achieve the rating of 1–2 in the absence of elements. As stated above, the additive constant refers to a hypothetical case, since all the vignettes comprises 2–4 elements as dictated by the underlying experimental design. Nonetheless, the additive constant is a good baseline. (Table 3) shows an additive constant of 3 for the total panel, and similar values hovering around -5 to +5 except for males (additive constant = 10) and for younger responses, age < 40 (additive constant = 13). We conclude that the respondents most likely to be dissatisfied are probably the younger males. Across the five groups the elements driving dissatisfaction tend to be those wherein the patient took control of the interaction, not the doctor. It may well be patients divide on the degree to which they want the doctor to seize control of the interaction. (Table 3) shows the strong performing elements, this time ‘strong performing’ operationally defined as a coefficient > 7.

Table 3. Performance of the elements in terms of driving negative responses (Bot2, Not-Revisit/Not-Recommend). Only strong performing elements (coefficient > 7) are shown.

 

Bot 2 (Not-Revisit/Not-Recommend)

Total

Male

Female

Age < 40

Age 40+

 

Additive constant

3

9

-3

13

-2

C1

Doctor let me talk without interruption

6

7

5

2

8

C2

Doctor spent as much time as I needed

5

8

3

3

7

C3

Doctor interested in what I thought about the situation

5

4

6

1

7

Response Time (>1.3 seconds for an element)

The experimental design allows us to look at the response time to the 16 different elements by key subgroup There are only a few elements which demand our attention, operationally defined as an estimated response time for the element of 1.3 seconds or great. There is no clear pattern of response times across groups. (Table 4) shows the longest response times.

Table 4. Performance of the elements in terms of driving response times. Only response times > 1.4 seconds for at least one subgroup are shown.

 

Response Time

Total

Male

Female

Age < 40

Age 40+

B3

Doctor made sure I understood the information

1.7

1.2

2.1

0.9

2.1

B4

Doctor validated and ensured my relevant information

1.3

1.0

1.4

0.7

1.6

B1

Doctor gave me information about my condition

1.3

0.6

1.8

0.9

1.5

B2

Doctor referred me to where I can learn more about my condition

1.2

0.2

1.9

0.5

1.5

A3

Doctor discussed the next step appropriate for me

1.0

0.6

1.3

0.2

1.5

A2

Involved as much as I want to be with this doctor

1.2

0.5

1.8

0.8

1.4

C1

Doctor let me talk without interruption

1.1

1.1

1.1

0.5

1.4

A1

Doctor encouraged to ask about what I didn’t understand

1.0

0.6

1.6

1.0

1.3

Interactions among Elements

The permutation strategy produces many different combinations, not just one limited set. One beneficial outcome is that it is possible to measure how elements or answers to one question affect the coefficients of other elements. This approach is called scenario analysis, and is only possible when the underlying experimental design is systematically permuted to create the many combinations. The more conventional approach, testing a limited number of combinations but with many people, ends up forcing the research to choose a limited number of combinations, and in turn, forever forego the opportunity to discover interactions. The strategy used here is known as scenario analysis. We will hold the elements or answers to one question constant (e.g., D, non-verbal communication). There are five different elements in question D, answers or elements D1, D2, D3, and D4. There is also one other element, the fifth, when D does not appear.

The question thus becomes simply ‘How does each of the non-verbal communications, D0-D4, affect the response to the other elements? We follow these three simple, straightforward steps:

  1. Create Strata: Sort the raw data set into five strata, based upon the specific answer provided by Question D (non-verbal action of the doctor). The design offers us four different answers (see Table 1), as well as those vignettes where, deliberately, an answer from Question D is omitted.
  2. Regression: Run a simple regression, using as predictors A1-C4, for Top2 and for Bot2, respectively, with an additive constant.
  3. Lay out the coefficients in the form shown in Table 5 (Top2).

We begin with the dependent variable being Top2 (Revisit/Recommend). (Table 5) shows the five different sets of coefficients for the 12 elements A1-C4. The four Elements D1-D4, do not appear in the coefficients for the simple reason that they are constant within a stratum. (Table 5) shows five columns of data, one for each stratum, defined by D=0 (no answer from Question D appears in the vignette), and then one column for each stratum (D=1, D=2, D=3, D=4). The coefficients appeared in shaded format and in bold type when the value is +9 or above, a value for the coefficient meaning that when the element is added to the vignette, the percent of respondent sayings ‘I’ll recommend / revisit’ jumps an additional 9%. Finally, the elements A1-C4 are sorted by their value when D=0, i.e., they are sorted by their performance in those vignettes which do not have any element from Question D.

(Table 5) shows a remarkable number of strong-performing elements. What is more interesting is that some elements interact dramatically with certain elements from a different question, but not with other elements from the same question. For example, consider elements C3 and C4: Doctor interested in what I thought about the situation, and I felt the doctor understood me. These are two strong performing elements, remaining so when combined with Element D1 (doctor listened carefully). Yet with any other element or answer from question D, these two elements, C3 and C4, performed poorly.

Table 5. Scenario analysis showing how elements (answers) from Question D synergize the rating of Revisit/Recommend when combined with other elements from other questions.

 

Top 2: Revisit/Recommend

None

Doctor kept the contact with me

Doctor listened carefully

Doctor greeted me respectfully

Doctor focused on me and not on the computer

 

 

D=0

D=1

D=2

D=3

D=4

 

 Additive constant

24

73

40

64

52

C1

Doctor let me talk without interruption

56

-22

-1

-12

-10

C3

Doctor interested in what I thought about the situation

36

-6

13

-20

-22

C4

I felt the doctor understood me

31

-2

17

-6

-1

B1

Doctor gave me information about my condition

20

-21

15

19

-2

B4

Doctor validated and ensured my relevant information

16

-9

-1

12

-18

C2

Doctor spent as much time as I needed

15

5

20

-16

-19

B2

Doctor referred me to where I can learn more about my condition

4

9

12

6

-9

B3

Doctor made sure I understood the information

1

-4

13

7

-2

A3

Doctor discussed the next step appropriate for me

-1

-6

0

-9

13

A2

Involved as much as I want to be with this doctor

-9

-11

4

-11

17

A4

Doctor set up a clear follow up plan with me

-13

-24

-8

-7

28

A1

Doctor encouraged to ask about what I didn’t understand

-38

-28

7

9

29

We do not yet know the reason for the strong performance of pairs of elements, and why some elements suppress each other, whereas other elements synergize with each other to create far stronger performances (e.g., B3 + D2; Doctor made sure I understood the information + Doctor listened carefully.) Fortunately, these Mind Genomics studies are straightforward experiments, easy and affordable to do, allowing the enterprising research to investigate these interactions in a systematic, structured way.

Mind-Sets in the Population

A key tenet of Mind Genomics is that for a topic area, no matter how granular, there may exist two or more alternative groups of ideas, mind-sets, representing alternative ways of thinking about what is important. The key here is that the mind-sets are combinations of ideas. At any one time an individual may be assigned to membership in one mind-set. There is no clear information about the lability of membership in mind-sets, i.e., whether over a lifetime a person may shift from membership in one mind-set to membership in another mind-set.

The mind-sets are hypothesized to exist and extracted from the raw data by a simple set of statistical processes coupled with interpretation.

  1. Individual Model: Each respondent generates a model relating the presence/absence of the elements to the ratings. The dependent variable is the rating, or now a binary transformation of the rating. The convention has been to divide the scale into two halves, with ratings of 1–6 becoming 0, and 7–9 becoming 100. This is similar to our division of the scale into 1–7 versus 8–9. For the preparation of data for clustering (the basis of mind-sets) we follow the convention, not the more stringent 1–7 and 8–9 bifurcation.
  2. Use All Coefficients: The 16 coefficients from the individuals’ model are used as inputs for the clustering.
  3. Clustering: A k-means clustering [54] first divides the respondents into two complementary and exhaustive sets and then afterwards repeats the task, dividing the respondents into three complementary and exhaustive sets. The separation into groups or clusters uses a ‘distance’ measure between each pair of respondents. The clustering places respondents into two or three groups so that the set of person-to-person distances within a cluster is small, but the distance between the different clusters is large. This process is purely mathematical and does not involve interpretation.
  4. Interpretation: The pattern of average coefficients across the 16 elements, tell us the ‘interpretability’ of the cluster. The clustering must ‘tell a story’ (interpretable) and be parsimonious. The fewer the number of clusters the better.
  5. Table 6 shows the summary data for the two mind-sets, for Top2 (Revisit/Recommend) and for Bot2 (Not Revisit/Not Recommend). We will look at the two mind-sets in reverse order of mind-set.

Table 6. The models for Top2, Bot2, and Response Time for the two mind-sets. Shown are only the strong performing elements for Top2 (coefficient > 9) and for Bot2 (coefficient > 7).

 

 

MS1

MS2

MS1

MS2

MS1

MS2

 

 

Top2: Revisit / Recommend

Bot2: Not-Revisit / Not-Recommend

Response Time

 

Additive constant

65

37

-2

6

NA

NA

 

Mind-Set 2 – Focused on empathy

 

 

 

 

 

 

D3

Doctor greeted me respectfully

-1

14

4

-1

0.9

0.9

C4

I felt the doctor understood me

-11

13

4

-2

0.9

1.1

D2

Doctor listened carefully

5

12

-2

5

0.4

1.5

C1

Doctor let me talk without interruption

-14

9

6

6

1.1

1.1

D4

Doctor focused on me and not on the computer

-5

9

2

2

0.6

0.7

Mind-Set 1 – Focused on Doctor providing information (it’s about authority)

A2

Involved as much as I want to be with this doctor

4

-4

-2

7

0.9

1.4

C3

Doctor interested in what I thought about the situation

-3

-4

0

8

0.6

0.6

Mind-Set 2 focuses on empathy. The additive constant is moderate [37]. It is the elements which do the work. These elements pertain to the emotional response to the situation, and the feeling that the doctor was focusing on the patient as a human being. At the same time, it is the doctor who listens but does not let the patient take control in terms of driving the diagnosis. Here are the strong elements which drive revisit/recommend. Mind-Set 1 at first appears to be generally ready to revisit/recommend, with an additive constant of 65. Nothing really seems to drive respondents in Mind-Set 1 to either to revisit/recommend or not. The coefficients are low. The key to Mind-Set 1 lies in the elements to which they attend, as revealed by the estimated response times. The response times for the elements below are the longest for Mind-Set 1.

Finding these Mind-Sets in the Population

Most studies in the emerging science of Mind Genomics do not find a simple co-variation of mind-sets and the straightforward measures of a person, such as age, gender, and even education or residence. There is no such thing as the mind-set of a so-called Millennial or GenX with respect to how they want the doctor to treat them. The popular press may give the impression that the different groups in the population, such as the aging Baby Boomers, the Echo Boomers, The Millennials, and the GenX can be identified by homogeneous but changing values. Some larger-scale studies with Mind Genomics on various topics for clients suggest that this is not the case. We cannot simply ‘know’ the mind-set to which a person belongs simply by knowing the age group to which the person belongs.

Recently, author Gere has created a technique using the average coefficients from the subgroups to assign new people to the mind-sets. The approach uses a Monte-Carlo simulation of alternative patterns of coefficients, based upon adding slight f ‘noise’ (random variation), and then determining which coefficients still best differentiate between two mind-sets or among three mind-sets. The results of the simulation create six questions based upon the elements, and two responses, or a total of 64 patterns. Each pattern ‘maps’ to one of either two mind-sets, or to one of three mind-sets, respectively.

Figure 2 shows the PVI. The respondent fills out the form and receives the information mind-set membership in a return email.

MIND GENOMICS 028_JCRM_f2

Figure 2. The PVI (personal viewpoint identifier) for this study.

Discussion

This study tested patient preferences while interacting with doctors. Findings stress patient’s expectations to be involved and to feel understood and being valued by the doctor.

  1. Respondents in Mind-Set 1 – patients expect the doctor to enhance their internal locus of control by providing them relevant, tailored, information clearly and making sure they understand the information the doctor provided. Mind-Set 1 expects the doctor to enable them to comfortably ask questions about what they didn’t understand.
  2. Respondents in Mind-Set 2 expect to feel that the doctor views them as equal, as a person, being sensitive to their feelings. Mind-Set 2 expects expect the doctor to greet them respectfully, to be empathic, to carefully listen to them and to understand them. They expect the doctor to listen to them without interrupting them.

Barriers to doctor-patient communication exist [55, 56]. Doctors, however, can improve their communication skills [57]. Findings call upon doctors to make a difference for patients by creating inspiration and trust through communication according to patient expectations by mind-sets, regardless of patient age, and gender. Although patients may understand their illness and health in general, they expect their doctors, as a medical authority, to inspire them to take greater responsibility for their health [58, 59]. Encouraging patients to be active in communication with their doctors will increase responsiveness, maintain patient trust and promote adherence and healthy behaviors. Doctor’s awareness to the communication a patient prefers will enable the doctor to choose between alternatives by mind-set segment to build trust and promote patients’ self-management of illness [60]. Focusing on communication skills which enhance patient’s internal locus of control greatly increases patients’ readiness to adopt behavioral changes [61]. These skills focus on process communication which deals with what patients believe will help them to take responsibility for their health rather than focus on the disease and explanations on what it is and ways of treating it.

Acknowledgement

Attila Gere thanks the support of Premium Postdoctoral Research Program of the Hungarian Academy of Sciences.

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Thoughts at a White Coat Ceremony

DOI: 10.31038/IMROJ.2019422

 

The first documented White Coat Ceremony was held 10 years after I entered medical school. Dr. Arnold P. Gold held his first White Coat Ceremony four years after that [1]. White Coat Ceremonies have spread throughout US medical schools and even internationally [2,3], largely through the support of the foundation established by Dr. Gold, his family and his colleagues [3]. I confess that when I first heard of these events sometime in the mid to late 1990s, the idea of presenting a white coat to entering medical students in a ceremony so that they would understand that they are beginning their entry into a profession, reminded me of an old Monty Python sketch. A middle-aged man with spectacles (not unlike me) goes into an employment office and asks if there are any job openings for a lion tamer. When asked about his qualifications, he pulls out a pith helmet and says, “I’ve got the hat”.

After I began attending White Coat Ceremonies in 2011, I realized my flippant initial reaction was unjust. I have come to appreciate White Coat Ceremonies as an opportunity for helping new students understand and embrace the values of the medical profession, with the white coat as a symbol of those values. Of course, the holistic admissions practices of most medical schools, at least in the US, aim to ensure that matriculated students possess many of the underlying humanistic qualities desired in physicians; and certainly, the students should understand that ultimately what makes one a physician is not the white coat but the person who is inside it.

However, even the apparently innocuous activity of the White Coat Ceremony has generated controversy. There was always some debate about the timing of the ceremony in the process of education: some schools would hold their ceremony at matriculation, while others might schedule it at the point in the curriculum where students shift from their preclinical studies to working in the clinics and wards. As earlier clinical exposure becomes more common, it is likely that White Coat Ceremonies held in the end of the second year of medical school will shift earlier in the educational process. More significant controversies revolve around the purpose and symbolism of the White Coat Ceremony itself.

For Dr. Arnold Gold, it seems clear that there was no intrinsic conflict between “humanism” and medical “professionalism” and the White Coat Ceremony represented both [3]. This perspective was certainly that held by physicians of his generation [4], and certainly is an aspirational goal even now. Even early in their history, White Coat Ceremonies were recognized as a tool for inculcating and teaching professionalism [5]. More recent commentators have argued that humanism, defined by values that are egalitarian and universal, has become distinct from professionalism, which may be parochial and culturally determined, and to at least some degree, self-interested [6]. It has also been suggested that the White Coat Ceremony is a defensive action by the medical profession, symbolizing a claim of entitlement in a world where physician leadership of healthcare is challenged [7]. Perhaps reflecting these perceived conflicts is a model in which a “profession-entry” ceremony is held early in the first year followed by a later “humanistic” ceremony including individual statements of values, a high level of student engagement, and artistic performances [2]. Most White Coat Ceremonies include recitation of some sort of commitment or oath: the meaning and appropriateness of such recitations has also been debated [8,9].

The widely discussed issue of physician burnout engages the issues reflected in debates about the appropriateness and meaning of White Coat Ceremonies. Challenges to the autonomy of the medical profession are not only of a financial or administrative nature, but also reflect challenges to the humanistic expectations of patient centeredness and empathy. For that reason, it has been suggested that the term “burnout” should be replaced by the term “moral injury” [10].

When I discuss these issues with students, either individually or in small group learning settings, I emphasize that medicine is one of the professions as traditionally defined. More specifically, it is one of the three characterized as “learned professions”. Medicine is also a vocation, or if one prefers, a “calling”. The word “vocation” derives from the same Latin root as “vocal”. It refers to something to which one is called or summoned, and accepting the call implies a commitment with attendant obligations. For medicine, the commitment is to the service of the patient. For each of us, the obligation is for that service always to reflect our best, with a further obligation that through lifelong learning we will strive to ensure that the gap between our best and the ever-shifting target of “THE best” is always small as circumstances permit. The White Coat Ceremony and the acceptance by a student of her or his first white coat symbolize recognition that they are beginning the path to that commitment and to the obligations that follow from it.

In thinking about these issues, I am reminded of things other than Monty Python. When I was in college, the US Navy ran a series of recruiting commercials with the tagline “It’s not a job, it’s an adventure”. Medicine is not just a job: it is a profession, a calling, a commitment. However, a lot of us believe it is also an adventure [11].

Adapted from remarks made at the James H. Quillen College of Medicine Class of 2022 White Coat Ceremony – July 20, 2018.  Dr. Means is a former dean of the College

The White Coat Ceremony was supported in part by the Arnold P. Gold Foundation.

References

  1. Gold A, Gold S (2006) Humanism in medicine from the perspective of the Arnold Gold Foundation: challenges to maintaining the care in health care. Journal of child neurology 21: 546–549.
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The Integrated Medicine route for women’s Health and oncology in the Local Health Unit (AUSL) of Bologna and in the Emilia-Romagna Region

DOI: 10.31038/IGOJ.2019243

Short Communication

In contemporary medicine hyperspecialistic and technological visions coexist with a widespread illiteracy about what is psychophysical wellbeing. People are looking for solutions that are able to take into account physical and mental illnesses as a whole. On the other hand, health professionals live the contradiction between the increase in scientific knowledge and the rigidity of the therapeutic intervention field. Among them the most common feeling is frustration, which comes out in fact from the feeling of being mechanicals of the body or of the brain rather than promoters or facilitators of human health.

This is particularly true in the field of women’s health and facing oncological diseases, where physical health is intertwined with personal, familiar, psychological and social aspects.

The integration proposal in the Emilia-Romagna Region and in the Local Health Unit of Bologna arises from these two discomforts: on the one hand from the need to know the effectiveness and the applicability of alternative and Complementary Medicine (CAM), according to the clinical efficacy criteria, within the services of the Local Health Unit and, on the other hand, from the request of women taking part in self-help groups for breast-operated women, who sought relief from side effects of adjuvant drugs.

Within the Local Health Unit of Bologna, the process of CAM integration in oncology and in the field of women’s health was born in 2004, together with the First Experimental Programme for the integration of CAM in the regional health system. Some study projects were proposed and carried out on women’s issues and with high social and health relevance.

First of all a pilot project exploring the effectiveness of acupuncture in a small group of women subjected to adjuvant therapy after breast cancer [1].

Then a survey on the free clinic services of the City of Bologna was carried out. The focus of the study was the use of CAM in women aged between 45 and 65 years (one year of observation) and the results showed that 30% of women used CAM professionals and/or CAM remedies, alone or together with replacement therapy. The survey, designed in collaboration with the University of Sydney, revealed a hidden side of CAM use and a trend that is still confirmed in the clinical reality [2,3].

Afterwards a pilot study about the use of a technique derived from acupuncture, the needle-injection in the acupuncture point SP 6 (Sanyinjiao) of Vitamin K1, in order to reduce menstrual pain in young women suffering from severe primary dysmenorrhea. At the beginning of menstrual pain, 19 young women (aged between 15 and 19 years) were treated. The method reduced pain (measured by VAS) by about 50% in acute and decreased the use of analgesic drugs; this result was kept reduced for about 4 months after the initial treatment [4].

In oncology, the results of the pilot project and of the AcCliMaT project have furthered the continuation of the works, throughout selection criteria that can be found in the Regional guidance document, which represents the theoretical basis and the reference methodological framework for the Third Regional Experimental Programme about CAM [1]. Starting from the criteria presented there, the choice of the study focus on the prevention / reduction / control of adverse events, related to non-physiological menopause(which represents a serious problem for the quality of life of women with breast cancer), has been privileged.

AcCliMaT Study Project

AcCliMaT is a pragmatic, randomized and controlled trial comparing acupuncture plus enhanced self-care versus enhanced self-care alone. A total of 190 women with breast cancer were randomly assigned. The acupuncture group received 10 traditional acupuncture treatment sessions, according to a therapeutic protocol derived from a consensus among the acupuncturists of the project group. Within the acupuncture treatment group, there was a reduction of the primary outcome, Hot Flash Score (HSF) that measures the intensity and frequency of hot flashes, significantly lower than the control group (46% difference between the two groups). The Menopause Quality of Life (MenQoL) questionnaire also showed a better quality of life in the group with acupuncture plus self-care; a result that tends to remain in the follow up.

The AcCliMaT study confirms what has been highlighted in literature: acupuncture represents a possibility of treating and improving the quality of life in post-intervention of women with breast cancer and the integration between acupuncture and self-care represents a further advantage for the reduction of hot flushes and for the control of the climacteric syndrome, improving the quality of life of women with breast cancer. This is the basis on which the project of Integrative Medicine in Oncology was set up [5].

Integrated Medicine in Oncology in Emilia-Romagna Region (Med.I.O.R.E.R.)

The Med.I.O.R.E.R project represents the link between the research phase and the construction of acupuncture services dedicated to women operated for breast cancer. It is a prospective, multicentre study evaluating a model of integration of CAM treatments in the oncology departments and services of the Healthcare Centres of the Emilia-Romagna Region and responds to the need, more and more frequently expressed by patients suffering from breast cancer, to reduce the side effects of chemo-radiotherapy and adjuvant therapy. The project aims at the construction of integrated medicine surgeries in which Traditional Acupuncture plus Self-care treatments will be offered. The Med.I.O.R.E.R. project involves the measurement of quantitative process indicators and the collection of qualitative data related to the satisfaction of both professionals and patients.

The Primary Outcomes: The Primary Outcomes are frequency of sending patients to the CAM surgery, effective use of the path by patients, compliance, average number of accesses per patient to the integrated medicine surgery and the number of patients included for each centre.

The Secondary Outcomes: The Secondary Outcomes are the level of integration of the Acupuncture plus Self-care intervention in the clinical oncological practice of the Healthcare Centres of the Emilia-Romagna Region, dedicated to the climacteric syndrome in women with breast cancer; the adequacy of the offer according to the demand (external pressure index); the adequacy of the integrated medical pathway within the organization (focus groups, interviews of integrated medicine).

Conclusion

The Integrated Medicine route in oncology goes on with great belief and satisfaction from professionals and women with breast cancer and demonstrates how the inclusion of CAM methods, supported by scientific evidence and local clinical experiences conducted with scientific criteria, represents an advantage for the quality of life of women with breast cancer. At the same time, it confirms what Zhang Xiaorui (WHO Coordination Officer) wrote on December 2000: “The scientific, safe and effective use of traditional medicine will certainly further promote the development of traditional medicine and traditional medicine will undoubtedly make more and more contributions to human health in the 21st century”.

References

  1. http://assr.regione.emilia-romagna.it/it/funzioni/mnc/doc-omncer
  2. Cardini F, LesiLombardoF,Van der Sluijs C (2010 )The use of complementary and alternative medicine by women experiencing menopausal symptoms in Bologna. BMC Women’s Health 10: 7.
  3. Corinnevander  Sluijs, Flavia L. Lombardo, GraziaLesi, Alan Bensoussan, Francesco Cardini (2013) Social and Cultural Factors Affecting Complementary and Alternative Medicine (CAM) Use during Menopause in Sydney and Bologna – Hindawi Publishing Corporation Evidence-Based Complementary and AlternativeMedicine 2013.
  4. Grazia Lesi, Annagiulia Gramenzi, Clarissa Frascà, Francesco Cardini, Clede Maria (2017) Acupuncture Point Injection of Vitamin K1 to Treat Severe Primary Dysmenorrhea: Case Series at a Women’s Health Service in Bologna. Garavini Chinese Medicine  8: 33–41.
  5. Grazia Lesi, GiorgiaRazzini, Muriel Assunta Musti, Elisa Stivanello, Chiara Petrucci, et al. Acupuncture As an Integrative Approach for the Treatment ofHot Flashes in Women With Breast Cancer: A ProspectiveMulticenter Randomized Controlled Trial (AcCliMaT) J Clin Oncol 4: 1795–802.

Aging and Care: Attitudes of undergraduate students towards elderly People

DOI: 10.31038/ASMHS.2019344

Abstract

Objectives: To consider and understand how the attitude toward elderly people among the adolescents, based on experience of interacting with or receiving assistance from elderly individuals. The study aims to analyze what kind of difference there is in the consciousness of the youth to the elderly by examining the relation between experience which contacts the elderly and support from the elderly in Japan.

Methods: The subjects were first-year students from four universities in Japan. This survey was used in this study concerns effect of experience interacting with the elderly on the attitude toward elderly people, based on the concept of the “attitude toward old people”(Kogan) model. Statistical evaluation of the data was included in variance analysis.

Results: Overall, 358 participants were surveyed, 125 males (34.9%) and 233 female (65.1%). The mean score Kogan for total participants 131.2±16.2. Those adolescents who had experience volunteer activities for the elderly, having cared for the elderly, having experience received caring from an older person were significantly high total score Kogan.

Discussions: The Attitudes of university students towards elderly people should be evaluated currently to be able to improve the provision of care for elderly people and to prevent possible negative beliefs through tracking elderly people.

Keywords

Attitudes toward Elderly, Experience with Older Adults, Supportive Relationship

Introduction

The ageing of the population is one of the challenging strategy of societies. Who would provide care for elderly people, may likely have a direct effect on the quality of care in the future. However, across the international studies support the gerontology as an adolescent is not a highly choicest aging care career [1]. Discovering the attitude of Japanese adolescents toward elderly people may help illuminate reasons gerontology is not a highly choicest career in Japan. It is reasonable to elucidate how the perception of elderly people, they are more likely to be educated in geriatric environment.

Therefore, it is responsible for educators and societies to understand the factors influencing adolescent attitude that drive adolescent’s experience of interacting with or receiving assistance from elderly individuals would be a good influence for positive attitudes to elderly people. The knowledge gained from this study can help guide aging related education program in Japan, thereby ensuring the developing of elderly care services of the growing elderly population. Japan’s aging rate is expected to reach about 40% in 2016 [2]. It is considered that there is a direct effect on the quality of the elderly support by how young people who shoulder the future elderly care in Japan of the declining birth rate perceive the elderly. In “Comprehensive Strategy for the Promotion of Policies for Dementia (2015)” [3] of the Ministry of Health, Labour and Welfare, it is important to examine what kind of value the young generation who shoulders the elderly care has for the elderly and what kind of education and enlightenment activity are necessary, because it is clarified that the understanding promotion to the elderly including the person of the dementia is positively taken in school education. In Japan, the majority of households are nuclear family units, however middle-age family member still plays an important role in the lives and assist care of elders. Younger family members do not live close to their elders and not interact with them.

Institutional care of elders in Japan is common, others are receiving home care services, day care support services, and Life support services at home. These services are developing in the world not only japan, but view augment between community-based caregiving and Institutional care [4]. Since the introduction of universal long-term care insurance (LTCI) in the spring of 2000,those aged 65 and over who need nursing care in their daily lives are eligible to receive the care services of LTCI. Consumers can choose the services and providers that they want. To that end, Japan has developed several services for elders who need care but the increase in the number of elderly people requiring LTCI, and associate costs of these services, are imposing a burden on our society. It has been reported that most institutions and service provider businesses face difficulties in their operation, specific human resource. From a health strategy for promoting understanding about elderly-including people with dementia in school education, examining the values of young people who are responsible for care of the elderly.

For the image of the elderly, it has been reported that the experience of living with the elderly is not an important determinant factor [5], the experience of interaction with the elderly, the frequency of interaction, the relationship and the way of involvement are related, and the attitude of parents and grandparents may also influence [6]. In addition, there is a tendency for people with little knowledge about dementia to have a positive image, and those who have experience of volunteering for elderly people with dementia to have a positive image compared to those without such experience. This indicates that not only knowledge about dementia, but also actual involvement with dementia may lead to a positive image.

Though it is clarified that studies which specialize affect the consciousness for the elderly of the youth, it is little examined from caring experience of the elderly, experience which received the care from the elderly. In this study, it was considered that it was necessary to examine the consciousness of the elderly by paying attention to both sides of the contact with the elderly such as learning which the youth specializes in experience, focusing on the university student who shifts from the adolescence to the adulthood. In this study, it was made that what kind of difference there is in the consciousness of the youth to the elderly by examining the relation between experience which contacts the elderly and support from the elderly. By this study, it aims at getting the suggestion for promoting the elderly understanding for the youth.

Methods

Study Sample

Participants for this study consisted of undergraduate students, who are first glade, at four universities in Japan. Students were selected using convenience sampling.

Measures

The demographic information included age, gender, department, status of cohabitation with elder people. Additional questions included experience regarding the elderly, whether presence/absence of volunteering experience with elder people, experience care for elder people, experience being taken care by elderly people, and perception about elderly care. The Japanese version of Kogan’s Attitudes towards Old People Scale (KAOP) was used in this survey. The response for favorable items and scored by assigning 1 point to “strong disagree”, 6 points to “strongly agree”, and the total positive items were calculated. A high score indicated a positive attitude toward elderly people.

Data Analysis

Descriptive statistics were used to report the demographic data. Statistical evaluation of the data was included in percentage, mean, Independent t-test was used to assess differences in score among categorical variables. A significant level of 0.05 was used for all analyses. SPSS Japanese version 25 was used for data entry and analysis.

Result

A convenience sample of 373 participants, among the responses excluding those with no responses to one or more items 358 responses were selected for the analysis. Participant characteristics are displayed in Table 1.

Table 1. Demographic characteristics of participants (N = 358)

Characteristic

n

% of Total Participants

Gender

Male

125

34.9

Female

233

65.1

Age

18–40

MEAN

18.96 ± 2.48

Subject Faculty

Nursing

157

43.9

Medical

95

26.5

Non-Health

106

29.6

Have experience living with an older person

156

43.5

Have experience living with a dementia older person

27

7.5

Have experience volunteer activities for an older person

131

36.5

Have experience caring for an older person

58

16.2

Have experience recieving from an older person

203

56.5

Age 18 to 40 years (M=18.96, SD=2.5), Sixty-five percent of the students were female and thirty-five percent of the students were male. Forty-three percent students have lived with the elderly. Thirty-six percent had experience of volunteer activities for the elderly, and caring experience for the elderly was sixteen percent, and the experience which received the care from the elderly was fifty-six percent.

The overall attitude score was in the positive direction (M=131.2, SD=16.2) with score ranging from a minimum of 57 to a maximum of 200 (Table 2). The participants’ mean score indicated slightly positive attitude toward elders. The mean total negative item score was 51.9 out of a possible highest score of 103. The mean total positive item score was 56.4 out of a possible score of 97. Both of these scores are within the range of positive attitudes according to Tomioka [7]. Total KAOP by sample characteristics used to assess the differences in mean score between and among variables, and significant differences were found. No significant differences were found in attitude scores within categories of living with elderly people, living with dementia elderly people. Those adolescents who had experience volunteer activities for the elderly, having cared for the elderly, having experience received caring from an older person were significantly higher total KAOP and negative item scores than those who had no having (Table 2).

Table 2. Total Kogan’s Attitudes toward Old People scale

Total KAOP

Negative Item Total

Positive Item Total

P

Median

Median

Median

Gender

Male

123.74

68.73

55.02

**

Female

135.25

78.12

57.13

Department

Nursing

135.52

78.31

57.21

**

Medicine

132.51

75.81

56.69

Non-Health

123.75

68.84

54.92

Living with an older person

Yes

131.61

75.34

56.23

ns

No

130.91

74.45

56.46

Living with a dementia older person

Yes

132.74

75.19

57.56

ns

No

131.08

74.81

56.28

Have experience volunteer activities for an older person

Yes

133.12

76.22

56.89

*

No

130.15

74.04

56.11

Have experience caring for an older person

Yes

134.43

78.16

56.28

*

No

130.66

74.23

56.43

Have experience recieving from an older person

Yes

131.16

75.25

55.91

*

No

128.64

72.68

55.96

** p<.01,* p<.05 ns:no significant

Discussion

Similar to the study conducted by Tomioka [7], Japanese college students’ attitude toward elderly in this study were generally slightly positive. Based on these results, Japanese adolescents exhibited a somewhat more positive attitudinal disposition toward elders than adolescents from other countries [8–10]. Previous study reported high negative attitude toward elderly people [8], however this study’s participants nurse and medical students have lower negative attitude than expected. Because the curricular emphases include gerontology and educational preparation given in many elementary schools and junior high school. In this study, students would be having experience volunteering activities with elderly people before college students. Female students held positive attitudes compared with male students. This finding was consistent with the majority of national and international studies. One factor might help explain the gender difference that the more caring nature of females [11].

The most statistically significant was interactive with elderly people through taking care for elderly or receiving care from elderly people. Those students who expressed tracking with elderly people had higher attitude scores, as seen in the study by Turgay et al. [12]. Therefore, continuing to be existing culture norms of respect and loyalty for elders may help positive attitudes of adolescents. Overall, these findings indicate that there is room for improvement in adolescent’ attitudes toward elderly people. The Attitudes of adolescents towards elderly people should be evaluated currently to be able to improve the provision of care for elderly people and to prevent possible negative beliefs through tracking elderly people. Educational preparation is a major factor in adolescent attitudes; therefore, gerontology education and experience connecting with elderly people should be important part of education curriculum.

References

  1. Brenda H, Jenny B (2001) Who will look after my Grandmother?. Journal of Gerontorogical Nursing 27: 12–17.
  2. Cabinet Office, Government of Japan (2012) Korei, kihon-kentoukai. Available at: http://www8.cao.go.jp/kourei/kihon-kentoukai/pdf/report-3.pdf
  3. Ministry of Health, Labor and Welfare (2015) Dementia policy promotion integrated strategy (new orange plan). Japan.
  4. William G, Cynthia M, Cready J & Pawelak E (2005) The Past and Future of Home and Community-Based Long-Term Care. A Multidisciplinary Journal of Population Health and Policy 83: 1468–0009.
  5. Hosaka K, Sodei T (1988) College student’s Image for the elderly-Analysis by SD Method. Journal Social gerontology 27, 22–33.(in Japanese)
  6. OkumuraY, Kuze J (2009) Factors related to the students’ image of elderly people- Comparison of the image of elderly with dementia and healthy elderly -, Journal of health sciences. Nihon Fukushi University 12: 31–38.(in Japanese)
  7. Tomioka H (2017) Attitude towards Aging and Old Adults among Japanese College Students-Its Relations to Aging Anxiety and Self-Efficacy-, Department Bulletin Paper. kyoikugakuronsyu 69: 61–79. (in Japanese)
  8. Matthew LS, Caroline DB, Clay C, SangNam A, Samuel DT, et al. (2017) Factors associated with ageist attitudes among college student, Geriatr Gerontol Int 17: 1698–1706.
  9. Alquwez N, Cruz JP, Almazan JU, Alamri MS, Mesde JJ (2018) The Arabic version of the Kogan Attitudes towards older People scale among Saudi nursing students; a psychometric analysis, Annuals of Saudi Medicine 38: 399–407.
  10. Bernardini Z, Moraru M, Kakache A, Macias N.(2008) Attitudes toward the elderly among students of health care related studies at the University of Salamanca, Spain. Journal of Continuing Education in the Health Professions 28: 86–90.
  11. Lambrinou E, Sourtzi P, Kalokerinou A, Lemonidou C (2009) Attitudes and knowledge of the Greek nursing students towards older people. Nursing Education Today 29: 617–622.
  12. Turgay AS, Sahin S, Aykar F, Sari D, Badir A et al. (2015) Attitude of Turkish nursing students toward elderly people. European Geriatric Medicine 6: 267–270.

A Systematic Review on the Effectiveness of Palmitoylethanolamide for the Treatment of Pain in Arthrogenic Temporomandibular Joint Dysfunction and Related Disorders

DOI: 10.31038/JDMR.2019243

Abstract

Arthrogenic temporomandibular joint dysfunction is a prevalent condition often associated with arthralgia. It is also commonly caused by osteoarthritis. Palmitoylethanolamide has been reported to exhibit analgesic, neuroprotective and anti-inflammatory effects in pain pathological conditions. This paper will critically appraise recent evidence on the effectiveness of palmitoylethanolamide for the treatment of pain in arthrogenic temporomandibular joint dysfunction and related disorders. This paper will assess both the magnitude and longevity of the analgesic effect of palmitoylethanolamide.

Method: An electronic database search was performed by two independent authors on the following databases: PubMed, Web of Science, Medline and Embase. A total of 23 articles were retrieved including relevant articles from reference lists. After the elimination of duplicates and further eligibility screening, a resultant total of 5 articles were suitable for review. One of these was a retrospective cohort study while the following 4 were randomised clinical trials. There was considerable heterogeneity of primary outcome variables and trial design across all selected studies which did not permit a meta-analysis of results.

Conclusion: Palmitoylethanolamide is effective for the treatment of pain in arthrogenic temporomandibular joint dysfunction and related disorders. However, the longevity of palmitoylethanolamide-induced analgesia remains unclear. Further high-quality trials are warranted to reveal the relative effectiveness of palmitoylethanolamide in comparison to current medication.

Keywords

Arthralgia, Pain, Palmitoylethanolamide, Temporomandibular Joint Dysfunction

Introduction

The Temporomandibular Joint (TMJ) is one of the most frequently used joints in the body. Over time, normal or parafunctional use can lead to the initiation of degenerative joint disease, [1]. Degenerative joint disease localised to the TMJ is termed: arthrogenic temporomandibular joint dysfunction (A-TMD), according to group III of the RDC/TMD, [2]. Current evidence shows that A-TMD accounts for 30% of all TMD cases, [3]. A-TMD has considerable global prevalence and accounts for a high proportion of socioeconomic costs, which are typically related with other psychological disorders, such as depression, [4,5]. A-TMD is a growing public health concern due to its debilitating repercussions on essential orofacial functions such as mastication, speaking and swallowing, [6], which in amalgamation with psychological comorbidities can ultimately impede patient quality of life.

Osteoarthritis (OA) is the most common degenerative TMJ disease associated with A-TMD, affecting 50% of individuals beyond the age of 65 years and existing in adolescents following TMJ trauma, [7,8]. The pathogenesis of OA involves a cascade of aberrant biomechanical alterations in the tissues of the joint that subsequently triggers the immune response. Immune cells instigate an inflammatory response by secreting various inflammatory mediators, [9]. The process is coupled with the activation and release of cartilage degrading factors such as matrix metalloproteinase and prostaglandin E which further damage the articular cartilage, [10]. This results in articular cartilage degradation and remodelling of the subchondral bone, causing chronic pain with a central sensitisation component in most cases, [11].

Sensory innervation of the TMJ is derived from the mandibular (V3) branch of the trigeminal cranial nerve. The inferior alveolar nerve (a branch of the mandibular nerve) provides sensory innervation to the mandibular dental arch, which is itself the third branch of the trigeminal nerve. Therefore, orofacial trauma in the mandibular vicinity can give rise to referred pain in the TMJ, [12].

Current pharmacological treatment of A-TMD quintessentially entails the use of acetaminophen or NSAIDs. Several studies have revealed that acetaminophen provides negligible short-term benefit for patients with OA, [13,14]. NSAIDs have proven to be more effective for pain relief than acetaminophen for patients with arthralgia, [15,16]. Despite the superior effectiveness of NSAIDs to acetaminophen, it is well-documented that long-term NSAID overuse has been associated with increased likelihood of adverse side effects such as gastric and cardiovascular complications [17,18]. Considering this, there is an urgent need to develop innovative drugs that produce both significant analgesic effects and minimal side effects.

Palmitoylethanolamide (PEA) is an endogenous N-acylethanolamine and is analogous to the endocannabinoid anandamide, [19] but without psychotropic influences. PEA has been described to induce analgesic, neuroprotective and anti-inflammatory effects in previous studies involving acute and chronic pain states, [20,21]. The precise mechanism of action of PEA is not entirely understood, although it has been posited that PEA may interact with peroxisome proliferator-activated receptor (PPAR)-α which exhibits anti-inflammatory effects, [22]. The literature also suggests that PEA mimics an endogenous ligand for the CB2 receptors, [23], which mediates analgesic effects in neuropathic pain states, [24]. The beneficial effects of PEA have been demonstrated in previous studies either alone or in combination with a different drug [25,26]. In this regard, PEA shows promising results for an innovative pharmacological intervention. However, the paucity of knowledge on the duration of the treatment effect derived from PEA warrants further investigation.

This systematic review aims to critically appraise evidence on the effectiveness of PEA for the treatment of pain in arthrogenic temporomandibular joint dysfunction and related disorders. Both the magnitude and longevity of the analgesic effect of PEA will be assessed.

Methods

This systematic review is grounded upon the recommendations of the PRISMA statement for systematic reviews, [27].

Data Sources and Search Strategy

An electronic literature search was conducted on the following databases: PubMed, Web of Science, Medline and Embase up to 14 July 2019, with no restrictions on the publication language or date. The key words inputted in this search were: Arthralgia; pain; palmitoylethanolamide and temporomandibular joint dysfunction. (Table S1) depicts the search terms and strategy (see supporting information). The reference list of provisionally selected studies was manually reviewed to identify studies that were absent from the electronic databases and were then included for further screening. We methodically contacted corresponding authors for studies with partial data [28–32].

Eligibility Criteria and Study Selection

The inclusion and exclusion criteria for study selection are itemised in (Table 1). Titles and abstracts of all studies found from the database search were manually screened for compatibility with the inclusion criteria by two review authors.  Data was extracted based on the nature of participants’ TMD, type of intervention, comparison or control interventions, relevant outcome variables and study design.

Table 1. Eligibility criteria for study selection.

Inclusion criteria

Exclusion criteria

Participants

1. Active A-TMD

2. Osteoarthritis

3. Orofacial trauma

1. Mixed TMD

2. Myogenic TMD

Experimental Intervention

PEA

Non-PEA treatment

Comparison or control intervention

1. NSAIDs

2. Opiates

3. Muscle relaxants

4. Analgesics

5. Benzodiazepines

6. Anticonvulsants

N/A

Primary outcome variable

Pain

Non-pain related

Study design

All designs

N/A

Notes: N/A: Not applicable, NSAID: Non-steroidal anti-inflammatory drugs PEA: Palmitoylethanolamide, TMD: Temporomandibular joint dysfunction

After selecting studies based on eligibility criteria, the kappa coefficient (k) for agreement among the reviewers was k = 0.937.

Data collection

A standardised proforma was used to systematically cumulate data on the type of study design, participant characteristics, intervention and control or comparison characteristics, primary outcome variables, and follow-up intervals if present. Additional pertinent data such as the funding source, potential conflict of interests between authors and reported risk of bias was also collected.

Risk of Bias and Quality Assessment

The risk of bias (RoB) and subsequent methodological quality of the selected studies was ascertained according to the Cochrane Risk of Bias Tool, [33] by two independent reviewers. The tool was used to assess bias from the following domains: random sequence generation, allocation concealment, blinding of participants and personnel, blinding of outcome assessment, incomplete outcome data, selective reporting, and other bias. Each domain was scored as either ‘low’, ‘high’ or ‘unclear’ RoB for each respective study. The overall RoB in a study was categorized as high quality if all criteria were scored as ‘low’ RoB; moderate quality if only one criterion was scored as ‘high’ RoB or if two criteria were scored as ‘unclear’ RoB and Low quality if two or more criteria were scored as ‘high’ RoB or if at least three criteria possessed ‘unclear’ RoB, [33].

Discrepancies in overall RoB classifications for each study between reviewers was settled by providing supporting reasons and a final consensus was reached. After critical appraisal of selected studies, there was a final agreement of k = 0.884 between reviewers.

Patient involvement

No patients with A-TMD were involved in the conceptualisation or completion of this review, assessment of outcomes, interpretation of findings, or editing of the manuscript.

Results

As shown in (Figure 1), 21 studies were obtained from the initial electronic database search and 2 additional studies were later found from a manual search of reference lists. After the elimination of duplicates, screening titles, abstracts and full texts, 5 studies with a cumulative total of 227 trial participants were included in this review.

JDMR-19-129-Immanuel _UK_F1

Figure 1. PRISMA flowchart of study selection.

Study characteristics

Details on the key characteristics of the 5 eligible studies are provided in (Table 2). A total of 4 randomised clinical trials (RCTs) and 1 retrospective cohort study were retrieved. Of the 185 participants who were randomised, 108 (58%) were assigned to receive PEA. The mean sample size was 45.4 (range: 24–111). The mean age of participants in human trials was 40.5 years (range: 18–60) and the median proportion of male individuals was 41.6% (range: 33–47%). No follow -up assessment was detected in 4 studies, yet a single study, [28] showed a follow-up period ranging from 3 to 7 days.

Table 2. Characteristics of selected studies.

Author(s), date, country

Participant characteristics

PEA Intervention

Comparison/ Control intervention

Assessment interval(s)

Outcome variable(s)

Bacci et al, 2011

Italy

Condition: Bilateral impacted lower third molar extractions

Treatment + control group combined:

n = 30

Total M: F = N/D

Mean age of total participants = 24.00 ± 21.21

m-PEA tablet

Dose: 300mg x2 tablets per day for 15 days

Unilateral impacted lower third molar extraction without m-PEA

Measurement at baseline, Follow-up at 3 days post-surgery and 7 days post-surgery

Pain assessed by VAS

Marini et al, 2012

Italy

Condition: TMJ osteoarthritis and arthralgia

1.PEA group: n = 12

2.Control group: n = 12

Total M: F = 8:16

Mean age of total participants = 39.00 ± 15.00

PEA tablet

Dose: 300mg in morning and 600mg in evening for days. Then 300mg x2 per day for 7 days.

Ibuprofen

Dose: 600mg x3 per day for 14 days

Measurement at baseline, day 1 before treatment and day 14. No follow-up.

Pain assessed by VAS

Bartolucci et al, 2018

Italy

Condition: Induced TMJ inflammation in rats

1.Sham group: n = 10

2.Sham + PEA: n = 10

3.CFA + vehicle: n = 10

4.CFA + PEA: n = 10

Total M: F = N/A

Mean age of total participants: N/A

Intraperitoneal m-PEA administration in:

1.Sham +PEA group

2.CFA + PEA group

Dose: 10 mg/kg

1.Sham group (Saline injection into left TMJ capsule)

2.CFA + vehicle group (50 µl of CFA injection into left TMJ capsule)

Measurement at 24 hours and 72 hours post-injection respectively. No follow-up.

Mechanical allodynia threshold

Marini et al, 2018

Italy

TMJ osteoarthritis and arthralgia

1.um-PEA + celecoxib group: n = 6

2.um-PEA group: n = 6

Total M: F = 5: 7

Mean age of total participants: 42.50 ± 24.75

um-PEA tablet + celecoxib tablet

Dose: um-PEA 600mg x1 + celecoxib 200mg in the morning and 200mg in the evening for first 4 days. Then, 600mg um-PEA daily for 14 days

um-PEA tablet (600mg for 14 days)

Measurement at baseline and each day for 14 days. No follow-up.

Pain assessed by VAS

Steels et al, 2019

Australia

Knee osteoarthritis

1.300mg PEA group: n = 36

2.600mg PEA group: n = 35

3.Placebo group: n = 40

Total M: F = N/D

Mean age of total participants: 57.00 ± 26.87

1.300mg PEA tablet group

Dose: 150mg x2 per day for 8 weeks

2.600mg PEA tablet group

Dose: 300mg x2 per day for 8 weeks

Placebo group (received maltodextrin x2 per day for 8 weeks)

Measurement at baseline, day 2, week 1, week 4 and week 8. No follow-up.

Pain assessed by NRS

Notes: CFA – Complete freund’s adjuvant, N/D – Not detected, NRS – Numerical rating scale, VAS – Visual analogue scale, m-PEA – Micronised palmitoylethanolamide, PEA – Palmitoylethanolamide, um-PEA – Unmicronised PEA.

The overall quality was moderate for 3 studies (60%) and low quality for 2 studies (40%). (Figure 2) shows the cumulative RoB on each RoB criterion presented as a percentage across all selected studies. More specifically, the risk of selection bias (sequence generation and allocation concealment) was unclear for 30% of studies and low for 70% of studies. The risk of performance bias (blinding of patients and investigators) and detection bias (blinding of investigators) was low for 20% and 10% of studies, respectively. Lastly, 60% of trials presented with low RoB for incomplete outcome data. Overall, we have interpreted the results of the included studies with moderate confidence in the quality of the studies in question. (Table 3) shows a comprehensive assessment of the RoB for each study. Figure 2 depicts the proportion of RoB for each criterion across all selected studies.

JDMR-19-129-Immanuel _UK_F2

Figure 2.A cumulative risk of bias graph representing the reviewer’s findings on each risk of bias criterion presented as a percentage across all selected studies in the literature review.

Table 3. Methodological quality appraisal of selected studies and associated risk of bias.

Study
(Author and year)

Random sequence generation

Allocation concealment

Blinding of assessors and participants

Blinding of outcome assessment

Incomplete outcome data

Selective reporting

Other bias

Overall quality rating

Bacci et al, 2011

Low

Unclear

High

Unclear

Low

Low

Low

Moderate

Marini et al, 2012

Low

Low

Low

Low

Low

Low

Unclear

Moderate

Bartolucci et al, 2018

Low

Unclear

High

Unclear

High

Low

High

Low

Marini et al, 2018

Low

Unclear

Unclear

Unclear

Unclear

Low

High

Low

Steels et al, 2019

Low

Low

Low

Unclear

Low

Low

High

Moderate

Notes: ‘High’, ‘low’ or ‘unclear’ risk of bias RoB.

Arthrogenic TMD

Three studies, [29,31,32] addressed the effectiveness of PEA on A-TMD. The participant eligibility criteria used for 2 of the 3 studies, [29,31] were based on group III of the Research Diagnostic Criteria for TMD (RDC/TMD). All 3 studies concluded that PEA is useful for attenuating A-TMD-related pain and few studies revealed that PEA is superior to common NSAIDs in pain reduction, [29,31]. All 3 studies concluded that PEA is an effective treatment for TMJ pain associated with A-TMD. Further details are shown in Table 2.

Osteoarthritis

One study, [30] investigated the effectiveness of PEA for the treatment of pain in patients with knee OA. As previously mentioned, the data from this trial is applicable to A-TMD due to the similar pathophysiology and symptomatology of both conditions. Steels et al, [30] implemented comprehensive eligibility criteria which only included patients with moderate knee OA and were medically stable. The study ultimately concluded that PEA is effective for pain attenuation in knee OA, and as such this finding is generalisable to A-TMD.

Orofacial pain

One study, [28] investigated the effectiveness of PEA following bilateral tooth extraction. Again, as previously stated, the data from this trial was deemed to be pertinent to A-TMD and provide further evidence to support or negate the effectiveness of PEA in pain reduction. The participant eligibility criteria were based on signs and symptoms as well as radiographic dentition assessment. This study also concluded that PEA demonstrated an ameliorative effect on orofacial pain.

Adverse events

The medical literature shows that PEA is well-tolerated by human subjects. A total of 2 separate mild adverse events were reported by 2 individual participants treated with 300 mg of Normast™ after an impacted molar tooth extraction, [28]. This represents an incidence risk of 0.88% across the pooled sample size of selected studies (227) and is therefore insignificant. One patient reported a transient episode of drowsiness after Normast™ treatment. Another patient reported a 2–3-hour episode of cardiac palpitations on the third day of the trial. This arose 1 hour after Normast™ administration, and subsequently the patient dropped out of the trial after this incident. This patient’s medical history showed evidence of cannabinoid use. Hence, it is therefore logical to suggest that the symptom reported by this patient was due to the synergic effect of PEA and tetrahydrocannabinol. The low rate of adverse events for PEA is encouraging, however we cannot definitively conclude whether the low incidence of adverse events depicts a true low risk based on the few published studies.

Discussion

Principal findings

In the present systematic review, we merged data from 5 studies involving 227 participants. These studies generally used a small sample size, with the largest consisting of 111 patients. Based on RCTs at moderate and low risk of bias, we discovered moderate to high quality evidence that PEA has a significant effect on pain reduction in A-TMD. This finding was also corroborated by a single animal study, [32]. However, the longevity of this analgesic effect remains inconclusive due to the dearth of trials that include a follow-up period.

PEA effectiveness

This systematic review shows that offering PEA to patients with A-TMD and associated conditions, may prove to be an effective pharmacological intervention to enhance clinical outcomes. All 5 studies in this review concluded that PEA was indeed effective for pain reduction.

Firstly, Bacci et al, [28] found that on the third day after extraction, the mean VAS recorded by the Normast™ group was 3.8 ± 3.09 cm, whereas the control group showed a change of 5.5 ± 2.42 cm. Similarly, this trend continued at the 7-day follow-up interval with the mean VAS for the Normast™ group inferior compared to the control group at 1.0 ± 1.82 cm and 1.5 ± 2.18 cm respectively. Despite this positive finding, the authors did not report a power calculation and the study used a small sample size of 30 participants, of which only 26 completed the protocol. Consequently, the small sample size may have increased the prospect of detecting a false-positive (Type II error) result, which reduces the power of the study. Although a strength of this study, was the implementation of a rigorous screening protocol and assessment for homogeneity of baseline characteristics which may have diminished the effect of confounding bias on the summative results.

In addition, the results of the study by Marini et al, [31] showed that VAS scores decreased to 37.42 ± 0.36 mm and 7.69 ± 0.16 mm in the ibuprofen and PEA groups respectively by the end of treatment. The difference between the mean VAS values at baseline and those obtained at treatment cessation between both groups was statistically significant (p = 0.0001). However, a limitation of this study was the short trial duration (14 days) and as such, there is uncertainty whether the favourable findings are sustainable in treated individuals in the long-term.

Another study by Marini et al, [29] showed a gradual decline in pain intensity following the administration of Celecoxib + um-PEA. Mean VAS scores reduced from 71.08 ± 8.7 mm at baseline to 5.5 ± 2.1 mm at treatment cessation, so the decrement in mean VAS score over time was vastly significant (p = 0.0001). However, the authors failed to report or potentially omitted data on the results for the um-PEA alone group and as such, it is difficult to deduce if um-PEA caused the statistically significant results observed. Yet, other similar studies have discovered significant results in favour of PEA. Thus, in this case, um-PEA was likely to have induced the significant analgesic effect in this trial.

Furthermore, Steels et al, [30] revealed that NRS pain scores were significantly reduced in the 300 mg PEA group (p = 0.0005) and 600 mg PEA group (p < 0.001) compared to the placebo group. In the 300 mg PEA group, there was a considerable increase in the number of participants that no longer experienced pain during the study (baseline, n = 8; week 1, n=15; week 4, n=17; and week 8, n=21). A similar trend was also observed for the 600 mg PEA group (baseline, n=9; week 1, n=14); week 4, n=23; and week 8, n=24). Overall, both groups demonstrated a 163% and 167% increase in absolute pain resolution respectively. However, the placebo group showed negligible dissimilarity in the number of patients that no longer experienced pain during the trial (baseline, n=13; week 1, n=14; week 4, n=11; week 8, n=11). This discrepancy highlights the marked effectiveness of PEA in pain attenuation for arthralgia.

The findings in the animal study by Bartolucci et al, [32] were considered with less weighting in this review due to both the limited validity of the trial design and the use of an unconventional outcome variable which made comparisons with other studies challenging. Despite this, the study did provide ancillary evidence as to the effectiveness of PEA. The authors reported that CFA-injected rats (induced A-TMD) treated with m-PEA, displayed reduced orofacial mechanical allodynia in comparison to the CFA-vehicle group. A criticism of this study resides in the difficulty to extrapolate these findings to human subjects due to the significant disparity in pharmacokinetics of PEA and dosage regimens in both species, conceivably leading to variation in effectiveness and toxicity of the drug. However, a benefit of this study is that it supports the superiority of m-PEA over um-PEA which will ultimately inform future human trials.

Strengths and limitations of this study

This systematic review is the first to investigate the effectiveness of PEA for the treatment of pain in A-TMD and related disorders. This review possesses several strengths. Firstly, we conducted a rigorous and extensive literature search, contacted several authors, and meticulously examined the reference lists of all provisional studies to find relevant articles. Therefore, the likelihood that a trial was missed, in the presence of an already limited evidence base, was low. Additionally, most included studies involved participants with similar characteristics that would be observed in clinical practice. Therefore, the results from this review is generalizable to the clinical population.

However, we acknowledge several limitations in this review. Solely studies published in peer-reviewed journals and in the English language were selected for review which may predispose our findings to publication bias. There may also be the potential for confirmation bias, owing to the selection and interpretation of data which validates pre-existing hypotheses. However, the utilisation of a systematic search strategy, methodological quality appraisal and independent reviewers may assuage this matter. Another short coming was the inclusion of trials whereby a placebo control group was absent, lacked blinding or possessed obscure blinding protocols. Such drawbacks may perhaps cause the gauged benefits of PEA to be understated or overestimated. Additionally, the significant heterogeneity in trial design, outcome variables and PEA formulation did not permit a meta-analysis, and therefore the clinical significance of PEA could not be assessed.

Implications for future research

The clinical data regarding the effectiveness and tolerability of PEA are promising, yet further randomised clinical trials are necessary to reveal the clinical significance of PEA on a larger scale. Due to the shortcomings of the included trials in this systematic review, we recommend several developments for future research on this topic: 1) Use randomised, placebo-controlled trial design to facilitate unbiased measurements on the effectiveness, tolerability and longevity of PEA ; 2) Consistent and complete reporting of adverse events in all study groups; 3) Conduct cost-effectiveness analysis such that the quality-adjusted life years can be established and inform policy makers ; 4) Implement trial follow-up assessments to assess the longevity or potential long-term side effects of PEA treatment;  5) Ensure trials are sufficiently powered, with statistically satisfactory homogeneity in outcome variables and participant characteristics to permit future meta-analyses; and 6) Conduct head-to-head comparisons with current medication to discover the relative effectiveness of PEA and further inform policy makers.

Conclusion

This systematic review imparts introductory evidence that PEA is effective for the treatment of pain in A-TMD and related disorders. The findings from this review are promising as PEA demonstrates a superior analgesic effect to some NSAIDs, yet the longevity of this effect remains indeterminate. Further high-quality trials with follow-up assessments are warranted to compare the effectiveness of PEA relative to various medications currently used for the treatment of pain in A-TMD.

Acknowledgement

We thank the authors of selected studies who provided clarification of their trials for this systematic review.

Abbreviations

A-TMD:

Arthrogenic temporomandibular joint dysfunction

M-PEA:

Micronised PEA

NSAID:

Non-steroidal anti-inflammatory drug

OA:

Osteoarthritis

PEA:

Palmitoylethanolamide

PRISMA:

Preferred Reporting Items for Systematic Reviews and Meta-Analyses

RCT:

Randomised clinical trial

RDC/TMD:

Research Diagnostic Criteria for Temporomandibular joint disorders

RoB:

Risk of bias

TMD:

Temporomandibular joint dysfunction

TMJ:

Temporomandibular joint

Um-PEA:

Unmicronised PEA

VAS:

Visual analogue scale

Table S1. Literature search terms and strategy

Database (search date)

Search

PubMed (14 July, 2019)

(palmitoylethanolamide OR Palmitoylethanolamide OR PEA) AND (temporomandibular joint dysfunction OR TMD OR temporomandibular joint disc disorder) AND (pain OR arthralgia)

Web of science (14 July, 2019)

(Palmitoylethanolamide OR PEA) AND (temporomandibular joint dysfunction OR temporo-mandibular disorder TMD OR TMJ)

Medline (14 July, 2019)

(Palmitoylethanolamide OR PEA) AND (TMD OR TMJ OR temporo-mandibular disorder OR temporomandibular joint dysfunction)

Embase (14 July, 2019)

#1 TMJ OR TMD OR temporomandibular AND joint OR ‘temporo-mandibular’ AND joint OR ‘temporo-mandibular’ AND disorder

#2 ‘palmitoylethanolamide’ OR PEA AND ‘Palmitoylethanolamide’

#1 and #2

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Recent trends and future challenges in the biomechanics of soft active materials

DOI: 10.31038/NAMS.2019234

 

Contemporary research in Mechanics involves profound crosstalk among historically different disciplines such as Biology, Medicine other than more traditional ones, e.g. Mathematics and Engineering. Such an interaction emerged as a novel, vigorous and highly productive discipline, namely Biomechanics [1]. In the last twenty year, theoretical and computational foundations in Biomechanics have been posed starting from cornerstone experimental campaigns [2]. Interestingly, as our understanding of the behavior of biological tissues increased, novel and more challenging questions arise [3–7]. In particular, the today challenge faces the theoretical and computational modeling of soft active materials, which inherently involve a sophisticated multiphysics setting [4–19]. To further complicate the scenario, state-of-the-art experimental imaging allowed us to understand the microstructural organization of soft media better at different scales [20–23]. As a consequence, scientific attention is needed for the quantitative characterization of spatio-temporal multiscale features implicated in the behavior of active biomaterials [24–26].

The present short commentary aims at stimulating a vast and variegate community to enforce more scientific energies towards such a challenging arena involving a quantitative understanding of complex materials. The prerequisite is a multi-and cross-disciplinary attitude implementing the interaction among different communities that must mutually influence each other. New groundbreaking ideas are expected to arise from these interactions finally resulting in significant advances in both theoretical, computational and applied science. A profound understanding of soft active materials represents a unique opportunity to introduce novel methodologies in urgent social contexts. Renewable energies [27], recycling processes [28], biocompatible and miniaturized sensors for next-generation biomedical devices [29], innovative pharmaceutical products and therapies [30] are only a few examples. Future human-related sustainability is tightly linked to our understanding of complex biological phenomena to be imitated in intelligent engineering applications.

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