Abstract

Interaction of polycystin-1 (PC1) and Gα12 is important for development of kidney cysts in autosomal dominant polycystic idney disease (ADPKD). The integrity of cell polarity and cell-cell adhesions (mainly E-cadherin-mediated adherens junction) is altered in the renal epithelial cells of ADPKD. However, the key signaling pathway for this alteration is not fully understood. Madin-Darby canine kidney (MDCK) cells maintain the normal integrity of epithelial cell polarity and adherens junctions. In other predicting model achieved an MCC of 0.915 and a sensitivity of 87.9% at the specificity level of 99.8% for 10-fold cross-validation test, and achieved an MCC of 0.895 and a sensitivity of 95.7% at the specificity level of 95.4% for independent set test. Here, in Biogenea Pharmaceuticals Ltd we discovered for the first time the GENEA-PolyGadherin-76112. A Rationally designed of Polycystin-1 and Gα12 poly-mimic pharmacophoric agents for the potential and future drug-based regulation of the cleavage of E-cadherin in kidney epithelial cells utilizing computer-aided Predicting netResearch and a BiogenetoligandorolTM based Scientific Project of drug-enzyme interaction on machine learning method