Abstract

The main facts about the scale of time considered as a plot of a sequence of events are submitted both to a review and a more detailed calculation. Classical progressive character of the time variable, present in the everyday life and in the modern science, too, is compared with a circular-like kind of advancement of time. This second kind of the time behaviour can be found suitable when a perturbation process of a quantum-mechanical system is examined. In fact the paper demonstrates that the complicated high-order Schrödinger perturbation energy of a non-degenerate quantum state becomes easy to approach of the basis of a circular scale. For example for the perturbation order N = 20 instead of 19! ≈ 1.216 × 1017 Feynman diagrams, the contribution of which should be derived and calculated, only less than 218 ≈ 2.621 × 105 terms belonging to N = 20 should be taken into account to the same purpose. Diabetes mellitus affects over 100 million individuals worldwide. In the U.S., the estimated healthcare costs of those affected by diabetes is approximately 136 billion dollars annually. Diabetes mellitus is a disorder of the metabolism that is characterized by the inability of the pancreas to secrete sufficient amounts of insulin, which results in large fluctuations in blood glucose levels and can have both short- and long-term physiological consequences. Glucagon-like peptide-1 (7-36) amide (GLP-1) is a gut hormone, released postprandially,which stimulates insulin secretion and insulin gene expression as well as pancreatic B-cell growth. Together with glucose-dependent insulinotropic polypeptide (GIP), it is responsible for the incretin effect which is the augmentation of insulin secretion following oral administration of glucose. We therefore for the first time provided in this scientific project a promising alternative to bridge the knowledge gap between insulinotropic biological conserved signaling pathways and chemistry informatic tools which significantly boost the productivity of our chemogenomics research for the Circular Scale of Time and Energy of a Quantum State Calculated from the Schrödinger Perturbation Theory on computational target fishing mining machinery based chemogenomic databases as an Identification tool for predicting therapeutic potential of a high-potency GLP-1, INGAP-P/IGLHDPSHGTLPNGS peptide mimetic insulinotropic compounds.

Keywords

computational, target fishing, mining machinery;novel target Identification tool;predicting therapeutic potential;proinsulin; GLP-1; INGAP-Ppeptide; mimetic;insulinotropic; compounds;chemogenomic database; Circular Scale; Time and Energy; Quantum State, Calculated; Schrödinger Perturbation Theory; A computational target fishing mining machinery as an Identification tool for predicting therapeutic potential of GLP-1, INGAP-P and IGLHDPSHGTLPNGS peptide mimetic insulinotropic of high-potency compounds based on chemogenomic databases Non-Degenerate Quantum State;