Abstract

We investigate the quantum discord of a two-qubit anisotropy XXZ Heisenberg chain with Dzyaloshinskii-Moriya (DM) interaction under magnetic field. It is shown that the quantum discord highly depends on the system’s temperature T, DM interaction D, homogenous magnetic field B and the anisotropy Δ. For lower temperature T, by modulating D and B, the quantum discord can be controlled and the quantum discord switch can be realized. Wilms’ Tumour 1 (WT1) is a zinc finger transcription factor that is overexpressed in acute myeloid leukaemia (AML). Its restricted expression in normal tissues makes it a promising target for novel immunotherapies aiming to accentuate the cytotoxic T lymphocyte (CTL) response against AML. It has been previously reported a phase I/II clinical trial of subcutaneous peptide vaccination with two separate HLA-A2-binding peptide epitopes derived from WT1, together with a pan-DR binding peptide epitope (PADRE), in Montanide adjuvant. Here, in Biogenea we have for the first time discovered an in silico Quantum Discord of a Two-Qubit Anisotropy XXZ Heisenberg Chain with Dzyaloshinskii-Moriya Interactions on a designed Fusion Inhibitor consisting of five cancer filtered conserved pharmacophoric chemical fragments with Greatly Promising Pharmaco-Mimic Properties to a Rationally Engineered Wilms’ Tumor Peptide as a future computer generated hyper-molecule for the potential treatment of the acute myeloid leukemia.

Keywords

in silico; Fusion Inhibitor; cancer filtered; conserved pharmacophoric; chemical fragments; Pharmaco-Mimic; Rationally Engineered; Wilms’ Tumor; Peptide; computer generated; hyper-molecule; acute myeloid leukemia;Quantum Discord, Heisenberg Chain, Dzyaloshinskii-Moriya Interaction, Anisotropy, Magnetic Field