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Abstract

We investigate the quantum discord of a two-qubit anisotropy XXZ Heisenberg chain with Dzyaloshinskii-Moriya (DM) interaction under magnetic field. It is shown that the quantum discord highly depends on the system’s temperature T, DM interaction D, homogenous magnetic field B and the anisotropy Δ. For lower temperature T, by modulating D and B, the quantum discord can be controlled and the quantum discord switch can be realized. Wilms’ Tumour 1 (WT1) is a zinc finger transcription factor that is overexpressed in acute myeloid leukaemia (AML). Its restricted expression in normal tissues makes it a promising target for novel immunotherapies aiming to accentuate the cytotoxic T lymphocyte (CTL) response against AML. It has been previously reported a phase I/II clinical trial of subcutaneous peptide vaccination with two separate HLA-A2-binding peptide epitopes derived from WT1, together with a pan-DR binding peptide epitope (PADRE), in Montanide adjuvant. Here, in Biogenea we have for the first time discovered an in silico Quantum Discord of a Two-Qubit Anisotropy XXZ Heisenberg Chain with Dzyaloshinskii-Moriya Interactions on a designed Fusion Inhibitor consisting of five cancer filtered conserved pharmacophoric chemical fragments with Greatly Promising Pharmaco-Mimic Properties to a Rationally Engineered Wilms’ Tumor Peptide as a future computer generated hyper-molecule for the potential treatment of the acute myeloid leukemia.

Keywords

in silico; Fusion Inhibitor; cancer filtered; conserved pharmacophoric; chemical fragments; Pharmaco-Mimic; Rationally Engineered; Wilms’ Tumor; Peptide; computer generated; hyper-molecule; acute myeloid leukemia;Quantum Discord, Heisenberg Chain, Dzyaloshinskii-Moriya Interaction, Anisotropy, Magnetic Field

Article Type

Research Article – Abstract

Publication history

Received: Sep 20, 2017
Accepted: Sep 25, 2017
Published: Oct 01, 2017

Citation

Grigoriadis Ioannis, Grigoriadis George, Grigoriadis Nikolaos, George Galazios (2017) An in silico Quantum Discord of a Two-Qubit Anisotropy XXZ Heisenberg Chain with Dzyaloshinskii-Moriya Interactions on a designed Fusion Inhibitor consisting of five cancer filtered conserved pharmacophoric chemical fragments with Greatly Promising Pharmaco-Mimic Properties to a Rationally Engineered Wilms’ Tumor Peptide as a future computer generated hyper-molecule for the potential treatment of the acute myeloid leukemia.

Authors Info

Grigoriadis Nikolaos
Department of IT Computer Aided Personalized Myoncotherapy, Cartigenea-Cardiogenea, Neurogenea-Cellgenea, Cordigenea-HyperoligandorolTM,
Biogenea Pharmaceuticals Ltd,
Thessaloniki, Greece;

Grigoriadis Ioannis
Department of Computer Drug Discovery Science, BiogenetoligandorolTM,
Biogenea Pharmaceuticals Ltd,
Thessaloniki, Greece;

Grigoriadis George
Department of Stem Cell Bank and ViroGeneaTM,
Biogenea Pharmaceuticals Ltd,
Thessaloniki, Greece;

George Galazios
Professor of Obstetrics and Gynecology,
Democritus University of Thrace,
Komotini, Greece;

E-mail: biogeneadrug@gmail.com

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