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Abstract

The Schrödinger perturbation energy for an arbitrary order N of the perturbation has been presented with the aid of a circular scale of time. The method is of a recurrent character and developed for a non-degenerate quantum state. It allows one to reduce the inflation of terms necessary to calculate known from the Feynman’s diagrammatical approach to a number below that applied in the original Schrödinger perturbation theory. Gene therapy using RNA interference (RNAi) technology has been explored to treat cancers, by regulating the expression of oncogene. However, even though small interfering RNA (siRNA), which triggers RNAi, may have great therapeutic potential, efforts at using them in vivo have been hampered by the difficulty of effective and safe delivery into cells of interest. Safe and efficient carrier for in vitro and in vivo siRNA delivery have been also developed by designed peptide libraries. These peptides are improved variants of a known peptide based siRNA carrier C6. Dark energy is shown to be the absolute value of the negative kinetic energy of the halo-like quantum wave modeled mathematically by the empty set in a five dimensional Kaluza-Klein (K-K) spacetime. Ordinary or position energy of the particle on the other hand is the dual of dark energy and is contained in the dynamic of the quantum particle modeled by the zero set in the same five dimensional K-K spacetime. The sum of both dark energy of the wave and the ordinary energy of the particle is exactly equal to the energy given by the well known formula of Einstein which is set in a four dimensional spacetime. Various interpretations of the results are presented and discussed based on the three fundamental energy density equations developed. In particular where E is the energy, m is the mass and c is the speed of light, is Hardy’s quantum entanglement and gives results in complete agreement with the cosmological measurements of WMAP and Supernova. On the other hand gives an intuitive explanation of negative gravity and the observed increased rate of cosmic expansion. Adding to one finds which as we mentioned above is Einstein’s famous relativity formula. We conclude that similar to the fact that the quantum wave interpreted generally as probability wave which is devoid of ordinary energy decides upon the location of a quantum particle, it also exerts a negative gravity effect on the cosmic scale of our clopen, i.e. closed and open universe. Analysis and conclusions are framed in a reader friendly manner in Figures 1-14 with detailed commentary Quantum Entanglement Dark Energy and Negative Gravity measurements plus Circular Scale of quantitative structure-activity relationship time as a Way of Calculating the Quantum-Mechanical Perturbation Energy Given by the Schrödinger Method with novel Stanisław Olszewski Accelerated Expansion Universe automated lazy learning modelings for the generation of pharmacophore-based custom fingerprinting of high quality atom encoding Endosomolytic Peptide-mimetic agent as siRNA carrier.

Keywords

Evaluation, Endosomolytic Biocompatible, Peptide-mimetic, Pharmacophores, Carriers, siRNA Delivery, Quantum-Mechanical Perturbation Energy, Circular Scale of Time1, Dark Kinetic Energy of the Quantum Wave; Ordinary Position Energy Quantum Particle; Anti Gravity; Negative Curvature; Collapse; Hawking-Hartle; Quantum Wave; Universe; Revising Einstein’s Relativity; Quantum Gravity;

Article Type

Research Article – Abstract

Publication history

Received: Sep 20, 2017
Accepted: Sep 25, 2017
Published: Oct 01, 2017

Citation

Grigoriadis Ioannis, Grigoriadis George, Grigoriadis Nikolaos, George Galazios (2017) Quantum Entanglement Dark Energy and Negative Gravity plus Circular Scale of quantitative structure-activity relationship time as a Way of Calculating the Quantum-Mechanical Perturbation Energy Given by the Schrödinger Method with novel Stanisław Olszewski Accelerated Expansion Universe automated lazy learning modelings for the generation of pharmacophore-based custom fingerprinting of high quality atom encoding Endosomolytic Peptide-mimetic agent as siRNA carrier.

Authors Info

Grigoriadis Nikolaos
Department of IT Computer Aided Personalized Myoncotherapy, Cartigenea-Cardiogenea, Neurogenea-Cellgenea, Cordigenea-HyperoligandorolTM,
Biogenea Pharmaceuticals Ltd,
Thessaloniki, Greece;

Grigoriadis Ioannis
Department of Computer Drug Discovery Science, BiogenetoligandorolTM,
Biogenea Pharmaceuticals Ltd,
Thessaloniki, Greece;

Grigoriadis George
Department of Stem Cell Bank and ViroGeneaTM,
Biogenea Pharmaceuticals Ltd,
Thessaloniki, Greece;

George Galazios
Professor of Obstetrics and Gynecology,
Democritus University of Thrace,
Komotini, Greece;

E-mail: biogeneadrug@gmail.com

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