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Abstract

A quantum analog of the computational complexity theory has been developed [7]–[8], with the introduction of complexity classes of easy and hard problems, the notion of difficulty being now with respect to the number of required operations on a quantum, instead of classical, computer. A new formulation of monotonically convergent algorithms which allows to optimize both the control duration and the field influence has been presented [9]. They apply this algorithm to the control of spin systems in Nuclear Magnetic Resonance and show how to implement CNOT gates in systems of two and four coupled spins. Also, a new formulation of quantum algorithm which allows to distribute amplitudes over two copies of small quantum subsystems has been proposed [10], where a standard algorithm designs a new method of a fixed number of copies and applied to the control of multi-qubit system. Keloids result from aberrations in the normal wound healing cascade and can lead to pruritus, contractures and pain. The underlying mechanisms of excessive scarring are not yet understood, and most therapeutic strategies remain unsatisfactory. Psoriasin (S100A7) and koebnerisin (S100A15) are released by keratinocytes during physiological wound healing. Psoriasin (S100A7) and koebnerisin (S100A15) are released by keratinocytes during physiological wound healing. S100 production is markedly decreased in keloid scar tissue. The disturbed epidermal S100 expression might contribute to keloid formation; thus, it has been previously studied their effect on dermal fibroblasts and extracellular matrix (ECM) production. Here, in Biogenea Pharmaceuticals Ltd we discovered for the first time the GENEA-AntiPsorerisin-10715. An in silico rational computer-aided designed of Antimicrobial Peptides Psoriasin (S100A7) and Koebnerisin (S100A15) mimetic pharmacophore for the Suppression of the Extracellular Matrix Production and Proliferation of Human Fibroblasts by Predicting interacting residues using long-distance information for the Collapsing a Perfect Superposition to a Chosen Quantum State without Measurements on in silico rational computer-aided design to Antimicrobial Peptide-mimetic Psoriasin (S100A7) and Koebnerisin (S100A15) high binding free energy pharmacophoric hyper-scaffolds as a novel synthetic pharmaco-ligand with potential inhibitory activities for the Suppression of the Extracellular Matrix Production and Proliferation of Human Fibroblasts in novel decoding hidden Markov models.

Keywords

Collapsing a Perfect Superposition; Chosen Quantum State; Measurement; rational computer-aided designed; Antimicrobial Peptide-mimetic; Psoriasin (S100A7); Koebnerisin; (S100A15); high binding free energy; pharmacophoric; hyper-scaffolds; novel synthetic pharmaco-ligand; potential inhibitory activities; Suppression of the Extracellular Matrix; Production; Proliferation of Human Fibroblasts.

Article Type

Research Article – Abstract

Publication history

Received: Sep 20, 2017
Accepted: Sep 25, 2017
Published: Oct 01, 2017

Citation

Grigoriadis Ioannis, Grigoriadis George, Grigoriadis Nikolaos, George Galazios (2017) Collapsing a Perfect Superposition to a Chosen Quantum State without Measurements on in silico rational computer-aided design to Antimicrobial Peptide-mimetic Psoriasin (S100A7) and Koebnerisin (S100A15) high binding free energy pharmacophoric hyper-scaffolds as a novel synthetic pharmaco-ligand with potential inhibitory activities for the Suppression of the Extracellular Matrix Production and Proliferation of Human Fibroblasts.

Authors Info

Grigoriadis Nikolaos
Department of IT Computer Aided Personalized Myoncotherapy, Cartigenea-Cardiogenea, Neurogenea-Cellgenea, Cordigenea-HyperoligandorolTM,
Biogenea Pharmaceuticals Ltd,
Thessaloniki, Greece;

Grigoriadis Ioannis
Department of Computer Drug Discovery Science, BiogenetoligandorolTM,
Biogenea Pharmaceuticals Ltd,
Thessaloniki, Greece;

Grigoriadis George
Department of Stem Cell Bank and ViroGeneaTM,
Biogenea Pharmaceuticals Ltd,
Thessaloniki, Greece;

George Galazios
Professor of Obstetrics and Gynecology,
Democritus University of Thrace,
Komotini, Greece;

E-mail: biogeneadrug@gmail.com

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